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고철우,구자훈,안두홍,김재식 慶北大學校 醫科大學 1989 慶北醫大誌 Vol.30 No.2
A prospective study was conducted to see the changes of immunologic indices and its significance in various renal diseases. Study population consist of 129 children; MCNS 42, MsPGN 10, MGN 4, FSGS 3, MPGN 2, RGH 32, HSP nephritis 28, and PIGN 8 cases. The following result was obtained. Total T cell (%) was increased druing relapse period of MCNS, MGN and MPGN compared to control, and changes of T cell susets was most marked in MCNS, showing decreased T_4 and T_8 resulting in low T_4/T_8 ratio during relapse period compared to remmision period. Serum immunoglobuling showed decreased IgG in MCNS, MsPGN, MGN and elevated IgM showed significant elevation during both relapse and remmision period compared to control group. In both IgA nephropathy and HSP nephritis, total T cell and T_4/T_8 ratio was increased during hematuric phase compared to control group, and in IgA nephropathy, T_4 cell was increased during hematuric phase compared to non-hematuric phase. Serum immunoglobulin showed increased IgA abd IgE in IgA nephropathy, and increased IgA and no significant change of IgE in HSP nephritis during hematuric phase. In summary, it can be concluded that both cellular and humoral immune mechanism play a significant role in the pathogenesis of primary renal diseases.
미세변화신증후군 환아에서의 혈청 ImmunoglibulinE치의 변화
김기호,이동석,고철우,구자훈 慶北大學校 醫科大學 1989 慶北醫大誌 Vol.30 No.2
A prospective study was conducted to determine the change of serum IgE and its significance in children with minimal change nephrotic syndrome(MCNS). Study population consisted of 33 biopsyproven MCNS and these children were grouped into infrequent relapser(IR, 3 cases), steroid dependant/frequent relapser(SD/FR, 25 cases), and partial responder(PR, 5 cases), according to the steroid therapy. Ten healthy children aged 2-12 year were used as control group. The foiiowing results were obtained. During relapse, serum IgE showed significant elevation(376.8±401.6 IU/dL) compared to the controls(48.8±36.9)(p<0.05). IgE elevation was more marked in SD/FR and PR group compared to IR group. In SD/FR group with positive allergy history, IgE elevation persisted into remmision period. However, it decreased to near normal range in SD/FR group without allergy history. In PR group, elevated IgE persisted into remmision period irrespective to allergy history. Proportion of lymphocytes bearing FCε R showed elevated level of 11.5±8.5% during relapse compared to 5.2±3.5 during remmision period. In summary, present study shows that high serum IgE and lympocyte bearing FCε R is seen during relapse period of MCNS irrespective to allergy history, especially in SD/FR and PR group, suggesting that immunologic mechanism involving IgE plays a significant role in the pathogenesis of MCNS.