http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Wei-dong Wang,Li-hua Zhang,Jia-Yan Ni,Xiong-ying Jiang,Dong Chen,Yao-ting Chen,Hong-liang Sun,Jiang-hong Luo,Lin-feng Xu 대한영상의학회 2018 Korean Journal of Radiology Vol.19 No.4
Objective: To meta-analytically compare combined transarterial chemoembolization (TACE) plus radiofrequency ablation (RFA) and surgical resection (SR) for the treatment of hepatocellular carcinoma (HCC) within the Milan criteria. Materials and Methods: PubMed, Medline, Embase, and Cochrane Library were searched for studies comparing these two therapies that were published between January 2006 and August 2017. Overall survival rate (OS), recurrence-free survival rate (RFS), major complications and the average length of hospital stay were compared between these two therapies. Metaanalytic pooled odds ratio (OR) was calculated using TACE plus RFA as the base category. Results: Seven case-control studies and one randomized trial were identified. Meta-analytic results revealed that, compared with SR, TACE plus RFA had significantly higher 1-year OS (OR for survival = 0.50, p = 0.009) and lower major complications (OR = 1.88, p = 0.02) after therapy. Three studies reported on the length of hospital stay. The average length ± standard deviation reported in individual studies for SR and TACE plus RFA groups was 19.8 ± 8.4 days and 7.4 ± 2.2 days, respectively; 18.7 ± 4.9 days and 11.5 ± 6.9 days, respectively; and 16.6 ± 6.7 days and 8.5 ± 4.1 days, respectively (p < 0.0001 for all studies). Three or 5-year OS and 1-, 3-, or 5-year RFS did not significantly differ between the two therapies. Conclusion: Combined TACE plus RFA may be an alternative to SR for the treatment of patients with HCC within Milan the criteria. Non-randomized design in most of the original studies was a limitation.
Wei, Guangfei,Yang, Feng,Wei, Fugang,Zhang, Lianjuan,Gao, Ying,Qian, Jun,Chen, Zhongjian,Jia, Zhengwei,Wang, Yong,Su, He,Dong, Linlin,Xu, Jiang,Chen, Shilin The Korean Society of Ginseng 2020 Journal of Ginseng Research Vol.44 No.6
Background: Panax quinquefolius and Panax notoginseng are widely used and well known for their pharmacological effects. As main pharmacological components, saponins have different distribution patterns in the root tissues of Panax plants. Methods: In this study, the representative ginsenosides were detected and quantified by desorption electrospray ionization mass spectrometry and high-performance liquid chromatography analysis to demonstrate saponin distribution in the root tissues of P. quinquefolius and P. notoginseng, and saponin metabolite profiles were analyzed by metabolomes to obtain the biomarkers of different root tissues. Finally, the transcriptome analysis was performed to demonstrate the molecular mechanisms of saponin distribution by gene profiles. Results: There was saponin distribution in the root tissues differed between P. quinquefolius and P. notoginseng. Eight-eight and 24 potential biomarkers were detected by metabolome analysis, and a total of 340 and 122 transcripts involved in saponin synthesis that were positively correlated with the saponin contents (R > 0.6, P < 0.05) in the root tissues of P. quinquefolius and P. notoginseng, respectively. Among them, GDPS1, CYP51, CYP64, and UGT11 were significantly correlated with the contents of Rg1, Re, Rc, Rb2, and Rd in P. quinquefolius. UGT255 was markedly related to the content of R1; CYP74, CYP89, CYP100, CYP103, CYP109, and UGT190 were markedly correlated with the Rd content in P. notoginseng.
EMI Noise Source Reduction of Single-Ended Isolated Converters Using Secondary Resonance Technique
Chen, Zhangyong,Chen, Yong,Chen, Qiang,Jiang, Wei,Zhong, Rongqiang The Korean Institute of Power Electronics 2019 JOURNAL OF POWER ELECTRONICS Vol.19 No.2
Aiming at the problems of large dv/dt and di/dt in traditional single-ended converters and high electromagnetic interference (EMI) noise levels, a single-ended isolated converter using the secondary resonance technique is proposed in this paper. In the proposed converter, the voltage stress of the main power switch can be reduced and the voltage across the output diode is clamped to the output voltage when compared to the conventional flyback converter. In addition, the peak current stress through the main power switch can be decreased and zero current switching (ZCS) of the output diode can be achieved through the resonance technique. Moreover, the EMI noise coupling path and an equivalent model of the proposed converter topology are presented through the operational principle of the proposed converter. Analysis results indicate that the common mode (CM) EMI noise and the differential mode (DM) EMI noise of such a converter are deduced since the frequency spectra of the equivalent controlled voltage sources and controlled current source are decreased when compared with the traditional flyback converter. Furthermore, appropriate parameter selection of the resonant circuit network can increase the equivalent impedance in the EMI coupling path in the low frequency range, which further reduces the common mode interference. Finally, a simulation model and a 60W experimental prototype of the proposed converter are built and tested. Experimental results verify the theoretical analysis.
Hua-wei Jiang,Jian-qiang Gao,Hong-wei Chen,Jun-fu Lu,Fu-mao Wang,Yang Wang,Zhen-xin Wu 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.7
Wind cap partial blockages and agglomeration are two of the most common gas-solid flow faults that occur under the actual operations of circulating fluidized bed boilers. Using the method of measuring pressure fluctuations, for the characterization of fluid dynamics in fluidized beds, has a great advantage, due to its flexible adaptation to any operating conditions to monitor fluidization. This paper presents research into the use of measuring and analyzing pressure fluctuations in wind caps, for the analysis of the gas-solid fluidization characteristics in a fluidized bed with wind cap partial blockages or agglomeration fault. Partial blockages in a wind cap near feeding side and partial blockages in another wind cap near recycling side as well as agglomeration of different extents were simulated in a cold circulating fluidized bed. Pressure fluctuations in the inlets of several wind caps were measured at different primary air velocities under different fault conditions. They were then analyzed with the methods of statistical average, standard deviation, wavelet analysis and homogeneous index. Based on the calculated characteristic parameters, the effects of gas-solid flow faults on the gas-solid fluidization characteristics were analyzed. Results showed that variations of characteristic parameters of pressure fluctuations were related to variations of the gas-solid flow condition, which were caused by wind cap partial blockages or agglomerations. It is shown that the proposed method is practical.
Jian-Wei Lv,Wei Wen,Chen Jiang,Qi-Bo Fu,Yin-Jun Gu,Ting-Ting Lv,Zhen-Dong Li,Wei Xue 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Our study aims to investigate the roles that microRNA-214 (miR-214) plays in the epithelial mesenchymal transition (EMT) process and the development of interstitial cystitis (IC) in postmenopausal women by targeting Mitofusin 2 (Mfn2). IC bladder tissues and adjacent normal bladder tissues were collected from postmenopausal women. Immunohistochemistry (IHC) staining was conducted. The target relationship between miR-214 and Mfn2 was determined by a dual luciferase reporter gene assay. Adipose-derived mesenchymal stem cells (ADMSCs) were extracted from postmenopausal rats and assigned to the blank, mimics, miR-214 inhibitors, mimics negative control (NC), inhibitors NC, Mfn2 siRNA, miR-214 inhibitors and Mfn2 siRNA groups. Exosomes secreted by transfected ADMSCs were instilled into the bladders of postmenopausal rats. The expression of miR-214 and Mfn2 mRNA and EMT markers was assessed by qRT-PCR and western blotting. It was confirmed that Mfn2 was the target gene of miR-214 in IC. Compared with the normal bladder tissues, miR-214 decreased, but Mfn2 increased in IC bladder tissues. Compared with the blank group, the expression of miR-214 and the expression levels of N-cadherin, Fibronectin, Twist1, Snail and Vimentin mRNA and protein increased, whereas the expression levels of Mfn2, E-cadherin and ZO-1 mRNA and protein decreased in the miR-214 mimics and Mfn2 groups. The expression of MiR-214 and the expression levels of N-cadherin, Fibronectin, Twist1, Snail and Vimentin mRNA and protein decreased, whereas the expression levels of Mfn2, E-cadherin and ZO-1 mRNA and protein increased in the miR-214 inhibitors group. Our findings indicate that the inhibition of miR-214 promotes the EMT process and contributes to bladder wall fibrosis by up-regulating Mfn2, thus leading to the occurrence of IC in postmenopausal women.
EMI Noise Source Reduction of Single-Ended Isolated Converters Using Secondary Resonance Technique
Zhang-yong Chen,Yong Chen,Qiang Chen,Wei Jiang,Rongqiang Zhong 전력전자학회 2019 JOURNAL OF POWER ELECTRONICS Vol.19 No.2
Aiming at the problems of large dv/dt and di/dt in traditional single-ended converters and high electromagnetic interference (EMI) noise levels, a single-ended isolated converter using the secondary resonance technique is proposed in this paper. In the proposed converter, the voltage stress of the main power switch can be reduced and the voltage across the output diode is clamped to the output voltage when compared to the conventional flyback converter. In addition, the peak current stress through the main power switch can be decreased and zero current switching (ZCS) of the output diode can be achieved through the resonance technique. Moreover, the EMI noise coupling path and an equivalent model of the proposed converter topology are presented through the operational principle of the proposed converter. Analysis results indicate that the common mode (CM) EMI noise and the differential mode (DM) EMI noise of such a converter are deduced since the frequency spectra of the equivalent controlled voltage sources and controlled current source are decreased when compared with the traditional flyback converter. Furthermore, appropriate parameter selection of the resonant circuit network can increase the equivalent impedance in the EMI coupling path in the low frequency range, which further reduces the common mode interference. Finally, a simulation model and a 60W experimental prototype of the proposed converter are built and tested. Experimental results verify the theoretical analysis.
Self-healing capacity of damaged rock salt with different initial damage
Chen, Jie,Kang, Yanfei,Liu, Wei,Fan, Jinyang,Jiang, Deyi,Chemenda, Alexandre Techno-Press 2018 Geomechanics & engineering Vol.15 No.1
In order to analyze the healing effectiveness of rock salt cracks affected by the applied stresses and time, we used the ultrasonic technology to monitor the ultrasonic pulse velocity (UPV) variations for different initial stress-damaged rock salts during self-healing experiments. The self-healing experiments were to create different conditions to improve the microcracks closure or recrystallized, which the self-healing effect of damaged salt specimens were analyzed during the recovery period about 30 days. We found that: The ultrasonic pulse velocity of the damaged rock salts increases rapidly during the first 9 days recovery, and the values gradually increase to reach constant values after 30 days. The damaged value and the healed value were identified based on the variation of the wave velocity. The damaged values of the specimens that are subject to higher initial damage stress are still keeping in large after 30 days recovery under the same recovery condition It is interesting that the damage and the healing were not in the linear relationship, and there also existed a damage threshold for salt cracks healing ability. When the damage degree is less than the threshold, the self-healing ratio of rock salt is increased with the increase in damage degree. However, while the damage degree exceeds the threshold, the self-healing ratio is decreased with the increase in damage.