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TRPV1 Is Associated with Testicular Apoptosis in Mice
Adrian S. Siregar,Marie Merci Nyiramana,Eun-Jin Kim,Eui-Jung Shin,Chang-Woon Kim,Dong Kun Lee,Seong-Geun Hong,Jaehee Han,Dawon Kang 한국동물생명공학회(구 한국동물번식학회) 2019 Journal of Animal Reproduction and Biotechnology Vol.34 No.4
Reproductive potential decreases with age. A decrease in male fertility is due to a combination of morphological and molecular alterations in the testes. Transient receptor potential vanilloid receptor-1 (TRPV1) is associated with aging and lifespan, and its activation causes apoptotic cell death in various cell types. However, the effect of TRPV1 on testicular apoptosis in aged mice has not yet been reported. TRPV1 knockout (KO) mice had a longer lifespan than that of wild-type (WT) mice. Lifespan was increased by 11.8% in male TRPV1 KO mice compared to that in WT mice. TRPV1 KO males lived approximately 100 days longer than WT males on average, and the maximum lifespan was markedly extended in TRPV1 KO mice compared with that in WT mice. The TRPV1 expression levels were highly increased in the testes of older mice. TRPV1 was expressed in the entire testes region of the old mice. In addition, old TRPV1 KO mice had lower testicular apoptosis than that of WT mice. Our results show that TRPV1 induces testicular apoptosis and suggest that TRPV1 may be associated with testicular aging.
Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma
Ally, Adrian,Balasundaram, Miruna,Carlsen, Rebecca,Chuah, Eric,Clarke, Amanda,Dhalla, Noreen,Holt, Robert A.,Jones, Steven J.M.,Lee, Darlene,Ma, Yussanne,Marra, Marco A.,Mayo, Michael,Moore, Richard A Elsevier 2017 Cell Vol.169 No.7
<P><B>Summary</B></P> <P>Liver cancer has the second highest worldwide cancer mortality rate and has limited therapeutic options. We analyzed 363 hepatocellular carcinoma (HCC) cases by whole-exome sequencing and DNA copy number analyses, and we analyzed 196 HCC cases by DNA methylation, RNA, miRNA, and proteomic expression also. DNA sequencing and mutation analysis identified significantly mutated genes, including <I>LZTR1</I>, <I>EEF1A1</I>, <I>SF3B1</I>, and <I>SMARCA4</I>. Significant alterations by mutation or downregulation by hypermethylation in genes likely to result in HCC metabolic reprogramming (<I>ALB</I>, <I>APOB</I>, and <I>CPS1</I>) were observed. Integrative molecular HCC subtyping incorporating unsupervised clustering of five data platforms identified three subtypes, one of which was associated with poorer prognosis in three HCC cohorts. Integrated analyses enabled development of a p53 target gene expression signature correlating with poor survival. Potential therapeutic targets for which inhibitors exist include WNT signaling, MDM4, MET, VEGFA, MCL1, IDH1, TERT, and immune checkpoint proteins CTLA-4, PD-1, and PD-L1.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Analysis of hepatocellular carcinomas integrates data of multiple genomic platforms </LI> <LI> Mutated genes reveal oncogenic processes altering hepatocyte energy balance </LI> <LI> Multiplex analyses suggest a key role for Sonic hedgehog signaling in HCC </LI> <LI> IDH mutations point to a HCC subgroup molecularly similar to cholangiocarcinoma </LI> </UL> </P> <P><B>Graphical Abstract</B></P> <P>[DISPLAY OMISSION]</P>
A cost-effective method to prepare size-controlled nanoscale zero-valent iron for nitrate reduction
Claudio Adrian Ruiz-Torres,Rene Fernando Araujo-Martinez,Gabriel Alejandro Martinez-Cas,J. Elpidio Morales-Sanchez,Tae-Jin Lee,Hyun-Sang Shin,Yuhoon Hwang,Abel Hurtado-Macias,Facundo Ruiz 대한환경공학회 2019 Environmental Engineering Research Vol.24 No.3
Nanoscale zero-valent iron (nZVI) has proved to be an effective tool in applied environmental nanotechnology, where the decreased particle diameter provides a drastic change in the properties and efficiency of nanomaterials used in water purification. However, the agglomeration and colloidal instability represent a problematic and a remarkable reduction in nZVI reactivity. In view of that, this study reports a simple and cost-effective new strategy for ultra-small (< 7.5%) distributed functionalized nZVI-EG (1-9 ㎚), with high colloidal stability and reduction capacity. These were obtained without inert conditions, using a simple, economical synthesis methodology employing two stabilization mechanisms based on the use of non-aqueous solvent (methanol) and ethylene glycol (EG) as a stabilizer. The information from UV-Vis absorption spectroscopy and Fourier transform infrared spectroscopy suggests iron ion coordination by interaction with methanol molecules. Subsequently, after nZVI formation, particle-surface modification occurs by the addition of the EG. Size distribution analysis shows an average diameter of 4.23 ㎚ and the predominance (> 90%) of particles with sizes < 6.10 ㎚. Evaluation of the stability of functionalized nZVI by sedimentation test and a dynamic light-scattering technique, demonstrated very high colloidal stability. The ultra-small particles displayed a rapid and high nitrate removal capacity from water.
Jungeon Lee,Adrian M. Chung Baek,Namhun Kim,Daeil Kwon 국제구조공학회 2022 Smart Structures and Systems, An International Jou Vol.29 No.6
Metal additive manufacturing (AM), also known as metal three-dimensional (3D) printing, produces 3D metal products by repeatedly adding and solidifying metal materials layer by layer. During the metal AM process, products experience repeated local melting and cooling using a laser or electron beam, resulting in product defects, such as warpage, cracks, and internal pores. Such defects adversely affect the final product. This paper proposes the in situ monitoring-based warpage prediction of metal AM products with experimental feature extraction. The temperature profile of the metal AM substrate during the process was experimentally collected. Time-domain features were extracted from the temperature profile, and their relationships to the warpage mechanism were investigated. The standard deviation showed a significant linear correlation with warpage. The findings from this study are expected to contribute to optimizing process parameters for metal AM warpage reduction.