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Deubiquitination and Stabilization of PD-L1 by CSN5
Lim, Seung-Oe,Li, Chia-Wei,Xia, Weiya,Cha, Jong-Ho,Chan, Li-Chuan,Wu, Yun,Chang, Shih-Shin,Lin, Wan-Chi,Hsu, Jung-Mao,Hsu, Yi-Hsin,Kim, Taewan,Chang, Wei-Chao,Hsu, Jennifer L.,Yamaguchi, Hirohito,Ding Elsevier 2016 Cancer cell Vol.30 No.6
<P><B>Summary</B></P> <P>Pro-inflammatory cytokines produced in the tumor microenvironment lead to eradication of anti-tumor immunity and enhanced tumor cell survival. In the current study, we identified tumor necrosis factor alpha (TNF-α) as a major factor triggering cancer cell immunosuppression against T cell surveillance via stabilization of programmed cell death-ligand 1 (PD-L1). We demonstrated that COP9 signalosome 5 (CSN5), induced by NF-κB p65, is required for TNF-α-mediated PD-L1 stabilization in cancer cells. CSN5 inhibits the ubiquitination and degradation of PD-L1. Inhibition of CSN5 by curcumin diminished cancer cell PD-L1 expression and sensitized cancer cells to anti-CTLA4 therapy.</P> <P><B>Highlights</B></P> <P> <UL> <LI> TNF-α stabilizes cancer cell PD-L1 in response to chronic inflammation </LI> <LI> Activation of NF-κB by TNF-α induces CSN5 expression leading to PD-L1 stabilization </LI> <LI> CSN5 enzyme activity controls T cell suppression via PD-L1 deubiquitination </LI> <LI> Destabilization of PD-L1 by CSN5 inhibitor curcumin benefits anti-CTLA4 therapy </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>[DISPLAY OMISSION]</P>
Hydrogen Bubbles and the Growth Morphology of Ramified Zinc by Electrodeposition
Hsu, Pei-Cheng,Seol, Seung-Kwon,Lo, Tsung-Nan,Liu, Chi-Jen,Wang, Chang-Liang,Lin, Chao-Sung,Hwu, Y.,Chen, C. H.,Chang, Liu-Wen,Je, J. H.,Margaritondo, G. The Electrochemical Society 2008 Journal of the Electrochemical Society Vol.155 No.5
Development of Phalaenopsis Flowering Quality Prediction Models
( Han-chun Hsu ),( Suming Chen ),( Chao-yin Tsai ),( Yung-huei Chang ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1
Phalaenopsis is an important exported flower in Taiwan and its flowering quality was reported to be correlated to its leaves’ carbohydrate contents and external traits. Phalaenopsis Sogo Yukidian 'V3' was used as the experimental samples in this research. A hand-held spectrometer and a hyperspectral system were used to build the carbohydrate content prediction models (CC model) respectively first, and then combined with leaves’ external traits obtained from hyperspectral imaging to build the flowering quality prediction model (FQ model). The advantage and application of FQ models built by both devices were compared. The results showed that the CC models built with MPLSR for glucose, fructose, sucrose, total soluble sugar, starch and total carbohydrates by hyperspectral system were all better than those by hand-held spectrometer. The results of FQ models with PLSDA and SVM also showed that the performance of hyperspectral system to discriminate quality levels was better. As for the ANN models’ results to predict the total number of flowers, the errors using both devices were all lower than 0.87. The research proved that using spectral technique to predict the interior contents in Phalaenopsis leaves or flowering quality were both feasible. Although the performance of hyperspectral imaging system is better than that of hand-held spectrometer, it was expensive and not as convenient as hand-held spectrometer. We can adopt some other ways such as using multispectral imaging system or optimize the performance of hand-held spectrometer if we want to apply the results to the Phalaenopsis industry.
Advanced Path-Migration Mechanism for Enhancing Signaling Efficiency in IP Multimedia Subsystem
( Kai-di Chang ),( Chi-yuan Chen ),( Shih-wen Hsu ),( Han-chieh Chao ),( Jiann-liang Chen ) 한국인터넷정보학회 2012 KSII Transactions on Internet and Information Syst Vol.6 No.1
Since Internet Protocol (IP) is the most important protocol in Next Generation Networks (NGNs), 3rd Generation Partnership Project (3GPP) utilizes Session Initial Protocol (SIP) based on IP as the base protocol for negotiating sessions in IP Multimedia Subsystem (IMS). Different from traditional circuit-switched network, in IMS, the media traffic and signaling are delivered through IP transport. The media traffic may affect the signaling efficiency in core network, due to traffic collisions and best effort packets delivery. This paper proposes a novel path-migration mechanism for enhancing the traffic efficiency in integrated NGN-IMS. The simulation results show that the interference and traffic collision can be reduce by applying proposed path-migration mechanism and the signaling efficiency in core network can be improved with higher system capability and voice quality.
Atypical Pulmonary Metastases from a True Malignant Mixed Tumor of the Parotid Gland
Wen-Chiung Lin,Chao-Shiang Li,Chih-Kung Lin,Tsun-Hou Chang,Tom, Yun-Cheng Chen,Hsian-He Hsu,Guo-Shu Huang 대한영상의학회 2009 Korean Journal of Radiology Vol.10 No.2
A 58-year-old male patient presented with a recurrent true malignant mixed tumor of the parotid gland. Patchy pulmonary opacities were identified with a chest radiograph. Subsequently, a CT scan of the chest showed pulmonary parenchymal consolidation with amorphous calcifications. This abnormality was confirmed to be the result of a metastatic true malignant mixed tumor by using CT-guided biopsy. The current case demonstrated an extremely rare example of atypical pulmonary metastases from a true malignant mixed tumor of the parotid gland showing an air-space pattern and calcification.
( Shu-Chen Wei ),( Ting-An Chang ),( Te-Hsin Chao ),( Jinn-Shiun Chen ),( Jen-Wei Chou ),( Yenn-Hwei Chou ),( Chiao-Hsiung Chuang ),( Wen-Hung Hsu ),( Tien-Yu Huang ),( Tzu-Chi Hsu ),( Chun-Chi Lin ) 대한장연구학회 2017 Intestinal Research Vol.15 No.3
Ulcerative colitis (UC) is an inflammatory bowel disease characterized by chronic mucosal inflammation of the colon, and the prevalence and incidence of UC have been steadily increasing in Taiwan. A steering committee was established by the Taiwan Society of Inflammatory Bowel Disease to formulate statements on the diagnosis and management of UC taking into account currently available evidence and the expert opinion of the committee. Accurate diagnosis of UC requires thorough clinical, endoscopic, and histological assessment and careful exclusion of differential diagnoses, particularly infectious colitis. The goals of UC therapy are to induce and maintain remission, reduce the risk of complications, and improve quality of life. As outlined in the recommended treatment algorithm, choice of treatment is dictated by severity, extent, and course of disease. Patients should be evaluated for hepatitis B virus and tuberculosis infection prior to immunosuppressive treatment, especially with steroids and biologic agents, and should be regularly monitored for reactivation of latent infection. These consensus statements are also based on current local evidence with consideration of factors, and could be serve as concise and practical guidelines for supporting clinicians in the management of UC in Taiwan. (Intest Res 2017;15:266-284)
( Shu-Chen Wei ),( Ting-An Chang ),( Te-Hsin Chao ),( Jinn-Shiun Chen ),( Jen-Wei Chou ),( Yenn-Hwei Chou ),( Chiao-Hsiung Chuang ),( Wen-Hung Hsu ),( Tien-Yu Huang ),( Tzu-Chi Hsu ),( Chun-Chi Lin ) 대한장연구학회 2017 Intestinal Research Vol.15 No.3
Crohn`s disease (CD) is a chronic relapsing and remitting inflammatory disease of the gastrointestinal tract. CD is rare in Taiwan and other Asian countries, but its prevalence and incidence have been steadily increasing. A steering committee was established by the Taiwan Society of Inflammatory Bowel Disease to formulate statements on the diagnosis and management of CD taking into account currently available evidence and the expert opinion of the committee. Thorough clinical, endoscopic, and histological assessments are required for accurate diagnosis of CD. Computed tomography and magnetic resonance imaging are complementary to endoscopic evaluation for disease staging and detecting complications. The goals of CD management are to induce and maintain remission, reduce the risk of complications, and improve quality of life. Corticosteroids are the mainstay for inducing re-mission. Immunomodulating and biologic therapies should be used to maintain remission. Patients should be evaluated for hepatitis B virus and tuberculosis infection prior to treatment and receive regular surveillance for cancer. These consensus statements are based on current local evidence with consideration of factors, and could be serve as concise and practical guidelines for supporting clinicians in the management of patients with CD in Taiwan. (Intest Res 2017;15:285-310)
Predicting the Anthocyanin Content of Kyoho Grapes by Nir Spectroscopy
( Si-yun Wang ),( Suming Chen ),( Chao-yin Tsai ),( Han-chun Hsu ),( Yung-huei Chang ) 한국농업기계학회 2018 한국농업기계학회 학술발표논문집 Vol.23 No.1
Kyoho grapes are in dark purple color. Anthocyanin plays a major role on the colors of berries, and contains antioxidant, anti-inflammatory, anticancer substance. The method of inspecting Anthocyanins so far is by either visual or destructive technique of using chemicals, but these methods could not carry out real-time accurate inspection. The aim of this study was to demonstrate the feasibility of non-destructive inspection in predicting Anthocyanin content by near-infrared spectroscopy. This study used the NIRS 6500 spectrometer ranged from 400 to 2500 nm. The prediction model of Anthocyanin content of Kyoho grapes was established by near-infrared spectroscopy and concentration of Anthocyanin. The results of this study showed the reliability and feasibility of near-infrared spectroscopy on predicting the Anthocyanin content of grapes. In the future, the Anthocyanin content can be quickly predicted by spectroscopic techniques.