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      • SCIESCOPUSKCI등재

        Effectiveness of alendronate as an adjunct to scaling and root planing in the treatment of periodontitis: a meta-analysis of randomized controlled clinical trials

        Chen, Jin,Chen, Qian,Hu, Bo,Wang, Yunji,Song, Jinlin Korean Academy of Periodontology 2016 Journal of Periodontal & Implant Science Vol.46 No.6

        Purpose: Alendronate has been proposed as a local and systemic drug treatment used as an adjunct to scaling and root planing (SRP) for the treatment of periodontitis. However, its effectiveness has yet to be conclusively established. The purpose of the present meta-analysis was to assess the effectiveness of SRP with alendronate on periodontitis compared to SRP alone. Methods: Five electronic databases were used by 2 independent reviewers to identify relevant articles from the earliest records up to September 2016. Randomized controlled trials (RCTs) comparing SRP with alendronate to SRP with placebo in the treatment of periodontitis were included. The outcome measures were changes in bone defect fill, probing depth (PD), and clinical attachment level (CAL) from baseline to 6 months. A fixed-effect or random-effect model was used to pool the extracted data, as appropriate. Mean differences (MDs) with 95% confidence intervals (CIs) were calculated. Heterogeneity was assessed using the Cochrane ${\chi}^2$ and $I^2$ tests. Results: After the selection process, 8 articles were included in the meta-analysis. Compared with SRP alone, the adjunctive mean benefits of locally delivered alendronate were 38.25% for bone defect fill increase (95% CI=33.05%-43.45%; P<0.001; $I^2=94.0%$), 2.29 mm for PD reduction (95% CI=2.07-2.52 mm; P<0.001; $I^2=0.0%$) and 1.92 mm for CAL gain (95% CI=1.55-2.30 mm; P<0.001; $I^2=66.0%$). In addition, systemically administered alendronate with SRP significantly reduced PD by 0.36 mm (95% CI=0.18-0.55 mm; P<0.001; $I^2=0.0%$) and increased CAL by 0.39 mm (95% CI=0.11-0.68 mm; P=0.006; $I^2=6.0%$). Conclusions: The collective evidence regarding the adjunctive use of alendronate locally and systemically with SRP indicates that the combined treatment can improve the efficacy of non-surgical periodontal therapy on increasing CAL and bone defect fill and reducing PD. However, precautions must be exercised in interpreting these results, and multicenter studies evaluating this specific application should be carried out.

      • KCI등재

        Competitive Influence Maximization on Online Social Networks under Cost Constraint

        ( Bo-lun Chen ),( Yi-yun Sheng ),( Min Ji ),( Ji-wei Liu ),( Yong-tao Yu ),( Yue Zhang ) 한국인터넷정보학회 2021 KSII Transactions on Internet and Information Syst Vol.15 No.4

        In online competitive social networks, each user can be influenced by different competing influencers and consequently chooses different products. But their interest may change over time and may have swings between different products. The existing influence spreading models seldom take into account the time-related shifts. This paper proposes a minimum cost influence maximization algorithm based on the competitive transition probability. In the model, we set a one-dimensional vector for each node to record the probability that the node chooses each different competing influencer. In the process of propagation, the influence maximization on Competitive Linear Threshold (IMCLT) spreading model is proposed. This model does not determine by which competing influencer the node is activated, but sets different weights for all competing influencers. In the process of spreading, we select the seed nodes according to the cost function of each node, and evaluate the final influence based on the competitive transition probability. Experiments on different datasets show that the proposed minimum cost competitive influence maximization algorithm based on IMCLT spreading model has excellent performance compared with other methods, and the computational performance of the method is also reasonable.

      • KCI등재

        Load Allocation Strategy for Command and Control Networks based on Interdependence Strength

        Bo Chen,Guimei Pang,Zhengtao Xiang,Hang Tao,Yufeng Chen 한국인터넷정보학회 2023 KSII Transactions on Internet and Information Syst Vol.17 No.9

        Command and control networks(C2N) exhibit evident multi-network interdependencies owing to their complex hierarchical associations, interleaved communication links, and dynamic network changes. However, the existing command and control networks do not consider the effects of dependent nodes on the load distribution. Thus, we proposed a command and control networks load allocation strategy based on interdependence strength. First, a new measure of interdependence strength was proposed based on the edge betweenness, which was followed by proposing the inter-layer load allocation strategy based on the interdependence strength. Eventually, the simulation experiments of the aforementioned strategy were designed to analyze the network invulnerability with different initial load capacity parameters, allocation model parameters, and allocation strategies. The simulation indicates that the strategy proposed in this study improved the node survival rate of the interdependent command and control networks model and successfully prevented cascade failures.

      • SCIESCOPUS

        Full-scale measurements of wind effects and modal parameter identification of Yingxian wooden tower

        Chen, Bo,Yang, Qingshan,Wang, Ke,Wang, Linan Techno-Press 2013 Wind and Structures, An International Journal (WAS Vol.17 No.6

        The Yingxian wooden tower in China is currently the tallest wooden tower in the world. It was built in 1056 AD and is 65.86 m high. Field measurements of wind speed and wind-induced response of this tower are conducted. The wind characteristics, including the average wind speed, wind direction, turbulence intensity, gust factor, turbulence integral length scale and velocity spectrum are investigated. The power spectral density and the root-mean-square wind-induced acceleration are analyzed. The structural modal parameters of this tower are identified with two different methods, including the Empirical Mode Decomposition (EMD) combined with the Random Decrement Technique (RDT) and Hilbert transform technique, and the stochastic subspace identification (SSI) method. Results show that strong wind is coming predominantly from the West-South of the tower which is in the same direction as the inclination of the structure. The Von Karman spectrum can describe the spectrum of wind speed well. Wind-induced torsional vibration obviously occurs in this tower. The natural frequencies identified by EMD, RDT and Hilbert Transform are close to those identified by SSI method, but there is obvious difference between the identified damping ratios for the first two modes.

      • KCI등재

        Acalypha australis L. Extract Attenuates DSS-Induced Ulcerative Colitis in Mice by Regulating Inflammatory Factor Release and Blocking NF-jB Activation

        Bo Chen,Yiqing Wang,YouYa Niu,Shenghua Li 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.9

        Ulcerative colitis (UC) is a chronic gastroenteric inflammatory disease that may cause life-threatening complications. Currently available therapeutic drugs are not as effective as expected, necessitating the development of new targetsand drugs. The etiology and pathogenetic mechanisms of UC are largely unclear; thus, the treatment effects are limited. Theaqueous extract of Acalypha australis L. (AAL) has shown good therapeutic efficacy in treating UC. AAL is used intraditional Chinese medicine owing to its hemostasis, detoxification, and heat clearance effects. Although astragalus has suchbroad-spectrum biological activities closely related to inflammation, its therapeutic efficacy for UC treatment has not beenreported, the underlying mechanism remains unknown. We studied the therapeutic effect of AAL on UC in mice and exploredits potential mechanism. Mice were treated with AAL aqueous extract for 7 days (20 mg/kg), after which the colon tissue wasassessed for damage (colon mucosal damage index [CMDI]), apoptosis (immunohistochemistry), and release of cytokines(enzyme-linked immunosorbent assay). The concentration of AAL aqueous extract at 20 mg/kg significantly improved theCMDI score and colon injury of UC model. It also reduced the serum levels of IL-2, IL-8, IL-17A, IL-22, IFN-c, and TNF-a,and decreased apoptosis in the colon. AAL water extract also significantly reduced the expression level of NF-jB pathwayrelatedproteins. In conclusion, AAL can protect against UC mainly by inhibiting the expression level of NF-jB pathwayrelatedproteins and reducing the release of inflammatory factors.

      • Possibility Distribution of Wind Power Fluctuation

        Bo Chen,Yuan Li 보안공학연구지원센터(IJUNESST) 2015 International Journal of u- and e- Service, Scienc Vol.8 No.1

        Volatility is the fixed property of wind power, how to describe the volatility of wind power quantitatively lacks effects methods currently. Based on the analysis of large quantities of testing data, it can be found that it is possible to adopt normal distribution to describe the possibility distribution of wind power fluctuating characteristics. Analysis demonstrates that min level component of wind power nearly occupies 2%-5% of the installed capacity of wind power station: when multiple wind power station outputs are overlapped, it can effectively reduce the proportion of min level component: the type of fans has very tiny effects on wind power fluctuation characteristics, but the current wind power out of wind power station has almost on influence on wind power fluctuation characteristics. Normal distribution also adapts to describe the possibility distribution of averaged power variation in adjacent time interval of wind power station, after the time interval is lengthened, due to decreased wind speed correlations, fluctuation characteristics of averaged power in adjacent intervals enhance.

      • KCI등재

        A Novel Method of Self-Healing in Cementitious Materials by Using Polyacrylic Hydrogel

        Bo Zhu,Qiu Li,Wei Chen,Wei Zou,Wanyu Chen 대한토목학회 2020 KSCE JOURNAL OF CIVIL ENGINEERING Vol.24 No.11

        Cementitious materials are the most widely used in the construction. However, cementitious materials have defects such as low tensile strength which is easy to cause the formation of cracks. In recent years, with the research and application of smart materials, intelligent cementitious materials with self-sensing, self-diagnosis and self-healing functions have received extensive researcher’s attention. In this paper, a polyacrylic hydrogel that could be utilized for self-healing of cementitious materials was designed, and the three-dimensional network structure of the hydrogel controlled the release rate of encapsulated repair agent. The phosphate-incorporated hydrogel was filled into cement slurry to prepare self-healing cementitious materials. After the cement sample cracked and water penetrated into the crack, the phosphate was released from hydrogel. Phosphate reacted with the calcium in the pore solution to form hydroxyapatite type minerals which healed the crack. The self-healing cementitious material is in a position to heal cracks of 300 μm in width. After healing for 28 days at 20oC and 95% of RH, the compressive strength of precracked specimens could reach 85% of that of intact ones.

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