http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Progressive Multifocal Leukoencephalopathy after Ibrutinib Therapy for Chronic Lymphocytic Leukemia
Mathias Lutz,Arik B. Schulze,Elisabeth Rebber,Stefanie Wiebe,Tarek Zoubi,Oliver M. Grauer,Torsten Keßler,Andrea Kerkhoff,Georg Lenz,Wolfgang E. Berdel 대한암학회 2017 Cancer Research and Treatment Vol.49 No.2
Progressive multifocal leukoencephalopathy (PML) is a devastating neurological disease observed nearly exclusively in immunocompromised patients. Recently, the introduction of monoclonal antibodies significantly inhibiting the immune system such as rituximab has led to an increase in PML cases. Although rituximab-based immunochemotherapy remains the standard of treatment for chronic lymphocytic leukemia (CLL), the importance of Bruton’s tyrosine kinase inhibitors such as ibrutinib is steadily increasing. However, long-term experiences regarding possible side effects of these new substances are rare. Here, we report the development of eventually fatal PML possibly associated with ibrutinib therapy for CLL after multiple prior treatment lines, including rituximab. To the best of our knowledge, this is the first study to report such findings. Since the last course of rituximab was applied over 3 years ago, it is conceivable that the strong B cell inhibition by ibrutinib led to PML. With increased awareness of this potential side effect, further clinical studies are certainly warranted to evaluate this possible association.
Berger, B,You, K,Lee, H-C,Mussenbrock, T,Awakowicz, P,Schulze, J IOP PUBLISHING 2018 PLASMA SOURCES SCIENCE AND TECHNOLOGY Vol.27 No.12
<P>The fundamental investigation of different electron heating modes is important in order to fully understand the generation of plasmas, as well as to optimize their technological applications. In this study, a capacitively coupled radio-frequency discharge is operated at its limit of comparably low plasma density. Phase resolved optical emission spectroscopy provides insights into the electron dynamics on a nanosecond time scale under these conditions. At low applied voltage amplitudes, it is observed that more than one electron beam is generated within a single phase of sheath expansion at a given electrode. When the voltage amplitude is increased these beams merge in time to a single electron beam. This effect has been predicted by particle in cell/Monte-Carlo collision simulations before and contradicts existing models that assume the generation of a single beam per sheath expansion phase by stochastic heating (Wilczek <I>et al</I> 2015 <I>Plasma Sources Sci. Technol.</I> <B>24</B> 024002; Wilczek <I>et al</I> 2016 <I>Phys. Plasmas</I> <B>23</B> 063514). In this study, results from a systematic experimental study of the effect are presented, which support the theoretically predicted phenomenon.</P>
Analysis of Particle Rearrangement during Sintering by Micro Focus Computed Tomography (μCT)
Nothe M.,Schulze M.,Grupp R.,Kieback B.,Haibel A.,Banhart J. 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1
The decrease of the distance between particle centers due to the growth of the sinter necks can be explained by the well known two-particle model. Unfortunately this model fails to provide a comprehensive description of the processes for 3D specimens. Furthermore, there is a significant discrepancy between the calculated and the measured shrinkage because particle rearrangements are not considered. Only the recently developed analysis of the particle movements inside of 3D specimens using micro focus computed tomography (μCT), combined with photogrammetric image analysis, can deliver the necessary experimental data to improve existing sintering theories. In this work, μCT analysis was applied to spherical copper powders. Based on photogrammetric image analysis, it is possible to determine the positions of all particle centers for tracking the particles over the entire sintering process and to follow the formation and breaking of the particle bonds. In this paper, we present an in-depth analysis of the obtaine data. In the future, high resolution synchrotron radiation tomography will be utilized to obtain in-situ data and images of higher resolution.
U. Ullmann,J. Metzner,C. Schulz,J. Perkins,B. Leuenberger 한국식품영양과학회 2005 Journal of medicinal food Vol.8 No.3
Commercial Coenzyme Q10 (CoQ10, ubiquinone) formulations are often of poor intestinal absorption. We investigated the bioavailability of DSM Nutritional Products Ltd. (Kaiseraugst, Switzerland) CoQ10 10% TG/P (all-Q??), a new tablet-grade formulation, with CoQ10 Q-Gel?? Softsules?? based on the Bio-Solv?? technology (Tishcon Corp., Salisbury, MD; marketed by Epic4Health™, Smithtown, NY) and Q-SorB?? (Nature’s Bounty™, Bohemia, NY). Twelve healthy male subjects participated in a randomized, three-period crossover bioequivalence study. Plasma CoQ10 was determined from pre-dose until 36 hours. To compare bioavailability, corrected maximum concentration (Cmax) and area under the curve from 0 to 14 hours [AUC(0-14 h)] were assessed and tested for bioequivalence. The bioequivalence ranges of 0.8–1.25 hour g/mL for AUC(0-14 h) and 0.75–1.33 g/mL for Cmax were applied. In summary, the kinetic profiles of all CoQ10 preparations revealed a one-peak plasma concentration–time course. Highest Cmax values were seen after Q-Gel application, whereas time to Cmax was nearly identical across all treatments. The AUC(0-14 h) values were highest for Q-Gel, narrowly followed by all-Q. The tests for bioequivalence showed a bioequivalence between Q-Gel and all-Q, and both preparations were found to have better bioavailability properties than Q-SorB. Although all-Q and Q-Gel have equivalent bioavailability properties, all-Q can be directly used in tablets, while this is not the case for Q-Gel or other similar forms.
Habib Pardes,Jung Jennifer,Wilms Gina Maria,Kokott-Vuong Alma,Habib Shahin,Schulz Jörg B.,Voigt Aaron 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
Hypoxia is an underlying pathophysiological condition of a variety of devastating diseases, including acute ischemic stroke (AIS). We are faced with limited therapeutic options for AIS patients, and even after successful restoration of cerebral blood flow, the poststroke mortality is still high. More basic research is needed to explain mortality after reperfusion and to develop adjunct neuroprotective therapies. Drosophila melanogaster (D.m.) is a suitable model to analyze hypoxia; however, little is known about the impacts of hypoxia and especially of the subsequent reperfusion injury on the behavior and survival of D.m . To address this knowledge gap, we subjected two wild-type D.m . strains (Canton-S and Oregon-R) to severe hypoxia (<0.3% O 2 ) under standardized environmental conditions in a well-constructed hypoxia chamber. During posthypoxic reperfusion (21% O 2 ), we assessed fly activity (evoked and spontaneous) and analyzed molecular characteristics (oxidative stress marker abundance, reactive oxygen species (ROS) production, and metabolic activity) at various timepoints during reperfusion. First, we established standard conditions to induce hypoxia in D.m . to guarantee stable and reproducible experiments. Exposure to severe hypoxia under defined conditions impaired the climbing ability and reduced the overall activity of both D.m . strains. Furthermore, a majority of the flies died during the early reperfusion phase (up to 24 h). Interestingly, the flies that died early exhibited elevated activity before death compared to that of the flies that survived the entire reperfusion period. Additionally, we detected increases in ROS and stress marker (Catalase, Superoxide Dismutase and Heat Shock Protein 70) levels as well as reductions in metabolic activity in the reperfusion phase. Finally, we found that changes in environmental conditions impacted the mortality rate. In particular, decreasing the temperature during hypoxia or the reperfusion phase displayed a protective effect. In conclusion, our data suggest that reperfusion-dependent death might be associated with elevated temperatures, predeath activity, and oxidative stress.
Advanced technologies for intuitive control and sensation of prosthetics
Erik J. Wolf,Theresa H. Cruz,Alfred A. Emondi,Nicholas B. Langhals,Stephanie Naufel,Grace C. Y. Peng,Brian W. Schulz,Michael Wolfson 대한의용생체공학회 2020 Biomedical Engineering Letters (BMEL) Vol.10 No.1
The Department of Defense, Department of Veterans Aff airs and National Institutes of Health have invested signifi cantlyin advancing prosthetic technologies over the past 25 years, with the overall intent to improve the function, participationand quality of life of Service Members, Veterans, and all United States Citizens living with limb loss. These investmentshave contributed to substantial advancements in the control and sensory perception of prosthetic devices over the past decade. While control of motorized prosthetic devices through the use of electromyography has been widely available sincethe 1980s, this technology is not intuitive. Additionally, these systems do not provide stimulation for sensory perception. Recent research has made signifi cant advancement not only in the intuitive use of electromyography for control but also inthe ability to provide relevant meaningful perceptions through various stimulation approaches. While much of this previouswork has traditionally focused on those with upper extremity amputation, new developments include advanced bidirectionalneuroprostheses that are applicable to both the upper and lower limb amputation. The goal of this review is to examine thestate-of-the-science in the areas of intuitive control and sensation of prosthetic devices and to discuss areas of explorationfor the future. Current research and development eff orts in external systems, implanted systems, surgical approaches, andregenerative approaches will be explored.