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RISS 인기검색어
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- 저자 : ( Sungmi Park ) (검색결과 28 건)
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Scoparone interferes with STAT3-induced proliferation of vascular smooth muscle cells
Park, Sungmi,Kim, Jeong-Kook,Oh, Chang Joo,Choi, Seung Hee,Jeon, Jae-Han,Lee, In-Kyu Nature Publishing Group 2015 Experimental and molecular medicine Vol.47 No.3
<P>Scoparone, which is a major constituent of <I>Artemisia</I> capillaries, has been identified as an anticoagulant, hypolipidemic, vasorelaxant, anti-oxidant and anti-inflammatory drug, and it is used for the traditional treatment of neonatal jaundice. Therefore, we hypothesized that scoparone could suppress the proliferation of VSMCs by interfering with STAT3 signaling. We found that the proliferation of these cells was significantly attenuated by scoparone in a dose-dependent manner. Scoparone markedly reduced the serum-stimulated accumulation of cells in the S phase and concomitantly increased the proportion of cells in the G0/G1 phase, which was consistent with the reduced expression of cyclin D<SUB>1</SUB>, phosphorylated Rb and survivin in the VSMCs. Cell adhesion markers, such as MCP-1 and ICAM-1, were significantly reduced by scoparone. Interestingly, this compound attenuated the increase in cyclin D promoter activity by inhibiting the activities of both the WT and active forms of STAT3. Similarly, the expression of a cell proliferation marker induced by PDGF was decreased by scoparone with no change in the phosphorylation of JAK2 or Src. On the basis of the immunofluorescence staining results, STAT3 proteins phosphorylated by PDGF were predominantly localized to the nucleus and were markedly reduced in the scoparone-treated cells. In summary, scoparone blocks the accumulation of STAT3 transported from the cytosol to the nucleus, leading to the suppression of VSMC proliferation through G1 phase arrest and the inhibition of Rb phosphorylation. This activity occurs independent of the form of STAT3 and upstream of kinases, such as Jak and Src, which are correlated with abnormal vascular remodeling due to the presence of an excess of growth factors following vascular injury. These data provide convincing evidence that scoparone may be a new preventative agent for the treatment of cardiovascular diseases.</P>
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Recent advances in the pathogenesis of microvascular complications in diabetes
Sungmi Park,Hyeon-Ji Kang,Jae-Han Jeon,Min-Ji Kim,In-Kyu Lee 대한약학회 2019 Archives of Pharmacal Research Vol.42 No.3
Millions of people worldwide have diabetes, which is diagnosed by fasting blood glucose levels exceeding 126 mg/dL. Regardless of the type of diabetes, prolonged hyperglycemia is damaging to several organs including eyes, kidneys, nerve, and/or heart. The damages are associated with a high risk of morbidity and mortality. Diabetes has been implicated in ischemia in the microvasculature of the target tissues, which occurs due to the insufficient perfusion of tissues. The resulting occlusion and pain affect the quality of life. Multiple therapeutic approaches have been proposed for a long time to overcome these vascular complications. Apart from systemically controlling high glucose levels, other therapeutic strategies are not well understood. In this review, we summarize the recent literature for biochemical/cellular targets that are being utilized for the treatment of diabetic microvascular diseases. These targets, which are closely associated with mitochondrial dysfunction, include the polyol and diacylglycerol-protein kinase C pathways, oxidative stress, non-enzymatic glycation and the formation of advanced glycation end products, and immune dysregulation/inflammation.
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Park, Boyoung,Shin, Aesun,Jung-Choi, Kyunghee,Ha, Eunhee,Cheong, Hae-Kwan,Kim, Hyun Jeong,Park, Kyung Hwa,Jang, Sungmi,Moon, Byung-In,Ha, Mina Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7
While several reproductive and lifestyle-related factors are already well-known as established risk factors for breast cancer, environmental factors have attracted attention only recently. The objective of the current study was to assess the association between the breast cancer incidences in females, the mortality rate and the number of motor vehicles on the one side and the consumption of gasoline which could work as a major source of air pollution at the other side. The breast cancer incidences and the mortality trends were compared with various indices of westernization like dietary patterns or industrialization with 10 years lag of time. Geographical variations with 10, 15 and 20 years lag of time were assessed between the breast cancer incidence in 2010 and the number of motor vehicles as well as the consumption of gasoline. The upward trend of motor vehicle numbers proved to be comparable to those of breast cancer incidence and mortality. However, the consumption of gasoline started to decrease since the mid-1990s. The geographic distribution of motor vehicle numbers and gasoline consumption in 1990 is in a positive correlation with the breast cancer incidence rates in 2010 and the 20-year lag time ($R^2$ 0.379 with the number of motor vehicles and 0.345 with consumption of gasoline). In a linear relationship between the breast cancer incidences in 2010 and the log transformed number of motor vehicles, the log transformed consumption of gasoline in 2000 also showed a positive relationship ($R^2$ 0.367 with the number of motor vehicles and 0.329 with consumption of gasoline). The results of the current study indicate that there may be a positive relation between the number of vehicles, gasoline consumption and the incidence of breast cancer from the aspects of long-term trends and geographical variation.
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박성미(Park, Sungmi),박종원(Park, Chongwon) 새한영어영문학회 2016 새한영어영문학 Vol.58 No.2
In line with the continuation of the inquiry on the effect of written corrective feedback, the hypotheses of this study start with the assumption that content based feedback group might yield better accuracy than grammar plus content based group or control group. The study tries to support this conjecture by administering pre, post, and delayed post test designs. Therefore, the research questions are as follows. (1) When it comes to accuracy, are there differences among content based feedback group, content plus grammar based feedback group and control group? (2) Are there interaction effects between modes of feedback and time? In answering to the questions of this study, it was indicated that there was no statistically significant difference among the three groups, but there does exist in terms of the lapse of time. Compared to the post tests results, there were dramatic changes in the delayed post test showing that content plus grammar group outperformed control group. Based upon the findings of the study, the educational and research implications will be addressed in detail.
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Park, Sunhee(박선희),Kim, Sungmi(김성미) 학습자중심교과교육학회 2016 학습자중심교과교육연구 Vol.16 No.10
본 연구는 소셜 미디어 중 하나인 페이스북을 활용한 학습의 효과를 분석하였다. 대학교교양 수업(2011년 2학기)과 전공 수업(2012년 1학기)에서 페이스북을 활용하여 수업을 시행하였고, 수업은 강의와 그룹 발표가 있는 오프라인과 소셜 미디어를 활용하는 온라인이 병행되는 블렌디드 학습으로 진행되었다. 성찰일지, 인터뷰, 참여관찰의 질적 분석으로 학습 촉진 요인과 저해 요인 도출하였다. 소셜 미디어 활용의 촉진 요인은 즉시적인 연결 증대, 여러 학습 주체와 친밀감 확장, 멀티미디어 중심의 실제적 과제 제시, 단문 댓글 활동을 통한 브레인스토밍 기회 증가, 지속적으로 긍정적인 상호작용 유도, 신기술에 대한 호 기심 유발 등으로 분석되었다. 한편, 학습 저해 요인은 정보 검색, 업로드, 저장, 수정 시 불편함, 미디어간 연동으로 인한 불필요한 정보 소음 증가, 타인에 대한 정보 부족으로 인한 상호작용의 비활성화, 사생활 침해 불편, 책임 회피, 신기술에 대한 낯섦과 거부감 등으로 나타났다. 따라서 교수자는 소셜 미디어를 활용하여 수업을 운영하고자 할 경우 학습의 촉 진 요인과 저해 요인을 고려하여 교수설계 전략을 도출해야 할 것이다. This study aims to analyze the effect of learning using Facebook, one of the social media. After designing and completing the liberal arts(2nd semester in 2011) and major courses(1st semester in 2012) in college using Facebook, the researcher derived the facilitating factors and conflicting factors through an qualitative analysis of students’ learning logs, interviews and participatory classroom observation The classes for the present research was proceeded as a type of blended learning, consisting of offline classroom learning with lectures and group presentations, and online learning using social media. In this research facilitating factors of learning through social media offers to increase immediate connection, to identify extended intimacy, to suggest multimedia based practical tasks, to provide more opportunity brain storming through text and feedback message, consistently to facilitate positive interaction, to stimulate curiosity about new technology. On the other hands, conflicting factors have included in inconvenience of searching, uploading, saving, and editing the information, increase in unnecessary information noise from linkage between media, deactivation in interaction with a lack of information of other person, a feeling of discomfort from privacy infringement, avoidance of responsibility, unfamiliarity and resistance toward the new technology. The result of this study may contribute to instructional design of learning through social media
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Park, Hyunjin,Yoo, Sungmi,Ahn, Hyungju,Bang, Joohee,Jeong, Yuri,Yi, Mihye,Won, Jong Chan,Jung, Sungjune,Kim, Yun Ho American Chemical Society 2019 ACS APPLIED MATERIALS & INTERFACES Vol.11 No.49
<P>Aromatic soluble polyimides (PIs) have been widely used in organic field-effect transistors (OFETs) as gate dielectric layers due to their promising features such as outstanding chemical resistance, thermal stability, low-temperature processability, and mechanical flexibility. However, the molecular structures of soluble PIs on the electrical characteristics of OFETs are not yet fully understood. In this work, the material, dielectric, and electrical properties are evaluated to systematically investigate the chemical structure effect of aromatic dianhydride and diamine monomers on the device performance. Four soluble PIs based on 4,4'-(Hexafluoroisopropylidene)diphthalic anhydride (6FDA) and 5-(2,5-Dioxotetrahydrofuryl)-3-methyl-3-cyclohexene-1,2-dicarboxylic anhydride, in which the monomeric precursors contain different backbones, side groups, and linkages, were employed to compare the chemical structure impact. The dielectric properties, which significantly affect the charge transport and crystallinity of OSC thin films, clearly depended on the soluble PI types as well as the surface energy and the thermal stability. Furthermore, the electrical characteristic measurement and parameter extraction of OFETs based on TIPS-pentacene revealed that the 6FDA-based soluble PIs, which lead to high field-effect mobility, near-zero threshold electric field, and outstanding electrical stability under bias stress, are the most promising gate dielectric candidates. Finally, low-temperature solution-processed OFETs are successfully integrated with ultrathin flexible substrates, and they exhibit no significant electrical performance loss after mechanical flexibility tests. This work presents a step forward in the development of soluble PI gate dielectrics for flexible electronic devices with high device performance.</P> [FIG OMISSION]</BR>
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