Analysis, Design and Implementation of an Interleaved Single-Stage AC/DC ZVS Converters

Lin, Bor-Ren,Huang, Shih-Chuan The Korean Institute of Power Electronics 2012 JOURNAL OF POWER ELECTRONICS Vol.12 No.2

An interleaved single-stage AC/DC converter with a boost converter and an asymmetrical half-bridge topology is presented to achieve power factor correction, zero voltage switching (ZVS) and load voltage regulation. Asymmetric pulse-width modulation (PWM) is adopted to achieve ZVS turn-on for all of the switches and to increase circuit efficiency. Two ZVS half-bridge converters with interleaved PWM are connected in parallel to reduce the ripple current at input and output sides, to control the output voltage at a desired value and to achieve load current sharing. A center-tapped rectifier is adopted at the secondary side of the transformers to achieve full-wave rectification. The boost converter is operated in discontinuous conduction mode (DCM) to automatically draw a sinusoidal line current from an AC source with a high power factor and a low current distortion. Finally, a 240W converter with the proposed topology has been implemented to verify the performance and feasibility of the proposed converter.

Alpinate Oxyphyllae Fructus Inhibits IGFII-Related Signaling Pathway to Attenuate Ang II-Induced Pathological Hypertrophy in H9c2 Cardiomyoblasts

Chuan-Te Tsai,Yung-Ming Chang,Shu-Luan Lin,Yueh-Sheng Chen,Yu-Lan Yeh,Viswanadha Vijaya Padma,Chin-Chuan Tsai,Ray-Jade Chen,Tsung-Jung Ho,Chih-Yang Huang 한국식품영양과학회 2016 Journal of medicinal food Vol.19 No.3

Angiotensin II (Ang II) is a very important cardiovascular disease inducer and may cause cardiac pathological hypertrophy and remodeling. We evaluated a Chinese traditional medicine, alpinate oxyphyllae fructus (AOF), for therapeutic efficacy for treating Ang II-induced cardiac hypertrophy. AOF has been used to treat patients with various symptoms accompanying hypertension and cerebrovascular disorders in Korea. We investigated its protective effect against Ang II-induced cytoskeletal change and hypertrophy in H9c2 cells. The results showed that treating cells with Ang II resulted in pathological hypertrophy, such as increased expression of transcription factors NFAT-3/p-NFAT-3, hypertrophic response genes (atrial natriuretic peptide [ANP] and b-type natriuretic peptide [BNP]), and Gαq down-stream effectors (PLCβ3 and calcineurin). Pretreatment with AOF (60–100 μg/mL) led to significantly reduced hypertrophy. We also found that AOF pretreatment significantly suppressed the cardiac remodeling proteins, metalloproteinase (MMP9 and MMP2), and plasminogen activator, induced by Ang II challenge. In conclusion, we provide evidence that AOF protects against Ang II-induced pathological hypertrophy by specifically inhibiting the insulin-like growth factor (IGF) II/IIR-related signaling pathway in H9c2 cells. AOF might be a candidate for cardiac hypertrophy and ventricular remodeling prevention in chronic cardiovascular diseases.

MicroRNA-21 Regulates the Invasion and Metastasis in Cholangiocarcinoma and May Be a Potential Biomarker for Cancer Prognosis

Huang, Qiang,Liu, Lei,Liu, Chen-Hai,You, Hao,Shao, Feng,Xie, Fang,Lin, Xian-Sheng,Hu, San-Yuan,Zhang, Chuan-Hai Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2

Background: MicroRNAs are noncoding RNA molecules that posttranscriptionally regulate gene expression. The aim of this study was to determine the role of microRNA-21 in cholangiocarcinomas and its relationship to cholangiocarcinoma RBE cell capacity for invasion and metastasis. Methods: MicroRNA-21 expression was investigated in 41 cases of cholangiocarcinoma samples by in situ hybridization and real-time PCR. Influence on cholangiocarcinoma cell line invasion and metastasis was analyzed with microRNA-21 transfected cells. In addition, regulation of reversion-inducing-cysteine-rich protein with kazal motifs (RECK) by microRNA-21 was elucidated to identify mechanisms. Results: In situ hybridization and real-time quantitative PCR results for patients with lymph node metastasis or perineural invasion showed significantly high expression of microRNA-21 (P<0.05). There was a dramatic decrease in cholangiocarcinoma cell line invasion and metastasis ability after microRNA-21 knockdown (P<0.05). However, overexpression significantly increased invasion and metastasis (P<0.05). Real-time PCR and Western-blot analysis showed that microRNA-21 could potentially inhibit RECK expression in RBE cells. Survival analysis showed that patients with higher expression levels of microRNA-21 more often had a poor prognosis (P<0.05). Conclusions: MicroRNA-21 may play an important role in cholangiocarcinoma invasion and metastasis, suggesting that MicroRNA-21 should be further evaluated as a biomarker for predicting cholangiocarcinoma prognosis.

Hydrodynamic coupling distance between a falling sphere and downstream wall

Lin, Cheng-Chuan,Huang, Hung-Tien,Yang, Fu-Ling Techno-Press 2018 Coupled systems mechanics Vol.7 No.4

In solid-liquid two phase flow, the knowledge of how descending solid particles affected by the presence of downstream wall is important. This work studies at what interstitial distance the velocity of a vertically descending sphere is affected by a downstream wall as a consequence of wall-modified hydrodynamic forces through a validated dynamic model. This interstitial distance-the hydrodynamic coupling distance ${\delta}_c-is$ found to decay monotonically with the approach Stokes number St which compares the particle inertia to viscous drag characterized by the quasi-steady Stokes' drag. The scaling relation ${\delta}_c-St-1$ decays monotonically as literature below the value of St equal to 10. However, the faster diminishing rate is found above the threshold value from St=10-40. Furthermore, an empirical relation of ${\delta}_c-St$ shows dependence on the drop height which clearly indicates the non-negligible effect of unsteady hydrodynamic force components, namely the added mass force and the history force. Finally, we attempt a fitting relation which embedded the particle acceleration effect in the dependence of fitting constants on the diameter-scaled drop height.

Prioritization of Sleep: Discrepancies Between Attitude and Practice

Ya-Chuan Huang,Tzu-Ting Lin,Chien-Ming Yang 대한수면연구학회 2023 Journal of sleep medicine Vol.20 No.3

Objectives: With the promotion of sleep through education, an increasing recognition of the importance of sleep among the general public has been observed. However, whether this increased recognition affects sleep practices is unknown. To provide direction for future sleep education programs, this study aimed to explore the consistency between people’s prioritization of sleep among their daily life activities and their actual practice when sleep conflicts with other activities.Methods: The study was a cross-sectional online survey with 898 adults (male:female=372:526; age=39.74±10.04 years). The participants were asked to complete an online survey that required them to 1) rate how important sleep was; 2) prioritize daily life activities including sleep, work, family activities, leisure activities, social activities, and exercise; and 3) recall the actions they undertook at the most recent instance when sleep conflicted with each of the other activities.Results: Although 70.7% of the participants prioritized sleep by placing it in their top three daily life activities, only 35.7% and 38.1% chose to go to sleep when it conflicted with work and family activities, respectively. Gender and occupational factors also significantly influenced the discrepancy between sleep attitudes and practices.Conclusions: Our study demonstrated an inconsistency between reporting sleep as a priority in daily life activities and actual behavioral practices when sleep conflicted with other activities. The results suggest that sleep education should not only emphasize the importance of sleep but also provide practical solutions for circumstances when sleep conflicts with other activities.

The Structure of Polysemy: A study of multi-sense words based on WordNet

( Jen Yi Lin ),( Chang Hua Yang ),( Shu Chuan Tseng ),( Chu Ren Huang ) 한국언어정보학회 2002 국제 워크샵 Vol.2002 No.-

The issues in polysemy with respect to the verbs in WordNet will be discussed in this paper. The hypernymy/hyponymy structure of the multiple senses is observed when we try to build a bilingual network for Chinese and English. There are several types of polysemic patterns and a co-hypernym may have the same word form as its subordinates. Fellbaum (2000) dubbed autotroponymy that the verbs linked by manner relation share the same verb form. However, her syntactic criteria seem not compatible to the hierarchies in WN. Either the criteria or the network should be reconducted. For most verbs in WN 1.7, polysemous relations are unlikely to extend over 3 levels of IS-A relation. Highly polysemous verbs are more complicated and may be involved in certain semantic structures. Semi-automatic sense grouping may be helpful for multimlinguital information retrieveal.

Analysis, Design and Implementation of an Interleaved Single-Stage AC/DC ZVS Converters

Bor-Ren Lin,Shih-Chuan Huang 전력전자학회 2012 JOURNAL OF POWER ELECTRONICS Vol.12 No.2

An interleaved single-stage AC/DC converter with a boost converter and an asymmetrical half-bridge topology is presented to achieve power factor correction, zero voltage switching (ZVS) and load voltage regulation. Asymmetric pulse-width modulation (PWM) is adopted to achieve ZVS turn-on for all of the switches and to increase circuit efficiency. Two ZVS half-bridge converters with interleaved PWM are connected in parallel to reduce the ripple current at input and output sides, to control the output voltage at a desired value and to achieve load current sharing. A center-tapped rectifier is adopted at the secondary side of the transformers to achieve full-wave rectification. The boost converter is operated in discontinuous conduction mode (DCM) to automatically draw a sinusoidal line current from an AC source with a high power factor and a low current distortion. Finally, a 240W converter with the proposed topology has been implemented to verify the performance and feasibility of the proposed converter.

The Lived Experiences of Foreign Spouses who Have Attempted Suicide in Taiwan

Yao-Yu Lin,Xuan-Yi Huang,Wen-Chuan Shao,Hong Chen 한국간호과학회 2009 한국간호과학회 학술대회 Vol.2009 No.10

Transcriptional analysis of Pieris rapae in response to P. rapae granulovirus

Hai-Jian Huang,Tong-Qiang Zhang,Qiao Lin, Jian-Hui Ye,Chuan-Xi ZHANG,Bao-Qin Zhang 한국응용곤충학회 2018 Journal of Asia-Pacific Entomology Vol.21 No.2

Pieris rapae granulovirus (PrGV) is an important pathogen that has been exploited as a microbial insecticide to control agriculture pests. They can specifically infect cabbage butterfly (Pieris rapae), causing a series of pathological symptoms. In this infected P. rapae at 6 h and 72 h. As a result, a series of host genes were significantly modulated following PrGV infection, including those correlated with exoskeleton, ribosome, heat shock protein (HSP), proteasome, oxidation-reduction and apoptosis. Taken together, our study unveiled the P. rapae response to PrGV at different time point and provided a potential strategy for pest management.

Nuclear Theranostics in Taiwan

Ko-Han Lin,Yi-Wei Chen,Rheun-Chuan Lee,Ling-Wei Wang,Fong-In Chou,Chi-Wei Chang,Sang-Hue Yen,Wen-Sheng Huang 대한핵의학회 2019 핵의학 분자영상 Vol.53 No.2

Boron neutron capture therapy and Y-90 radioembolization are emerging therapeutic methods for uncontrolled brain cancers and hepatic cancers, respectively. These advanced radiation therapies are heavily relied on theranostic nuclear medicine imaging before the therapy for the eligibility of patients and the prescribed-dose simulation, as well as the post-therapy scanning for assessing the treatment efficacy. In Taiwan, the Taipei Veterans General Hospital is the only institute performing the BNCT and also the leading institute performing Y-90 radioembolization. In this article, we present our single institute experiences and associated theranostic nuclear medicine approaches for these therapies.