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- 저자 : Bao Hua Wang (검색결과 35 건)
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Bao Hua Wang,Jiacheng Zhang,Weilong Wang,Yuchen Sun 한국자동차공학회 2024 International journal of automotive technology Vol.25 No.2
A vehicle system motion decoupling control method was proposed to address challenges in controlling articulated heavyvehicles (AHVs). The method, based on diff erential geometry theory, focused on distributed electric drive AHVs. Its objectivewas to separate the highly nonlinear and strongly coupled dynamics system into two relatively independent subsystems:longitudinal and lateral motions. Additionally, a robust controller was designed to improve the vehicle’s resistance toexternal disturbances like side winds. Simulation tests using a TruckSim model of a distributed electric drive AHV showsignifi cant improvements compared to vehicles without decoupling control. The rearward amplifi cation (RA) is reducedby 4.5%, the longitudinal velocity deviation by 67.5%, and the yaw rate deviation by 69.7%. The vehicle also demonstratesenhanced stability when subjected to strong breeze disturbances. To validate the control performance in real-time systems,the hardware-in-the-loop tests were conducted, which confi rms the eff ectiveness of the proposed control approach in practicalapplications.
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High Expression of Forkhead Box Protein C2 is Related to Poor Prognosis in Human Gliomas
Wang, Yao-Wu,Yin, Chun-Li,Zhang, Hong-Yi,Hao, Jin-Min,Yang, Yue-Ye,Liao, Heng,Jiao, Bao-Hua Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.24
Background: Increasing evidence has indicated that high Forkhead box protein C2 (FOXC2) level is closely associated with the development, progression, and poor prognosis of a variety of tumors. However, the relationship between FOXC2 and the progression of human gliomas remains to be clarified. The aim of present study was to assess FOXC2 expression and to explore its contribution in human gliomas. Materials and Methods: Realtime quantitative PCR was performed to examine FOXC2 expression in 85 pairs of fresh frozen glioma tissues and corresponding non-neoplastic brain tissues. Associations of FOXC2 expression with clinicopathological factors and prognosis of glioma patients were statistically analyzed. Results: The relative mRNA expression of FOXC2 was significantly higher in glioma tissues than the corresponding non-neoplastic brain tissues (p<0.001). In addition, high FOXC2 expression was significantly associated with advanced pathological grade (P=0.005) and the low Karnofsky performance score (KPS) (p=0.003), correlating with poor survival (p<0.001). Furthermore, multivariate Cox regression analysis showed that high FOXC2 expression was an independent predictor of overall survival (p=0.006). Conclusions: FOXC2 may act as an oncogenic gene and represent a potential regulator of aggressive development and a candidate prognostic marker in human gliomas.
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Glucosamine induces cell death via proteasome inhibition in human ALVA41 prostate cancer cell
Bao-Qin Liu,Hua-Qin Wang,Xin Meng,Chao Li,Yan-Yan Gao,Ning Li,Xiao-Fang Niu,Yifu Guan 생화학분자생물학회 2011 Experimental and molecular medicine Vol.43 No.9
Glucosamine, a naturally occurring amino monosaccharide,has been reported to play a role in the regulation of apoptosis more than half century. However the effect of glucosamine on tumor cells and the involved molecular mechanisms have not been thoroughly investigated. Glucosamine enters the hexosamine biosynthetic pathway (HBP) downstream of the rate-limiting step catalyzed by the GFAT (glutamine:fluctose-6-phosphate amidotransferase), providing UDPGlcNAc substrates for O-linked β-N-acetylglucosamine (O-GlcNAc) protein modification. Considering that O-GlcNAc modification of proteasome subunits inhibits its activity, we examined whether glucosamine induces growth inhibition via affecting proteasomal activity. In the present study, we found glucosamine inhibited proteasomal activity and the proliferation of ALVA41 prostate cancer cells. The inhibition of proteasomal activity results in the accumulation of ubiquitinated proteins, followed by induction of apoptosis. In addition, we demonstrated that glucosamine downregulated proteasome activator PA28γ and overexpression of PA28γ rescued the proteasomal activity and growth inhibition mediated by glucosamine. We further demonstrated that inhibition of O-GlcNAc abrogated PA28γ suppression induced by glucosamine. These findings suggest that glucosamine may inhibit growth of ALVA41 cancer cells through downregulation of PA28γ and inhibition of proteasomal activity via O-GlcNAc modification.
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Bao, Li-Dao,Niu, Jian-Xiang,Song, Hui,Wang, Yi,Ma, Rui-Lian,Ren, Xian-Hua,Wu, Xin-Lin Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.8
Objective: The current meta-analysis was performed to address a more accurate estimation of the association between glutathione S-transferase P1 (GSTP1) codon 105 polymorphism and risk of gastric cancer (GC), which has been widely reported with conflicting results. Methods: A comprehensive literature search was conducted to identify all the relevant studies. Fixed or random effect models were selected based on the heterogeneity test. Publication bias was estimated using Begg's funnel plots and Egger's regression test. Results: A total of 20 studies containing 2,821 GC cases and 6,240 controls were finally included in the analyses. Overall, no significant association between GSTP1 polymorphism and GC risk was observed in worldwide populations. However, subgroup analysis stratified by ethnicity showed that GSTP1 polymorphism was significantly associated with increased risk of GC in Asians (G vs. A, OR = 1.273, 95%CI=1.011-1.605; GG vs. AA, OR=2.103, 95%CI=1.197-3.387; GG vs. AA+AG, OR =2.103, 95%CI=1.186-3.414). In contrast, no significant association was found in Caucasians in any genetic models, except for with AG vs. AA (OR=0.791, 95%CI=0.669-0.936). Furthermore, the GSTP1 polymorphism was found to be significantly associated with GC in patients with H. pylori infection and in those with a cardiac GC. Subgroup analysis stratified by Lauren's classification and smoking status showed no significant association with any genetic model. No studies were found to significantly influence the pooled effects in each genetic mode, and no potential publication bias was detected. Conclusion: This meta-analysis suggested that the GSTP1 polymorphism might be associated with increased risk of GC in Asians, while GSTP1 heterozygote genotype seemed to be associated with reduced risk of GC. Since potential confounders could not be ruled out completely, further studies are needed to confirm these results.
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ASYMPTOTIC DISTRIBUTION OF THE DISCOUNTED PROPER DEFICIT IN THE DISCRETE TIME DELAYED RENEWAL MODEL
Bao, Zhen-Hua,Wang, Jing Korean Mathematical Society 2011 대한수학회보 Vol.48 No.2
In this paper we consider the discrete time delayed renewal risk model. We investigate what will happen when the distribution function of the discounted proper deficit is asymptotic in the initial surplus. In doing this we establish several lemmas regarding some related ruin quantities in the discrete time delayed renewal risk model, which are of significance on their own right.
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Antioxidant Flavone Glycosides from the Root of Pteroxygonum giraldii
Bao-Lin Li,Lin-Ling Jiang,Hui-Chun Wang,Zhan-Jun Yang,Xi-Quan Zhang,Hong-Mei Gu,Xian-Hua Tian 대한화학회 2009 Bulletin of the Korean Chemical Society Vol.30 No.7
Two new flavone glycosides, giraldiin A and B, together with three known compounds, annulatin, myricetin 3-O-α-L-rhamnopyranoside and gallic acid, were isolated from the ethanol extract of the root of Pteroxygonum giraldii Damm. et Diels. The structures of giraldiin A and B are designated as 3'-(α-L-arabinopyranosyloxy)-4',5,5',7-tetrahydroxy-3-methoxyflavone and 4'-(β-D-glucopyranosyloxy)-5,5',7-trihydroxy-2',3-dimethoxyflavone, respectively,on the basis of detailed spectroscopic analyses. The free radical scavenging activity of giraldiin A was evaluated by decolouring spectrophotometry of pentamethine cyanine dye (Cy5) with Fe2+-H2O2 Fenton radical generating system. The results indicated the hydroxyl free radical scavenging activity of giraldiin A (ED50 = 23.7 nmol/mL) is higher than that of some known antioxidants such as rutin, puerarin, daidzein and 2,6-di-tertbutyl-4-methylphenol.
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Antioxidant Flavone Glycosides from the Root of Pteroxygonum giraldii
Li, Bao-Lin,Yang, Zhan-Jun,Jiang, Lin-Ling,Zhang, Xi-Quan,Gu, Hong-Mei,Wang, Hui-Chun,Tian, Xian-Hua Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.7
Two new flavone glycosides, giraldiin A and B, together with three known compounds, annulatin, myricetin 3-O-$\alpha$- L-rhamnopyranoside and gallic acid, were isolated from the ethanol extract of the root of Pteroxygonum giraldii Damm. et Diels. The structures of giraldiin A and B are designated as 3'-($\alpha$-L-arabinopyranosyloxy)-4',5,5',7- tetrahydroxy-3-methoxyflavone and 4'-($\beta$-D-glucopyranosyloxy)-5,5',7-trihydroxy-2',3-dimethoxyflavone, respectively, on the basis of detailed spectroscopic analyses. The free radical scavenging activity of giraldiin A was evaluated by decolouring spectrophotometry of pentamethine cyanine dye (Cy5) with $Fe^{2+}-H_2O_2$ Fenton radical generating system. The results indicated the hydroxyl free radical scavenging activity of giraldiin A (E$D_{50}$ = 23.7 nmol/mL) is higher than that of some known antioxidants such as rutin, puerarin, daidzein and 2,6-di-tertbutyl-4-methylphenol.
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