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Jeongmin Lee,Sangwook Lee,Wooram Jung,Guk Bae Kim,Taehun Kim,Jiwon Seong,장혜민,Young Noh,Na Kyung Lee,Boo Rak Lee,Jung-Il Lee,Soo Jin Choi,Wonil Oh,Namkug Kim,Seunghoon Lee,Duk L. Na 대한의학회 2022 Journal of Korean medical science Vol.37 No.31
Background: To deliver therapeutics into the brain, it is imperative to overcome the issue of the blood-brain-barrier (BBB). One of the ways to circumvent the BBB is to administer therapeutics directly into the brain parenchyma. To enhance the treatment efficacy for chronic neurodegenerative disorders, repeated administration to the target location is required. However, this increases the number of operations that must be performed. In this study, we developed the IntraBrain Injector (IBI), a new implantable device to repeatedly deliver therapeutics into the brain parenchyma. Methods: We designed and fabricated IBI with medical grade materials, and evaluated the efficacy and safety of IBI in 9 beagles. The trajectory of IBI to the hippocampus was simulated prior to surgery and the device was implanted using 3D-printed adaptor and surgical guides. Ferumoxytol-labeled mesenchymal stem cells (MSCs) were injected into the hippocampus via IBI, and magnetic resonance images were taken before and after the administration to analyze the accuracy of repeated injection. Results: We compared the planned vs. insertion trajectory of IBI to the hippocampus. With a similarity of 0.990 ± 0.001 (mean ± standard deviation), precise targeting of IBI was confirmed by comparing planned vs. insertion trajectories of IBI. Multiple administrations of ferumoxytol-labeled MSCs into the hippocampus using IBI were both feasible and successful (success rate of 76.7%). Safety of initial IBI implantation, repeated administration of therapeutics, and long-term implantation have all been evaluated in this study. Conclusion: Precise and repeated delivery of therapeutics into the brain parenchyma can be done without performing additional surgeries via IBI implantation.
Anti-oxidant and anti-inflammatory activities of the various kinds of herbal tea
Lee, Jin Wook,Eo, Hyun Ji,Park, Gwang Hun,Song, Hun Min,Woo, So Hee,Kim, Mi Kyoung,Eom, Jung Hye,Lee, Man Hyo,Lee, Jeong Rak,Koo, Jin Suk,Jeong, Jin Boo The Korea Association of Herbology 2014 大韓本草學會誌 Vol.29 No.2
Objectives : Reactive oxygen species (ROS) are involved in a wide spectrum of diseases including chronic inflammation and cancer. In this study, we investigated the antioxidant activities and anti-inflammatory effects of the extracts from the herbal teas such as Lonicera japonica Thunberg (L. japonica), Chrysanthemum morifolium Ramat (C. morifolium), Mentha arvensis L. (M. arvensis), and P.rhizoma. Methods : Anti-oxidant activity was evaluated using DPPH radical scavenging assay and $Fe^{2+}$ chelating assay. And DNA cleavage assay was performed to evaluate an anti-oxidative effect. Anti-inflammatory effect was performed using NO generation assay and western blot in LPS-stimulated RAW264.7 cell line. Results : L. japonica scavenged DPPH radical by 9.8% at 12.5 ${\mu}g/ml$, 24.8% at 25 ${\mu}g/ml$, 34.3% at 50 ${\mu}g/ml$, 61.1% at 100 ${\mu}g/ml$ and 75.8% at 200 ${\mu}g/ml$, respectively. In addition, C. morifolium and M. arvensis removed DPPH radical by 15.6% and 10.4% at 12.5 ${\mu}g/ml$, 34.8% and 22.8% at 25 ${\mu}g/ml$, 66.9% and 43.3% at 50 ${\mu}g/ml$, 87.4% and 69.1% at 100 ${\mu}g/ml$, and 92.1% and 73.2% at 200 ${\mu}g/ml$, respectively. However, P. rhizoma did not affect on DPPH radical scavenging. The $Fe^{2+}$ chelating activity was highest in L. japonica, but lowest in P. rhizoma among the herbal teas. In addition, the extracts from L. japonica, C. morifolium and M. arvensis inhibited oxidative DNA damage via its anti-oxidant activity. In anti-inflammatory effect, the extracts from C. morifolium inhibited NO production. In addition, it suppressed the $NF-{\kappa}B$ signaling pathway in LPS-stimulated RAW 264.7 cells. Conclusions : Together, this study indicates that L. japonica, M. arvensis and C. morifolium possess the protective effect against the oxidative DNA damage. Furthermore, C. morifolium exerts an anti-inflammatory effect.
Oxidation controlled Black phosphorus/WS₂ nanocomposit photocatalyst for water treatment
Rak Hyun Jeong,Dong In Kim,Ji Won Lee,Jin-Hyo Boo 한국진공학회 2021 한국진공학회 학술발표회초록집 Vol.2021 No.2
We synthesized black phosphorus that was oxidized properly and easily at a low cost and made a catalyst for water quality improvement through composite with WS<sub>2</sub>. Through these composites, we studied nanocatalysts that satisfy bandgap changes and disadvantages of each other. This material was measured by TEM, SEM, XRD, XPS, UV-VIS spectrophotometer, FT-IR and RAMAN spectroscopy. Such catalyst materials are used in various fields such as hydrogen generation, atmospheric purification, and water purification.
폐경 전 , 후 여성들의 신체구성과 골밀도와의 상관관계
이동희,김성수,천병옥,함경수,황부근,정용락,정승삼 고려대학교 스포츠과학연구소 2000 스포츠科學論叢 Vol.11 No.-
The purpose of this study investigated on body composition and bone mineral density in pre and post menopause. Subjects for this purpose consisted to residents of Seoul cities over 30 years a total a 41 adults women(30 aged 13, 40 aged 14, 50 aged 14). Variables of the study included comparison for physique, body composition and bone mineral density(BMD) in age, degree of pre and post menopause, relationship between physique, body composition factors and bone mineral density. The results as follows; 1. different of bone mineral density in pre and postmenopause. 1) In factors of trunk BMD showed in significantly different pre menopause group less then post menopause group. 2) In factors of ribs BMD showed in significantly different pre menopause group less then post menopause group. 3) In factors of spine BMD showed in significantly different pre menopause group less then post menopause group. 4) In factors of pelvis BMD showed in significantly different pre menopause group less then post menopause group. 5) In factors of total BMD showed in significantly different pre menopause group less then post menopause group. 2. Relationship between the body composition and bone mineral density. 1) Age and trunk BMD(r=-0.43), pelvis have significant negative relation. 2) Weight and trunk BMD(r=0.52), ribs BMD(r=0.54), spine BMD(r=0.53), total BMD(r=0.53) have significant positive relation. 3) LBM and trunk BMD(r=0.52), ribs BMD(r=0.54), spine BMD(r=0.53), total BMD(r=0.53) have significant positive relation.