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Phospholipid dynamics in ex vivo lung cancer and normal lung explants
Lesko Julia,Triebl Alexander,Stacher-Priehse Elvira,Fink-Neuböck Nicole,Lindenmann Jörg,Smolle-Jüttner Freyja-Maria,Köfeler Harald C.,Hrzenjak Andelko,Olschewski Horst,Leithner Katharina 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
In cancer cells, metabolic pathways are reprogrammed to promote cell proliferation and growth. While the rewiring of central biosynthetic pathways is being extensively studied, the dynamics of phospholipids in cancer cells are still poorly understood. In our study, we sought to evaluate de novo biosynthesis of glycerophospholipids (GPLs) in ex vivo lung cancer explants and corresponding normal lung tissue from six patients by utilizing a stable isotopic labeling approach. Incorporation of fully 13 C-labeled glucose into the backbone of phosphatidylethanolamine (PE), phosphatidylcholine (PC), and phosphatidylinositol (PI) was analyzed by liquid chromatography/mass spectrometry. Lung cancer tissue showed significantly elevated isotopic enrichment within the glycerol backbone of PE, normalized to its incorporation into PI, compared to that in normal lung tissue; however, the size of the PE pool normalized to the size of the PI pool was smaller in tumor tissue. These findings indicate enhanced PE turnover in lung cancer tissue. Elevated biosynthesis of PE in lung cancer tissue was supported by enhanced expression of the PE biosynthesis genes ETNK2 and EPT1 and decreased expression of the PC and PI biosynthesis genes CHPT1 and CDS2 , respectively, in different subtypes of lung cancer in publicly available datasets. Our study demonstrates that incorporation of glucose-derived carbons into the glycerol backbone of GPLs can be monitored to study phospholipid dynamics in tumor explants and shows that PE turnover is elevated in lung cancer tissue compared to normal lung tissue.
CMOS Compatible Fabrication Technique for Nano-Transistors by Conventional Optical Lithography
Horst, C.,Kallis, K.T.,Horstmann, J.T.,Fiedler, H.L. The Institute of Electronics and Information Engin 2004 Journal of semiconductor technology and science Vol.4 No.1
The trend of decreasing the minimal structure sizes in microelectronics is still being continued. Therefore in its roadmap the Semiconductor Industries Association predicts a printed minimum MOS-transistor channel length of 10 nm for the year 2018. Although the resolution of optical lithography still dramatically increases, there are known and proved solutions for structure sizes significantly below 50 nm up to now. In this work a new method for the fabrication of extremely small MOS-transistors with a channel length and width below 50 nm with low demands to the used lithography will be explained. It's a further development of our deposition and etchback technique which was used in earlier research to produce transistors with very small channel lengths down to 30 nm, with a scaling of the transistor's width. The used technique is proved in a first charge of MOS-transistors with a channel area of W=200 nm and L=80 nm. The full CMOS compatible technique is easily transferable to almost any other technology line and results in an excellent homogeneity and reproducibility of the generated structure size. The electrical characteristics of such small transistor will be analyzed and the ultimate limits of the technique will be discussed.
The Effect of Breast Hypertrophy on Patient Posture
Lapid, Oren,de Groof, E. Joline,Corion, Leonard U.M.C.,Smeulders, Mark J.C.,van der Horst, Chantal M.A.M. Korean Society of Plastic and Reconstructive Surge 2013 Archives of Plastic Surgery Vol.40 No.5
Background One of the reasons women with macromastia chose to undergo a breast reduction is to relieve their complaints of back, neck, and shoulder pain. We hypothesized that changes in posture after surgery may be the reason for the pain relief and that patient posture may correlate with symptomatic macromastia and may serve as an objective measure for complaints. The purpose of our study was to evaluate the effect of reduction mammaplasty on the posture of women with macromastia. Methods A prospective controlled study at a university medical center. Forty-two patients that underwent breast reduction were studied before surgery and an average of 4.3 years following surgery. Thirty-seven healthy women served as controls. Standardized lateral photos were taken. The inclination angle of the back was measured. Regression analysis was performed for the inclination angle. Results Preoperatively, the mean inclination angle was 1.61 degrees ventrally; this diminished postoperatively to 0.72 degrees ventrally. This change was not significant (P-value=0.104). In the control group that angle was 0.28 degrees dorsally. Univariate regression analysis revealed that the inclination was dependent on body mass index (BMI) and having symptomatic macromastia; on multiple regression it was only dependent on BMI. Conclusions The inclination angle of the back in breast reduction candidates is significantly different from that of controls; however, this difference is small and probably does not account for the symptoms associated with macromastia. Back inclination should not be used as a surrogate "objective" measure for symptomatic macromastia.
Displacement field estimation for a two-dimensional structure using fiber Bragg grating sensors
Rapp, Stephan,Kang, Lae-Hyong,Han, Jae-Hung,Mueller, Uwe C,Baier, Horst Institute of Physics Publishing 2009 Smart materials & structures Vol.18 No.2
<P>The structure shape itself is of great interest for many aerospace applications. For example, the stability of the surface shape of large, high precision or space reflectors is essential for the communication performance. The knowledge of static and dynamic displacements of these structures would provide the possibility to enhance their performance by appropriate countermeasures. During operation, however, the direct measurement of displacements of the whole structure is often difficult. This study investigates whole displacement field estimation using strain measurement and a displacement–strain-transformation approach. The use of fiber Bragg gratings (FBGs) as strain sensors for this application offers the possible implementation of an integrated sensor network including many measurement points within only a few optical fibers. This paper discusses many issues related to the displacement field estimation of a dynamically excited plate using a transformation matrix based on a modal approach. In order to reduce systematic displacement estimation errors due to aliasing, a parametric study was performed and the sensor locations were optimized. Experimental validation was also conducted using a cantilever plate equipped with 16 FBG sensors in an optimized configuration. The estimated displacements showed good agreements with those measured directly from laser displacement sensors. </P>