최근 에너지와 환경에서 촉매의 역할

하백현 한양대학교 에너지·환경기술연구소 1994 에너지·環境技術論文集 Vol.1 No.-

제올라이트의 구조와 성질

하백현 ( Baik Hyun Ha ) 한국화학공학회 1978 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.16 No.1

Last twenty years, application of zeolite in petrochemical industry has been rapidly increased and continued, in research field, to understand its basic nature. In this first fact, general zeolite structure and physicochemical properties such as ion exchange property, acidity, adsorptivity and catalytic activity are presented as a review with emphasis on recent advances in research aspect, especially in adsorption equilibrium data correlation equation and catalytic active centers.

Inhibition of Drp1 Ameliorates Synaptic Depression, Aβ Deposition, and Cognitive Impairment in an Alzheimer's Disease Model

Baek, Seung Hyun,Park, So Jung,Jeong, Jae In,Kim, Sung Hyun,Han, Jihoon,Kyung, Jae Won,Baik, Sang-Ha,Choi, Yuri,Choi, Bo Youn,Park, Jin Su,Bahn, Gahee,Shin, Ji Hyun,Jo, Doo Sin,Lee, Joo-Yong,Jang, Cho Society for Neuroscience 2017 The Journal of neuroscience Vol.37 No.20

<P>Excessive mitochondrial fission is a prominent early event and contributes to mitochondrial dysfunction, synaptic failure, and neuronal cell death in the progression of Alzheimer's disease (AD). However, it remains to be determined whether inhibition of excessive mitochondrial fission is beneficial in mammal models of AD. To determine whether dynamin-related protein 1 (Drp1), a key regulator of mitochondrial fragmentation, can be a disease-modifying therapeutic target for AD, we examined the effects of Drp1 inhibitor on mitochondrial and synaptic dysfunctions induced by oligomeric amyloid-beta(A beta) in neurons and neuropathology and cognitive functions in A beta precursor protein/presenilin 1 double-transgenic AD mice. Inhibition of Drp1 alleviates mitochondrial fragmentation, loss of mitochondrial membrane potential, reactive oxygen species production, ATP reduction, and synaptic depression in A beta-treated neurons. Furthermore, Drp1 inhibition significantly improves learning and memory and prevents mitochondrial fragmentation, lipid peroxidation, BACE1 expression, and A beta deposition in the brain in the AD model. These results provide evidence that Drp1 plays an important role in A beta-mediated and AD-related neuropathology and in cognitive decline in an AD animal model. Therefore, inhibiting excessive Drp1-mediated mitochondrial fission may be an efficient therapeutic avenue for AD.</P>

<small>L</small>-Ascorbic acid 2-phosphate and fibroblast growth factor-2 treatment maintains differentiation potential in bone marrow-derived mesenchymal stem cells through expression of hepatocyte growth factor

Bae, Sung Hae,Ryu, Hoon,Rhee, Ki-Jong,Oh, Ji-Eun,Baik, Soon Koo,Shim, Kwang Yong,Kong, Jee Hyun,Hyun, Shin Young,Pack, Hyun Sung,Im, Changjo,Shin, Ha Cheol,Kim, Yong Man,Kim, Hyun Soo,Eom, Young Woo,L Informa UK Ltd. 2015 Growth factors Vol.33 No.2

<P>L-ascorbic acid 2-phosphate (Asc-2P) acts as an antioxidant and a stimulator of hepatocyte growth factor (HGF) production. Previously, we reported that depletion of growth factors such as fibroblast growth factor (FGF)-2, epidermal growth factor (EGF), FGF-4 and HGF during serial passage could induce autophagy, senescence and down-regulation of stemness (proliferation via FGF-2/-4 and differentiation via HGF). In this study, we investigated the proliferation and differentiation potential of BMSCs by FGF-2 and Asc-2P. Co-treatment with FGF-2 and Asc-2P induced optimal proliferation of BMSCs and increased the accumulation rate of BMSC numbers during a 2-month culture period. Moreover, differentiation potential was maintained by co-treatment with FGF-2 and Asc-2P via HGF expression. Adipogenic differentiation potential by FGF-2 and Asc-2P was dramatically suppressed by c-Met inhibitors (SU11274). These data suggest that co-treatment with FGF-2 and Asc-2P would be beneficial in obtaining BMSCs that possess 'stemness'' during long-term culture.</P>

급성 요로감염 환아의 신장 반흔 예측요인

백준현,박영하,황성수,전정수,김성훈,이성용,정수교 대한핵의학회 2003 핵의학 분자영상 Vol.37 No.4

목적 : 본 연구는 요로 감염 환아의 추적 ^(99m)Tc DMSA신 피질 스캔으로 신장 반흔을 진단하고, 감염 초기 스캔 소견, 요관 역류, 신장 섭취율, 연령, 성 등 관련 요인들이 신장 반흔에 미치는 영향을 분석하고자 하였다. 대상 및 방법 : 임상증상, 소변 검사 및 뇨 배양 검사로 요로 감염으로 진단된 14세 이하의 환자 83명을 대상으로 하였다. 남아 50명, 여아가 33명이었고 평균 연령은 33.7개월 이었다. 치료 시작 일주일 이내에 DMSA스캔과 배뇨성 방광 요도술을 시행하였으며, 적절한 항생제 치료 후 6개월 이후에 추적 스캔을 하였다. 추적 스캔에서 감염 초기 보였던 피질 결손이 회복되지 않은 경우를 신 반흔으로 진단하였으며, 피질 결손을 1; 신장상부나 하부의 큰 결손으로 신장 의연은 불분명하나 변형은 없는 경우. 2 ; 작은 결손으로 신장 외연의 뚜렷한 변형이 없는 경우. 3 ; 단일 결손으로 신장 외연의 국소적인 변형을 일으킨 경우. 4 ; 정상 혹은 작은 크기의 신장으로 외연의 변형이 있는 경우. 5 ; 다발성 피질 결손이 있는 경우. 6 ; 국소적인 이상 소견 없이 미만성으로 신장 섭취가 감소한 경우로 분류하였다. 배뇨성 방광 요도술에서 요관 역류는 5단계로 분류하였다. 결과 : 166개의 신장 중 감염 초기 신 피질 스캔에서 결손을 보인 신장은 115개(69.3%) 이었고, 추적 검사에서 신장 반흔으로 진단된 신장은 65개(56.5%)였다. 신 피질 스캔에서 3, 4, 5 형태 결손의 75%, 77%, 78%에서 신장 반흔이 발생된 반면, 1, 2, 6 형태 결손의 65%, 77%, 50%에서 결손이 회복되었다. 회복이 어려운 3, 4, 5 형태 결손으로 신장 반흔을 진단할 경우 DMSA스캔의 민감도, 특이도, 정확도는 각각 76.9%, 85.1%, 81.9%였다. 요관 역류는 감염 초기 스캔에서 3, 4, 5 형태의 결손을 보인 경우 역류 유무 및 정도가 신장 반흔과 유의한 연관성을 보인 반면, 1, 2, 6 형태의 결손을 보인 경우 신장 반흔과의 연관성은 유의하지 않았다. 로지스틱 분석에서 감염 초기 DMSA 스캔에서 회복 가능성이 적은 3, 4, 5 형태의 결손이 있을 경우 그렇지 않을 경우에 비해 신장 반흔을 일으킬 19.1배였다. 경한 요관 역류 나 증증 역류가 있을 경우 신장 반흔을 일으킬 위험이 각각 3.5배, 14.4배 였다. 신장 섭취율도 신장 반흔과 연관성이 있었으나 신장 반흔 위험도는 유의하지 않았다. 연령 및 성별은 신반흔과 유의한 연관성이 없었다. 결론 : 요로 감염 초기 ^(99m)Tc DMSA 스캔에서 결손이 신장 외연의 변형을 일으키거나 다발성일 경우, 신장 반흔으로 진행될 가능성이 높으며, 적극적인 치료가 필요하다. Purpose : The purpose of this study was to evaluate the usefulness of ^(99m)Tc DMSA scintigraphy on the dignosis of a renal scar in children with urinary tract infection. Materials and Methods : Eighty three patients were included in this study, who were diagnosed as the urinary tract infection on the basis of sympton, urinalysis and urine culture. ^(99m)Tc DMSA scintigraphy and voiding cystoureterography were performed within 7days before the treatment in all patients. We classified the scintigraphic findings as follow s ; 1 ; a large hypoactive upper or lower pole, 2 ; a small hypoactive area. 3 ; single defect resulting in localized deformity of the cutlines. 4 ; deformed outlines in a small or normal sized kidney. 5 ; multiple defects. 6 ; diffuse hypoactive kidney without regional impairment. Follow-up scintigraphy was done at least 6 months after the initial study. When the abnormality on the initial scintigraphy was not completely resolved on the follow up scr, the lesion was defined as containing a scar. Results : One hundred and fifteen renal units of 166 units(69.3%) showed abnormal findings on the DMSA scintigraphy. 65 units(56.5%) was diagnosed as containing renal scars on follow-up scintigraphies. Incidences of renal scar among renal units showing pattern 3, 4 and 5 on the initial scan was 75%, 78% and 78%, respectively. Whereas many of renal units showing 1, 2 and 6 pattern were recovered(65%, 76%, 50%). Sensitivity, specificity and accuracy of pattern-based DMSA scintigraphic findings on the diagnosis of renal scar was 76.9%, 85.1%%, respectively. VUR was significantly associated with the renal scar when the initial DMSA shows unrecoverable findings(pattern 3, 4, 5). Odds ratio of the renal scar in a kidney showing unrecoverable initial scintigraphic findings was 19.1. Odds ratio in a kidney with mild or moderate-to-severe VUR was 3.5 and 14.4 respectively. Conclusion : In the urinary tract infection, renal scar was significantly developed in a kidney showing unrecoverable findings on the initial DMSA scan and VUR on voiding cystoureterography.

八物湯이 생체의 젖산내성 및 회복률에 미치는 영향

하장,백태현 대한한방성인병학회 2000 韓方成人病學會誌 Vol.6 No.1

Objective : To investigate the effect of Palmul-tang on Lactate Tolerance and Recovery Rate in the human body Methods : We picked up sixteen athletes who live in a training camp where they are equal in diet and condition of life. As separated them into two groups. One group was medicated Palmul-tang, and the other group was medicated Pogostemonis herba as placebo. Maximal oxygen consumption in steady increasing maximal exercise, anaerobic threshold to the threshold of lactate, lactate tolerance and recovery rate were analyzed as contrasted with before and after medication. Results : In Palmul-tang medicated group, maximal oxygen consumption, ventilation, heart rate with the maximal exercise were not much different than in Pogostemonis herba. Time to all-out with the maximal exercise was significantly longer than in it. Oxygen consumption and ventilation to the threshold of lactate were significantly larger than in it. The threshold level of lactate stood by rate of maximal oxygen consumption were much larger than in it. The exercise strength to the threshold level of lactate was significantly larger than in it. The blood concentration of lactate at the rest time and immediately after exercise were not much different than in it, but it was significantly less at the recovery time for fifteen minutes after exercise. The recovery rate of lactate at the recovery time for fifteen minutes was significantly larger than in it. Conclusions : According to the above results, it is considered that Palmul-tang has treatment effects on the recovery of fatigue after exercise, and then on the recovery of general fatigue.

드부룬 라덱스이탈식풍선카테터를 이용한 외상성 경동맥해면정맥동루의 치험례

백원현,이재수,하영수,강준기,송진언,이해규,신경섭,박용휘 대한신경외과학회 1985 Journal of Korean neurosurgical society Vol.14 No.4

A case of traumatic carotid-cavernous fistula treated using Debrun's latex detatchable balloon catheter is reported. The patient was a 33-year-old man, who has complaints of proptosis and chemosis of left eye 2 months after motor vehicle accident. The cerebral angiography showed direct fistula between intracavernous portion of internal carotid artery and cavernous sinus as high flow - high pressure type. After complete radiologic and neruologic examination, the fistulous opening was successfully occluded by Debrun's latex detatchable balloon with transient ischemic attack, which was resolved 2 hours after the procedure

망막아세포종 세포의 tyrosine hydroxylase와 serotonin N-acetyltransferase의 활성에 미치는 melatonin의 영향

신현태,정미영,진병관,윤경식,백행운,백형환,조용호 慶熙大學校 醫科大學 1997 慶熙 醫大 論文集 Vol.22 No.1

흰쥐 심근에서 유리 지방산이 세포막 활동전위와 ATP-민감성 칼륨통로 활성에 미치는 영향

김재하,주정민,박종,백영홍,국현,정한성,정명호,조정관,박종춘,강정채 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.12

Determination of Ovalbumin in Processed Foods by Immunological Methods

Ji-Hyun Seo,Ju-Woon Lee,Sin-Bok Kang,Ha-Baik Lee,Hong-Sun Yook,Mee Ree Kim,Kee-Hyuk Kim,Myung-Woo Byun 한국식품영양과학회 2002 Preventive Nutrition and Food Science Vol.7 No.4

Allergens in processed foods may place persons with food allergies at significant risk when the labels do not provide sufficient warnings or identification of high-risk ingredients. Because egg proteins are common food allergens, this study was carried out to identify hen's egg albumin (ovalbumin, OVA) in five commercially processed foods containing egg (custard, cookie and pasta), and chicken meat (sausage and meatball) by immunological methods using commercially produced murine monoclonal immunoglobulin G (M-IgG), immunoblotting and enzyme linked immunosorbent assay (ELISA). Sample buffer with chelating and reducing agents was prepared and used for the preparation of the protein fractions from the foods. Most bands in sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) profile (5~15% gradient gel) presented at 75 kDa below. OVA (43 kDa) in the sample lanes could not be visually observed on the gel. However, OVA in solutions prepared from custard and cookie could be detected by M-IgG, but were not detected in sausage and pasta. OVA in all samples could be quantitatively determined by the equation obtained from the standard curve by ELISA. Cookie and custard containing egg white and egg, respectively, contained very high concentrations of OVA. OVA in the other products were present in relatively low concentrations, but sufficiently high to pose possible risk of allergy. ELISA is a very sensitive and precise method for the identification and quantification of allergens in food products including allergy-inducible materials.