芎歸蔥蘇理中湯과 그 構成藥物群이 alloxan 으로 誘發된 高血糖 白鼠에 미치는 影響

朴宣東,崔外哲 대한본초학회 2001 大韓本草學會誌 Vol.16 No.2

The purpose of this study was to research the effect of Gunggwichongsoyjungtant(芎歸蔥蔬理中湯) and its component groups on diabetes in alloxan-induced diabetic rats. Sprague-Dawley male rats weighing 200±10 gm were randomly assigned to two normal, two control and eight experimental groups. The experimental groups were classified into Gunggwichongsoyijungtant(GT group), Bogihyulyak(G-1 group), Onleeyak(G-2 group) and Balsanyigiyak(G-3 group). Diabetes was experimentally induced by abdomental injection of 100 ㎎/㎏ of body weight of alloxan. Animals were sacrificed at the 6th and 11th day of diabetic states. The results were obtained as follows: In carbohydrate metabolism, the level of glucose in control group was three-fold higher after alloxan injection than that of normal group. In GT group the level of glucose was decreased by 48% compared with that of control group, and in component groups it was decreased by 72%, 81%, and 82% respectively. In fat metabolism, the level of triglyceride in serum were lower in GT group by 74% with high significant difference and had similar tendency in components groups compared with that of control group. The levels of total cholesterol in serum were lower in GT group by 81% with significancy and had similar tendency in components groups. And the levels of HDL on serum were increased in GT group by 144% with significant difference. And in component group it had similar tendency compared with that of control group. In protein metabolism, the level of total protein and albumin were higher in GT group by 121% and 134% respectively with high significant difference, and G-1, G-2 group in component group also increased with significant difference compared with control group. In kidney function, the level of creatinine and BUN were decreased in GT group by 77% and 62% respectively with high significant difference, and other groups were lower but with no significancy compared with control group. In liver function, the level of GOT, GPT, γ-GTP, ALP and bilirubin were lower in GT group with significant difference. And in component group, it had similar tendency compared with control group. These results suggest that Gunggwichongsoyijungtant(芎歸蔥蔬理中湯) has strong effect on diabetes, so it is useful to prevent diabetes, and G-1 group had more effect on diabetes than any other groups in component groups.

프랑킨센스 오일의 피부노화 억제 효과(Ⅱ)

최외숙(Oi-Sook Choi),권미화(Mi-Hwa Kwon),공민규(Min-Kyu Kong),이순희(Soon-Hee Lee),강성례(Sung-Rye Gang),김필순(Pil-Sun Kim),김영철(Young-Chul Kim) 환경독성보건학회 2008 환경독성보건학회지 Vol.23 No.2

The purpose of this study was to investigate the effects of frankincense oil in skin aging animal model. Skin aging was induced by both the irradiation of UVB and the application of squalene monohydroperoxide (Sq-OOH) to the back of experimental animals for 4 weeks. And at the same time experimental materials were applied topically. Six to seven weeks female SHR-1 hairless mice were divided into five groups including nor-mal (N: saline), control (C: UVB+Sq-OOH+saline), vehicle control (VC: UVB+Sq-OOH+jojoba oil), positive control (PC: UVB+Sq-OOH+0.01% retinoic acid) and experimental (E: UVB+Sq-OOH+3% Frankincense oil) groups, five animals each group. Lipid lamella and lipid content in stratum corneum of the E group were almost intact with a regular arrangement which were similar to the N group. Collagen fibers in dermis of the E group were almost intact with a regular arrangement which were similar to the N group. Relatively much less number of mast cells and inflammatory cells were found in the E group compared to the C group. The activities of XO, SOD and CAT were no significant difference between the E and N groups. In conclusion, the application of frankincense oil to the skin aging animal model reduced both the generation of free radicals and the damage of skin tissues. Therefore, frankincense oil can be used practically for the prevention or improvement of skin aging in terms of health promotion and beauty for the people.

Hairless 마우스에서 제라늄 오일의 피부노화 억제 효과(2) -조직학적 관찰을 중심으로-

김영철 ( Young Chul Kim ),민경진 ( Kyung Jin Min ),최외숙 ( Oi Sook Choi ) 한국미용학회 2008 한국미용학회지 Vol.14 No.2

To evaluate the skin aging inhibition effect of geranium oil, skin aging animal model was produced by both the irradiation of UVB and the application of squalene-OOH to SHR-1 hairless mice for 4 weeks. And at the same time 3% of geranium oil diluted in jojoba oil was applied topically. Lipid lamella and lipid content in stratum corneum of the geranium application group were almost intact with a regular arrangement which were similar to the normal group. Collagen fibers in dermis of the geranium application group were almost intact with a regular arrangement which were similar to the normal group. Relatively much less number of mast cells and inflammatory cells were found in geranium application group compared to the control group. The activities of XO, SOD and CAT were no significant difference between the geranium oil application group and normal group. In conclusion, the application of geranium oil to the skin aging animal model reduced both the generation of free radicals and the damage of skin tissues. Therefore, geranium oil can be used practically for the prevention or improvement of skin aging in terms of health promotion and beauty for the people.

Microstructure and Magnetic Properties of Sn added MnBi Bulk Magnets

Yang Yang,Jung Tae Lim,Jihoon Park,Hui-Dong Qian,Oi Lun Li,Jong-Woo Kim,Chul-Jin Choi 한국자기학회 2021 한국자기학회 학술연구발표회 논문개요집 Vol.31 No.2

Rare-earth free permanent magnets are current emerging issues of industry for the growing market demands. Among the rare-earth free permanent magnets, MnBi has attracted attention for large magnetocrystalline anisotropy constant (K₁ ≈ 1.6 MJ/m³, at 300 K) and unique positive temperature coefficient of coercivity (Hc). The low-temperature phase (LTP) of MnBi exhibits a saturation magnetization (Ms) of 80 emu/g, and the theoretical maximum energy product (BH)max 17.7 MGOe at room temperature. However, it is a challenge to fabricate MnBi bulk magnets while maintaining the superior magnetic properties of the powder, especially to prevent the reduction of Hc from powder to bulk. The effects of Sn adding on the microstructure and magnetic properties of MnBi bulk magnets have been systematically investigated. As kwon, the pure MnBi bulk magnets are challenging to reach high Hc in previous studies, and a few reference works have been reported about research on fabrication of high Hc MnBi bulks by adding the third element. It was found that the Sn-added MnBi bulk magnets show the increased Hc and the improved squareness, apparently related to restructuring the intergranular phase due to Sn element addition. The Hc of MnBi bulk magnet with 3 wt.% Sn reaches 11.6 kOe, which is 35 % higher than that of the pure MnBi magnet. In the sample of 1 wt.% Sn added MnBi bulk magnet, the Hc was elevated to 10.0 kOe, and the maximum energy product (BH)max was recorded of 7.84 MGOe at room temperature. This makes Sn added MnBi bulk magnet a promising candidate for next-generation rare-earth-free bulk magnets. 〈그림 본문참조〉

Effects of homogenization temperature on magnetic properties of Mn₄C bulk magnets

Baochao Zhang,Tianhong Zhou,Xing Zheng,Youngwoon Song,Pingzhan Si,Oi Lun Li,Chul-Jin Choi,Jihoon Park 한국자기학회 2024 한국자기학회 학술연구발표회 논문개요집 Vol.34 No.1

Effects of Sn Addition on the Microstructure and Magnetic Properties of MnBi Bulk Magnets

Yang Yang,Jung Tae Lim,Jihoon Park,Hui-Dong Qian,Oi Lun Li,Jong-Woo Kim,Chul-Jin Choi 한국자기학회 2021 한국자기학회 학술연구발표회 논문개요집 Vol.31 No.1

Rare-earth free permanent magnets are current emerging issues of industry for the growing market demands. Among the rare-earth free permanent magnets, MnBi has attracted attention for large magneto crystalline anisotropy constant (K1 ≈ 1.6 MJ/m³, at 300 K) [1] and unique positive temperature coefficient of coercivity (H_c) [2]. The low-temperature phase (LTP) of MnBi exhibits a saturation magnetization (M_s) of 80 emu/g, and the theoretical maximum energy product (BH)_max 17.7 MGOe at room temperature [3]. However, it is a challenge to fabricate MnBi bulk magnets while maintaining the superior magnetic properties of the powder, especially to prevent the reduction of H_c from powder to bulk. The effects of Sn adding on the microstructure and magnetic properties of MnBi bulk magnets have been systematically investigated. As kwon, the pure MnBi bulk magnets are challenging to reach high H_c in previous studies, and a few reference works have been reported about research on fabrication of high H_c MnBi bulks by adding the third element. It was found that the Sn-added MnBi bulk magnets show the increased H_c and the improved squareness, apparently related to restructuring the intergranular phase due to Sn element addition. The H_c of MnBi bulk magnet with 3 wt.% Sn reaches 11.6 kOe, which is 35 % higher than that of the pure MnBi magnet. In the sample of 1 wt.% Sn added MnBi bulk magnet, the H_c was elevated to 10.0 kOe, and the maximum energy product (BH)_max was recorded of 7.84 MGOe at room temperature. This makes Sn added MnBi bulk magnet a promising candidate for next-generation rare-earth-free bulk magnets.

The effects of composition on microstructure and magnetic properties of MnBi alloys

Yang Yang,Yongho Shin,Hui-Dong Qian,Ping-Zhan Si,Jihoon Park,Oi Lun Li,Jong-Woo Kim,Chul-Jin Choi 한국자기학회 2018 한국자기학회 학술연구발표회 논문개요집 Vol.2018 No.11

대황감초음자(大黃甘草飮子)와 그 구성약물군(構成藥物群)이 Alloxan 유도 당뇨(糖尿) 백서(白鼠)의 혈청 조성 및 항산화 효과에 미치는 영향

고원도,곽동걸,신화석,최오철,박선동,Go Won-Do,Gwak Dong-Gul,Shin Hwa-Seog,Choi Oi-Chul,Park Sun-Dong 대한한의학방제학회 2002 大韓韓醫學方劑學會誌 Vol.10 No.2

The purpose of this study was to reseach the effect of Daehwanggamchoeumja(大黃甘草飮子) and its component groups on diabetes, free radicals, and antioxidants system in Alloxan-induced diabetic rats. The experimental group was divided into three groups: Daehwanggamchoeumja(DG), and its components groups, Gamdutang (Gamcho&Daedu; DG-I) and Daehwanggamchotang(DG-2). The results were obtained as follows: 1. In the study of effect on diabetic metabolic dysfunction(Glucose, Triglyceride, Total Cholesterol, HDL Cholesterol, Total Protein, Albumin, Creatine, BUN), only DG has a significant effect. 2. In the study on free radical scavenging effect in vitro(the suppressing effect on peroxidation of linoleic acid on concentration, the scavenging effect of DPPH radical, inhibitory effect of superoxide in xanthine-xanthine oxidase system, inhibitory effect on lipid peroxidation reaction by hydroxy radical in $H_2O_2Fe^{2-}$system, and the effect on Nitrate reductase activity), DG and DG-2 have more effect than DG-l relatively. 3. In the study on antioxidants system in vivo(The level of serum LPO, The level of hepatic LPO, Catalase, GSH, GST), only DG has a significant effect. These results suggest that Daehwanggamchoeumja(大黃甘草飮子) has an effect on diabetes, peroxidative damage by free radical, so it seems to be useful to prevent and treat diabetes. The mechanisms of these are supposed to be involved in antioxidant and three drugs' cooperative synergy effect.

Effects of Ga-doping on the microstructure and magnetic properties of MnBi alloys

Yang, Yang,Kim, Jong-Woo,Si, Ping-Zhan,Qian, Hui-Dong,Shin, Yongho,Wang, Xinyou,Park, Jihoon,Li, Oi Lun,Wu, Qiong,Ge, Hongliang,Choi, Chul-Jin Elsevier 2018 JOURNAL OF ALLOYS AND COMPOUNDS Vol.769 No.-

<P><B>Abstract</B></P> <P>The low temperature phase Mn<SUB>55</SUB>Bi<SUB>45-<I>x</I> </SUB>Ga<SUB> <I>x</I> </SUB> (<I>x</I> = 0, 1, 3, 5, and 10) alloys were prepared by induction melting process with subsequent low temperature annealing. The effects of Ga-doping on the crystal structure and magnetic properties of the alloys were systematically studied. The room temperature coercivities of Mn<SUB>55</SUB>Bi<SUB>45-<I>x</I> </SUB>Ga<SUB> <I>x</I> </SUB> after ball milling increased from 1.43 T for <I>x</I> = 0 to 1.66 T for <I>x</I> = 5, while the saturation magnetization decreased from 60.7 Am<SUP>2</SUP>/kg (<I>x</I> = 0) to 45.1 Am<SUP>2</SUP>/kg (<I>x</I> = 5). The maximum energy product (<I>BH</I>)<SUB>max</SUB> of Mn<SUB>55</SUB>Bi<SUB>44</SUB>Ga powders reached 7.87 MGOe. The Curie temperature of the Mn<SUB>55</SUB>Bi<SUB>45-<I>x</I> </SUB>Ga<SUB> <I>x</I> </SUB> alloys increased from 633 K to 658 K with increasing Ga concentration in the range of 0 ≤ <I>x</I> ≤ 5.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Effects of doping Ga on the microstructural and magnetic properties of MnBi alloy. </LI> <LI> The MnBi-Ga powders are achieved by surfactant assisted high energy ball milling. </LI> <LI> The maximum energy produce (<I>BH</I>)<SUB>max</SUB> shows 7.87 MGOe for Mn<SUB>55</SUB>Bi<SUB>44</SUB>Ga sample. </LI> <LI> The coercivity of Mn<SUB>55</SUB>Bi<SUB>40</SUB>Ga<SUB>5</SUB> after ball milling reached 1.66 T at room temperature. </LI> <LI> The elevated curie temperature (<I>T</I> <SUB>c</SUB>) by doping Ga makes it a possible candidate for high temperature applications. </LI> </UL> </P>

The effect of Sn substitution on magnetic properties of MnBi

Yang Yang,Jong-Woo Kim,Jihoon Park,Jung Tae Lim,Hui-Dong Qian,Oi Lun Li,Chul-Jin Choi 한국자기학회 2019 한국자기학회 학술연구발표회 논문개요집 Vol.29 No.2