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Cherry Tomatoes Ameliorate Scopolamine-induced Amnesia in Mice
Won-Hee Choi,Jiyun Ahn,Suna Kim,Tae-Youl Ha 한국식품영양과학회 2008 Preventive Nutrition and Food Science Vol.13 No.4
Cherry tomatoes are rich in antioxidants, which may protect against neurodegeneration and consequent memory loss. This study was conducted to investigate the effect of cherry tomatoes on scopolamine-induced amnesia in mice. Male ICR mice (4 weeks old) were maintained for 4 weeks on a diet containing 10 or 20% tomato powder (TP), and then administered scopolamine (1 ㎎/㎏ body weight, i.p.) 45 min before memory testing. Passive avoidance and Morris water maze testing revealed that scopolamine-induced amnesia was significantly reduced in the TP groups compared to the non TP-received (control) group. Accordingly, acetylcholinesterase activities in the serum and brain of TP groups were lower than those in the control group. These findings suggest that cherry tomatoes may be useful for the prevention of neurodegenerative diseases such as amnesia and Alzheimer’s disease.
Choi, Won Hee,Ahn, Jiyun,Jung, Chang Hwa,Jang, Young Jin,Ha, Tae Youl American Diabetes Association 2016 Diabetes Vol.65 No.9
<P>There has been great interest in the browning of fat for the treatment of obesity. Although beta-lapachone (BLC) has potential therapeutic effects on obesity, the fat-browning effect and thermogenic capacity of BLC on obesity have never been demonstrated. Here, we showed that BLC stimulated the browning of white adipose tissue (WAT), increased the expression of brown adipocyte-specific genes (e.g., uncoupling protein 1 [UCP1]), decreased body weight gain, and ameliorated metabolic parameters in mice fed a high-fat diet. Consistently, BLC-treated mice showed significantly higher energy expenditure compared with control mice. In vitro, BLC increased the expression of brown adipocyte-specific genes in stromal vascular fraction-differentiated adipocytes. BLC also controlled the expression of miR-382, which led to the upregulation of its direct target, Dio2. Upregulation of miR-382 markedly inhibited the differentiation of adipocytes into beige adipocytes, whereas BLC recovered beige adipocyte differentiation and increased the expression of Dio2 and UCP1. Our findings suggest that the BLC-mediated increase in the browning of WAT and the thermogenic capacity of BAT significantly results in increases in energy expenditure. Browning of WAT by BLC was partially controlled via the regulation of miR-382 targeting Dio2 and may lead to the prevention of diet-induced obesity.</P>
High Sensitivity Micro-fabricated Fluxgate Sensor with a Racetrack Shaped Magnetic Core
Choi, Won-Youl,Kim, So-Jung The Korean Institute of Electrical and Electronic 2005 Transactions on Electrical and Electronic Material Vol.6 No.3
We present a micro fluxgate magnetic sensor having solenoid coils and racetrack shaped magnetic core, which was designed to decrease the .operating power and magnetic flux leakage. Electroplated copper coils of $6\;{\mu}m$ thickness and the core of $3\;{\mu}m$ thickness were separated by benzocyclobutane (BCB) having a high insulation and good planarization characters. Permalloy $(Ni_{0.8}Fe_{0.2})$ as a magnetic core was also electroplated under 2000 gauss to induce the magnetic anisotropy. The core had the high DC effective permeability of $\~1,300$ and coercive field of $\~0.1$ Oe. The fabricated fluxgate sensor had the very small actual size of $3.0\times1.7\;mm^2$. The fluxgate sensor with a racetrack shaped core had the high sensitivity .of $\~350$ V/T at excitation condition of 3 $V_{P-P}$ and 2 MHz square wave. When two fluxgates were perpendicularly aligned in terrestrial field, their two-axis output signals were very useful to commercialize an electronic azimuth compass for the portable navigation system.
High Sensitivity Micro-fabricated Fluxgate Sensor with a Racetrack Shaped Magnetic Core
Won-Youl Choi,김소정 한국전기전자재료학회 2005 Transactions on Electrical and Electronic Material Vol.6 No.3
We present a micro fluxgate magnetic sensor having solenoid coils and racetrack shaped magnetic core, which was designed to decrease the operating power and magnetic flux leakage. Electroplated copper coils of 6 μm thickness and the core of 3 μm thickness were separated by benzocyclobutane (BCB) having a high insulation and good planarization characters. Permalloy (Ni0.8Fe0.2) as a magnetic core was also electroplated under 2000 gauss to induce the magnetic anisotropy. The core had the high DC effective permeability of ~1,300 and coercive field of ~0.1 Oe. The fabricated fluxgate sensor had the very small actual size of 3.0 ´ 1.7 mm2. The fluxgate sensor with a racetrack shaped core had the high sensitivity of ~350 V/T at excitation condition of 3 VP-P and 2 MHz square wave. When two fluxgates were perpendicularly aligned in terrestrial field, their two-axis output signals were very useful to commercialize an electronic azimuth compass for the portable navigation system.
Cherry Tomatoes Ameliorate Scopolamine-induced Amnesia in Mice
Choi, Won-Hee,Ahn, Ji-Yun,Kim, Su-Na,Ha, Tae-Youl The Korean Society of Food Science and Nutrition 2008 Preventive Nutrition and Food Science Vol.13 No.4
Cherry tomatoes are rich in antioxidants, which may protect against neurodegeneration and consequent memory loss. This study was conducted to investigate the effect of cherry tomatoes on scopolamine-induced amnesia in mice. Male ICR mice (4 weeks old) were maintained for 4 weeks on a diet containing 10 or 20% tomato powder (TP), and then administered scopolamine (1 mg/kg body weight, i.p.) 45 min before memory testing. Passive avoidance and Morris water maze testing revealed that scopolamine-induced amnesia was significantly reduced in the TP groups compared to the non TP-received (control) group. Accordingly, acetylcholinesterase activities in the serum and brain of TP groups were lower than those in the control group. These findings suggest that cherry tomatoes may be useful for the prevention of neurodegenerative diseases such as amnesia and Alzheimer's disease.
Choi, Hyun-Jong,Kim, Tae Woo,Na, Young-Heum,Seo, Doo-Won,Woo, Sang-Kuk,Huh, Joo-Youl,Kim, Sun-Dong Elsevier 2018 Journal of Power Sources Vol.406 No.-
<P><B>Abstract</B></P> <P>The effects of applying an inner coating of nanosized gadolinium-doped ceria, Gd<SUB>0.1</SUB>Ce<SUB>0.9</SUB>O<SUB>2-δ</SUB>, sols on the porous NiFe-metal support for solid oxide fuel cell application are investigated. The GDC nanosols are synthesized by a sol-gel method using metal-alkoxide precursors and the Ni/Fe ratio of metal support is optimized. Field-emission transmission electron microscope reveals that the synthesized sols have particle size of 2–3 nm. Metal supports based on alloys composed of Ni and Fe are used in this work, and the ratio of Ni/Fe is optimised. In case of Ni/Fe ratio of 9:1, high porosity (≥ 57%) metal supports are obtained and the physico-chemical compatibility between the NiFe-metal supports and the Ni-GDC anodes is improved. The I-V results demonstrate a remarkable improvement in the power density of the GDC nanosol-coated button cell (677 mW cm<SUP>−2</SUP>) compared to that of the uncoated cell (437 mW cm<SUP>−2</SUP>) at 650 °C. The total area specific resistance after the coating GDC nanosols significantly decrease from 0.226 Ω cm<SUP>2</SUP> to 0.125 Ω cm<SUP>2</SUP>. These results reflect that GDC nanosols play an important role in reducing the resistances due to the effective expansion of the triple phase boundary and the improved connectivity of the ionically conductive phase.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A GDC nanosol is synthesised by a sol-gel process using metal-alkoxide precursors. </LI> <LI> Total ASR after the coating of GDC nanosols decreased from 0.226 to 0.125 Ωcm<SUP>2</SUP>. </LI> <LI> Nanosol coating improves the electrochemical performance of metal supported SOFCs. </LI> </UL> </P>
Choi, Won-Youl,Park, No-Suk,Wiesner, Mark R.,Kim, Jong-Oh IWA Publishing 2010 Water Science & Technology Vol.62 No.4
<P>A self-organized nano-structured, photocatalytic TiO2 membrane with large surface area of anatase crystallites was successfully fabricated by anodization. The nano-structured anodized TiO2 membrane was characterized using SEM, XRD and TEM techniques and the operational parameters to fabricate such as anodization time and applied anodic potential were also investigated. The anodized TiO2 membrane showed high photocatalytic performance in terms of refractory organics decomposition, bacteria inactivation and membrane permeability, which suggests that problems of conventional photocatalytic treatment and membrane filtration in water and wastewater treatment may be reduced using this combined process.</P>