http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Choi, Chun-Yeon,Jo, Guk-Heui,Lee, Jung-Im,Seo, Young-Wan,Han, Tae-Jun,Choi, Il-Whan,Liu, Kwang-Hyeon,Oh, Sang-Taek,Kim, Dong-Eun,Jang, Won-Hee,Seog, Dae-Hyun,Park, Yeong-Hong,Yea, Sung-Su The Korean Society of Toxicogenomics and Toxicopro 2009 Molecular & cellular toxicology Vol.5 No.2
Alaria esculenta is a brown seaweed found in the Arctic. This study investigated the protective effect of A. esculenta extract (AEE) against oxidant-mediated injury and its mode of action in RAW264.7 macrophages. The methyl thiazolyl tetrazolium (MTT) assay showed that $H_2O_2$ treatment reduced cell viability, whereas AEE protected cells from $H_2O_2$-mediated cytotoxicity in a dose-dependent manner. Because heme oxygenase-1 (HO-1) is known to protect cells against oxidative damage, we investigated the effect of AEE on HO-1 gene expression and HO enzyme activity. The protective effect of AEE against $H_2O_2$-induced injury was correlated with increased HO enzyme activity. AEE also induced HO-1 mRNA and protein expression, as determined RT-PCR and Western blotting, respectively. To characterize the mechanisms by which AEE induces HO-1 gene expression, we examined the effect of AEE on the nuclear translocation of NF-E2-related factor-2 (Nrf2) and Akt phosphorylation. AEE treatment activated upstream signaling for HO-1 gene expression, including the nuclear translocation of Nrf2 and Akt phosphorylation. Collectively, these results suggest that AEE has anti-oxidant activity that is mediated, at least in part, via the activation of Nrf2 and Akt and the subsequent induction of HO-1 gene expression.
Antitumor Components Isolated from the Heartwood Extract of Dalbergia odorifera
( Chun Whan Choi ),( Yeon Hee Choi ),( Mi Ran Cha ),( Young Sup Kim ),( Gyu Hwan Yon ),( Young Kyoon Kim ),( Sang Un Choi ),( Young Ho Kim ),( Shi Yong Ryu ) 한국응용생명화학회 2009 Applied Biological Chemistry (Appl Biol Chem) Vol.52 No.4
Ongoing search for promising antitumor components from plant resources, we found that the methanol extract from the heartwood of Dalbergia odorifera (Leguminosae) demonstrated a significant inhibition on the proliferation of human tumor cell lines including multidrug resistant cells in vitro. Intensive bioassay-guided purification of the extract finally led to the isolation of seven flavonoids and two phenolic components as active constituents for antitumor property, in vitro, i.e., medicarpin (1), 2-hydroxy-3,4-dimethoxybeuzaldehyde (2), formononetin (3), tectorigenin (4), mucronulatol (5), (3R)-5`-methoxyvestitol (6), hydroxyobtustyrene (7), liquiritigenin (8), and (3R)-calussequinone (9), respectively.
Antitumor Components Isolated from the Heartwood Extract of Dalbergia odorifera
Choi, Chun-Whan,Choi, Yeon-Hee,Cha, Mi-Ran,Kim, Young-Sup,Yon, Gyu-Hwan,Kim, Young-Kyoon,Choi, Sang-Un,Kim, Young-Ho,Ryu, Shi-Yong The Korean Society for Applied Biological Chemistr 2009 Applied Biological Chemistry (Appl Biol Chem) Vol.52 No.4
Ongoing search for promising antitumor components from plant resources, we found that the methanol extract from the heartwood of Dalbergia odorifera (Leguminosae) demonstrated a significant inhibition on the proliferation of human tumor cell lines including multidrug resistant cells in vitro. Intensive bioassay-guided purification of the extract finally led to the isolation of seven flavonoids and two phenolic components as active constituents for antitumor property, in vitro, i.e., medicarpin (1), 2-hydroxy-3,4-dimethoxybenzaldehyde (2), formononetin (3), tectorigenin (4), mucronulatol (5), (3R)-5'-methoxyvestitol (6), hydroxyobtustyrene (7), liquiritigenin (8), and (3R)-calussequinone (9), respectively.
α-Glucosidase Inhibitiors from Seed Extract of Paeonia Lactiflora
( Chun Whan Choi ),( Yeon Hee Choi ),( Mi Ran Cha ),( Jee Hee Park ),( Young Sup Kim ),( Young Kyoon Kim ),( Sang Un Choi ),( Gyu Hwan Yon ),( Kyung Sik Hong ),( Young Ho Kim ),( Shi Yong Ryu ) 한국응용생명화학회 2009 Applied Biological Chemistry (Appl Biol Chem) Vol.52 No.6
Alpha-glucosidase inhibitors are oral antihyperglycemic agents that act on alpha-glucosidase competitively, delaying intestinal carbohydrate absorption and lessening postprandial increases in glucose levels. In the search for new classes of α-glucosidase inhibitors extracted from natural resources, 420 different plant extracts were evaluated for their inhibitory effect on α-glucosidase, in vitro. Amongst the tested extracts, the seed extract of Paeonia lactiflora (Paeoniaceae) demonstrated a significant degree of inhibition on the enzyme, according to dose. Extensive bioassay-guided fractionation of the extract resulted in the isolation of six materials, luteolin (1), resveratrol (2), trans-ε-viniferin (3), gnetin H (4), suffruticosol A (5) and suffruticosol B (6), that are active agents for α-glucosidase inhibition. Resveratrol (2) is a well-known naturally occurring hydroxystilbene, particularly abundant in wine and some related stilbene oligomers. Materials (3-6) exhibited relatively strong inhibition of α-glucosidase and their IC50 values were calculated as: 0.92mM (2), 3.15mM (3), 1.15 mM (4), 2.53mM (5) and 3.15mM (6). In contrast, the (IC50) value of the reference drug, acarbose, was estimated as 8.28mM in vitro.
Antitumor Components Isolated from the Heartwood Extract of Dalbergia odorifera
( Chun Whan Choi ),( Yeon Hee Choi ),( Mi Ran Cha ),( Young Sup Kim ),( Gyu Hwan Yon ),( Young Kyoon Kim ),( Sang Un Choi ),( Young Ho Kim ),( Shi Yong Ryu ) 한국응용생명화학회 2009 Journal of Applied Biological Chemistry (J. Appl. Vol.52 No.4
Antioxidant Constituents and a New Triterpenoid Glycoside from Flos Lonicerae
Choi, Chun-Whan,Jung, Hyun-Ah,Kang, Sam-Sik,Choi, Jae-Sue 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.1
As a component of our continuing investigations into herb-derived antioxidant agents, we have evaluated the antioxidant effects of Flos Lonicerae (Lonicera japonica flowers), via 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical, total reactive oxygen species (ROS), hydroxyl radical (OH), and peroxynitrite $(ONOO^-)$ assays. Among the methanolic extract and the dichloromethane, ethyl acetate, n-butanol, and water fractions, the EtOAc fraction of Flos Lonicerae exhibited marked scavenging/inhibitory activities, as follows: $IC_{50}$ values of 4.37, $27.58{\pm}0.71,\;0.47{\pm}0.05,\;and\;12.13{\pm}0.79{\mu}g/mL$ in the DPPH, total ROS, $ONOO^-$, and OH assays, respectively. Via a bioactivity-guided fractionation approach, a new triterpenoid glycoside, oleanolic acid $28-O-{\alpha}-L-rhamnopyranosyl-(1{\rightarrow}2)-[{\beta}-D-xylopyranosyl(1{\rightarrow}6)]-{\beta}-D-glucopyranosylester$ (12), along with eleven known compounds, including chrysoeriol(1), luteolin (2), 5-hydroxymethyl-2-furfural (3), caffeic acid (4), protocatechuic acid (5), chrysoeriol $7-O-{\beta}-D-glucopyranoside$ (6), isorhamnetin $3-O-{\beta}-D-glucopyranoside$ (7), kaempferol $3-O-{\beta}-D-glucopyranoside$ (8), quercetin $3-O-{\beta}-D-glucopyranoside$ (9), hederagenin $3-O-{\alpha}-L-arabinopyranoside$ (10), and luteolin $7-O-{\beta}-D-glucopyranoside$ (11), were isolated from the EtOAc fraction. The structures of isolated compounds 1-12 were elucidated via spectroscopic analyses. Compound 12 was isolated from a natural source for the first time. Compounds 2, 4, 5, 7, 9, and 11 evidenced marked scavenging activities, with $IC_{50}$ values of $2.08-11.76{\mu}M$ for DPPH radicals, and $1.47-6.98{\mu}M\;for\;ONOO^-$.
${\alpha}$-Glucosidase Inhibitiors from Seed Extract of Paeonia lactiflora
Choi, Chun-Whan,Choi, Yeon-Hee,Cha, Mi-Ran,Park, Jee-Hee,Kim, Young-Sup,Kim, Young-Kyoon,Choi, Sang-Un,Yon, Gyu-Hwan,Hong, Kyung-Sik,Kim, Young-Ho,Ryu, Shi-Yong The Korean Society for Applied Biological Chemistr 2009 Applied Biological Chemistry (Appl Biol Chem) Vol.52 No.6
Alpha-glucosidase inhibitors are oral antihyperglycemic agents that act on alpha-glucosidase competitively, delaying intestinal carbohydrate absorption and lessening postprandial increases in glucose levels. In the search for new classes of ${\alpha}$-glucosidase inhibitors extracted from natural resources, 420 different plant extracts were evaluated for their inhibitory effect on ${\alpha}$-glucosidase, in vitro. Amongst the tested extracts, the seed extract of Paeonia lactiflora (Paeoniaceae) demonstrated a significant degree of inhibition on the enzyme, according to dose. Extensive bioassay-guided fractionation of the extract resulted in the isolation of six materials, luteolin (1), resveratrol (2), trans-${\varepsilon}$-viniferin (3), gnetin H (4), suffruticosol A (5) and suffruticosol B (6), that are active agents for ${\alpha}$-glucosidase inhibition. Resveratrol (2) is a well-known naturally occurring hydroxystilbene, particularly abundant in wine and some related stilbene oligomers. Materials (3-6) exhibited relatively strong inhibition of ${\alpha}$-glucosidase and their $IC_{50}$ values were calculated as: 0.92mM (2), 3.15mM (3), 1.15 mM (4), 2.53mM (5) and 3.15mM (6). In contrast, the ($IC_{50}$) value of the reference drug, acarbose, was estimated as 8.28mM in vitro.