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Park, Chan Woo,Lee, Sun Hee,Yang, Kwang Moon,Lee, In Ho,Lim, Kyung Teak,Lee, Ki Heon,Kim, Tae Jin The Korean Society for Reproductive Medicine 2016 Clinical and Experimental Reproductive Medicine Vol.43 No.2
Objective: The aim of this study was to report a case series of in vitro matured (IVM) oocyte freezing in gynecologic cancer patients undergoing radical surgery under time constraints as an option for fertility preservation (FP). Methods: Case series report. University-based in vitro fertilization center. Six gynecologic cancer patients who were scheduled to undergo radical surgery the next day were referred for FP. The patients had endometrial (n=2), ovarian (n=3), and double primary endometrial and ovarian (n=1) cancer. Ex vivo retrieval of immature oocytes from macroscopically normal ovarian tissue was followed by mature oocyte freezing after IVM or embryo freezing with intracytoplasmic sperm injection. Results: A total of 53 oocytes were retrieved from five patients, with a mean of 10.6 oocytes per patient. After IVM, a total of 36 mature oocytes were obtained, demonstrating a 67.9% maturation rate. With regard to the ovarian cancer patients, seven IVM oocytes were frozen from patient 3, who had stage IC cancer, whereas one IVM oocyte was frozen from patient 4, who had stage IV cancer despite being of a similar age. With regard to the endometrial cancer patients, 15 IVM oocytes from patient 1 were frozen. Five embryos were frozen after the fertilization of IVM oocytes from patient 6. Conclusion: Immature oocytes can be successfully retrieved ex vivo from macroscopically normal ovarian tissue before radical surgery. IVM oocyte freezing provides a possible FP option in patients with advanced-stage endometrial or ovarian cancer without the risk of cancer cell spillage or time delays.
홍기택 ( Ki Teak Hong ),임병찬 ( Byung Chan Lim ),문진수 ( Jin Soo Moon ),고재성 ( Jae Sung Ko ) 대한소화기학회 2021 대한소화기학회지 Vol.77 No.5
Mitochondrial DNA (mtDNA) depletion syndrome comprises diseases resulting from a deficiency of proteins involved in mtDNA synthesis. MPV17 is a mitochondrial membrane protein whose mutation causes mitochondrial deoxynucleotide insufficiency. MPV17-related hepatocerebral mtDNA depletion syndrome is a rare autosomal recessive disease. This case report describes the clinical manifestations of MPV17-related hepatocerebral mtDNA depletion syndrome analyzed by performing whole-exome sequencing (WES). A 17-month-old girl presented with developmental delay, jaundice, and failure to thrive. The laboratory findings revealed cholestatic hepatitis, increased lactate-to-pyruvate ratio, and prolongation of the prothrombin time. She developed a hypoglycemic seizure. Brain magnetic resonance imaging revealed extensive demyelination of the white matter. WES detected the p.Leu151fs and p.Pro98Leu variants in MPV17. Her parents and sibling were found to be MPV17 heterozygous carriers. She was administered supportive treatment, such as replacement of fat-soluble vitamins and cornstarch to prevent further hypoglycemic events. The patient is currently being considered for liver transplantation. Overall, WES can help diagnose hepatocerebral mtDNA depletion syndrome in patients with hepatopathy, developmental delay, lactic acidosis, and hypomyelination based on brain magnetic resonance imaging. (Korean J Gastroenterol 2021;77:248-252)
배대경,권오수,임찬택,Bae, Dae-Kyung,Kwon, Oh-Soo,Lim, Chan-Teak 대한관절경학회 2001 대한관절경학회지 Vol.5 No.2
목적 : 반월상 연골 손상은 내,외측에서 단독으로 파열되거나 인대손상과 동반되어 자주 발생하는데 지금까지 내측 반월상연골 손상에 대한 보고는 많으나 외측 반월상 연골 단독 손상에 대한 보고는 흔하지 않다. 이에 저자들은 외측 반월상 연골 단독 손상의 치료 결과를 임상적으로 분석하고자 한다. 대상 및 방법 : 1997년 1월부터 2000년 6월까지 경희대학교 의과대학 정형외과학 교실에서 외측 반월상 연골 손상으로 진단되어 수술적 치료를 받은 총 329례 중 최소 1년 이상 추시관찰이 가능했던 80례를 대상으로 임상적 평가를 후향적으로 시행하였다. 환자의 평균 연령은 30.2세(15세$\~$47세), 평균 추시기간은 1년 3개월(1년$\~$3년 3개월)이었다. 80례를 원판형 연골 손상군과 비 원판형 연골 손상군, 운동 선수군과 비 운동선수군 및 봉합술 시행군과 절제술 시행군으로 분류하고 Tegner 활동도와 Lysholm score를 이용하여 임상적 평가를 시행하였다. 결과 : 비 원판형 연골군에서 종파열의 빈도와 봉합술 시행의 빈도가 원판형 연골군보다 더 높았으며 운동 선수군에서 봉합술이 더 많이 시행되었다. 봉합술 시행군에서 절제술 시행군보다 통계학적으로 의미있는 우수한 임상결과를 보였다. 결론 : 외측 반월상 연골은 절제술 시행 후 불안정성을 초래할 수 있고 봉합술이 수기상 용이하지는 않으나 더 나은 술 후 성적을 얻기 위해서는 종파열뿐만 아니라 수평파열 및 복합파열에서도 부분절제술 후 가능한 한 봉합술을 시행하는 것이 바람직할 것으로 사료된다. Purpose : To analyze the clinical results of isolated lateral meniscus injury according to discoid versus non-discoid, athletes versus non-athletes and repaired cases versus cases treated with meniscectomy. Materials and Methods : Between January 1997 and June 2000, arthroscopic lateral meniscus surgery was performed in 329 cases. We reviewed 80 cases of isolated lateral meniscus injury without associated ligament injury or other pathologic condition retrospectively. The study population was composed of 54 males and 26 females with average age of 30.2 years(range, $17\~40$ years). Average follow up period was 15 months(range, $12\~39$ months). Eighty cases were classified into three categories; discoid group versus non-discoid group, athletes versus non-athletes, repaired cases versus cases treated with meniscectomy. Clinical evaluation was performed using Lysholm knee score and Tegner activity. Results : Non-discoid group had higher incidence of longitudinal tear than discoid group. Athletes group had higher incidence of repaired cases than non-athletes group. The repaired group had better clinical result than patient treated with meniscectomy group. Conclusion : Although lateral meniscus has some special features including anatomic mobility which can cause instability after meniscectomy and technical difficulties in repairing, it is recommended repairing meniscus tear not only longitudinal but also horizontal and complex tear to obtain better clinical results.
이용걸(Yong Girl Rhee),하정한(Jeong Han Ha),임찬택(Chan Teak Lim),박경준(Kyoung Jun Park) 대한정형외과학회 2005 대한정형외과학회지 Vol.40 No.2
목적: 비외상성 견관절 질환에 있어서의 견관절 부분 치환술과 전 치환술의 임상적 결과 및 합병증을 비교 분석하고자 한다. 대상 및 방법: 견관절의 비외상성 질환으로 견관절 치환술을 시행한 32명 34예를 대상으로 하였다. 류마티스성 관절염이 16예(47%)로 가장 많았으며 골성 관절염이 9예, 무혈성 괴사가 4예 등이었다. 11예에서는 부분 치환술을, 23예에서는 전치환술을 시행하였다. 결과: 부분 치환술의 경우 운동시 동통은 수술 전 7.09에서 0.91로 감소되었고 전방 거상은 평균 137, 외회전 및 외전은 각각 평균 55°와 131°였으며, ASES 점수는 평균 82.4점이었다. 전치환술의 경우는 동통이 수술 전 7.04에서 1.17로 감소하였으며, 전방 거상, 외회전 및 외전은 각각 평균 132, 44° 및 132°였다. ASES 점수는 평균 81.2점이었다. 류마티스성 관절염의 경우 부분 치환술과 전 치환술에서 ASES 점수는 각각 평균 77.8점과 78.1점이었다. 퇴행성 관절염의 경우는 각각 평균 84.7점과 90.8점이었다. 관절와 침식은 부분 치환술을 받은 3예에서 나타났으며 관절와 해리는 전 치환술을 받은 2예에서 관찰되었다. 결론: 비외상성 환자에서의 견관절 치환술로 양호한 결과를 얻을수 있었고 부분 치환술과 전 치환술의 결과는 많은 차이가 없었다. 류마티스성 관절염 보다 퇴행성 관절염에서의 결과가 더 좋았으며, 류마티스성 관절염에서는 대부분의 경우 전치환술을 시행하였다. Purpose: To compare the clinical outcomes and complications of hemiarthroplasty (HHR) and total shoulder arthroplasty (TSR) in non-traumatic arthritis patients. Materials and Methods: Thirty-two patients (34 shoulders) underwent shoulder arthroplasty for non-traumatic shoulder arthropathy. There were sixteen patients with rheumatoid arthritis, nine with osteoarthritis, four with avascular necrosis and etc. HHR was performed in eleven shoulders and TSR in twenty-three shoulders. Results: In HHR, the pain score decreased from preoperatively 7.09 to 0.91 postoperatively. The mean forward elevation was 137° and the mean external rotation at the side and abduction were 55° and 131°, respectively. The mean ASES score was 82.4. In TSR, the pain score decreased from 7.04 preoperatively to 1.17 postoperatively. The mean forward elevation, external rotation at the side and abduction were 132°, 44°, and 132°, respectively. The mean ASES score was 81.2. In rheumatoid arthritis, the mean ASES score of the HHR and TSR were 77.8 and 78.1, respectively. In osteoarthritis, the mean ASES score was 84.7 and 90.8, respectively. During the follow up, glenoid erosion was observed in three HHR cases, and glenoid loosening in two TSR case. Conclusion: HHR and TSR produced similar results in terms of the functional improvement. The clinical results were much better in patients with osteoarthritis than in those with rheumatoid arthritis, and TSR was performed on most cases of rheumatoid arthritis.