Cariprazine — an Alternative Treatment for Clozapine-resistant Schizophrenia?

Adam Montgomery(Adam Montgomery ),Marianna Rogowska(Marianna Rogowska ),Luiz Dratcu(Luiz Dratcu ) 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.1

Treatment-resistant schizophrenia (TRS) poses a significant therapeutic challenge in psychiatric practice. Clozapine is recognized as a treatment of choice in TRS but is not always effective in alleviating patients’ symptoms. Additionally, clozapine therapy is associated with multiple side effects and monitoring requirements that often limit its use and negatively affect patients’ compliance with the treatment. Although clozapine augmentation options are available, there is currently no alternative monotherapy proven to be effective in TRS. We present a case of a young man with TRS who failed to respond to appropriate trials of risperidone, aripiprazole and also clozapine, and who experienced impairing adverse effects of clozapine that made further clozapine treatment not only futile but also detrimental to his health. He was successfully treated with cariprazine monotherapy, which culminated in the remission of his both positive and negative symptoms of psychosis as well as in the marked improvement in social functioning. Cariprazine, a newer atypical antipsychotic endowed with a D3-preferring mode of action, may offer a better tolerated and more acceptable treatment option for patients with difficult-to-treat psychotic symptoms.

Patterns of failure for hypopharynx cancer patients treated with limited high-dose radiotherapy treatment volumes

Adam Burr(Adam Burr ),Paul Harari(Paul Harari ),Aaron Wieland(Aaron Wieland ),Randall Kimple(Randall Kimple ),Gregory Hartig(Gregory Hartig ),Matthew Witek(Matthew Witek ) 대한방사선종양학회 2022 Radiation Oncology Journal Vol.40 No.4

Purpose: Optimal radiotherapy treatment volumes for patients with locally advanced hypopharynx squamous cell carcinoma should ensure maximal tumor coverage with minimal inclusion of normal surrounding structures. Here we evaluated the effectiveness of a direct 3-mm high-dose gross tumor volume to planning target volume expansion on clinical outcomes for hypopharynx cancers. Materials and Methods: We performed a retrospective analysis of patients with hypopharynx carcinoma treated between 2004 and 2018 with primary radiotherapy using a direct high-dose gross tumor volume to planning target volume expansion and with or without concurrent systemic therapy. Diagnostic imaging of recurrences was co-registered with the planning CT. Spatial and volumetric analyses of contoured recurrences were compared with planned isodose lines. Failures were initially defined as in field, marginal, elective nodal, and out of field. Each failure was further classified as central high-dose, peripheral high-dose, central intermediate/low-dose, peripheral intermediate/low-dose, and extraneous. Clinical outcomes were analyzed by Kaplan-Meier estimation. Results: Thirty-six patients were identified. At a median follow-up at 52.4 months, estimated 5-year overall survival was 59.3% (95% confidence interval [CI], 36.3%–74.1%), 5-year local and nodal control was 71.7% (95% CI, 47.1%–86.3%) and 69.9% (95% CI, 57.0%–82.6%), respectively. The most common failure was in the high-dose primary target volume. The gastrostomy tube retention rate at 1 year among patients without recurrence was 13.0% (95% CI, 3.2%–29.7%). Conclusion: Minimal high-dose target volume expansions for hypopharynx cancers were associated with favorable locoregional control. This approach may enable therapy intensification to improve clinical outcomes.

The Interplay of Parental Financial Behaviour and Financial Literacy and The Moderating Effects of Parental Income

Adam Ndou People&Global Business Association 2023 Global Business and Finance Review Vol.28 No.6

Purpose: The moderating effect of parental income on parental financial behaviour and financial literacy is increasingly becoming important. The objective of this study was to determine whether the relationship between parental financial behaviour and financial literacy of young adults is moderated by parental income. Design/methodology/approach: Financial literacy was measured through financial knowledge, financial behaviour, financial attitudes, and financial decision-making. Quantitative research approach was adopted for this study. Self-administered questionnaire was used to collect data among young adults in South Africa. Moderated regression analysis was used to analyse data. Four hypotheses were tested. Findings: The results showed that Parental income moderated the relationship of Parental financial behaviour with financial behaviour, financial attitude, and financial decision-making. Furthermore, the results indicated that parental income did not moderate the relationship of Parental financial behaviour and financial knowledge. Therefore, the overall results indicated that the relationship between parental financial behaviour and financial literacy is moderated by parental income. Research limitations/implications: Due to the low levels of general literacy among the respondents, which negatively affected data collection; some young adults did not understand the questionnaire and withdrew from participating in the study. Furthermore, even though confidentiality and anonymity were guaranteed, respondents were reluctant to participate in the study. They feared exposing their financial position and displayed a lack of trust. Originality/value: This study is amongst the first to investigate whether the relationship between parental financial behaviour and financial literacy is moderated by parental income. This study concluded by providing recommendations and suggestions for future research.

Measuring displacements of a railroad bridge using DIC and accelerometers

Adam Hoag,Neil A. Hoult,W. Andy Take,Fernando Moreu,Hoat Le,Vamsi Tolikonda 국제구조공학회 2017 Smart Structures and Systems, An International Jou Vol.19 No.2

Railroad bridges in North America are an integral but aging part of the railroad network and are typically only monitored using visual inspections. When quantitative information is required for assessment, railroads often monitor bridges using accelerometers. However without a sensor to directly measure displacements, it is difficult to interpret these results as they relate to bridge performance. Digital Image Correlation (DIC) is a non-contact sensor technology capable of directly measuring the displacement of any visible bridge component. In this research, a railroad bridge was monitored under load using DIC and accelerometers. DIC measurements are directly compared to serviceability limits and it is observed that the bridge is compliant. The accelerometer data is also used to calculate displacements which are compared to the DIC measurements to assess the accuracy of the accelerometer measurements. These measurements compared well for zero-mean lateral data, providing measurement redundancy and validation. The lateral displacements from both the accelerometers and DIC at the supports were then used to determine the source of lateral displacements within the support system.

Race and Legitimacy in Acts 17:26: An Approach from Political Theology

Adam F. Braun 연세대학교 신과대학(연합신학대학원) 2021 신학논단 Vol.106 No.-

더글라스(Frederick Douglas)는 자신의 유명한 편지에서 사도행전 17장 26절에 기대어 “노예들에게 독립기념일이란 무엇인가?”라고 질문한다. 더글라스는 “당신들은 ‘인류의 모든 족속을 한 혈통으로 만드사 온 땅에 살게 하심’을 믿는다고 고백했다”라고 지적함으로써, 자신의 반대 세력들의 믿음을 인용하여 자신의 주장에 대한 정당성을 확보하고자 한 것이었다. 본 논문은 사도행전 17장 26절을 노예폐지론자, 다문화주의자, 그리고 인종분리주의자들이 어떻게 수용하였는지 살펴본다. 이 과정에서 본 논문은, 코츠코(Adam Kotsko)의 신자유주의 이론 모델처럼, 인종문제를 정치신학적 관점에서 접근하고자 한다. 따라서 필자는 사도행전 17:26에서 인종 담론은 차이점들을 지우고 모두가 동일하게 보이게 만든다는 점을 지적하고자 한다. Frederick Douglass appeals to Acts 17:26 in his famous letter, “What to the slave is the Fourth of July?” Douglass intends to gain legitimacy to his argument by conjuring the beliefs of his opponents, when he says, “You profess to believe ‘that, of one blood, God made all nations of men to dwell on the face of all the earth.’” While Acts certainly relies on political theology to legitimize “men” in the face of “all nations,” this paper will concern itself with recent invocations of this form of legitimization of the human, one which is made up of different races. In particular, I want to look at the series of essays from The Gospel Coalition"s Tim Keller and his treatment of race. This paper will analyze uses of Acts 17:26 in so-called “multiculturalist” discourses and Tim Keller’s work on The Gospel Coalition. Through this analysis, this paper will consider race, like Kotsko"s neoliberalism, as its own legitimizing political theology. Race legitimates all into a sameness that erases difference.

Influence of Municipal Wastewater on Rice Seed Germination, Seedling Performance, Nutrient Uptake, and Chlorophyll Content

Adam Bin Puteh,Umaru Mohamed Gassama,Mohamed Ridzwan Abd-Halim,Bashiru Kargbo 한국작물학회 2015 Journal of crop science and biotechnology Vol.18 No.1

The sand medium experiment was conducted in the laboratory with the aim of evaluating the suitability of municipal wastewater (treated and untreated) at different concentrations (0, 2.5, 5, 10, 25, 50, and 100%) for irrigation purposes on seed germination, seedling performance, nutrient uptake, and chlorophyll content of rice (MR220). The utilization of municipal wastewater for irrigation purposes has developed an important way to exploit the nutrients it contains. The study indicated a significant (P < 0.05) difference between untreated and treated municipal wastewater for seedling length (SL), root volume (RV), root surface area (RSA), seedling vigor index (SVI), and root : shoot ratio (R : S) while no significant different was observed between untreated and treated municipal wastewater for germination percentage (GP) and percentage phytotoxicity (PPT). The municipal wastewaters had stimulatory effect on the rice seeds at lower wastewater concentrations (< 25%) while inhibitory effect was observed at higher wastewater concentrations (> 50%). N, P, K, Ca, Mg, Zn, Fe, Cu, and Mn were high in the untreated municipal wastewater compare to treated municipal wastewater. Seedlings irrigated with untreated municipal wastewater have high seed germination, seedling performance with high nutrient uptake compare to treated municipal wastewater. The municipal wastewaters showed inhibitory effect on chlorophyll content. The inhibition effect was observed at > 50% concentration of both untreated and treated municipal wastewater while promoting effects were observed at lower (< 25%) concentration. The rice MR220 variety showed better growth resistance, tolerance, and adaptability to wastewater. This can be due to its excellent genetic makeup and capacity to sustain the toxicity. Conclusively, municipal wastewater could be recommended as a good source of water and nutrient for seed germination and seedling performance.

Single-sex schooling, gender essentialist ideology and STEM career aspiration in Hong Kong

Adam Ka-Lok Cheung,Anita Kit-Wa Chan 한국사회학회 2018 한국사회학회 심포지움 논문집 Vol.2018 No.5

Identifying the Significance of Factors Affecting Creep of Concrete: A Probabilistic Analysis of RILEM Database

Adam, Ihab,Taha, Mahmoud M. Reda Korea Concrete Institute 2011 International Journal of Concrete Structures and M Vol.5 No.2

Modeling creep of concrete has been one of the most challenging problems in concrete. Over the years, research has proven the significance of creep and its ability to influence structural behavior through loss of prestress, violation of serviceability limit states or stress redistribution. Because of this, interest in modeling and simulation of creep has grown significantly. A research program was planned to investigate the significance of different factors affecting creep of concrete. This research investigation is divided into two folds: first, an in-depth study of the RILEM creep database and development of a homogenous database that can be used for blind computational analysis. Second: developing a probabilistic Bayesian screening method that enables identifying the significance of the different factors affecting creep of concrete. The probabilistic analysis revealed a group of interacting parameters that seem to significantly influence creep of concrete.

How Authoritarian Regimes Maintain Domain Consensus: North Korea's Information Strategies in the Kim Jong-un Era

Adam Cathcart,Christopher Green,Steven Denney 한국학중앙연구원 한국학중앙연구원 2014 THE REVIEW OF KOREAN STUDIES Vol.17 No.2

The North Korean government of Kim Jong-un is experiencing multiple simultaneous challenges to its legitimacy, but few could be more serious than the inflow and circulation of information in society. This paper uses three case studies to specifically examine how the North Korean state is responding to this danger by actively projecting narratives of transformation: “re-defectors,” sports, and Kim Jong-un’s court orchestra, the Moranbong Band. In every case, it becomes clear that the state is employing an active strategy, not only responding to negative external portrayals, but also trying to shape its own image both within and without its borders. In order to understand how the state interacts with the North Korean public, this paper employs Thomas Callaghy’s trifurcated “domain consensus” as a framework by which to sub-categorize Pyongyang’s approach: normative, utilitarian, and coercive. It focuses on the first of these types of consensus formation, the normative, by exploring the information strategies used by the Kim Jong-un government as it seeks to promote a revised Weberian “reciprocity of expectations” with the population.

Mircea Eliade. Perenniality and Universality of Archetypes

아담 제오르제타(Georgeta Adam) 아시아·중동부유럽학회 2009 동유럽발칸학 Vol.11 No.1

뛰어난 종교사학자에 의해 이루어진 상상의 시학 연구에 커다란 발전을 도모하는 새로운 논쟁이 최근 연구 활동 속에 야기되고 있다. 미르체아 엘리아데는 시학과 상상학의 영역에서 최초의 길을 연 학자로써 그의 연구 업적은 가스통 바슐라르, 알베르트 베건, 휴고 프리드리히, 질베르 뒤랑, 잔 부르고 등 이 분야의 용어론과 방법론의 기초를 정립한 고명한 이론가들보다도 - 지난 세기 40년대에 시작하여 동시대에 이르기 까지 - 선행된바 적지 않다. 따라서 엘리아데 가 추구한 이상적 상위, 즉 분열과 (재)구성은 그의 논제에 감탄을 금치 못한 후대의 동시대 학자들에 이르러 그 가치가 높게 평가되었다. 우리는 상징 일관성,이미지, 구상과 상상, 원형, 신화와 동시대에서의 퇴보 등과 같은 용어들을 언급한 미르체아 엘리아데 이론의 새로운 요소들에 커다란 관심을 표명하고 있다. 엘리아데의 반실증적 반응은 바슐라르, 뒤랑, 부르고의 경우와도 비슷하게 매우 격렬하다. 그들과 비슷했지만 그들보다는 앞서 엘리아데는 크리스트교 과학(과 학주의)의 경직된 철학적 교의를 거절하면서, 융에 의해 처음 그리고 이후 20세기에 이르기까지 상징, 상징주의, 이미지를 언급한 모든 인문과학에 의해 재발견된 사실과 이미지의 다양성에 수반되는 개념들을 받아들이고 발전시켰다. The current research work is meant to bring new arguments in favour of the remarkable contribution brought to the studies on the poetics of the imaginary made by the brilliant exegete of the history of religions. The major idea of this study focuses on the fact that Mircea Eliade is a genuine road opener in the domain of the poetics, of the imaginary, sometimes preceding the researches initiated – starting the fourth decade of the past century until the contemporary epoch – by famous theoreticians, who had laid the bases of methodology and terminology in this field: Gaston Bachelard, Albert Beguin, Hugo Friedrich, Gilbert Durand, Jean Burgos and so on and so forth. Therefore, Eliade’s ideative differences, dissociations and constructions were appreciated at their true value only after those of some contemporary scholars who had admiringly taken over his theses. We would like to bring to the focus of attention new elements of Mircea Eliade’s theories referring to such terms as symbols coherence, image, imagination and imaginary,archetypes, myths and their degradation in the contemporary world and so on and so forth. Eliade’s anti‐positivist reaction is quite violent, being similar to the position of Bachelard, Durand, Burgos. Just like the others, but prior to them, he has taken over and developed concepts pertaining to the multiplicity of the image, a reality restored first by C.G. Jung and afterwards rediscovered by all the humanistic sciences which have currently referred, in the 20th century, to symbols, symbolism, image, rejecting the stiffening philosophical doctrines of Christian sciences(scientism).