http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Amirthalingam, Sivashanmugam (검색결과 14 건)
- 무료
- 기관 내 무료
- 유료
-
-
Amirthalingam Vinailosni,Ataa Nur Syuhada Mohd,Mahmuddin Siti Sarah,Adam Nur Azura,Nai Yu-Shin,Lau Wei Hong 한국응용곤충학회 2024 Journal of Asia-Pacific Entomology Vol.27 No.1
Heterotrigona itama and Geniotrigona thoracica become popular in Malaysia as honey producer in the 21st century. Like other bee species, stingless bees can be infected by pathogens. Disease-related population declines may affect honey production, agricultural productivity, and biodiversity. Thus, this study aimed to evaluate the health status of stingless bee colonies in selected bee farms in Malaysia. Adults Heterotrigona itama and Geniotrigona thoracica were collected from 79 colonies in 9 farms and screened for known pathogens of honey bees and stingless bees using 15 primer sets. All results were negative, indicating the absence of these pathogens in the bee specimens. During the bee sampling at Infoport Halal Hub UPM, we encountered a collapsed colony of H. itama. A fungal isolate was isolated and confirmed to be Aspergillus caelatus. Virulence tests revealed that A. caelatus exhibited high virulence to both H. itama and G. thoracica. Infected larvae became lethargic after 1–2 day after treatment (DAT) with white mycelium developed on their integument. The fungus caused 100 % larval mortality in both H. itama and G. thoracica after 8 DAT, with LC 50 values of 7.58 × 10 3 conidia/µl and 6.24 × 10 3 conidia/ µl respectively. Yellow-green conidia were observed on the cadavers. A. caelatus demonstrated high virulence towards both H. itama and G. thoracica, leading to severe larval mortality. This study represents the first documented case of a disease infecting stingless bees in Malaysia. Future research is needed to assess the prevalence of A. caelatus in various stingless bee species and other pollinators within the country.
-
Pavithiran, Amirthalingam,Bathige, S.D.N.K.,Kugapreethan, Roopasingam,Priyathilaka, Thanthrige Thiunuwan,Yang, Hyerim,Kim, Myoung-Jin,Lee, Jehee Elsevier 2018 Fish & shellfish immunology Vol.74 No.-
<P><B>Abstract</B></P> <P>Akirins, members of the NF-κB signaling pathway, are highly conserved nuclear proteins, which regulate gene expression in many physiological processes, including immunity, myogenesis, carcinogenesis, and embryogenesis. The akirin family in teleost fish consists of two to three genes. In the present study, three akirin genes from <I>Hippocampus abdominalis</I> were identified from a transcriptome database and designated as <I>HaAkirin1</I>, <I>HaAkirin2(1)</I>, and <I>HaAkirin2(2)</I>. The nuclear localization of <I>HaAkirin1</I> and <I>HaAkirin2(1)</I> was confirmed by subcellular localization analysis. In contrast, diffused localization of <I>HaAkirin2(2)</I> was identified in the nucleus and cytoplasm that confirmed the aberrant nature of the nuclear localization signal. Phylogenetic analysis revealed a closer relationship of HaAkirins with other known teleost akirins. All three <I>HaAkirin</I> transcripts were ubiquitously expressed in all examined tissues with higher expression in ovary tissue. Immune challenge with LPS, poly I:C, and <I>Streptococcus iniae</I> exhibited a significant increase in the expression of all three <I>HaAkirins</I> in kidney and liver tissues. NF-κB luciferase assays revealed that relative luciferase activity was significantly higher for all three <I>HaAkirin</I> genes than mock controls. These results suggest that <I>HaAkirin</I> genes might play a role in regulating NF-κB dependent immune gene expression and their expression could be induced by bacterial and viral pathogen recognition molecular patterns.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Three akirin genes (<I>Haakirins</I>) were identified from <I>Hippocampus abdominalis</I>. </LI> <LI> The loss of second nuclear localization signal was identified in <I>Haakirin2(2).</I> </LI> <LI> All three <I>Haakirins</I> were prominently expressed in gonadal tissues. </LI> <LI> All three <I>Haakirins</I> were upregulated after challenging with LPS, poly I:C, and <I>S. iniae.</I> </LI> <LI> The expression of NF-κB reporter gene was induced by all three <I>Haakirins.</I> </LI> </UL> </P>
-
Shanmugavani, Amirthalingam,Lalitha, Murugan,Narayanan Kutty, Rajeesh Kumar,Vasylechko, Leonid,Lee, Yun Sung,Lakshmipathi, Senthilkumar,Kalai Selvan, Ramakrishnan Elsevier 2018 ELECTROCHIMICA ACTA Vol.283 No.-
<P><B>Abstract</B></P> <P>By varying Co:Sb molar ratio, crystalline CoSb<SUB>2</SUB>O<SUB>4</SUB> was synthesized through surfactant free hydrothermal method. The tetragonal crystal structure and phase composition of cobalt antimonate were obtained through XRD Rietveld refinement method. CoSb<SUB>2</SUB>O<SUB>4</SUB> exhibits a direct band gap of 2.89 eV was computed using First-principle density functional theory (DFT) calculations. Here, the Fermi energy level is upshifted to conduction band region, representing the n-type behaviour of the CoSb<SUB>2</SUB>O<SUB>4</SUB> unit cell. The oxidation state of +2 and + 3 of Co was identified through X-ray photoelectron spectroscopy analysis (XPS). Formation of submicron size, rod shape particles was confirmed by Transmission electron microscopic (TEM) images. Cyclic voltammogram exhibits a specific capacitance of 598 F g<SUP>−1</SUP> at 2 mV s<SUP>−1</SUP> in 1 M KOH. More importantly, Galvanostatic charge-discharge analysis (GCD) delivered the specific capacitance of 382 F g<SUP>−1</SUP> at 1 mA cm<SUP>−2</SUP>. For practical application, an asymmetric supercapacitor is constructed using Ni<SUB>3</SUB>(Fe(CN)<SUB>6</SUB>)<SUB>2</SUB>(H<SUB>2</SUB>O) as a positive electrode and synthesized one-dimensional CoSb<SUB>2</SUB>O<SUB>4</SUB> as a negative electrode, which offered a maximum specific capacitance of 279 Fg<SUP>-1</SUP> at 1 mV s<SUP>−1</SUP>. Cycling stability of the fabricated device demonstrated the retention of almost 100% and hence depicts its promising nature as an efficient electrode for supercapacitor application.</P>
-
-
-
Veeramani Raveendranath,Thangarasu Kavitha,Amirthalingam Umamageswari 대한척추신경외과학회 2019 Neurospine Vol.16 No.4
Objective: The cervical spine consists of 4 typical and 3 atypical vertebrae. The uncinate process is one of the unique features of the cervical vertebrae. Uncinectomy and uncoforaminotomy are widely used to decompress the nerve in the intervertebral foramen and to remove osteophytes from the uncinate process. Morphometric analyses of the uncinate process help spine surgeons obtain a 3-dimensional orientation for approaching the cervical spine with minimal risk to the surrounding vascular and neural structures. This study aims to analyze the morphometry of uncinate process of cervical vertebrae with relevant to cervical spine surgery. Methods: Eighty dry adult cervical vertebrae were studied, and 11 parameters were measured. Seven parameters were paired and 4 were unpaired. Results: The height of the uncinate process progressively increased from C3 to C6 and decreased at C7. The length of the uncinate process increased from C3 to C6–7. The width was greatest at C6 and smallest at C3. The vertebral body width and anteroposterior diameter gradually increased from C3 to C7. The parameters of the lamina also increased from C3 to C7. Conclusion: Precise knowledge about the cervical vertebrae is useful for diagnosing both common and uncommon causes of symptoms and for choosing an appropriate approach. Thus, it helps to increase the success rate of cervical surgery.
-
Vijayasree Vayalanellore Giridharan,Rajarajan Amirthalingam Thandavarayan,Vasudevan Mani,Taranalli Ashok Dundapa,Kenichi Watanabe,Tetsuya Konishi 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.9
Cognitive disorders such as dementia, attention deficits, and Alzheimer's disease (AD) have been well investigated. However, effective interventions for the promotion and progression of AD are unavailable to date. The present work was undertaken to investigate the effects of the aqueous (300 and 500 mg/kg) and alcoholic (300 and 500 mg/kg) extracts of Ocimum sanctum Linn. leaves as an antidementic and anticholinesterase agent and also as an immunostimulant in rats. Maximal electroshock, atropine, and cyclosporine were used to induce dementia. The passive avoidance task was used for assessing memory. Acetylcholinesterase (AChE) activity was estimated in different parts of the brain, and immune status was studied using dinitrochlorobenzene (DNCB) skin sensitivity tests. In all the three models both aqueous and alcoholic O. sanctum extracts decreased the time taken to reach the shock-free zone and the number of mistakes and significantly decreased the AChE activity in rats. O. sanctum treatment significantly increased the induration in the DNCB skin test. Therefore, O. sanctum was shown to be useful for the management of experimentally induced cognitive dysfunctions in rats.
-
Arun Kumar Rajendran,Deepthi Sankar,Sivashanmugam Amirthalingam,김환,Jayakumar Rangasamy,Nathaniel S. Hwang 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Sensing the mechanical properties of the substrates or the matrix by the cells and the tissues, the subsequent downstream responses at the cellular, nuclear and epigenetic levels and the outcomes are beginning to get unraveled more recently. There have been various instances where researchers have established the underlying connection between the cellular mechanosignalling pathways and cellular physiology, cellular differentiation, and also tissue pathology. It has been now accepted that mechanosignalling, alone or in combination with classical pathways, could play a significant role in fate determination, development, and organization of cells and tissues. Furthermore, as mechanobiology is gaining traction, so do the various techniques to ponder and gain insights into the still unraveled pathways. This review would briefly discuss some of the interesting works wherein it has been shown that specific alteration of the mechanical properties of the substrates would lead to fate determination of stem cells into various differentiated cells such as osteoblasts, adipocytes, tenocytes, cardiomyocytes, and neurons, and how these properties are being utilized for the development of organoids. This review would also cover various techniques that have been developed and employed to explore the effects of mechanosignalling, including imaging of mechanosensing proteins, atomic force microscopy (AFM), quartz crystal microbalance with dissipation measurements (QCMD), traction force microscopy (TFM), microdevice arrays, Spatio-temporal image analysis, optical tweezer force measurements, mechanoscanning ion conductance microscopy (mSICM), acoustofluidic interferometric device (AID) and so forth. This review would provide insights to the researchers who work on exploiting various mechanical properties of substrates to control the cellular and tissue functions for tissue engineering and regenerative applications, and also will shed light on the advancements of various techniques that could be utilized to unravel the unknown in the field of cellular mechanobiology.
-
Mesenchymal Stem Cell Spheroids: A Promising Tool for Vascularized Tissue Regeneration
Kang Yoonjoo,Na Jinwoo,Karima Gul,Amirthalingam Sivashanmugam,Hwang Nathaniel S.,Kim Hwan D. 한국조직공학과 재생의학회 2024 조직공학과 재생의학 Vol.21 No.5
Background Mesenchymal stem cells (MSCs) are undifferentiated cells that can differentiate into specific cell lineages when exposed to the right conditions. The ability of MSCs to differentiate into particular cells is considered very important in biological research and clinical applications. MSC spheroids are clusters of MSCs cultured in three dimensions, which play an important role in enhancing the proliferation and differentiation of MSCs. MSCs can also participate in vascular formation by differentiating into endothelial cells and secreting paracrine factors. Vascularization ability is essential in impaired tissue repair and function recovery. Therefore, the vascularization ability of MSCs, which enhances angiogenesis and accelerates tissue healing has made MSCs a promising tool for tissue regeneration. However, MSC spheroids are a relatively new research field, and more research is needed to understand their full potential. Methods In this review, we highlight the importance of MSC spheroids’ vascularization ability in tissue engineering and regenerative medicine while providing the current status of studies on the MSC spheroids’ vascularization and suggesting potential future research directions for MSC spheroids. Results Studies both in vivo and in vitro have demonstrated MSC spheroids’ capacity to develop into endothelial cells and stimulate vasculogenesis. Conclusion MSC spheroids show potential to enhance vascularization ability in tissue regeneration. Yet, further research is required to comprehensively understand the relationship between MSC spheroids and vascularization mechanisms. Background Mesenchymal stem cells (MSCs) are undifferentiated cells that can differentiate into specific cell lineages when exposed to the right conditions. The ability of MSCs to differentiate into particular cells is considered very important in biological research and clinical applications. MSC spheroids are clusters of MSCs cultured in three dimensions, which play an important role in enhancing the proliferation and differentiation of MSCs. MSCs can also participate in vascular formation by differentiating into endothelial cells and secreting paracrine factors. Vascularization ability is essential in impaired tissue repair and function recovery. Therefore, the vascularization ability of MSCs, which enhances angiogenesis and accelerates tissue healing has made MSCs a promising tool for tissue regeneration. However, MSC spheroids are a relatively new research field, and more research is needed to understand their full potential. Methods In this review, we highlight the importance of MSC spheroids’ vascularization ability in tissue engineering and regenerative medicine while providing the current status of studies on the MSC spheroids’ vascularization and suggesting potential future research directions for MSC spheroids. Results Studies both in vivo and in vitro have demonstrated MSC spheroids’ capacity to develop into endothelial cells and stimulate vasculogenesis. Conclusion MSC spheroids show potential to enhance vascularization ability in tissue regeneration. Yet, further research is required to comprehensively understand the relationship between MSC spheroids and vascularization mechanisms.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
