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Vibration isolation system with a compact damping system for power recycling mirrors of KAGRA
Akiyama, Y,Akutsu, T,Ando, M,Arai, K,Arai, Y,Araki, S,Araya, A,Aritomi, N,Asada, H,Aso, Y,Bae, S,Baiotti, L,Barton, M A,Cannon, K,Capocasa, E,Chen, C-S,Chiu, T-W,Cho, K,Chu, Y-K,Craig, K,Dattilo, V,Do Institute of Physics 2019 Classical and quantum gravity Vol.36 No.9
<P>A vibration isolation system called the Type-Bp system used for power recycling mirrors has been developed for KAGRA, the interferometric gravitational-wave observatory in Japan. A suspension of the Type-Bp system passively isolates an optic from seismic vibration using three main pendulum stages equipped with two vertical vibration isolation systems. A compact reaction mass around each of the main stages allows for achieving sufficient damping performance with a simple feedback as well as vibration isolation ratio. Three Type-Bp systems were installed in KAGRA, and were proved to satisfy the requirements on the damping performance, and also on estimated residual displacement of the optics.</P>
Conditional PTEN-deficient Mice as a Prostate Cancer Chemoprevention Model
Koike, Hiroyuki,Nozawa, Masahiro,De Velasco, Marco A,Kura, Yurie,Ando, Naomi,Fukushima, Emiko,Yamamoto, Yutaka,Hatanaka, Yuji,Yoshikawa, Kazuhiro,Nishio, Kazuto,Uemura, Hirotsugu Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.5
Background: We generated a mouse model of prostate cancer based on the adult-prostate-specific inactivation of phosphatase and tensin homolog (PTEN) using the Cre-loxP system. The potential of our mice as a useful animal model was examined by evaluating the chemopreventive efficacy of the anti-androgen, chlormadinone acetate (CMA). Materials and Methods: Six-week-old mice were treated subcutaneously with $50{\mu}g/g$ of CMA three times a week for 9 or 14 weeks and sacrificed at weeks 15 and 20. Macroscopic change of the entire genitourinary tract (GUT) and histologically evident prostate gland tumor development were evaluated. Proliferation and apoptosis status in the prostate were examined by immunohistochemistry. Results: CMA triggered significant shrinkage of not only the GUT but also prostate glands at 15 weeks compared to the control (p=0.017 and p=0.010, respectively), and the trend became more marked after a further five-weeks of treatment. The onset of prostate adenocarcinoma was not prevented but the proliferation of cancer cells was inhibited by CMA, which suggested the androgen axis is critical for cancer growth in these mice. Conclusions: Conditional PTEN-deficient mice are useful as a preclinical model for chemoprevention studies and serve as a valuable tool for the future screening of potential chemopreventive agents.
Nuclear Pore Complex Protein Sequences Determine Overall Copolymer Brush Structure and Function
Ando, D.,Zandi, R.,Kim, Y.,Colvin, M.,Rexach, M.,Gopinathan, A. Biophysical Society ; Published for the Biophysica 2014 Biophysical journal Vol.106 No.9
The transport of cargo across the nuclear membrane is highly selective and accomplished by a poorly understood mechanism involving hundreds of nucleoporins lining the inside of the nuclear pore complex (NPC). Currently, there is no clear picture of the overall structure formed by this collection of proteins within the pore, primarily due to their disordered nature. We perform coarse-grained simulations of both individual nucleoporins and grafted rings of nups mimicking the in vivo geometry of the NPC and supplement this with polymer brush modeling. Our results indicate that different regions or blocks of an individual NPC protein can have distinctly different forms of disorder and that this property appears to be a conserved functional feature. Furthermore, this block structure at the individual protein level is critical to the formation of a unique higher-order polymer brush architecture that can exist in distinct morphologies depending on the effective interaction energy between the phenylalanine glycine (FG) domains of different nups. Because the interactions between FG domains may be modulated by certain forms of transport factors, our results indicate that transitions between brush morphologies could play an important role in regulating transport across the NPC, suggesting novel forms of gated transport across membrane pores with wide biomimetic applicability.
Infrared probe of the bulk insulating response inBi2−xSbxTe3−ySeytopological insulator alloys
Post, K. W.,Lee, Y. S.,Chapler, B. C.,Schafgans, A. A.,Novak, Mario,Taskin, A. A.,Segawa, Kouji,Goldflam, M. D.,Stinson, H. T.,Ando, Yoichi,Basov, D. N. American Physical Society 2015 Physical review. B, Condensed matter and materials Vol.91 No.16