http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
The association between dietary sodium intake and adiposity, inflammation, and hormone markers
Choi, Jeong-Hwa,Heo, Young-Ran 한국영양학회 2017 Journal of Nutrition and Health Vol.50 No.6
Purpose: Excess intake of sodium is a major diet-related risk factor for human diseases including hypertension and cancer as well as obesity and inflammation. However, findings are still controversial, and evidence is lacking in Koreans. Therefore, for better understanding of the role of dietary sodium intake in disease etiology, this study investigated the effects of dietary sodium intake on adiposity, inflammation, and hormones in Koreans. Methods: A total of 80 males and females joined the study. The general characteristics and dietary intake data were investigated by trained interviewers using a questionnaire and 24-h dietary recall, respectively. For the markers of adiposity, body weight, body mass index, percent of body fat, visceral fat area, and waist and hip circumference were measured. For the inflammation and hormone markers, leptin, adiponectin, insulin, tumor necrosis factor-α, and interleukin-6 were also analyzed. Results: Multivariate linear regression analyses suggested that dietary sodium intake was not associated with adiposity. However, dietary sodium showed a significant association with insulin level: Plasma insulin concentration increased with sodium intake independent of other dietary intake or percent of body fat (β= 0.296, adjusted r² = 0.276, p < 0.01). Other markers for inflammation and hormonal responses were not associated with dietary sodium intake. Conclusion: Findings suggested that dietary sodium intake may be a critical modifying factor in the level of plasma insulin. However, it showed a limited effect on obesity and other inflammation markers and hormone levels. These findings should be confirmed in larger, well-designed investigations.
Choi, Jae-Hoon,Park, Jong-Gil,Jeon, Hyung-Jun,Kim, Mi-Sun,Lee, Mi-Ran,Lee, Mi-Ni,Sonn, Seong-Keun,Kim, Jae-Hong,Lee, Mun-Han,Choi, Myung-Sook,Park, Yong-Bok,Kwon, Oh-Seung,Jeong, Tae-Sook,Lee, Woo-Son Korean Society for Biochemistry and Molecular Bion 2011 Experimental and molecular medicine Vol.43 No.8
A variety of benzylidenethiazole analogs have been demonstrated to inhibit 5-lipoxygenase (5-LOX). Here we report the anti-atherogenic potential of 5-(4-hydroxy-2,3,5-trimethylbenzylidene) thiazolidin-2,4-dione (HMB-TZD), a benzylidenethiazole analog, and its potential mechanism of action in LDL receptor-deficient ($Ldlr^{-/-}$) mice. HMB-TZD Treatment reduced leukotriene $B_4$ ($LTB_4$) production significantly in RAW264.7 macrophages and SVEC4-10 endothelial cells. Macrophages or endothelial cells pre-incubated with HMB-TZD for 2 h and then stimulated with lipopolysaccharide or tumor necrosis factor-alpha (TNF-${\alpha}$) displayed reduced cytokine production. Also, HMB-TZD reduced cell migration and adhesion in accordance with decreased proinflammatory molecule production $in$ $vitro$ and $ex$ $vivo$. HMB-TZD treatment of 8-week-old male $Ldlr^{-/-}$ mice resulted in significantly reduced atherosclerotic lesions without a change to plasma lipid profiles. Moreover, aortic expression of pro-atherogenic molecules involved in the recruitment of monocytes to the aortic wall, including TNF-${\alpha}$, MCP-1, and VCAM-1, was downregulated. HMB-TZD also reduced macrophage infiltration into atherosclerotic lesions. In conclusion, HMB-TZD ameliorates atherosclerotic lesion formation possibly by reducing the expression of proinflammatory molecules and monocyte/macrophage recruitment to the lesion. These results suggest that HMB-TZD, and benzylidenethiazole analogs in general, may have therapeutic potential as treatments for atherosclerosis.
Choi, Jung Ran,Kim, Jeong-Oh,Kang, Dae Ryong,Shin, Jung-Young,Zhang, Xiang Hua,Oh, Ji Eun,Park, Ji-Young,Kim, Kyoung-Ah,Kang, Jin-Hyoung Korean Cancer Association 2015 Cancer Research and Treatment Vol.47 No.3
<P><B>Purpose</B></P><P>Dose-limiting toxicities of docetaxel are widely considered to be neutropenia, anemia, skin toxicity, and nausea. One of the factors that limit the use of docetaxel is its unpredictability of inter-individual variation in toxicity.</P><P><B>Materials and Methods</B></P><P>In order to identify the genetic factors that affect the risk of docetaxel-induced toxicities, we recruited patients who received docetaxel chemotherapy. We genotyped 92 patients with single-nucleotide polymorphisms (SNPs) in 5 genes: <I>CYP3A4</I> (<I>CYP3A4<SUP>*</SUP>1B</I>, <I>CYP3A4<SUP>*</SUP>18</I>, and <I>CYP3A4<SUP>*</SUP>3</I>), <I>CYP3A5</I> (<I>CYP3A5<SUP>*</SUP>2</I> and <I>CYP3A5<SUP>*</SUP>3</I>), <I>ABCB1</I> (C1236T, G2677G/T, and C3435T), <I>SLCO1B3</I> (rs11045585), and <I>ABCC2</I> (rs12762549).</P><P><B>Results</B></P><P>Out of 92 patients, 70 had grade 3 or 4 neutropenia; 4 had grade 1 or 2; and 18 had no toxicity (76.1%, 4.3%, and 19.6%, respectively). The findings of the SNP analysis showed that patients with TT genotype of <I>ABCB1</I> 3435C>T polymorphism showed significantly higher risk of neutropenia and anemia (p=0.029 and p=0.044, respectively). There were significant associations between docetaxel-induced leucopenia and 2677G/T of <I>ABCB1</I> and rs12762549 of <I>ABCC2</I> (p=0.025 and p=0.028, respectively). In a multivariate analysis, we observed that patients carrying 2677G>T in <I>ABCB1</I>might be associated with higher risk of chemo-resistance when treated with docetaxel (odds ratio [OR], 6.48; confidence interval, 1.92 to 21.94; p=0.003). In a subgroup analysis of non-small cell lung cancer patients, a significant association of tumor response with G2677T/A (OR, 4.54) in <I>ABCB1</I> and <I>SLCO1B3</I> (OR, 9.44) was observed.</P><P><B>Conclusion</B></P><P>Our data suggest that <I>ABCB1</I> (2677G/T) and <I>SLCO1B3</I> (rs11055585) might be major genetic predictors of docetaxel-related toxicities in patients receiving docetaxel chemotherapy.</P>
Choi, Jeong-Ran,Lee, Young Sil,Park, Soo-Jin Elsevier 2014 Journal of industrial and engineering chemistry Vol.20 No.5
<P><B>Abstract</B></P> <P>In this work, the effects of electroless Ni–B plating on thermal conductivity and fracture toughness of Ni–B multi-walled carbon nanotubes (MWCNTs)/epoxy matrix composites were examined. From the results, it was found that the thermal conductivity increases with increasing contents of electroless Ni–B MWCNTs. The critical stress intensity factor (<I>K</I> <SUB>IC</SUB>) also increased with increasing contents of electroless Ni–B MWCNTs. However, it rather decreased at over 10phr. It is considered that this is because non-uniform distribution and partial entanglement occurred in case the contents of electroless Ni–B MWCNTs were high.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The electroless Ni–B plated MWNCTs were processed by 2 steps (activation process and metal deposition process). </LI> <LI> The thermal conductivity increases with increasing contents of electroless Ni–B MWCNTs. </LI> <LI> The heat transfer is attributed to increase the number of contact points between the Ni–B MWCNTs and the epoxy matrix with increasing content of Ni–B MWCNTs. </LI> <LI> Paper proposed to “Journal of Industrial and Engineering Chemistry”. </LI> </UL> </P>
Jeong, Junhui,Kim, Minbum,Heo, Ji Hye,Bang, Mi-Young,Bae, Mi Ran,Kim, Jungmin,Choi, Jae Young Lippincott Williams Wilkins 2015 Otology & Neurotology Vol.36 No.2
OBJECTIVE: Perimodiolar electrode arrays were developed to improve stimulation of specific neuronal populations and to decrease power consumption; however, they can damage the cochlear structure. We examined and compared psychophysical parameters of perimodiolar and lateral-type electrode arrays in patients who received a different type of bilateral cochlear implant (CI) in each ear. STUDY DESIGN: Retrospective analysis. SETTING: Tertiary referral center. PATIENTS: Eight child patients (three males, five females) received a different CI in each ear (perimodiolar array and lateral array). They received the CIs sequentially (n = 7) or simultaneously (n = 1). INTERVENTIONS: Diagnostic, therapeutic, and rehabilitative. MAIN OUTCOME MEASURES: Electrically evoked compound action potential, threshold level, comfort level, and dynamic range (DR) of the basal, mid, and apical electrodes were compared. We also surveyed battery consumption for each device. RESULTS: Electrically evoked compound action potential threshold, threshold level, and comfort level were lower for the perimodiolar-type electrode array than for the lateral-type electrode array in most patients. However, the DR for the perimodiolar array was narrower than for the lateral array. For most patients, there was little difference in battery life. CONCLUSION: Although the level of electrical energy required for auditory stimulation seems to be lower for the perimodiolar electrode array than for the laterally placed array, the DR was wider and the amount of battery consumption was similar. The electrode array should be chosen by considering various patient factors, such as residual hearing.