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KWON, SANGHOON,KIM, DONGBUM,PARK, BYOUNG KWON,WU, GUANG,PARK, MIN CHUL,HA, YANG-WHA,KWON, HYUNG-JOO,LEE, YOUNGHEE Spandidos Publications 2013 Oncology reports Vol.29 No.2
<P>The innovation of a peptide vaccine strategy may contribute to the development of efficacious and convenient cancer vaccines. Recently, we formulated an efficacious peptide vaccine without carriers using the natural phosphodiester bond CpG-DNA and a special liposome complex [Lipoplex(O)]. The peptide vaccine targeting a tumor antigen, transmembrane 4 superfamily member 5 protein (TM4SF5), was confirmed to have preventive and therapeutic effects in a mouse hepatocellular carcinoma (HCC) model. In this study, we demonstrated that the isotype-switched (IgM(-)IgD(-)) B cell population increased after immunization and that the functional memory response persisted for at least 70 days after the final immunization of mice. Delayed implantation of BNL-HCC cells significantly induced the peptide-specific IgG2a production in the immunized mice. Accordingly, tumor growth was inhibited and the survival rate increased. These results suggest that our peptide vaccine induces memory response, which is essential for cancer vaccine application.</P>
The Failure of Redistributive Policy in the Progressive Era Urban Politics
( Byoung Kwon Sohn ) 한국세계지역학회 2006 世界地域硏究論叢 Vol.24 No.2
Although the Progressive reform movement in the United States during the early 20(th) century swept the whole nation, the concrete reform measures taken at various tiers of government were not the same. Depending on the regions and the government types, different social and political needs were paid attention to by different types of reformers. On the other hand, with respect to the levels of governments, different tiers of government addressed different types of social and political issues, and the nature of the reforms driven by those governments were also different. Differentiating the policy responses of various levels of government to social demands, this paper aims at explaining why redistributive policies could hardly be formulated and implemented at the local level of government during the Progressive era. This research question is based on the very premise that the reasons of absence, or failure, of redistributive policies at the municipal level should be different from those at the federal level. With this premise in mind, one of the main arguments of this paper is that the urban business-reform coalition, forged during this Progressive period on the basis of shared interest in efficiency, systematically edged out the redistributive type of policies, such as welfare policy, which were to entail, by nature, new tax imposition on upper-and middle-income groups, massive top-down resource transfer, and the possibility of political mismanagement and corruption. The business-reform coalition invented various institutional schemes such as commission and/or. manager governments to protect their interests, eluding the demands of redistributive nature from the mass.
Nano-Fenton Reactors as a New Class of Oxidative Stress Amplifying Anticancer Therapeutic Agents
Kwon, Byeongsu,Han, Eunji,Yang, Wonseok,Cho, Wooram,Yoo, Wooyoung,Hwang, Junyeon,Kwon, Byoung-Mog,Lee, Dongwon American Chemical Society 2016 ACS APPLIED MATERIALS & INTERFACES Vol.8 No.9
<P>Cancer cells, compared to normal cells, are under oxidative stress associated with an elevated level of reactive oxygen species (ROS) and are more vulnerable to oxidative stress induced by ROS generating agents. Thus, manipulation of the ROS level provides a logical approach to kill cancer cells preferentially, without significant toxicity to normal cells, and great efforts have been dedicated to the development of strategies to induce cytotoxic oxidative stress for cancer treatment. Fenton reaction is an important biological reaction in which irons convert hydrogen peroxide (H2O2) to highly toxic hydroxyl radicals that escalate ROS stress. Here, we report Fenton reaction-performing polymer (PolyCAFe) micelles as a new class of ROS-manipulating anticancer therapeutic agents. Amphiphilic PolyCAFe incorporates H2O2-generating benzoyloxycinnamaldehyde and iron-containing compounds in its backbone and self-assembles to form micelles that serve as Nano-Fenton reactors to generate cytotoxic hydroxyl radicals, killing cancer cells preferentially. When intravenously injected, PolyCAFe micelles could accumulate in tumors preferentially to remarkably suppress tumor growth, without toxicity to normal tissues. This study demonstrates the tremendous translatable potential of Nano-Fenton reactors as a new class of anticancer drugs.</P>
CCTV-Based Multi-Factor Authentication System
Kwon, Byoung-Wook,Sharma, Pradip Kumar,Park, Jong-Hyuk Korea Information Processing Society 2019 Journal of information processing systems Vol.15 No.4
Many security systems rely solely on solutions based on Artificial Intelligence, which are weak in nature. These security solutions can be easily manipulated by malicious users who can gain unlawful access. Some security systems suggest using fingerprint-based solutions, but they can be easily deceived by copying fingerprints with clay. Image-based security is undoubtedly easy to manipulate, but it is also a solution that does not require any special training on the part of the user. In this paper, we propose a multi-factor security framework that operates in a three-step process to authenticate the user. The motivation of the research lies in utilizing commonly available and inexpensive devices such as onsite CCTV cameras and smartphone camera and providing fully secure user authentication. We have used technologies such as Argon2 for hashing image features and physically unclonable identification for secure device-server communication. We also discuss the methodological workflow of the proposed multi-factor authentication framework. In addition, we present the service scenario of the proposed model. Finally, we analyze qualitatively the proposed model and compare it with state-of-the-art methods to evaluate the usability of the model in real-world applications.
Synthesis and In Vitro Cytotoxicity of Cinnamaldehydes to Hyman Solid Tumor Cells
Kwon, Byoung-Mog,Lee, Seung-Ho,Choi, Sang-Un,Park, Sung-Hee,Lee, Chong-Ock,Cho, Young-Kwon,Sung, Nack-Do,Bok, Song-Hae The Pharmaceutical Society of Korea 1998 Archives of Pharmacal Research Vol.21 No.2
Cinnamaldehydes and related compounds were synthesized from various cinnamic acids based on the $2^{I}$-hydroxycinnamaidehyde isolated from the bark of Cinnamomum cassia Blume. The cytotoxicity to human solid tumor cells such as A549, SK-OV-3, SK-MEL-2, XF498 and HCT15 were measured. Cinnamic acid, cinnamates and cinnamyl alcohols did not show any cytotoxicity against the human tumor cells. Cinnamaldehydes and realted compounds were resistant to A549 cell line up to 15 .mu.g/ml. In contrast, HCT15 and SK-MEL-2 cells were much sensitive to these cinnamaidehyde analogues which showed $ED{50} values 0.63-8.1{\mu}g/ml.$Cytotoxicity of the saturated aldehydes was much weak compared to their unsaturated aldehydes. From these studies, it was found that the key functional group of the cinnamaldehyde-related compounds in the antitumor activity is the propenal group.p.
Molecules of the Tumor Necrosis Factor (TNF) Receptor and Ligand Superfamilies: Endless Stories
Kwon, Byung-Suk,Kwon, Byoung-Se Korean Society for Biochemistry and Molecular Biol 1999 Journal of biochemistry and molecular biology Vol.32 No.5
Tumor necrosis factor (TNF) receptor members have unique structures composed of 2-4 cysteine - rich pseudorepeats in the extracellular domain. On ligation by trimeric ligand molecules, oligomerization of three receptor molecules occurs, which in turn activates the receptor and recruits intracellular signaling molecules to the cytoplasmic tail to initiate biological events. Recently, the numbers of tumor necrosis factor receptor and ligand family members have been rapidly expanding. Functional characterization of the new members has indicated redundant roles with other known members as well as provided insights into novel functions. In particular, identification of soluble decoy receptors which have the ability to bind multiple ligands highlights a complex control mechanism of immune responses by these molecules. Studies of the new members have also revealed that the TNF receptor and ligand family members play an important role in other than the immune system.
( Byoung Soo Kwon ),( Jin Woo Song ),( Jooae Choi ),( Kyung Hyun Do ),( Eun Jin Chae ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Background: The new diagnostic guideline for idiopathic pulmonary fibrosis (IPF) advocated the use of four diagnostic categories of high resolution computed tomography (HRCT) patterns. However, it is not known whether the disease course differs according to the HRCT pattern. The aim of this study was to investigate the impact of HRCT patterns on survival and lung function changes in patients with IPF. Methods: Clinical data were retrospectively reviewed in 337 patients with IPF (all biopsy-proven cases) diagnosed from 1995 to 2016 at Asan Medical Center. HRCT patterns were classified according to 2018 IPF diagnositic criteria. Results: The median follow-up period was 43.7 months. The mean age of the patients was 62.5 years, and 74.2% were male. Among HRCT patterns, UIP, probable UIP, indeterminate for UIP, and alternative diagnosis were identified in 163 (48.4%), 110 (32.6%), 33 (9.8%), and 31 (9.2%) patients, respectively. The indeterminate for UIP group showed higher lung function and exercise capacity compared with other groups. Alternative diagnosis group also showed lesser frequent male and ever smokers than other groups. However, there were no differences in age and the results of bronchoalveolar lavage fluid analysis between groups. Of total subjects, the median survival period was 59.2 months, and indeterminate for UIP group showed better prognosis compared to other groups. They also showed lesser decline in FVC during follow-up. In the multivariate Cox analysis adjusted by age, ever-smokers, lung function, exercise capacity and use of antifibrotic agents, indeterminate for UIP pattern was independent prognostic factor (hazard ratio 0.321, 95% confidence interval 0.163-0.631, P=0.001). Conclusions: In this study, patients with indeterminate for UIP pattern on HRCT have more preserved lung function and exercise capacity, lesser decline in lung function and better survival compared to others, suggesting that HRCT pattern of UIP may be useful in predicting prognosis.