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Preparation and characterization of epoxidized microbial oil
Xinde Chen,Dan Yang,Lian Xiong,Bo Wang,Xuefang Chen,Can Wang,Hairong Zhang,Haijun Guo 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.3
The potential of microbial oil derived from yeasts through fermentation using crops biomass for the formation of plasticizers was investigated. Plasticizers were formed via epoxidation reaction. Five factors of the orthogonal experiment (reaction temperature, time, weight ratio of H2O2/MO, H2SO4/MO, and HCOOH/MO) have been used for optimization of parameters. To further enhance the iodine value of microbial oil and increase the epoxy value of the epoxide, an amount of soybean oil was added. The products were characterized by FTIR, 13C-NMR and 1H-NMR. Under the optimum condition, the epoxy value and the iodine value of epoxide product were 6.21% and 1.8 g I2/100 g with a yield of 91.86% at an oil conversion of 98.43%. This study successfully demonstrated the conversion of crops biomass into value-added chemicals using simple and conventional chemical reactions.
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Shen Xuefang,Chen Xiangyuan,Wang Jing,Liu Jing,Wang Zhiyao,Hua Qing,Wu Qichao,Su Yanguang,He Huanzhong,Hu Yuqin,Meng Zhipeng,Xiong Wanxia,Zhu Minmin 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-
Hyperglycemia-mediated endothelial inflammation participates in the pathogenesis of cardiovascular complications in subjects with diabetes. Previous studies reported that phosphatase and tensin homolog deleted on chromosome ten (PTEN) and SET8 participate in high glucose-mediated endothelial inflammation. In this study, we hypothesize that SET8 regulates PTEN expression, thus contributing to high glucose-mediated vascular endothelial inflammation. Our data indicated that plasma soluble intercellular adhesion molecule-1 (sICAM-1) and endothelial selectin (e-selectin) were increased in patients with diabetes and diabetic rats. PTEN expression was augmented in the peripheral blood mononuclear cells of patients with diabetes and in the aortic tissues of diabetic rats. Our in vitro study indicated that high glucose increased monocyte/endothelial adhesion, endothelial adhesion molecule expression and p65 phosphorylation in human umbilical vein endothelial cells (HUVECs). Moreover, high glucose led to endothelial inflammation via upregulation of PTEN. Furthermore, high glucose inhibited SET8 expression and histone H4 lysine 20 methylation (H4K20me1), a downstream target of SET8. SET8 overexpression reversed the effects of high-glucose treatment. shSET8-mediated endothelial inflammation was counteracted by siPTEN. Furthermore, SET8 was found to interact with FOXO1. siFOXO1 attenuated high glucose-mediated endothelial inflammation. FOXO1 overexpression-mediated endothelial inflammation was counteracted by siPTEN. H4K20me1 and FOXO1 were enriched in the PTEN promoter region. shSET8 increased PTEN promoter activity and augmented the positive effect of FOXO1 overexpression on PTEN promoter activity. Our in vivo study indicated that SET8 was downregulated and FOXO1 was upregulated in the peripheral blood mononuclear cells of patients with diabetes and the aortic tissues of diabetic rats. In conclusion, SET8 interacted with FOXO1 to modulate PTEN expression in vascular endothelial cells, thus contributing to hyperglycemia-mediated endothelial inflammation.
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Hailong Li,Hai-Rong Zhang,Lian Xiong,Xuefang Chen,Can Wang,Chao Huang,Xin-De Chen 한국섬유공학회 2019 Fibers and polymers Vol.20 No.5
Cellulose was isolated from wheat straw by the combined pretreatment including dilute acid hydrolysis, ethanolextraction, and alkaline H2O2 delignification. The effects of varying the parameters on carboxymethylation on isolatedcellulose were investigated. Furthermore, the chemical structure of carboxymethyl cellulose (CMC) prepared from wheatstraw was characterized by Fourier transform infrared spectroscopy, X-ray diffraction, and scanning electron microscopeanalysis. The isolated cellulose is mainly composed of cellulose without hemicellulose and with minors of lignin and ash. The optimal conditions for carboxymethylation were base concentration, 20 %; reaction temperature, 70 oC; reaction time,2 h; mass ratio of etherifying agent to cellulose, 1.75. Under the optimized conditions, CMC with high degree of substitution(0.88) and low viscosity (18 mPa·s) was synthesized. Chemical structural characterization showed the feasibility of thepreparation of CMC from wheat straw. The constituents of wheat straw would be maximally utilized by the proposed method.
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IL-17 Imbalance Promotes the Pyroptosis in Immune-Mediated Liver Injury Through STAT3-IFI16 Axis
Wenfang Xu,Yanan Wang,Changzhong Jin,Weiyang Zhang,Jiangnan Chen,Xuefang Chen,Junli Gao,Junshun Gao,Hong Wang 대한면역학회 2023 Immune Network Vol.23 No.6
Autoimmune hepatitis (AIH) affects all age group and occurs mainly in women. Pyroptosis is a novel programmed cell death featured with cell bursting and release of proinflammatory cytokines. A deeper understanding of AIH pathogenesis will contribute to novel therapy for AIH patients. Here, we aimed to investigate the role of IL-17 in immune-mediated liver injury. The levels of cytokines were measured by ELISA, and mRNA levels of STAT3 and IFN gammainducible protein 16 (IFI16) were detected by PCR. Expressions of STAT3, IFI16, gasdermin D and cleaved caspase-1 were measured by western-blotting. Immunohistochemical staining and transmission electron microscopy were applied to evaluate liver histopathological changes of the treated mice. Our results showed that the levels of IFI16 was increased in hepatocytes treated with IL-17 protein, and further elevated after STAT3-overexpressed (STAT3-OE) lentivirus treatment. The levels of IFI16 were reduced in hepatocytes treated with IL-17 neutralizing Ab (nAb), but were significantly increased after STAT3-OE treatment. Pyroptosis was observed in hepatocytes treated with IL-17 protein, and further cell damage was observed after STAT3-OE lentivirus treatment. Liver damage was alleviated in mice treated with IL-17 nAb, however sever damage was experienced after STAT3-OE lentivirus treatment. A binding interaction between IFI16 and STAT3 was detected in IL-17 treated hepatocytes. Glutathione transaminase activity was enhanced in concanavalin A-induced AIH mice compared to the control group (p<0.01). IL-17 plays an important role in activating STAT3 and up-regulating IFI16, which may promote the pyroptosis in AIH-related liver injury through STAT3-IFI16 axis.
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Current progress on gold recovery from refractory ore and waste electrical and electronic equipment
Ji Xuran,Shen Zhijie,Xu Wenping,Yao Shimiao,Zhang Hairong,Xiong Lian,Li Hailong,Guo Haijun,Chen Xuefang,Chen Xinde 한국화학공학회 2023 Korean Journal of Chemical Engineering Vol.40 No.9
The physical and chemical properties of gold promote its application, such as in the high-tech, electronic products, and aerospace industries. The easily leachable ore is gradually depleted. Thus, it becomes necessary to extract gold from other resources such as refractory ore and electrical and electronic equipment. The normal method of leaching for gold is cyanide leaching, but it is very dangerous for both environment and operator. Non-cyanide leaching methods, including thiourea leaching, halide leaching, and sulfate leaching have been developed to substitute cyanide leaching. A variety of methods to enrich gold from leaching solutions are described in this paper, including solvent extraction, electrowinning, activated carbon adsorption, and ion exchange resins. Among those methods, ion exchange resins can adsorb gold with high adsorption efficiency and regenerate easily as well. This paper focuses on the research progress of the recovery of gold from non-cyanide leachates by ion exchange resins, summarizes the existing resin types and elution processes, points out the limitations in the application of current ion exchange resins, and discusses possible solutions.
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