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분자모델링에 의한 시메티딘, 파모티딘, 라니티딘 유도체 등의 H_2-길항제의 수용액상의 형태에 관한 연구
박경래,문병기 충남대학교 약학대학 의약품개발연구소 1998 藥學論文集 Vol.14 No.-
The solution structure of cimetidine, famotidine and ranitidine was investigated using molecular dynamics simulation on the basis of MM^+ Force Field. The solution environment was mimicked only implicity by the use of constant dielectric constant. To search a most stable conformation starting from the crystal structure the geometry optimization was not the proper method. The dynamics simulation time necessary to sample the reasonable global potential energy minima was 1ns to 4ns even with these small organic molecules. After the sufficient time of free dynamics the molecules could set to most stable conformations which are quite different from that in X-ray structures.
申善澔,李基商,文病淳 圓光大學校 韓醫學硏究所 1995 원광한의학 Vol.5 No.1
The present experiment was desinged to investigate the effects of Dansamyeum water extracts on the Cardivascular System in the Experimental Animals. Thus, the changes of blood pressure and heart rate were measured after oral administration. Measurments of Mortality rate were observed for measuring the effects of Dansamyeum water extract. Dansamyeum water extracts against pulmonary thromboembolism induced by collagen the mixture 90.1㎖/10g, 2㎖/㎏ B.W) plus serotonin(5㎎/㎏ B.W) in mouse. The effect of Dansamyeum water extract was examined by observing the change of collagen-induced platelet aggregation coagulation activity, ex vivo and in vitro fibrinolytic activity of euglobulin fraction in rats. The results were summarized as followings. 1. Dansamyeum dropped the blood pressure in spontaneous hypertensive rat. 2. The drug increased the auricular blood flow in rabbit. 3. The drug relaxed the artery contraction by pretreated norepinephrine in rat. 4. The drug inhibited the death rate of mouse which were led to thromboembolism by serotonin and collagen. 5. The drug inhibited the platelet aggregation in rat. 6. The drug prolonged the prothrombin time and activated partial thromboplastin time on the test of plasma coagulation factor activity in rat, but was not valuable. 7. The drug increased the antithrombin activity in rat and the fibrinogen lyses time was reduced and lyses area was increased. 8. Dansamyeum reduced fibrinogen lyses time of rat in vitro assay. According to the above mentioned results, Dansamyium increased the blood flow and dropped the blood pressure by the dilation of blood vessel. And the drug presented the antithrombin acivity, inhibited the platelet aggregation.
Eco-friendly Recycling Process of Magnesium Alloy Scrap
( Byoung-gi Moon ),( Jun Ho Bae ),( Ha-sik Kim ),( Ki-ho Koh ) 한국폐기물자원순환학회(구 한국폐기물학회) 2019 ISSE 초록집 Vol.2019 No.-
Magnesium is the lightest metal element among structural metal materials, and has been applied to automobiles and mobile electronic devices due to its unique light weight, excellent castability, and machinability. However, a large amount of sulfur hexafluoride (SF<sub>6</sub>) gas, which is one of the greenhouse gases, is used to prevent extreme oxidative loss and ignition of the molten metal due to the high reactivity with oxygen during the manufacture of the magnesium ingot, the productization and the recycling process. This is offsetting the effect of reducing carbon dioxide emissions through weight reduction of vehicles. Especially, sulfur hexafluoride gas is known to have the highest greenhouse effect, of which GWP (Global Warming Potential) is estimated at 23,900 times that of carbon dioxide. Furthermore, the use of fluoride compounds was strictly restricted in the European Union since 2018. Therefore, it is inevitable to develop a technique for drastically reducing the use amount thereof. The purpose of this study is to reduce the amount of greenhouse gases used during the melting and refining of scrap by using the flame retardant technology which can increase the ignition temperature and improve the corrosion resistance of the magnesium products. For the experiment, calcium (Ca) and yttrium (Y) were added to prevent the severe oxidation and ignition in the melting process for recycling AM50 scrap, which is a typical magnesium alloy used in automobiles. In order to suppress the reaction between those additive elements and magnesium chloride (MgCl<sub>2</sub>) which is usually contained in commercial fluxes, newly developed CaCl<sub>2</sub>- based fluxes were applied for the refining process. The average recovery rate and the ratio of the amount of carbon dioxide to the total amount of recycled materials (kg<sub>CO2</sub>/kg<sub>Mg</sub>) for the five-stage consecutive process were estimated from the results of singlestage process. Experimental results using a continuous refining plant consisting of two 130 kg furnace and an ingot casting system show that the recovery rate was up to 91.9%, and the amount of greenhouse gas consumption was about 0.58 kg<sub>CO2</sub>/kg<sub>Mg</sub> which is about 92% lower than that in the typical recycling process of magnesium alloys. This technology is expected to contribute greatly to the reduction of greenhouse gas consumption during scrap melting and refining.
Effect of milling on the soft magnetic behavior of nanocrystalline alloy cores
Moon, Byoung-Gi,Sohn, Keun Yong,Park, Won-Wook,Lee, Taek-Dong Elsevier 2007 Materials science & engineering. properties, micro Vol.449 No.-
<P><B>Abstract</B></P><P>The variation of soft magnetic properties of nanocrystalline Fe<SUB>73</SUB>Si<SUB>16</SUB>B<SUB>7</SUB>Nb<SUB>3</SUB>Cu<SUB>1</SUB> (numbers indicate at.%) alloy powder cores as a function of milling time has been investigated. Amorphous ribbons were pulverized using a hammer mill after crystallization heat treatment at 550°C for 1h. Ball milling was carried out for the pulverized flake powder at room temperature for up to 36h. The powders were classified into 53–75μm and under 45μm particles and mixed with a binder for consolidation into a toroidal shape. The consolidated powder was annealed at 450°C for 1h for stress relief. Results show that the consolidation density of the flake-shaped nanocrystalline alloy powder increased by 2.5–5% in theoretical density (0.2–0.4g/cm<SUP>3</SUP>) by the ball milling process. The density increase is attributed mainly to the morphological change due to the milling, which yields smoothened particle edges. Excess milling induced fracture of particles, resulting in reduced density due to the reappearance of sharp edges. In coarse flake powder the permeability is mainly controlled by the density of the consolidates whereas it is dominated by the size distribution of particles in finer powder. The intrinsic coercivity of the powder was significantly influenced by the residual stress and demagnetization effect arising from the change in morphology.</P>
Effect of Strontium Addition on the Microstructures and Mechanical Properties of Mg-5Al-3Ca Alloys
Moon, Byoung-Gi,Kim, Kyung-Hyun,Lee, Hyuck Mo The Japan Institute of Metals 2011 MATERIALS TRANSACTIONS Vol.52 No.6
<P>The effect of adding up to 4 mass% of strontium to Mg-5Al-3Ca alloys was investigated in terms of microstructural and mechanical properties. The major interdendritic intermetallic compounds of as-cast alloys changed from the Mg<SUB>2</SUB>Ca phase to a combination of the (Mg,Al)<SUB>2</SUB>Ca and Al<SUB>4</SUB>Sr phases. The morphology of the interdendritic α-Mg/Al<SUB>4</SUB>Sr eutectic phase also changed from a coarse lamellar structure at a low strontium concentration to a bulk-like ultrafine lamellar structure at a high strontium concentration (4 mass%). The creep resistance was improved by the addition of up to 2 mass% strontium but it was saturated at a higher strontium concentration.</P>
문병기 ( Byoung Gi Moon ),유봉선 ( Bong Sun You ),고기호 ( Ki Ho Koh ) 대한금속재료학회(구 대한금속학회) 2013 대한금속·재료학회지 Vol.51 No.1
Magnesium alloys are emerging materials for green cars because they have the lowest density among structural metallic materials. With the increased use of magnesium the development of more effective magnesium recycling technology for all scrap types becomes more important. This paper extensively reviews the recycling technology of end-of-life magnesium scrap. Firstly, it describes the typical refining processes for sorted clean scrap such as flux and fluxless remelting. And it describes the several processes which are feasible to separate magnesium lloys from a light metal shredder fraction containing aluminum and other light matters or to remove surface contaminants and coated layers containing organic matters such as hydrocarbon compounds or harmful metallic elements such as nickel, copper, iron, and chromium. It also introduces the existing purification techniques for a seriously contaminated magnesium melt due to the incomplete removal of impurities.Finally, it discusses the cleanliness assessment techniques of magnesium alloy.