http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Plasminogen Activator Inhibitor-1: Potential Inflammatory Marker in Late-life Depression
Seung-Hoon Lee(Seung-Hoon Lee),Cheolmin Shin(Cheolmin Shin),Young-Hoon Ko(Young-Hoon Ko),Moon-Soo Lee(Moon-Soo Lee),Moon Ho Park(Moon Ho Park),Chi-Un Pae(Chi-Un Pae),Ho-Kyoung Yoon(Ho-Kyoung Yoon),Cha 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.1
Objective: Although several previous studies have examined the association between late-life depression and blood adipokine levels, a marker of chronic inflammation, no studies have comprehensively considered the effects of metabolic syndrome, which is known to affect blood adipokine levels. This study examined blood adipokine levels in geriatric depression after adjusting for the effects of metabolic syndrome. Methods: Participants were selected from the Ansan Geriatric Study (depression group [n = 76] and control group [n = 76]). Blood concentrations of four adipokines (adiponectin, resistin, neutrophil-gelatinase-associated lipocalin [NGAL], and plasminogen activator inhibitor-1 [PAI-1]) were measured using immunoassays. The effects of blood adipokine concentration on the diagnosis of depression were analyzed using multivariate logistic regression to adjust for the effects of metabolic syndrome and potential confounding factors. Results: When the effects of metabolic syndrome and potential confounding factors were adjusted, only PAI-1 could explain the diagnosis of depression among all the adipokines. The depression group showed a lower blood PAI-1 level than the control group. Adiponectin, resistin, and NGAL could not explain the diagnosis of depression when the effects of metabolic syndrome and potential confounding factors were adjusted. Conclusion: This study suggests the possibility that the blood PAI-1 levels in clinically pathological late-life depression may show contrasting results to those with subclinical depressive symptoms. Additionally, considering that most previous studies have been conducted with pre-geriatric populations, the study suggests the possibility that geriatric depression may show inflammatory changes with patterns that are different from those of depression in the pre-geriatric population.
Cheolmin Shin(Cheolmin Shin),Sang Won Jeon(Sang Won Jeon),Seung-Hoon Lee(Seung-Hoon Lee),Chi-Un Pae(Chi-Un Pae),Narei Hong(Narei Hong),Hyun Kook Lim(Hyun Kook Lim),Ashwin A. Patkar(Ashwin A. Patkar ) 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.1
Objective: Anxious depression is associated with greater chronicity, higher severity of symptoms, more severe functional impairment, and poor response to drug treatment. However, evidence for first-choice antidepressants in patients with anxious depression is limited. This study aimed to compare the efficacy and safety of escitalopram, desvenlafaxine, and vortioxetine in the acute treatment of anxious depression. Methods: Patients (n = 124) with major depressive disorder and high levels of anxiety were randomly assigned to an escitalopram treatment group (n = 42), desvenlafaxine treatment group (n = 40), or vortioxetine treatment group (n = 42) in a 6-week randomized rater-blinded head-to-head comparative trial. Changes in overall depressive and anxiety symptoms were assessed using the 17-item Hamilton Depression Rating Scale (HAMD) and Hamilton Anxiety Rating Scale (HAMA), respectively. Results: Patients demonstrated similar baseline-to-endpoint improvement in scores and similar response and remission rates for HAMD and HAMA. Analysis of the individual HAMD items revealed that desvenlafaxine significantly reduced anxiety somatic scores (p = 0.013) and hypochondriasis scores (p = 0.014) compared to escitalopram. With respect to the individual HAMA items, desvenlafaxine treatment showed significantly lower scores for respiratory symptoms (p = 0.013) than escitalopram treatment and cardiovascular symptoms (p = 0.005) than vortioxetine treatment. The treatments were well tolerated, with no significant differences. Conclusion: Our results indicated no significant differences in the efficacy and tolerability of escitalopram, desvenlafaxine, and vortioxetine in this subtype of patients with anxious depression during the acute phase of treatment.
애플리케이션 통합을 위한 ROA 기반 정보 공유 모델 연구
이철민(CheolMin Lee),이원석(WonSeok Lee),이정원(JeongWon Lee),손진수(JinSoo Sohn) 한국통신학회 2009 한국통신학회 학술대회논문집 Vol.2009 No.6
IT 기업에서의 시스템 및 애플리케이션의 통합, 즉 IT 인프라 통합은 자원 활용과 서비스의 효율성 측면에서 중요한 부분으로 인식되고 있다. IT 인프라 통합 솔루션은 여러 가지 다양한 기술과 서로 다른 추상화 수준을 전반적으로 다뤄야 하는 복잡한 시스템이지만 IT 기술, 특히 웹서비스(Web Services; WS) 기술의 발전으로 융통성 있는 통합 구조로 정의할 수 있게 되었다. 최근 웹 서비스 기술의 경향을 보면 SOAP 을 중심으로 하는 표준 프로토콜의 복잡성을 피하고, REST(REpresentational State Transfer)를 이용한 웹 서비스 구축이 선호되고 있다. 본 논문에서는 기업의 애플리케이션 통합을 위해서 REST 를 이용한 ROA(Resource Oriented Architectures) 구축에 대해서 소개하고 이러한 ROA 를 기반으로 하여 IT 인프라의 각 시스템간의 정보 공유 모델에 대해서 논하고자 한다.
건축자재 라돈 방출에 의한 실내공기 중 라돈농도 예측에 관한 연구
이철민 ( Cheolmin Lee ),곽윤경 ( Yoonkyung Gwak ),이동현 ( Donghyun Lee ),이다정 ( Dajeong Lee ),조용석 ( Yongseok Cho ) 한국환경과학회 2015 한국환경과학회지 Vol.24 No.9
Radon exhalation rates have been determined for samples of concrete, gypsum board, marble, and tile among building materials that are used in domestic construction environment. Radon emanation was measured using the closed chamber method based on CR-39 nuclear track detectors. The radon concentrations in apartments of 100 households in Seoul, Busan and Gyeonggi Provinces were measured to verify the prediction model of indoor radon concentration. The results obtained by the four samples showed the largest radon exhalation rate of 0.34314 Bq/m2·h for sample concrete. The radon concentration contribution to indoor radon in the house due to exhalation from the concrete was 31.006 ± 7.529 Bq/m3. The difference between the prediction concentration and actual measured concentration was believed to be due to the uncertainty resulting from the model implementation.
라돈 노출 유효선량 평가를 위한 연간 평균 라돈 농도 예측모델 개발
이철민 ( Cheolmin Lee ),강대용 ( Daeyong Kang ),고상백 ( Sangbaek Koh ),조용석 ( Yongseog Cho ),이다정 ( Dajeong Lee ),이슬비 ( Sulbee Lee ) 한국환경과학회 2016 한국환경과학회지 Vol.25 No.8
This research, sponsored by the Korean Ministry of Environment in 2014, was the first epidemiological study in Korea that investigated the health impact assessment of radon exposure. Its purpose was to construct a model that calculated the annual mean cumulative radon exposure concentrations, so that reliable conclusions could be drawn from environment-control group research. Radon causes chronic lung cancer. Therefore, the long-term measurement of radon exposure concentration, over one year, is needed in order to develop a health impact assessment for radon. Hence, based on the seasonal correction model suggested by Pinel et al.(1995), a predictive model of annual mean radon concentration was developed using the year-long seasonal measurement data from the National Institute of Environmental Research, the Korea Institute of Nuclear Safety, the Hanyang University Outdoor Radon Concentration Observatory, and the results from a 3-month (one season) survey, which is the official test method for radon measurement designated by the Korean Ministry of Environment. In addition, a model for evaluating the effective annual dose for radon was developed, using dosimetric methods. The model took into account the predictive model for annual mean radon concentrations and the activity characteristics of the residents.
왕느릅나무 껍질 열수 추출물의 마우스에서의 in vivo 면역조절 효과
이인환(Inhwan Lee),권다혜(Da Hye Kwon),이선희(Sun Hee Lee),이성도(Sung Do Lee),김덕원(Deok Won Kim),이종환(Jong-Hwan Lee),현숙경(Sook Kyung Hyun),김철민(CheolMin Kim),김병우(Byoung Woo Kim),강경화(Kyung-Hwa Kang),황혜진(Hye Jin Hwang 한국생명과학회 2014 생명과학회지 Vol.24 No.10
약용식물은 염증, 감염증, 암과 같은 질병에 광범위하게 사용되고 있으며, 전통적으로 오래 동안 사용되어 왔다. 왕느릅나무(Ulmus macrocarpa Hance)는 느릅나무의 한 종으로서 중국, 일본을 비롯해 한국 전역에 분포하고 있으며, 줄기와 뿌리의 껍질을 유백피라 하여 한의학에서 피부염, 유방염, 부종 등에 사용하여 왔다. 이 연구의 목적은 유백피의 열수 추출물(Ulmus cortex water extract, UCWE)이 면역조절 기능을 가지고 있는지를 조사하는 것이다. UCWE 식이농도 30 mg/kg, 100 mg/kg, 300 mg/kg의 3개 군으로 나누어 14일 동안 식이한 후 면역반응을 측정하였다. IL-2, IL-12, IFN-γ 의 혈중 농도가 UCWE를 식이한 군에서 유의적으로 증가하였으며, lymphokine activated killer cells (LAK)을 이용한 세포매개 세포독성 시험에서도 정상군에 비해 UCWE를 식이한 군에서 유의적으로 증가하였다. 그러나, 간, 신장, 비장, 흉선의 무게변화는 UCWE를 식이한 군과 정상군과의 차이가 없었다. 이는 300 ㎎/㎏ 고농도의 2주간 식이가 장기에 영향을 거의 미치지 않는다는 것을 암시한다고 생각된다. 따라서, UCWE는 내부 장기에는 영향을 주지 않으며 면역기능을 향상시키는 효과를 가진다고 여겨진다. Traditional medicinal plants are widely used to treat many diseases, such as inflammation, infections, and even cancer. Ulmus macrocarpa Hance, a Chinese elm species, is distributed in Korea, China, and Japan. The stem bark is widely employed in Korean traditional medicine to treat dermatitis, mastitis, and edema. The aim of this study was to investigate whether water extract of U. macrocarpa Hance bark (Ulmus cortex) has a immune-modulating function in a mouse model. Three different concentrations (30 ㎎/㎏, 100 mg/kg, and 300 ㎎/㎏) of Ulmus cortex water extract (UCWE) were orally administered to mice for 14 days, and their immune responses were analyzed. Cytokines, such as interleukin (IL)-2, IL-12, and IFN-γ, increased in the blood of UCWE-fed groups when compared with a control group. In contrast, the IL-4 level did not change in any of the UCWE-fed groups Cell-mediated cytotoxicity was also assayed using lymphokine-activated killer cells (LAK). LAK showed greater cytotoxicity in the UCWE-fed groups than LAK in the control group. Internal organ indices, such as liver, kidney, spleen, and thymus, were similar in all the groups, including the control group, indicating that UCWE may have been nontoxic in the experimental animals. These data suggest that UCWE has an immune-modulating function in a mouse model.
Lee, Kyongsu,Kim, Sunbo,Kim, YoungKuk,Park, Cheolmin,Balaji, Nagarajan,Han, Changsoon,Choi, Byoungdeog,Lee, Jaehyeong,Dao, Vinh Ai,Lee, Youn-Jung American Scientific Publishers 2017 Journal of Nanoscience and Nanotechnology Vol.17 No.5
<P>Single-and multi-crystalline silicon (c-Si) photovoltaic (PV) devices are the most popular solar cells and have provided the highest energy conversion efficiencies. The doping profile of POCl3 diffusion is crucial for silicon solar cells. To achieve the optimized junction depth, the doping temperature and time are varied. The process sequences are explained by variation of the diffusion coefficient and solubility with variations which have to prove to be achieve necessary. Hydrofluoric acid is used for the wet chemical etching process to avoid kinks in the active dead layer at the silicon surface during emitter formation and at high phosphorus concentrations. To control the phosphorus concentration on the surface, the etch time is also varied. The manipulated two-step doping heat profile with different doping temperatures and times increased the V-oc and fill factor, thereby increasing the conversion efficiency (eta) of the cell. The experimental results were consistent with AFORS-HET simulation results. Additionally, the manipulated two-step doping heat profile is more favorable for obtaining improved passivation and uniformity. For the emitter doped with two-step heat profile, the performance of a single-crystalline solar cell was found to be V-oc = 629 mV, J(sc) = 37.98 mA/cm(2), FF=78.79%, and eta = 18.84%. For a multi-crystalline silicon solar cell, these values were found to be V-oc = 634 mV, J(sc) = 35.50 mA/cm(2), FF = 77.35%, and eta = 17.90%.</P>
Review of domestic and international methods of measuring radon in residential buildings
Cheolmin Lee,Dajeong Lee 대한직업환경의학회 2016 대한직업환경의학회지 Vol.28 No.-
Radon, a source of natural background radiation, has been a subject of extensive studies as a major causative agent of lung cancer at the domestic and international levels. This study investigated and compared domestic and international methods of radon measurement. In the United States, radon is measured through primary and secondary testing, and a similar method is used in Canada. In the United Kingdom, only long-term radon measurements are taken with seasonal adjustments. In the Republic of Korea, both long-term and short-term measurements are taken with only primary testing. Through this study, standards for domestic radon measurement methods and improvement plans could be suggested.
Lee, Ji Yong,Lee, Jieun,Jang, Yu Jin,Lee, Juyon,Jang, Yoon Hee,Kochuveedu, Saji Thomas,Park, Cheolmin,Kim, Dong Ha Royal Society of Chemistry 2011 Chemical communications Vol.47 No.6
<P>A versatile and facile route to control the composition of plasmonic nanoparticles (NP) aligned in a configuration of two dimensional nano-arrays is presented by applying galvanic displacement reactions on a pre-defined noble metal NP arrays which were prepared from diblock copolymer inverse micelles containing metal precursors.</P> <P>Graphic Abstract</P><P>Plasmonic nanoparticle arrays with controlled composition and dielectric environment were fabricated by applying galvanic displacement reactions on diblock copolymer templates. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0cc04369a'> </P>