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Long-term outcomes of single-port laparoscopic myomectomy using a modified suture technique
( Mina Kang ),( Jihye Kim ),( Tae-joong Kim ),( Jeong-won Lee ),( Byoung-gie Kim ),( Duk-soo Bae ),( Chel Hun Choi ) 대한산부인과학회 2020 Obstetrics & Gynecology Science Vol.63 No.2
Objective To evaluate the long-term outcomes, including the pregnancy outcome and recurrence rate after single-port laparoscopic myomectomy (LM) using a modified suture technique with a Hem-o-lok clip (Choi’s LM) and conventional 4-port LM. Methods A retrospective study of patients who underwent Choi’s LM (n=55) and 4-port LM (n=102) in a single institutional hospital was conducted. Patients with <3 symptomatic myomas sized <10 cm each and operated on by a single surgeon were included. Recurrence was confirmed when a myoma measuring ≥3 cm was detected. Results The patients in both groups had similar demographic characteristics. Single (76.4% vs. 62.7%) and intramural (52.7% vs. 56.9%) tumors were commonly detected in both groups in the mean diameter (6.8±1.5 cm vs. 7.0±1.6 cm; P=0.40). In Choi’s LM, 16 patients (29.1%) needed an additional port; those who were nulliparous and/or had a large leiomyoma more frequently required an additional port (P=0.023 and 0.04, respectively). During a median follow-up period of 69 months, 17 patients (7.1% vs. 14.6%) had recurrence. The size of dominant myomas at recurrence was significantly smaller in patients who underwent Choi’s LM (3.4±0.7 cm vs. 5.7±2.4 cm; P=0.004). All 13 patients in both groups who successfully conceived had a full-term delivery. No major complications occurred during pregnancy. Conclusion Although an additional port was frequently used, the long-term outcomes of patients who experienced recurrence and pregnancy after Choi’s LM were acceptable. Considering its usability, Choi’s LM is feasible for the treatment of uterine leiomyoma.
Direct inhibition of eIF4E reduced cell growth in endometrial adenocarcinoma
Choi, Chel Hun,Lee, Ji-Soo,Kim, Seong Rim,Lee, Yoo-Young,Kim, Chul-Jung,Lee, Jeong-Won,Kim, Tae-Joong,Lee, Je-Ho,Kim, Byoung-Gie,Bae, Duk-Soo Springer-Verlag 2011 Journal of cancer research and clinical oncology Vol.137 No.3
Choi, Chel Hun,Song, Sang Yong,Kang, Heeseok,Lee, Yoo-Young,Kim, Chul-Jung,Lee, Jeong-Won,Kim, Tae-Joong,Kim, Byoung-Gie,Lee, Je-Ho,Bae, Duk-Soo Blackwell Publishing Asia 2010 JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH -TO Vol.36 No.2
<P>Abstract</P><P>Aim: </P><P>To better predict treatment responses for managing bulky cervical carcinoma with neoadjuvant chemotherapy (NAC).</P><P>Methods: </P><P>The expression of p-STAT3 was analyzed by immunohistochemistry using paraffin-embedded pretreatment cervical biopsy tissues. The study included 29 patients with bulky IB to IIA cervical squamous cell carcinoma treated with NAC.</P><P>Results: </P><P>Twenty (69.0%) of 29 patients were scored as p-STAT3-positive. Pathological response to chemotherapy (complete response or residual tumor with less than 3 mm stromal invasion) was observed in eight patients (27.6%). The p-STAT3-positive patients had a longer disease-free survival compared to p-STAT3-negative patients (<I>P</I> = 0.03), though they had more frequent clinical nodal involvement (<I>P</I> = 0.046).</P><P>Conclusion: </P><P>Pretreatment assessment of p-STAT3 expression may provide additional information for the identification of patients with cervical cancer who have a favorable prognosis.</P>
( Chel Hun Choi ),( Nam Kyeong Kim ),( Kidong Kim ),( Yong Jae Lee ),( Keun Ho Lee ),( Jong-min Lee ),( Kwang Beom Lee ),( Dong Hoon Suh ),( Sunghoon Kim ),( Min Kyu Kim ),( Seok Ju Seong ),( Myong Ch 대한산부인과학회 2022 대한산부인과학회 학술대회 Vol.108 No.-
Objective: To identify the effect of subcutaneous (SQ) drain on wound dehiscence and infection in patients who underwent midline laparotomy for gynecological disease. Methods: Patients planned to undergo midline laparotomy for gynecologic disease, BMI< 35, age >18 years and ECOG performance status 0-2 were 1:1 randomized to case (with SQ drain) vs. control (without SQ drain) at 9 institutes in Korea, from February 2021 to December 2021. We compared the incidence of wound dehiscence at 4 weeks post-surgery and cumulative incidence of wound dehiscence and infection up to 4 weeks post-surgery between case and control group. Results: Of the 174 randomized patients (case 84, control 90), 12 patients were dropped due to follow-up loss (case 5, control 7) and 162 patients (intention-to-treat [ITT] cohort: case 79, control 83) were included. Fourteen patients (case 10, control 4) did not follow assigned intervention depending on the operator’s decision because the SQ layer was either too thick or too thin, and were excluded from per-protocol [PP] analysis (case 69, control 79). In ITT cohort, the frequency of cancer surgery (63/79 [79.7%] vs. 64/83 [77.1%]; p=0.683) and surgery time (mean ± standard deviation = 227.7±133.9 minutes vs. 226.7±118.2 minutes; p=0.960) were comparable in the case and control group. Mean wound length was also similar in both groups (case vs. control; 24.2 cm vs. 24.3 cm; p=0.933). There were no significant differences in the incidence of wound dehiscence at 4 weeks post-surgery (1/79 [1.3%] vs. 2/83 [2.4%]; p>0.999), the cumulative incidence of wound dehiscence (7/79 [8.9%] vs. 5/83 [6.0%]; p=0.491), and the cumulative incidence of wound infection (1/79 [1.3%] vs. 0/83 [0.0%]; p=0.488) between case and control group. PP analysis showed similar result to ITT analysis. Conclusion: SQ drain insertion did not decrease wound dehiscence and infection in patients who underwent midline laparotomy for gynecological disease.
Meta-analysis of the effects of beta blocker on survival time in cancer patients
( Chel Hun Choi ),( Tae Jong Song ),( Tae Hyun Kim ),( Jun Kuk Choi ),( Jin Young Park ),( Aera Yoon ),( Yoo Young Lee ),( Tae Joong Kim ),( Duk Soo Bae ),( Jeong Won Lee ),( Byoung Gie Kim ) 대한산부인과학회 2012 대한산부인과학회 학술대회 Vol.99 No.-
Knowledge of the role of beta blockers on cancer survival may be helpful for cancer patients.This study was to elucidate the potential benefit of beta blockers on cancer survival. We comprehensively searched PubMed, Embase, and the Cochrane Library from their inception to April 2013. Two authors independently screened and reviewed the eligibility of each study and coded the participants, treatment, and outcome characteristics. The primary outcomes were overall survival (OS) and disease-free survival (DFS). Twelve studies published between 1993 and 2013 were included in the final analysis. Four papers reported results from 10 independent groups, resulting in a total of 18 comparisons based on data obtained from 20,898 subjects. Effect sizes (hazard ratios) were heterogeneous and random effects models were used in the analyses. The meta-analysis demonstrated that beta blocker use can improve OS (HR=0.79; 95% CI 0.67 - 0.93; p=0.004) and DFS (HR=0.69; 95% CI 0.53 - 0.91; p=0.009). Although statistically not significant, the effect size was greater in patients with low stage cancer or cancer treated primarily with surgery than in patients with high stage cancer or cancer treated primarily without surgery (HR: 0.60 vs. 0.78, and 0.60 vs. 0.80, respectively). Although only two study codes were analyzed, the studies using nonselective beta blockers showed that there was no overall effect on OS (HR = 0.52, 95% CI: 0.09 - 3.04). This meta-analysis provides evidence that beta blocker use can prolong the survival of cancer patients, especially patients with early stage cancer treated primarily with surgery.
Choi, Chel Hun,Lee, Jeong-Won,Lee, Yoo-Young,Kim, Ha-Jeong,Song, Taejong,Kim, Min-Kyu,Kim, Tae-Joong,Kim, Byoung-Gie,Bae, Duk-Soo Raven Press 2012 Annals of surgical oncology Vol.19 No.12
<P>The aim of this study was to compare the surgical and oncologic outcomes of laparoscopic-assisted radical vaginal hysterectomy (LARVH) with that of laparoscopic radical hysterectomy (LRH) for early-stage cervical cancer.</P>
재발성 자궁경부암에서 TIP (Paclitaxel, ifosfamide, cisplatin) 항암 화학요법의 효과에 관한 연구
최철훈 ( Chel Hun Choi ),김철중 ( Chul Jung Kim ),이선주 ( Sun Joo Lee ),이정원 ( Jeong Won Lee ),박창수 ( Chang Soo Park ),손영수 ( Young Soo Son ),김병기 ( Byoung Gie Kim ),이제호 ( Je Ho Lee ),배덕수 ( Duk Soo Bae ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.11
Development of orthotopic patient-derived tumor xenograft models in endometrial cancer
( Hyun-jin Choi ),( Eun Jin Heo ),( Young Jae Cho ),( Ji Eun Hong ),( Hye-kyung Jeon ),( Doo-yi Oh ),( Yoon-la Choi ),( Sangyong Song ),( Jung-joo Choi ),( Yoo-young Lee ),( Chel Hun Choi ),( Tae-joon 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-
목적: To evaluate orthotopic xenografting of endometrial cancer(EM Ca) in mice for development of novel translational research platform in endometrial cancer. 방법: Fresh surgical specimens were taken from patients with EM Ca after surgery at Department of Obstetrics and Gynecology, Samsung Medical Center, Seoul, Korea between December, 2011 to February, 2016. We successfully established PDXs by orthotopic and subrenal capsule implantation of patient’s EM Ca tissues into female BALB/C-nude mice. The subrenal capsule implatation method were that pieces of EM Ca specimens from patients were meticulosely grafted in the subrenal capsule. Mean while, estrogen preconditioning was done for orthotopic implatation by given a daily s.c injection of 0.1μg estradial for three days. After then, pieces of EM Ca specimens from patients were meticulosly grafted in the enlarged mice’s uterus. The H&E staining, short tandem repeat, array comparative genomic hybridization, human and mouse albumin test and cancer panel were conducted to verifythe histopathologic and genetic similarity between the PDXs and primary patient’s tissues. 결과: Orthotopic PDX engraftment rate were sucessful in 100% (3/3 cases). While, Successful rate of subrenal capsule implantation method was 55.6% (10/18 cases). In orthotopic PDXs, median duration of first generation of PDX develoment from implantation of patient’s tissues was 5.43month (range: 0.83-6.63 month). And, in subrenal capsule implantation PDXs, median duration of first generation was 5.05month (range : 4.17-9.33 month). Both methods were proved to preserve histopathologic and genetic silimarity between PDXs and the primary patient’s tissues. 결론: The PDXs for endometiral cancer with histopathologic and genetic stability can be efficiently developed by an orthotopic implantation method rather than a subrenal capsule implantation method. This method can a promising platform for conducting translational research and future precision medicine in endomerial cancer.