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Portland cement structure and its major oxides and fineness
A. Nosrati,Y. Zandi,M. Shariati,K. Khademi,M. Darvishnezhad Aliabad,A. Marto,M.A. Mu’azu,E. Ghanbari,M.B. Mahdizadeh,A. Shariati,M. Khorami 국제구조공학회 2018 Smart Structures and Systems, An International Jou Vol.22 No.4
Predicting the compressive strength of concrete has been considered as the initial phase across the cement production processing. The current study has focused on the integration of the concrete compressive strength in 28 days with the mix of the major oxides and fine aggregates as an experimental formula through the use of two types of Portland cement resulting the compressive strength of the concrete highly dependent on time.
A New Allelic Variant in the PANK2 Gene in a Patient with Incomplete HARP Syndrome
Myriam Ley Martos,María Jesús Salado Reyes,Rosario Marín Iglesias,Carmen Gutiérrez Moro,Manuel Lubián Gutiérrez,Lorena Estepa Pedregosa 대한파킨슨병및이상운동질환학회 2020 Journal Of Movement Disorders Vol.13 No.3
Pantothenate kinase-associated neurodegeneration (PKAN) is a rare autosomal recessive disease characterized by iron deposition in the basal ganglia, primarily in the globus pallidus and substantia nigra. Common clinical manifestations include dystonia, parkinsonism, spasticity, neuropsychiatric disorders and retinal degeneration. PKAN is included in the spectrum of disorders related to neurodegeneration with brain iron accumulation (NBIA), which includes eleven diseases.
Portland cement structure and its major oxides and fineness
Nosrati, A.,Zandi, Y.,Shariati, M.,Khademi, K.,Aliabad, M. Darvishnezhad,Marto, A.,Mu'azu, M.A.,Ghanbari, E.,Mahdizadeh, M.B.,Shariati, A.,Khorami, M. 국제구조공학회 2018 Smart Structures and Systems, An International Jou Vol.22 No.4
Predicting the compressive strength of concrete has been considered as the initial phase across the cement production processing. The current study has focused on the integration of the concrete compressive strength in 28 days with the mix of the major oxides and fine aggregates as an experimental formula through the use of two types of Portland cement resulting the compressive strength of the concrete highly dependent on time.
Dephosphorylation of DBC1 by Protein Phosphatase 4 Is Important for p53-Mediated Cellular Functions
이지혜,Guillaume Adelmant,Jarrod A. Marto,이동현 한국분자세포생물학회 2015 Molecules and cells Vol.38 No.8
Deleted in breast cancer-1 (DBC1) contributes to the regulation of cell survival and apoptosis. Recent studies demonstrated that DBC is phosphorylated at Thr454 by ATM/ATR kinases in response to DNA damage, which is a critical event for p53 activation and apoptosis. However, how DBC1 phosphorylation is regulated has not been studied. Here we show that protein phosphatase 4 (PP4) dephosphorylates DBC1, regulating its role in DNA damage response. PP4R2, a regulatory subunit of PP4, mediates the interaction between DBC1 and PP4C, a catalytic subunit. PP4C efficiently dephosphorylates pThr454 on DBC1 in vitro, and the depletion of PP4C/PP4R2 in cells alters the kinetics of DBC1 phosphorylation and p53 activation, and increases apoptosis in response to DNA damage, which are compatible with the expression of the phosphomimetic DBC-1 mutant (T454E). These suggest that the PP4-mediated dephosphorylation of DBC1 is necessary for efficient damage responses in cells.
Enhancement of Soft Soil Behaviour by using Floating Bottom Ash Columns
Razieh Moradi,Aminaton Marto,Ahmad Safuan A Rashid,Mohammad Moeen Moradi,Abideen Adekunle Ganiyu,Mohamad Hafeezi Abdullah,Suksun Horpibulsuk 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.6
The current disposition worldwide is for sustainable construction, and the application of by-products is one of the ways to achieve it. In this research, bottom ash was used as a substitute material in a granular column to decrease settlement and enhance the bearing capacity of soft soil. Bottom ash is a derivate of the coal burning process, it has similar engineering properties to sand and fine gravel. A set of reduced scale physical modelling tests were performed on floating bottom ash columns to assess the improvement in the bearing capacity of the composite ground. The results clearly showed that the bearing capacity of the model soil was greatly improved with the installation of bottom ash column sand. There was an obvious enhancement of the load capacity of the granular columns when they were encased. The usage of bottom ash instead of aggregate or sand for granular columns will reduce the project cost and it aligns with the goal of sustainable construction development.
Dephosphorylation of DBC1 by Protein Phosphatase 4 Is Important for p53-Mediated Cellular Functions
Lee, Jihye,Adelmant, Guillaume,Marto, Jarrod A.,Lee, Dong-Hyun Korean Society for Molecular and Cellular Biology 2015 Molecules and cells Vol.38 No.8
Deleted in breast cancer-1 (DBC1) contributes to the regulation of cell survival and apoptosis. Recent studies demonstrated that DBC is phosphorylated at Thr454 by ATM/ATR kinases in response to DNA damage, which is a critical event for p53 activation and apoptosis. However, how DBC1 phosphorylation is regulated has not been studied. Here we show that protein phosphatase 4 (PP4) dephosphorylates DBC1, regulating its role in DNA damage response. PP4R2, a regulatory subunit of PP4, mediates the interaction between DBC1 and PP4C, a catalytic subunit. PP4C efficiently dephosphorylates pThr454 on DBC1 in vitro, and the depletion of PP4C/PP4R2 in cells alters the kinetics of DBC1 phosphorylation and p53 activation, and increases apoptosis in response to DNA damage, which are compatible with the expression of the phosphomimetic DBC-1 mutant (T454E). These suggest that the PP4-mediated dephosphorylation of DBC1 is necessary for efficient damage responses in cells.
Norberg, Erik,Lako, Ana,Chen, Pei-Hsuan,Stanley, Illana A,Zhou, Feng,Ficarro, Scott B,Chapuy, Bjoern,Chen, Linfeng,Rodig, Scott,Shin, Donghyuk,Choi, Dong Wook,Lee, Sangho,Shipp, Margaret A,Marto, Jarr Macmillan Publishers Limited, part of Springer Nat 2017 CELL DEATH AND DIFFERENTIATION Vol.24 No.2
<P>Diffuse large B-cell lymphomas (DLBCLs) are a highly heterogeneous group of tumors in which subsets share molecular features revealed by gene expression profiles and metabolic fingerprints. While B-cell receptor (BCR)-dependent DLBCLs are glycolytic, OxPhos-DLBCLs rely on mitochondrial energy transduction and nutrient utilization pathways that provide pro-survival benefits independent of BCR signaling. Integral to these metabolic distinctions is elevated mitochondrial electron transport chain (ETC) activity in OxPhos-DLBCLs compared with BCR-DLBCLs, which is linked to greater protein abundance of ETC components. To gain insights into molecular determinants of the selective increase in ETC activity and dependence on mitochondrial energy metabolism in OxPhos-DLBCLs, we examined the mitochondrial translation pathway in charge of the synthesis of mitochondrial DNA encoded ETC subunits. Quantitative mass spectrometry identified increased expression of mitochondrial translation factors in OxPhos-DLBCL as compared with the BCR subtype. Biochemical and functional assays indicate that the mitochondrial translation pathway is required for increased ETC activity and mitochondrial energy reserves in OxPhos-DLBCL. Importantly, molecular depletion of several mitochondrial translation proteins using RNA interference or pharmacological perturbation of the mitochondrial translation pathway with the FDA-approved inhibitor tigecycline (Tigecyl) is selectively toxic to OxPhos-DLBCL cell lines and primary tumors. These findings provide additional molecular insights into the metabolic characteristics of OxPhos-DLBCLs, and mark the mitochondrial translation pathway as a potential therapeutic target in these tumors.</P>
Dephosphorylation Enables the Recruitment of 53BP1 to Double-Strand DNA Breaks
Lee, D.H.,Acharya, Sanket S.,Kwon, M.,Drane, P.,Guan, Y.,Adelmant, G.,Kalev, P.,Shah, J.,Pellman, D.,Marto, Jarrod A.,Chowdhury, D. Cell Press 2014 Molecular cell Vol.54 No.3
Excluding 53BP1 from chromatin is required to attenuate the DNA damage response during mitosis, yet the functional relevance and regulation of this exclusion are unclear. Here we show that 53BP1 is phosphorylated during mitosis on two residues, T1609 and S1618, located in its well-conserved ubiquitination-dependent recruitment (UDR) motif. Phosphorylating these sites blocks the interaction of the UDR motif with mononuclesomes containing ubiquitinated histone H2A and impedes binding of 53BP1 to mitotic chromatin. Ectopic recruitment of 53BP1-T1609A/S1618A to mitotic DNA lesions was associated with significant mitotic defects that could be reversed by inhibiting nonhomologous end-joining. We also reveal that protein phosphatase complex PP4C/R3β dephosphorylates T1609 and S1618 to allow the recruitment of 53BP1 to chromatin in G1 phase. Our results identify key sites of 53BP1 phosphorylation during mitosis, identify the counteracting phosphatase complex that restores the potential for DDR during interphase, and establish the physiological importance of this regulation.
Hegar, Badriul,Wibowo, Yulianti,Basrowi, Ray Wagiu,Ranuh, Reza Gunadi,Sudarmo, Subianto Marto,Munasir, Zakiudin,Atthiyah, Alpha Fardah,Widodo, Ariani Dewi,Supriatmo, Supriatmo,Kadim, Muzal,Suryawan, A The Korean Society of Pediatric Gastroenterology 2019 Pediatric gastroenterology, hepatology & nutrition Vol.22 No.4
Human breast milk contains numerous biomolecules. Human milk oligosaccharides (HMOs) are the third most abundant component of breast milk, after lactose and lipids. Amongst the synthetized HMOs, 2'-fucosyllactose (2'-FL) and lacto-N-neotetraose (LNnT) are widely studied and are considered safe for infant nutrition. Several studies have reported the health benefits of HMOs, which include modulation of the intestinal microbiota, anti-adhesive effect against pathogens, modulation of the intestinal epithelial cell response, and development of the immune system. The amount and diversity of HMOs are determined by the genetic background of the mothers (HMO secretors or non-secretors). The non-secretor mothers secrete lower HMOs than secretor mothers. The breastfed infants of secretor mothers gain more health benefit than those of non-secretor mothers. In conclusion, supplementation of infant formula with 2'-FL and LNnT is a promising innovation for infant nutrition.