http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( Naganathan Selvakumar ),( Selvakumar Naganathan ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Hepatic artery intimal dissection (HAD) followed by hepatic artery thrombosis (HAT) is serious complication of liver transplantation. There is paucity of information in literature on the management options for HAD encountered during surgery. In this study we describe a new classification and technique for the management of HAD during living donor liver transplant (LDLT). Methods: Based on the longitudinal extent of intimal dissection, HAD was classified into 4 types. Management was based on the availability of adequate length of hepatic artery and availability of alternate source of inflow. The dissected hepatic artery itself was used for arterial anastomosis in cases with preserved flow in the dissected artery and paucity of an alternative sources of arterial inflow. The technique of using the dissected artery is based on close approximation of tunica intima to media with the first two sutures of the arterial anastomosis. Patients with HAD were compared with those without HAD for evaluation of risk factors for intimal dissection. Results: 47 (2.4%) patients developed HAD during surgery. 22 (46.7%) patients had type II dissection for whom the other (right or the left) undissected hepatic artery was used for anastomosis. 20 (45%) patients were found to have major (type III or IV) dissection. The dissected artery was used for anastomosis in 9 of (45%) of these patients. Post-operative HAT developed in only one out of the 9 patients. Pre-existing portal vein thrombosis (PVT) and prior trans arterial embolization (TAE) were found to be major risk factors for development of intimal dissection. Conclusions: Classification
Selvakumar Gopal,Murugesan Chandrasekaran,Charlotte Shagol,Kiyoon Kim,Tongmin Sa 한국토양비료학회 2012 한국토양비료학회지 Vol.45 No.4
Microorganisms present in the rhizosphere soil plays a vital role in improving the plant growth and soil fertility. Many kinds of fertilizers including chemical and organic has been approached to improve the productivity. Though some of them showed significant improvement in yield, they failed to maintain the soil properties. Rather they negatively affected soil eventually, the land became unsuitable for agricultural. To overcome these problems, microorganisms have been used as effective alternative. For past few decades, plant growth promoting rhizobacteria (PGPR) and arbuscular mycorrhizal fungi (AMF) have been used as effective inoculants to enhance the plant growth and productivity. PGPR improves the plant growth and helps the plant to withstand biotic and abiotic stresses. AM fungi are known to colonize roots of plants and they increase the plant nutrient uptake. Spore associated bacteria (SAB) are attached to spore wall or hyphae and known to increase the AMF germination and root colonization but their mechanism of interaction is poorly known. Better understanding the interactions among AMF, SAB and PGPR are necessary to enhance the quality of inoculants as a biofertilizers. In this paper, current knowledge about the interactions between fungi and bacteria are reviewed and discussed about AMF spore associated bacteria.
Selvakumar Edwardraja,Ganapathiraman Munussami,Amit Goyal,이선구 한국생물공학회 2016 Biotechnology and Bioprocess Engineering Vol.21 No.6
There is a considerable interest in the detection of GFP-like proteins due to their structural stability and functional usefulness. GFP-like proteins share highly conserved beta-barrel fold with 11 beta-strands. However, their low sequence identity hampers efficient identification of their homologous proteins from database. In this study, an attempt was made to generate a fingerprint for efficient detection of GFP-like proteins. Overlapped conserved residues (OCR)-based approach has been used to design a protein fingerprint based on sequentially and structurally conserved residues in secondary structures to detect homologous proteins very efficiently. Therefore, a fingerprint for GFP-like fold was designed using the OCR approach. However, its specificity was too low to be used for the identification of novel proteins. The conserved residues of loop regions were added and optimized to improve its specificity without losing its high sensitivity. The optimized fingerprint was employed to scan NR database. A total of 20 hypothetical proteins were detected, among which nine were validated as potential GFP-like homologs.
Generation of Anti-c-Met Single Domain Antibody Fragment Based on Human Stable Frameworks
Selvakumar Edwardraja,Sriram Sokalingam,Govindan Raghunathan,Bum-Yeol Hwang,이선구 한국생물공학회 2012 Biotechnology and Bioprocess Engineering Vol.17 No.6
The size reduction is an important issue in the biomedical application of antibody and single domain antibody fragment is recognized as very attractive tool. However, it is very time-consuming and laborious to generate the fragment antibody with targeted binding function. Here,we investigated the possibility to prepare single domain antibody (sdAb) by a simple grafting method based on stable human consensus framework sequences. The complementarity determining region sequences in VH domain of anti-c-Met scFv from rabbit were grafted with the human VH3 consensus framework sequences, which generated the anti-c-Met single domain antibody showing almost same binding activity to its scFv form. The generated single domain antibody could be produced as functional form in oxidizing cytoplasm of E. coli, but produced as inactive form in reducing cytoplasm. The structural analysis of the homology models gave us the insight on the stability of the single domain antibody. In this report, we have demonstrated that the very stable human consensus framework sequence can be used for the generation of active anti-c-Met sdAb via complementarity determining regions grafting. We expect that this kind of grafting method for the generation of sdAb may provide us with the opportunities to prepare sdAbs based on the known antibody sequences.