Difference in prognostic impact of lateral pelvic lymph node metastasis between pre- and post-neoadjuvant chemoradiotherapy in rectal cancer patients

Byeo Lee Lim,박인자,Young Il Kim,Chan Wook Kim,Jong Lyul Lee,Yong Sik Yoon,Seok-Byung Lim 대한외과학회 2023 Annals of Surgical Treatment and Research(ASRT) Vol.104 No.4

Purpose: The prognostic significance and treatment of lateral pelvic lymph node metastasis (mLPLN) in rectal cancer patients receiving neoadjuvant chemoradiotherapy (nCRT) are not well understood. In this study, we evaluated the impact of mLPLN identified in imaging modality on outcomes. Methods: Between January 2008 and December 2016, 1,535 patients who underwent radical resection following nCRT were identified. The association between mLPLN and disease-free survival (DFS), overall survival (OS), local recurrence- free survival (LRFS), and pelvic recurrence-free survival (PRFS) was analyzed, along with risk factors associated with OS and DFS. Results: Overall, 329 (21.4%) of the 1,535 patients experienced disease recurrence; 71 (4.6%) had local recurrence, 25 (1.6%) had pelvic recurrence, and 312 (20.3%) had distant recurrence. The pre- and post-nCRT mLPLN (–) groups had better DFS, LRFS, PRFS, and OS than the (+) groups. LPLN sampling (LPLNs) was implemented in 24.0% of the pre-nCRT mLPLN (+) group and in 28.8% of the post-nCRT mLPLN (+) group. There was no significant difference in OS and LRFS between LPLNs group and no LPLNs group in pre- and post-nCRT mLPLN (+) groups. Pre-nCRT mLPLN was associated with poor OS (hazard ratio [HR], 1.43; P = 0.009) and post-nCRT mLPLN was associated with poor DFS (HR, 1.49; P = 0.002). Conclusion: Pre- and post-nCRT mLPLN (+) have different prognostic effects. Post-nCRT mLPLN appears to be more important for disease control. However, pre-nCRT mLPLN should not be disregarded when devising a treatment strategy since it is an independent risk factor for OS.

Clinical Characteristics of Hyalinizing Trabecular Tumor (HTT)

Byeo Lee Lim(임벼리),Ki-wook Chung 대한외과학회 2021 대한외과학회 학술대회 초록집 Vol.2021 No.5

Evolution of CYP102D1 from Streptomyces avermitilis to Increase Hydroxylation Activity towards Kaempferol

Byeo-Ri AN,Kwon-young CHOI,Eunok JUNG,Da-Hye JUNG,Wonji CHOI,Byung-Gee KIM 한국생물공학회 2012 한국생물공학회 학술대회 Vol.2012 No.4

응급실 과밀화 해결을 위한 데이터 분석 기반 응급실 혼잡도 예측 모형 연구

김벼울(Byeo Wool Kim),윤용익(Yong Ik Yoon) 한국데이터정보과학회 2018 한국데이터정보과학회지 Vol.29 No.5

본 연구는 전국에 있는 414개 응급의료센터의 2017년 자료를 토대로 응급실의 특성 및 지역적 특성을 반영하여 응급실 혼잡도를 실시간으로 예측하는 모형을 개발했다. 예측모형 개발에는 데이터마이닝 기법 중 다중선형회귀분석, 부분집합선택, 능형회귀, Lasso, 주성분회귀분석 방법을 적용하였으며, 주성분회귀분석이 가장 높은 예측력을 보였다. 또한, 예측모형을 개발하는데 있어 전체 응급의료 기관을 기준으로 한 예측모형(92.73%) 보다 응급의료기관 유형에 따라 세분화한 예측모형의 예측력이 더 높게 나타났다. 특히, 가장 혼잡한 유형인 권역의료센터의 예측정도는 97.37%로 나타났다. 본 연구에서 개발된 응급실 혼잡도 예측모형은 응급실 간의 지역네트워크를 형성하고, 응급실 과밀화 문제를 해결하기 위한 기초자료가 될 수 있을 것이다. This research developed a model that predicts the congestion of the emergency room in real time based on the 2017 data of 414 emergency medical institutions nationwide. In the development of the predictive model, data mining techniques such as multiple linear regression analysis, subset selection, ridge regression, Lasso and principal component regression were applied, and principal component regression method showed high prediction power. The predictive power of the subdivided prediction models (especially regional emergency medical center (97.37%)) according to the types of emergency medical institution was higher than that of the predictive model based on the entire emergency medical institutions (92.73%). The emergency room congestion predictive model developed in this research can be used as basic data to solve the problem of overcrowding of emergency room and form a regional network between the emergency rooms.

수정된 양손집중연습이 불완전 경수 손상 환자의 손 기능과 작업수행에 미치는 영향

한벼리(Byeo-Ri Han),이상헌(Sang-Heon Lee) 대한치료과학회 2022 대한치료과학회지 Vol.14 No.1

Objective: The purpose of this study is to investigate the effect of modified bimanual massed practice training on hand function and occupational performance of a incomplete tetraplegia patient. Methods: The participant was a 27 years old man diagnosed with C7/C7(s), C6/C6(m) incomplete tetraplegia ASIA-C. The patient performed developed modified bimanual massed practice with a total of 20 sessions, 30 minute 5 sessions per each week for 4 weeks modified according to domestic clinical setting. Results: The mean value of dynamometer on the right hand progressively improved through baseline A1(mean 2.96 kg), intervention B(mean 3.07 kg), baseline A2(mean 3.50 kg). And on the left hand, it also increased from B(mean 2.64 kg) to A2(mean 3.04 kg). In the Box and block test, the right hand improved from A1(47 unit) to B(52.55 unit) and maintained for A2, and the left hand improved through A1(46.4 unit), B(47.2 unit), and A2(49.8 unit). And the results of Assessment of Motor and Process skills showed that motor skills improved from before (0.0 logit) to after(0.7 logit), and process skills also improved from 0.7 logit to 1.0 logit. Conclusion: This study results support that the modified bimanual massed practice training is beneficial in improving hand function and occupational performance in a incomplete cervical spinal cord injury patient.

마이크로웨이브 가열 하수 슬러지 고온 열분해에 의한 바이오 연료 에너지 생산

정벼리(Byeo Ri Jeong),전영남(Young Nam Chun) 大韓環境工學會 2017 대한환경공학회지 Vol.39 No.1

현재까지 에너지의 지속적인 요구는 대부분 화석연료에 의해 충족되고 있다. 하지만 화석연료의 한계성과 온실가스발생 등의 환경문제로 인해 새로운 대체에너지 연구 개발에 대한 관심이 크다. 탈수 하수 슬러지를 연료 에너지로 전환하기 위해 슬러지 촤와 흑연의 두 가지 열수용체를 적용한 경우 마이크로웨이브 열분해 특성을 파악하였다. 두 수용체 모두 열분해 생성물 발생량은 가스, 슬러지 촤 그리고 타르 순으로 생성되었다. 열분해의 경우 생성가스의 주성분은 수소와 메탄이고 일부 경질 탄화수소 등이 포함되었다. 흑연 수용체의 경우 중질타르가 다량 발생되었고, 많은 양의 경질탄화수소가 발생되었다. 이 상의 실험결과로 볼 때 탈수 하수 슬러지의 마이크로웨이브 열분해에 의해 생성된 가스를 연료로 이용이 가능하지만, 가스 중에 함유된 응축성 PAH 타르를 처리해야 한다. The recent gradual increase in the energy demand is mostly met by fossil fuel, but the research on and development of new alternative energy sources is drawing much attention due to the limited fossil fuel supply and the greenhouse gas problem. This paper assesses the feasibility of producing fuel energy from a dewatered sewage sludge by microwave-induced pyrolysis with sludge char and graphite receptor. Both receptors produced gas, char, and tar in order from product amount. The gas produced for the sludge char receptor contained mainly hydrogen and methane with a small amount of light hydrocarbons. The graphite receptor generated higher gravimetric tar and generated higher light tar. Through the results, the product gas from the microwave processes of wet sewage sludge might be possible as a fuel energy. But the product gas has to be removed the condensable PAH tars.

Frequency of a non-rising increase of serum CA-125 levels during chemotherapy treatment in recurrent patients of advanced epithelial ovarian cancer (EOC) after reviously being treated optimally

( Eun Byeo Go ),( Keuna Kim ),( Su Bun Jean ),( Eun Joo Joung ),( Seul Ki You ),( Sang Hun Lee ),( Soo Eong Lee ),( Jun Woo Ahn ),( Hyun Jin Roh ),( Yang Soon Kwon ) 대한산부인과학회 2015 대한산부인과학회 학술대회 Vol.101 No.-

중세 국어의 ‘니’와 ‘리’ 종결문의 어미 생략 현상

나벼리(Na Byeo-Ri) 우리말학회 2020 우리말연구 Vol.61 No.-

이 글에서는 15세기 국어의 텍스트를 중심으로 ‘니’와 ‘리’로 끝나는 문장에서 일어나는 생략 현상에 대해 살펴보았다. 곧, <용비어천가>, <월인천강지곡>, <월인석보>, <청산별곡>, <가시리> 등의 텍스트에 나타나는 생략 현상을 종합해 보면, 15세기 문헌에서 ‘니’와 ‘리’로 끝맺는 문장은 기존에 알려진 것처럼 ‘-ᅌᅵ다, -ᅌᅵᆺ가, -ᅌᅵᆺ고’와 같은 특정한 어미만 생략된 것이 아니며, 선어말 어미인 ‘-니-’와 ‘-리-’의 뒤에 실현될 수 있는 모든 어미가 다 생략될 수 있다는 것을 알 수 있었다. 그리고 ‘니’와 ‘리’ 뒤에서 일어나는 어미의 생략 양상을 기존에 설정된 생략의 일반적 유형인 ‘문맥 생략’과 ‘상황 생략’으로 나누었다. 그리고 문맥 생략은 다시 ‘텍스트의 내적 구조’에 따른 문맥 생략과 ‘상호텍스트성’에 따른 문맥 생략으로 구분하였다. 상황 생략도 역시 상관적 발화 장면에서의 상황 생략과 단독적 발화 장면에서의 상황 생략으로 구분하였다. 이와 같이 ‘니’와 ‘리’의 종결문에 나타나는 어미의 생략 현상은 운문뿐만 아니라 산문에서도 일어난다. 이러한 점을 감안하면 ‘니’와 ‘리’의 종결문에 나타나는 어미의 생략 현상은 율격의 제약뿐만 아니라, 생략 현상이 일어나는 일반 원리를 따르고 있다는 사실을 알 수 있었다. 따라서 ‘니’와 ‘리’ 종결문은 상대 높임의 등분이 특정한 등분으로 고정되어 있는 것이 아니라, 담화의 맥락에 따라서 개별적으로 결정된다. In this article, I looked at the ending omission of the pre-final ending words ‘-니-’ and ‘-리-’ which appear in Yongbieocheonga or Worincheongangjigok. However, considering the omission of the context in Cheongsanbyeolgok or Gasiri, the intertext in Worincheongangjigok and Seokbosangjeol, the correlative scenes seen in Worinseokbo, and the exclusive scenes in Yongbieocheonga or Worincheongangjigok, the conclusion of 니 and 리 was the result of omitting the words that should be follows after -니- and -리- . In particular, not only certain final endings, such as ‘-ᅌᅵ다, -ᅌᅵᆺ가, -ᅌᅵᆺ고’ are omitted as claimed by the omission theory. But that both the final ending and pre-final endings follows after ‘-니-’ and ‘-리-’ can be omitted. As the conclusoin of this article, the ending omission of the pre-final ending words are the result of general omission. Therefore, it can be seen that the level of relative exaltation of the closing ending of 니 and 리 is not determined by the closing ending of -니- and -리- , but by the context of the discourse.

중세 한국어 ‘이ᅀᅡ’의 문법적 성격과 실현 양상 -『법화경언해』를 중심으로-

나벼리(Na Byeo-Ri) 우리말학회 2021 우리말연구 Vol.67 No.-

15∼16세기의 중세 한국어에서 나타나는 ‘이ᅀᅡ’에 대하여 여러 가지의 논의가 있었다. 곧, 선행 연구에서는 ‘이ᅀᅡ’를 주격 조사인 ‘-이’와 보조사인 ‘-ᅀᅡ’가 결합한 복합 형식으로 처리하기도 하고, ‘이ᅀᅡ’ 자체를 보조사인 ‘-ᅀᅡ’의 변이 형태로 처리하기도 하였다. 이와는 달리 ‘이ᅀᅡ’를 계사(繫辭)의 ‘-이-’의 활용 형태로 보고 ‘-ᅀᅡ’를 계사의 어간에 붙는 연결 어미로 처리하는 견해도 있었다. 이러한 다양한 논의에도 불구하고 15∼16세기에 쓰인 ‘이ᅀᅡ’의 문법적인 성격을 명확하게 규명하지는 못했다. 이와 같은 상황을 고려하여 이 글에서는 ‘이ᅀᅡ’와 관련한 선행 연구의 내용을 재검증하여서, ‘이ᅀᅡ’의 문법적인 성격을 주격 조사인 ‘-이’와 보조사인 ‘-ᅀᅡ’가 결합한 복합 형식임을 밝혔다. 그리고 󰡔법화경언해󰡕에 나타난 실제의 예문을 통하여, 주격 조사인 ‘-이’에 한정 강조의 뜻을 나타내는 보조사인 ‘-ᅀᅡ’가 실현되는 조건을 규명하였다. There have been various discussions about ‘iza(이ᅀᅡ)’ appearing in the Korean language of the 15th and 16th centuries. Thus, in previous studies, ‘iza(이ᅀᅡ) was treated as a complex form in which the nominative case marker ‘-i(-이) and the auxiliary particle ‘-za(-ᅀᅡ) were combined, and ‘iza(이ᅀᅡ) itself was treated as a variation form of the auxiliary particle ‘-za(-ᅀᅡ) . On the other hand, there was an opinion that ‘iza(이ᅀᅡ)’ was viewed as a form of conjugation of ‘-i(-이-)-’ in the copula and ‘-za(-ᅀᅡ)’ as a connecting ending attached to the stem of the copula. Despite these various discussions, the grammatical nature of ‘iza(이ᅀᅡ)’ used in the 15th and 16th centuries has not been clearly identified. Considering this situation, this article re-examines the contents of previous studies related to ‘iza(이ᅀᅡ)’ and examines the grammatical characteristics of ‘iza(이ᅀᅡ) by using the nominative case marker ‘-i(-이) and the auxiliary partcle ‘-za(-ᅀᅡ) . It is revealed that it is a combined complex form. And through the example sentences shown in the ‘Beophwagyeongeonhae(法華經諺解) , the conditions under which the nominative case marker ‘-i(-이) and the auxiliary partcle ‘-za(-ᅀᅡ) are realized were clarified.

Detection and phylogenetic analysis of norovirus from individual septic tanks in the drainage basin of the coastal area located in the Jaran Bay of Korea

Ham, In Tae,Kim, Byeo Ri,Park, Yu Jeong,Jung, Yeun Joong,Park, Kunbawui,Kwon, Ji Young,Mok, Jong Soo,Yu, Hongsik The Korean Society of Fisheries and Aquatic Scienc 2021 Fisheries and Aquatic Sciences Vol.24 No.1

Norovirus (NoV) prevalence was investigated in 100 sewage samples collected from 35 individual septic tanks around the drainage basin of Jaran Bay, Korea in January, May, and July of 2017. Genotypes and diversity of NoV strains detected in sewage samples were also assessed using the conventional RT-PCR and phylogenetic analysis. NoV GI or GII were detected in 22 (22.0%) and 24 (24.0%) samples, respectively. Thirteen genotypes were identified with three dominant genotypes (GI.9, GII.5 and GII.17) and GII.17 showed relatively higher prevalence during the survey period. GII.17 strains were clustered into recombinant type variant or NoV GII.17 Kawasaki variant. NoV GII.17 strains were considered emergent epidemic variants with widespread circulation. NoV surveillance strategy should include both environmental (sewage) and clinical data to reveal minor NoV genotypes likely cause of asymptomatic or underreported infections in the local population.