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Chen, Ying-Chen,Lin, Chih-Yang,Huang, Hui-Chun,Kim, Sungjun,Fowler, Burt,Chang, Yao-Feng,Wu, Xiaohan,Xu, Gaobo,Chang, Ting-Chang,Lee, Jack C IOP 2018 Journal of Physics. D, Applied Physics Vol.51 No.5
<P>Sneak path current is a severe hindrance for the application of high-density resistive random-access memory (RRAM) array designs. In this work, we demonstrate nonlinear (NL) resistive switching characteristics of a HfO<SUB> <I>x</I> </SUB>/SiO<SUB> <I>x</I> </SUB>-based stacking structure as a realization for selector-less RRAM devices. The NL characteristic was obtained and designed by optimizing the internal filament location with a low effective dielectric constant in the HfO<SUB> <I>x</I> </SUB>/SiO<SUB> <I>x</I> </SUB> structure. The stacking HfO<SUB> <I>x</I> </SUB>/SiO<SUB> <I>x</I> </SUB>-based RRAM device as the one-resistor-only memory cell is applicable without needing an additional selector device to solve the sneak path issue with a switching voltage of ~1 V, which is desirable for low-power operating in built-in nonlinearity crossbar array configurations.</P>
Inflammatory Endotypes and Tissue Remodeling Features in Antrochoanal Polyps
Chen Cai-Ling,Wang Yu-Ting,Yao Yin,Pan Li,Guo Bei,Zhu Ke-Zhang,Ma Jin,Wang Nan,Li Xue-Li,Deng Yi-Ke,Liu Zheng 대한천식알레르기학회 2021 Allergy, Asthma & Immunology Research Vol.13 No.6
Purpose: The pathogenic mechanisms of antrochoanal polyps (ACPs) remain largely unknown. This study aimed to characterize inflammatory patterns and tissue remodeling features in ACPs. Methods: Inflammatory cell infiltration and tissue edema severity as well as fibrin deposition in ACPs and bilateral eosinophilic and noneosinophilic nasal polyps (NPs) were studied with immunohistochemical and immunofluorescence staining. Cytokine levels in sinonasal tissues were detected with the Bio-Plex assay. The expression of coagulation and fibrinolytic markers was measured using reverse-transcription polymerase chain reaction and enzyme-linked immunosorbent assays. Results: Compared to control tissues and bilateral eosinophilic and noneosinophilic NPs, ACPs had higher levels of neutrophil infiltration and expression of myeloperoxidase (MPO), interleukin (IL)-8 and interferon (IFN)-γ. In total, 94.4% of ACPs demonstrated an eosinophil cationic protein/MPO ratio of < 1, compared to 79.0% of noneosinophilic and 26% of eosinophilic NPs. Principle component and multiple correspondence analyses revealed a neutrophilic and type 1 inflammation pattern in ACPs. Compared to control tissues, edema scores and fibrin deposition were increased, whereas d-dimer and tissue plasminogen activator (tPA) levels were decreased in ACPs and bilateral NPs, with more prominent changes in ACPs even than in eosinophilic NPs. The tPA levels were negatively correlated with IFN-γ, IL-8, and MPO levels in ACPs. Neutrophils were the major cellular source of IFN-γ in ACPs, and the number of IFN-γ+ neutrophils was elevated in ACPs than in control tissues and bilateral eosinophilic and noneosinophilic NPs. Conclusions: ACPs are characterized by the neutrophilic and type 1 inflammation endotype. Neutrophil-derived IFN-γ is associated with reduced tPA production in ACPs.
EA-D p45-IgG as a Potential Biomarker for Nasopharyngeal Carcinoma Diagnosis
Chen, Hao,Luo, Yao-Ling,Zhang, Lin,Tian, Li-Zhen,Feng, Zhi-Ting,Liu, Wan-Li Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12
Aim: To identify new biomarkers for NPC diagnosis with an anti-EBV Western blot test kit. Methods: Serum samples from 64 NPC patients and healthy subjects with four specific VCA-IgA/EA-IgA profiles were tested with an anti-EBV Western blot test kit from EUROIMMUN AG. Proteins were quantified with scores of intensity visually assigned to the protein bands. The markers which showed statistical differences between the NPC and non-NPC subjects were further evaluated in another 32 NPC patients and 32 controls in comparison with established biomarkers including VCA-IgA, EA-IgA, EBV-related protein IgG, and EBV DNA. Results: Among the markers screened, EA-D p45-IgG showed a statistically significant difference (p < 0.05) between NPC and non-NPC subjects with VCA-IgA positivy. In 32 VCA-IgA positive NPC patients and 32 control subjects, the diagnostic accuracy of EA-D p45-IgG was 78.1% with a positive predictive value of 77.8% and a negative predictive value of 78.6%. In the verification experiment, the specificity and sensitivity of EA-D p45-IgG were 75.0% and 90.6 %, respectively. Conclusions: EA-D p45-IgG might be a potential biomarker for NPC diagnosis, especially among VCA-IgA positive subjects.
Yao Zhang,Zaiqiang Hu,Hao Chen,Ting Xue 대한토목학회 2018 KSCE JOURNAL OF CIVIL ENGINEERING Vol.22 No.11
The pre-soaking method is widely used to address loess collapsibility. However, this method requires a long construction time and has a limited application range. To foster the strengths and avoid the weaknesses of the pre-soaking method regarding ease of use, acid-addition collapsibility tests and acid-addition shear tests were performed to investigate the effect of combining the pre-soaking method with the use of an acetic acid solution. This approach is based on the principle that acid can dissolve cemented connections, which is the main factor of loess collapsibility, in a short period of time. Moreover, a Scanning Electron Microscope (SEM) was used to observe the features of loess samples before and after these tests. The SEM images also confirm our inferred conclusions. The experimental results showed that, compared with the conventional pre-soaking method, the addition of acetic acid sharply decreases the loess collapsibility under low pressure condition and reduces the construction time. In addition, the proposed approach simultaneously increases the strength of modified soil under low pressure conditions. Further, the addition of acetic acid allows the pre-soaking method to be applied to a non-self-weight collapsible loess, to which the conventional pre-soaking method cannot be applied.
High-strength concrete deep beams with web openings strengthened by carbon fiber reinforced plastics
Wen-Yao Lu,Hsin-Wan Yu,Chun-Liang Chen,Shen-Lung Liu,Ting-Chou Che 사단법인 한국계산역학회 2015 Computers and Concrete, An International Journal Vol.15 No.1
The objective of this study is to examine the effect of carbon fiber reinforced polymer (CFRP) on the shear strengths of deep beams with web openings. A total of 18 high-strength concrete deep beams with web openings were tested. Twelve were externally wrapped with four layers of CFRP, six of them strengthened in the horizontal direction and the others in the vertical direction. The parameters of the configuration of CFRP, the sizes of the openings and the locations of the openings were covered in this study. The test results indicates the shear strengths of deep beams with openings sized 60×40 mm were about 16% higher than that with openings sized 68×68 mm. For deep beams with openings sized 60×40 mm, the lower the locations of openings the higher the shear strengths were. The test results also indicate the shear strengths of deep beams with web openings strengthened by CFRP wrapped in the vertical direction can be enhanced by about 10%. However, the shear strengths of deep beams with web openings strengthened by CFRP wrapped in the horizontal direction can only be enhanced by about 6%. The shear strengths of deep beam, with different size and location of web openings and strengthened by different configuration of CFRP can be reasonably predicted by the empirical formulas of Kong and Sharp.
Fang Ting,Liu Suyi,Chen Liying,Ren Yating,Lu Dingqi,Yao Xinyi,Hong Tao,Zhang Xvfeng,Xie Zhimin,Yang Kepeng,Wang Xinchang 한국유전학회 2023 Genes & Genomics Vol.45 No.9
Background As a multisystemic autoimmune illness, the basic mechanisms behind the pathophysiology of systemic lupus erythematosus (SLE) remain poorly understood. Objective We aimed to investigate the possible significance of SLE’s DNA methylation and gain further insight into potential SLE-related biomarkers and therapeutic targets. Methods We used whole genome bisulfite sequencing (WGBS) method to analyze DNA methylation in 4 SLE patients and 4 healthy people. Results 702 differentially methylated regions (DMRs) were identified, and 480 DMR-associated genes were annotated. We found the majority of the DMR-associated elements were enriched in repeat and gene bodies. The top 10 hub genes identified were LCK, FYB, PTK2B, LYN, CTNNB1, MAPK1, GNAQ, PRKCA, ABL1, and CD247. Compared to the control group, LCK and PTK2B had considerably decreased levels of mRNA expression in the SLE group. Receiver operating characteristic (ROC) curve suggested that LCK and PTK2B may be potential candidate biomarkers to predict SLE. Conclusions Our study improved comprehension of the DNA methylation patterns of SLE and identified potential biomarkers and therapeutic targets for SLE.
Numerical analysis of steady and transient processes in a directional solidification system
Lin, Ting-Kang,Lin, Chung-Hao,Chen, Ching-Yao Techno-Press 2016 Coupled systems mechanics Vol.5 No.4
Manufactures of multi-crystalline silicon ingots by means of the directional solidification system (DSS) is important to the solar photovoltaic (PV) cell industry. The quality of the ingots, including the grain size and morphology, is highly related to the shape of the crystal-melt interface during the crystal growth process. We performed numerical simulations to analyze the thermo-fluid field and the shape of the crystal-melt interface both for steady conditions and transient processes. The steady simulations are first validated and then applied to improve the hot zone design in the furnace. The numerical results reveal that, an additional guiding plate weakens the strength of vortex and improves the desired profile of the crystal-melt interface. Based on the steady solutions at an early stage, detailed transient processes of crystal growth can be simulated. Accuracy of the results is supported by comparing the evolutions of crystal heights with the experimental measurements. The excellent agreements demonstrate the applicability of the present numerical methods in simulating a practical and complex system of directional solidification system.
Numerical analysis of steady and transient processes in a directional solidification system
Lin, Ting-Kang,Lin, Chung-Hao,Chen, Ching-Yao 테크노프레스 2016 Multiscale and multiphysics mechanics Vol.1 No.2
Manufactures of multi-crystalline silicon ingots by means of the directional solidification system (DSS) is important to the solar photovoltaic (PV) cell industry. The quality of the ingots, including the grain size and morphology, is highly related to the shape of the crystal-melt interface during the crystal growth process. We performed numerical simulations to analyze the thermo-fluid field and the shape of the crystalmelt interface both for steady conditions and transient processes. The steady simulations are first validated and then applied to improve the hot zone design in the furnace. The numerical results reveal that, an additional guiding plate weakens the strength of vortex and improves the desired profile of the crystal-melt interface. Based on the steady solutions at an early stage, detailed transient processes of crystal growth can be simulated. Accuracy of the results is supported by comparing the evolutions of crystal heights with the experimental measurements. The excellent agreements demonstrate the applicability of the present numerical methods in simulating a practical and complex system of directional solidification system.