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- 저자 : Carron, Michele (검색결과 5 건)
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Cystic fibrosis gene therapy, novel strategies for improving long-term therapeutic efficacy
( Juliette Delhove ),( Patricia Cmielewski ),( Nigel Farrow ),( Chantelle Carpentieri ),( Alexandra Sarah Ann Mc Carron ),( Nicole Reyne ),( Nathan Rout-pitt ),( Bernadette Boog ),( Martin Donnelley ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Background: Cystic fibrosis (CF) is a genetic disease caused by mutations in the CF transmembrane conductance regulator (CFTR) protein. CF results in airway surface dehydration and the inability to clear mucus, which leads to chronic infections, inflammation, and premature death most commonly due to respiratory failure. Gene therapy can be used to insert a correct copy of the CFTR gene into the genome to restore organ function by fixing the underlying genetic condition independent of CFTR mutation type. Lentiviruses (LV) are a promising gene therapy vehicle as they stably integrate the therapeutic gene into the genome. To achieve permanent genetic correction, we are focusing on developing vectors to improve cell targeting and specificity to overcome the current challenges of CF gene therapy. Methods: LV vectors containing reporter genes (LacZ, Luc-GFP) or epitope-tagged CFTR were developed and tested in vitro. Subsequently, each vector was administered to the nasal epithelia or lungs of CF mice or rats. Transduction efficiency, duration, localisation and CFTR function were assessed using histology, electrophysiological measurements, and in vivo bioluminescence imaging. Results: LV vectors containing reporter genes or CFTR have been shown to successfully transduce the lung and express transgenes long-term. Non-specific alveoli cells and macrophages are transduced in conjunction with a low proportion of therapeutically-relevant basal cells. Importantly, LV vector containing tagged or non-tagged CFTR produced functional correction of the nasal potential difference with tagging of CFTR having no effect on CFTR function. Conclusions: We have shown that our vector has the potential for long-term expression, and can correct CF mutation-induced electrophysiological defects. Using vector-surface engineering strategies, we now aim to overcome the current challenges of basal cell targeting, immune responses, and off-target transduction of non-therapeutic cell types. Combatting these critical obstacles will enable full and rapid progress in gene therapy treatment for this life-limiting disease.
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PECS II block is associated with lower incidence of chronic pain after breast surgery
De Cassai, Alessandro,Bonanno, Claudio,Sandei, Ludovica,Finozzi, Francesco,Carron, Michele,Marchet, Alberto The Korean Pain Society 2019 The Korean Journal of Pain Vol.32 No.4
Background: Breast cancer is complicated by a high incidence of chronic postoperative pain (25%-60%). Regional anesthesia might play an important role in lowering the incidence of chronic pain; however it is not known if the pectoral nerve block (PECS block), which is commonly used for breast surgery, is able to prevent this complication. Our main objective was therefore to detect any association between the PECS block and chronic pain at 3, 6, 9, and 12 months in patients undergoing breast surgery. Methods: We conducted a prospective, monocentric, observational study. We enrolled 140 consecutive patients undergoing breast surgery and divided them in patients receiving a PECS block and general anesthesia (PECS group) and patients receiving only general anesthesia (GA group). Then we considered both intraoperative variables (intravenous opioids administration), postoperative data (pain suffered by the patients during the first 24 postoperative hours and the need for additional analgesic administration) and development and persistence of chronic pain (at 3, 6, 9, and 12 mo). Results: The PECS group had a lower incidence of chronic pain at 3 months (14.9% vs. 31.8%, P = 0.039), needed less intraoperative opioids (fentanyl $1.61{\mu}g/kg/hr$ vs. $3.3{\mu}g/kg/hr$, P < 0.001) and had less postoperative pain (3 vs. 4, P = 0.017). Conclusions: The PECS block might play an important role in lowering incidence of chronic pain, but further studies are needed.
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PECS II block is associated with lower incidence of chronic pain after breast surgery
Alessandro De Cassai,Claudio Bonanno,Ludovica Sandei,Francesco Finozzi,Michele Carron,Alberto Marchet 대한통증학회 2019 The Korean Journal of Pain Vol.32 No.4
Background: Breast cancer is complicated by a high incidence of chronic postoperative pain (25%-60%). Regional anesthesia might play an important role in lowering the incidence of chronic pain; however it is not known if the pectoral nerve block (PECS block), which is commonly used for breast surgery, is able to prevent this complication. Our main objective was therefore to detect any association between the PECS block and chronic pain at 3, 6, 9, and 12 months in patients undergoing breast surgery. Methods: We conducted a prospective, monocentric, observational study. We enrolled 140 consecutive patients undergoing breast surgery and divided them in patients receiving a PECS block and general anesthesia (PECS group) and patients receiving only general anesthesia (GA group). Then we considered both intraoperative variables (intravenous opioids administration), postoperative data (pain suffered by the patients during the first 24 postoperative hours and the need for additional analgesic administration) and development and persistence of chronic pain (at 3, 6, 9, and 12 mo). Results: The PECS group had a lower incidence of chronic pain at 3 months (14.9% vs. 31.8%, P = 0.039), needed less intraoperative opioids (fentanyl 1.61 μg/kg/hr vs. 3.3 μg/kg/hr, P < 0.001) and had less postoperative pain (3 vs. 4, P = 0.017). Conclusions: The PECS block might play an important role in lowering incidence of chronic pain, but further studies are needed.
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A Rare Cause of Thoracic Spinal Cord Compression by Multiple Large Tarlov Cysts
Ahmed-Salem Kleib,Sidi-Mohamed Salihy,Hussein Hamdi,Romain Carron,Outouma Soumaré,Ahmed-Salem Kleib 대한신경손상학회 2018 Korean Journal of Neurotrauma Vol.15 No.1
Spinal extradural arachnoid cyst (SEAC) is a rare cause of spinal cord compression. Bifocal location of thoracic and sacralSEACs is rarely reported in the literature. We report a case of thoracic spinal cord compression by SEAC associated withasymptomatic multiple sacral Tarlov cysts (TC). The surgical management and postoperative outcome of the patient arediscussed. A 34-year-old woman was referred to the hospital for acute thoracic pain with a history of chronic long-standing back pain. She complained of walking diffculties. Neurological examination demonstrated incomplete spastic paraplegia with sensory level in T9. Magnetic resonance imaging revealed a large cystic formation from T7-11 and at the levelof the sacrum. We performed laminectomies at the level of interest from T7-11. The cysts were dissected from the underlying dura after removal of the cerebrospinal fluid. We found nerve tissue in the cysts. We excised the cyst and preservedthe nerve roots. Subsequently, a duraplasty was performed with autologous grafts from the lumbar fascia. The conditionof the patient improved after surgery and he was recovering well at follow-up. Although the surgical treatment of TC iscontroversial, especially at the sacral lumbar level, decompression at the dorsal level in this case is indisputable
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