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Effects of Oral Rutaecarpine on the Pharmacokinetics of Intravenous Chlorzoxazone in Rats
Bista, Sudeep R.,Lee, Sang-Kyu,Thapa, Dinesh,Kang, Mi-Jeong,Seo, Young-Min,Kim, Ju-Hyun,Kim, Dong-Hyeon,Jahng, Yurng-Dong,Kim, Jung-Ae,Jeong, Tae-Cheon Korean Society of ToxicologyKorea Environmental Mu 2008 Toxicological Research Vol.25 No.4
It has been reported that hepatic microsomal cytochrome P450(CYP) 2E1 is responsible for the metabolism of chlorzoxazone(CZX) to 6-hydroxychlorzoxazone. The present study was undertaken to assess the possible interaction of rutaecarpine, an alkaloid originally isolated from the unripe fruit of Evodia rutaecarpa, with CZX. Male Spraque-Dawley rats were administered with 80 mg/kg/day of oral rutaecarpine for three consecutive days. Twenty four hr after the pre-treatment with rutaecarpine, the rats were treated with 20 mg/kg of intravenous CZX. Rat hepatic microsomes isolated from rutaecarpine-treated rats showed greater(50% increase) activity of p-nitrophenol hydroxylase(a marker of CYP2E1) when compared with the control rats. Compared with control rats, the AUC of CZX was significantly smaller(84% decrease) possibly due to significantly faster CL(646% increase) in rats pretreated with rutaecarpine. This could be, at least partially, due to induction of CYP2E1 by rutaecarpine.
Rabindra Bista,장재우,심춘보 한국정보과학회 2008 데이타베이스 연구 Vol.24 No.2
Recently, Wireless Sensor Networks (WSNs) are widely used in the various fields of physical world such as environment tracking and personal health status monitoring to change our daily lives. As a result, has been is much research on developing applications for WSNs. But, as sensor nodes are tightly integrated into the physical world, we need to know about low level details of the sensor hardware and the network protocols and hence application development is always a cumbersome task. Moreover, sensor nodes are resources constraint, which restricts to apply traditional application designing paradigms. In this regards, there are many middleware devised as a platform to enhance the development of the applications for WSNs by bridging the gap between the high level application and the low level details of the WSNs. However, many designing principles, issues and challenges have to be addressed by the middleware due to the resources constraint nature of sensor nodes and low bandwidth of WSNs. In this paper, we explore several relevant middleware for the WSNs to provide some insights on the current status of them existing in this literature. For this, we first present middleware designing principles, issues and challenges. Then, we classify the relevant middleware on the basis of their application area in the physical world. Finally, we evaluate several middleware to show their strength to address the designing principles, issues and challenges. 최근 무선 센서 네트워크(Wireless Sensor Networks : WSNs)는 환경 감시(environment tracking), 개인 건강 상태 감지(personal health status monitoring) 실생활의 다양한 분야에서 활용되며, 우리의 일상 생활에 많은 변화를 주고 있다. 이에 따라 무선 센서 네트워크 상에서의 다양한 응용을 개발하는 연구가 활성화되고 있다. 그러나 WSN 응용 개발을 위해서는 센서 노드 하드웨어, 네트워크 프로토콜과 같은 하부 구조에 대한 상세한 지식이 요구된다. 또한 센서 노드 내의 제한된 자원을 고려한 설계 패러다임(paradigm)이 필요하다. 이러한 문제를 해결하기 위하여, WSN 응용과 센서 노드 하드웨어의 중간에 위치하여 둘 사이의 유연한 통합을 지원하는 다양한 WSN 미들웨어가 개발되었다. 그러나 개발된 미들웨어들은 각기 다른 개발 목표를 지니고 있기 때문에, 상호간의 비교가 난해하다. 이에 본 연구에서는 WSN 미들웨어의 현 상황을 고찰함으로써, 해당 분야의 연구에 대하여 기여하고자 한다. 이를 위해 첫째, 센서 노드 미들웨어들의 개발 목표에 기반한 특성들을 살펴본다. 둘째, 각 응용 분야에 따른 미들웨어의 분류를 제시한다. 마지막으로 각 미들웨어의 강점 및 약점에 대하여 평가한다.
Design of Spatial Similarity Measure for Moving Object Trajectories in Spatial Network
Rabindra Bista(라빈드라 비스타),Jae-Woo Chang(장재우) 한국정보과학회 2006 한국정보과학회 학술발표논문집 Vol.33 No.2C
Similarity search in moving object trajectories in an active area of research. In this paper, we introduce a new concept of measure that computes spatial distance (similarity) between two trajectories of moving objects on road networks. In addition, we propose an algorithm that generates a sequence of matching edge pairs for two trajectories that are to be compared and computes spatial distance between them which in non Euclidian in nature. With an example, we explain how our algorithm works to show spatial similarity between trajectories of moving objects in spatial network.
Reconciling the WTO Effects on Trade at the Extensive and Intensive Margins
Rishav Bista 한국국제경제학회 2015 International Economic Journal Vol.29 No.2
Empirical studies examining the impact of World Trade Organization (WTO) membership have produced disparate results. These studies, however, have focused on total aggregate trade flows. In this paper, we utilize disaggregated product level data to examine the impact of WTO membership on the product level extensive and intensive margin of imports. Utilizing the Poisson Pseudo-Maximum Likelihood (PPML) estimation that allows for heteroskedasticity in trade data and accounting for several estimation issues, we do not find a positive impact on either margins between WTO member country-pairs. Once we examine asymmetries in trade flows across countries based on their level of development, we find that developing WTO members experience an increase in the extensive margin from industrial member countries. Additionally, the industrial WTO members also experience an increase in the extensive margin from developing WTO members. Results suggest that WTO facilitates the North–South trade relationship, which has been largely absent in trade literature.
Effects of Oral Rutaecarpine on the Pharmacokinetics of Intravenous Chlorzoxazone in Rats
Sudeep R. Bista,Sang Kyu Lee,Dinesh Thapa,Mi Jeong Kang,Young Min Seo,Ju Hyun Kim,Dong Hyeon Kim,Yurngdong Jahng,Jung Ae Kim,Tae Cheon Jeong 한국독성학회 2008 Toxicological Research Vol.24 No.3
It has been reported that hepatic microsomal cytochrome P450 (CYP) 2E1 is responsible for the metabolism of chlorzoxazone (CZX) to 6-hydroxychlorzoxazone. The present study was undertaken to assess the possible interaction of rutaecarpine, an alkaloid originally isolated from the unripe fruit of Evodia rutaecarpa, with CZX. Male Spraque-Dawley rats were administered with 80 mg/kg/day of oral rutaecarpine for three consecutive days. Twenty four hr after the pre-treatment with rutaecarpine, the rats were treated with 20 ㎎/㎏ of intravenous CZX. Rat hepatic microsomes isolated from rutaecarpine-treated rats showed greater (50% increase) activity of p-nitrophenol hydroxylase (a marker of CYP2E1) when compared with the control rats. Compared with control rats, the AUC of CZX was significantly smaller (84% decrease) possibly due to significantly faster CL (646% increase) in rats pretreated with rutaecarpine. This could be, at least partially, due to induction of CYP2E1 by rutaecarpine.
The Effects of Rutaecarpine on the Pharmacokinetics of Acetaminophen in Rats
이상규,Sudeep R. Bista,Hemin Jeong,Dong Hyeon Kim,강미정,장영동,정태천 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.12
Rutaecarpine, an alkaloid originally isolated from the unripe fruit of Evodia rutaecarpa, has been shown to be anti-inflammatory as it inhibits cyclooxygenase-2. It induces the activities of hepatic CYP 1A2, 2B, and 2E1 in rats. A possible interaction between rutaecarpine and acetaminophen (APAP) was investigated in male Sprague Dawley rats in the present study. When 25 mg/kg APAP was intravenously administered concurrently with 80 mg/kg rutaecarpine, the area under the curve of APAP in plasma was significantly decreased when compared to that of APAP alone. When the rats were pre-treated orally with 40 and 80 mg/kg rutaecarpine for 3 days, the % value of Cmax and area under the curve of acetaminophen-sulfate conjugate were significantly decreased to 56.4% and 61.7% of the vehicle control group, respectively. These results suggest that rutaecarpine might cause changes in the pharmacokinetic parameters of APAP in rats.
The Effects of Rutaecarpine on the Pharmacokinetics of Acetaminophen in Rats
Lee, Sang-Kyu,Bista, Sudeep R.,Jeong, He-Min,Kim, Dong-Hyeon,Kang, Mi-Jeong,Jahng, Yurng-Dong,Jeong, Tae-Cheon 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.12
Rutaecarpine, an alkaloid originally isolated from the unripe fruit of Evodia rutaecarpa, has been shown to be anti-inflammatory as it inhibits cyclooxygenase-2. It induces the activities of hepatic CYP 1A2, 2B, and 2E1 in rats. A possible interaction between rutaecarpine and acetaminophen (APAP) was investigated in male Sprague Dawley rats in the present study. When 25 mg/kg APAP was intravenously administered concurrently with 80 mg/kg rutaecarpine, the area under the cure of APAP in plasma was significantly decreased when compared to that of APAP alone. When the rats were pre-treated orally with 40 and 80 mg/kg rutaecarpine for 3 days, the % value of $C_{max}$ and area under the curve of acetaminophen-sulfate conjugate were significantly decreased to 56.4% and 61.7% of the vehicle control group, respectively. These results suggest that rutaecarpine might cause changes in the pharmacokinetic parameters of APAP in rats.