Molecular Identification of Diphyllobothrium latum from a Pediatric Case in Taiwan

Yu-Chin An,Chia-Cheng Sung,Chih-Chien Wang,Hsin-Chung Lin,Kuang-Yao Chen,Fu-Man Ku,Ruei-Min Chen,Mei-Li Chen,Kuo-Yang Huang 대한기생충학열대의학회 2017 The Korean Journal of Parasitology Vol.55 No.4

Enhancement of Aggregation-Induced Emission in Dye-Encapsulating Polymeric Micelles for Bioimaging

Wu, Wen-Chung,Chen, Ching-Yi,Tian, Yanqing,Jang, Sei-Hum,Hong, Yuning,Liu, Yang,Hu, Rongrong,Tang, Ben Zhong,Lee, Yi-Ting,Chen, Chin-Ti,Chen, Wen-Chang,Jen, Alex K.-Y. WILEY-VCH Verlag 2010 Advanced Functional Materials Vol.20 No.9

<P>Three amphiphilic block copolymers are employed to form polymeric micelles and function as nanocarriers to disperse hydrophobic aggregation-induced emission (AIE) dyes, 1,1,2,3,4,5-hexaphenylsilole (HPS) and/or bis(4-(N-(1-naphthyl) phenylamino)-phenyl)fumaronitrile (NPAFN), into aqueous solution for biological studies. Compared to their virtually non-emissive properties in organic solutions, the fluorescence intensity of these AIE dyes has increased significantly due to the spatial confinement that restricts intramolecular rotation of these dyes and their better compatibility in the hydrophobic core of polymeric micelles. The effect of the chemical structure of micelle cores on the photophysical properties of AIE dyes are investigated, and the fluorescence resonance energy transfer (FRET) from the green-emitting donor (HPS) to the red-emitting acceptor (NPAFN) is explored by co-encapsulating this FRET pair in the same micelle core. The highest fluorescence quantum yield (∼62%) could be achieved by encapsulating HPS aggregates in the micelles. Efficient energy transfer (>99%) and high amplification of emission (as high as 8 times) from the NPAFN acceptor could also be achieved by spatially confining the HPS/NPAFN FRET pair in the hydrophobic core of polymeric micelles. These micelles could be successfully internalized into the RAW 264.7 cells to demonstrate high-quality fluorescent images and cell viability due to improved quantum yield and reduced cytotoxicity.</P> <B>Graphic Abstract</B> <P>Highly efficient fluorescence probes are achieved through the encapsulation of aggregation-induced emission molecules, 1,1,2,3,4,5-hexaphenylsilole (HPS) and/or bis(4-(N-(1-naphthyl) phenylamino)-phenyl)fumaronitrile (NPAFN) in the core of polymeric micelles. Bright fluorescence cell images are shown with tunable colors of green directly from HPS aggregates and red through efficient fluorescence resonance energy transfer (FRET) from HPS aggregates to NPAFN aggregates. <img src='wiley_img_2010/1616301X-2010-20-9-ADFM200902043-content.gif' alt='wiley_img_2010/1616301X-2010-20-9-ADFM200902043-content'> </P>

Research on Correlation between Innovative Activities & Development Strategies of New Product and Development Performance in Taiwan's High-tech Companies

Chung, Yi-Chan,Tsai, Chih-Hung,Deng, Wei-Jaw,Chen, Wen-Chin The Korean Society for Quality Management 2006 The Asian Journal on Quality Vol.7 No.2

Due to the advancement of technology and rapidly changing environment of the market, the life cycle of high-tech products is becoming shorter. The enterprise must constantly innovate and select correct development strategy of new product in order to respond to customers' demands for upgrading operational performance of industry. Development of new product is the critical activity for enterprise's survival and growth. This research focuses on the effects of Taiwan high-tech companies' introduction of innovative activity and development strategy of new product on development performance of new product for analysis and exploration. The result findings reveal that: (1) High execution degree of innovative activity has positive effect on the implementation of development strategy of new product; (2) The companies with better implementation of development strategy of new product reveal better development performance; (3) The companies with higher degree of execution of innovative activity and better execution of development strategy of new product reveal better development performance of new product.

Fabrication of blue top-emitting organic light-emitting devices with highly saturated color

Chin H.Chen,Chung-Chun Lee,Andrew T.Hu,Shih Feng Hsu 한국물리학회 2004 Current Applied Physics Vol.4 No.6

Blue top-emitting organic light-emitting devices (TOLEDs) with highly saturated color were developed by microcavity eect. Thedevice structure studied was glass/reective silver/indium-tin oxide (ITO)/organic electroluminescent stack/semi-transparent cathode(calcium/silver). By changing the thicknesses of ITO and organic layers in the microcavity structure device doped withp-bis(p-N,N-di-phenyl-aminostyryl)benzene (DSA-ph), highly saturated color with Commission Internationale de L’Eclairage chromaticitycoordinates (CIEx;y) of (0.14, 0.08) was obtained.

Magnetization Reversal of Co/Pd Multilayers on Si Substrates and AAO Membranes

Chin-Chung Yu,Yung-Shiang Teng,Yu-Kuan Huang,Shih-Yuan Chen,Yeong-Der Yao 한국자기학회 2008 한국자기학회 학술연구발표회 논문개요집 Vol.- No.-

Effect of a vertical guide plate on the wind loading of an inclined flat plate

Chung, Kung-Ming,Chou, Chin-Cheng,Chang, Keh-Chin,Chen, Yi-Jun Techno-Press 2013 Wind and Structures, An International Journal (WAS Vol.17 No.5

Wind tunnel experiments were performed to study the wind loads on an inclined flat plate with and without a guide plate. Highly turbulent flow, which corresponded to free-stream turbulence intensity on the flat roof of low-rise buildings, was produced by a turbulence generation grid at the inlet of the test section. The test model could represent a typical solar collector panel of a solar water heater. There are up-stream movements of the separation bubble and side-edge vortices, more intense fluctuating pressure and a higher bending moment in the turbulent flow. A guide plate would result in higher lift coefficient, particularly with an increased projected area ratio of a guide plate to an inclined flat plate. The value of lift coefficient is considerably lower with increased free-stream turbulent intensity.

Order Imbalances in Options and Volatility Risk Premium on Equity Index

Chin-Ho Chen,Huimin Chung,Wen-Liang G. Hsieh,Shu-Fang Yuan 한국재무학회 2011 한국재무학회 학술대회 Vol.2011 No.09

This study explores the impact of aggregate daily order imbalances in options on volatility risk premium on its underlying index. Two types of volatility risk premium, ex-post and ex-ante volatility risk premiums, are included to address this issue. Based on Taiwan stock index and options (TXO) data over the period from January 1, 2005 to December 31, 2009, several interesting results emerge. First, order imbalances in near-month options, especially for call options’, have a predominant influence on ex-post and ex-ante volatility risk premiums. Next, order imbalances of near-month options in either direction, excess buy orders or excess sell order, have distinct effect on volatility risk premium. Overall, the increased level of excess buy orders drives ex-post and ex-ante volatility risk premiums upward, but downward only for excess sell orders in call options. Finally, ex-post and ex-ante volatility risk premiums are positively related to order imbalances of near-month options in respond to continuous price variations. Nonetheless, there is no significant relation for index price jumps.

Clinical and Histologic Features of Patients with Biopsy-Proven Metabolic Dysfunction-Associated Fatty Liver Disease

( Shang-chin Huang ),( Hau-jyun Su ),( Jia-horng Kao ),( Tai-chung Tseng ),( Hung-chih Yang ),( Tung-hung Su ),( Pei-jer Chen ),( Chun-jen Liu ) 대한간학회 2021 Gut and Liver Vol.15 No.3

Background/Aims: Fatty liver disease is defined as a cluster of diseases with heterogeneous etiologies, and its definition continues to evolve. The novel conceptional criteria for metabolic dysfunction-associated fatty liver disease (MAFLD) were proposed in 2020 to avoid the exclusion of a certain subpopulation, but their evaluations have been limited. We aimed to examine and compare the clinical as well as histologic features of MAFLD versus nonalcoholic fatty liver disease (NAFLD) in patients with biopsy-proven hepatic steatosis. Methods: From January 2009 to December 2019, 175 patients with histology-proven hepatic steatosis and 10 with cryptogenic cirrhosis who were treated at National Taiwan University Hospital, Taipei, Taiwan, were enrolled. Patients were classified into different groups according to the diagnostic criteria of MAFLD and NAFLD. The clinical and histologic features were then analyzed and compared. Results: In total, 76 patients (41.1%) were diagnosed with both MAFLD and NAFLD, 81 patients (43.8%) were diagnosed with MAFLD alone, nine patients (4.9%) were diagnosed with NAFLD alone, and 19 patients (10.3%) were diagnosed with neither. Those with MAFLD alone exhibited a higher degree of disease severity regarding histology and laboratory data than those with NAFLD alone. Advanced fibrosis was associated with the presences of hepatitis B virus infection and metabolic diseases. Conclusions: The novel diagnostic criteria for MAFLD include an additional 38.9% of patients with hepatic steatosis and can better help identify those with a high degree of disease severity for early intervention than can the previous NAFLD criteria. (Gut Liver 2021;15:451-458)

Dexamethasone Downregulates Expressions of 14-3-3β and γ-Isoforms in Mice with Eosinophilic Meningitis Caused by Angiostrongylus cantonensis Infection

Hung-Chin Tsai,Yu-Hsin Chen,Chuan-Min Yen,Li-Yu Chung 대한기생충학ㆍ열대의학회 2019 The Korean Journal of Parasitology Vol.57 No.3

Steroids are commonly used in patients with eosinophilic meningitis caused by A. cantonensis infections. The mechanism steroids act on eosinophilic meningitis remains unclear. In this mouse experiments, expressions of 14-3-3 isoform β and γ proteins significantly increased in the CSF 2-3 weeks after the infection, but not increasedin the dexa- methasone-treated group. Expression of 14-3-3 β, γ, ε, and θ isoforms increased in brain meninges over the 3-week pe- riod after infection and decreased due to dexamethasone treatment. In conclusion, administration of dexamethasone in mice with eosinophilic meningitis decreased expressions of 14-3-3 isoform proteins in the CSF and in brain meninges.

The planning strategy of robotics technology for nuclear decommissioning in Taiwan

Tu Chung Yi,Chen Kuen Tsann,Ting Kuen,Yang Sheng Chin 한국원자력학회 2024 Nuclear Engineering and Technology Vol.56 No.1

According to the market research report, the nuclear decommissioning services market is currently experiencing considerable growth, with a projected Compound Annual Growth Rate (CAGR) of nearly 13% during the 2020–2024 forecast period. This expansion is primarily fueled by the advancement of Industry 4.0, in conjunction with the emergence of cutting-edge technologies such as the Internet of Things, big data, artificial intelligence, and 5G. Even though the fact that robots have already been utilized in the nuclear industry, their adoption has been hindered by conservative regulations. However, the nuclear decommissioning market presents an opportunity for the advancement of robotics technology. The British have already invested heavily in encouraging the use of intelligent robots for nuclear decommissioning, and other countries, such as Taiwan, should follow suit. Taiwan’s flourishing robotics development industry in manufacturing, logistics, and other domains can be leveraged to introduce advanced robotics in the decommissioning of its nuclear power plants. By doing so, Taiwan can establish itself as a competitive player in the nuclear decommissioning services market for the next two decades.