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Surface Charge Modification of Polyethyleneimine for Enhanced Renal Clearance and Bioimaging
이성수,임원봉,정진석,조단비,조가영,박민호,현훈 한국고분자학회 2018 Macromolecular Research Vol.26 No.13
Polyethyleneimine (PEI) has emerged as a potentially effective carrier for gene delivery. To overcome the cytotoxicity of PEI in vivo, the biodistribution and clearance of PEI conjugated with near-infrared fluorophores (NIRF) were imaged in mice. To confirm the effect of surface charge on enhanced renal clearance, PEI was conjugated with three different types of NIRF: positively charged PEI-NIRF+, negatively charged PEI-NIRF-, and zwitterionic PEI-NIRF± conjugates, which were intravenously injected into mice. The biodistribution and body clearance were monitored under an NIR fluorescence imaging system at 4 h and 24 h postinjection. All organs and tissues were resected to further compare the distribution of each PEI-NIRF conjugate in two mice at 4 h and 24 h. The results showed that the zwitterionic PEINIRF± conjugate was most rapidly cleared, primarily through the kidneys of the mice within 24 h postinjection. In conclusion, the biodistribution of zwitterionic PEI-NIRF± was found to be significantly different from that of positively and negatively charged PEI-NIRF conjugates with increased renal clearance. Thus, zwitterionic PEI-NIRF± could be a promising gene delivery carrier that can potentially reduce the side effects of conventional cationic polymers such as cytotoxicity and non-specific binding in vivo.
Near-infrared fluorescent sorbitol probe for tumor diagnosis in vivo
이성수,임원봉,조단비,정진석,김수빈,조가영,민정준,최은영,현훈 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.64 No.-
This study evaluated the near-infrared (NIR)fluorescent probe Sorbitol-ZW800-1 as tracer for targetedtumor imaging of multiple cancer types. Preliminarily, Sorbitol-ZW800-1 conjugate was validated in vivoon breast (MCF-7) cancer cell lines. Subsequently, the tracer was tested in xenograft mouse models withmalignant breast (MDA-MB-231), lung (NCI-H460), and colorectal (HT-29) tumors, respectively. Importantly, the Sorbitol-ZW800-1 conjugate showed highly selective tumor uptake in various tumormice models. Moreover, biodistribution for 24 h exhibited the significantfluorescence signals in tumorsand kidneys. Therefore, sorbitol is a promising candidate as a potential cancer targeting agent for theaccurate detection of cancer cells.
Al_2O_3 기판위에 증착한 ZnGa_2O_4 형광체 박막의 산소분압에 따른 형광특성
이성수 한국센서학회 2002 센서학회지 Vol.11 No.2
ZnGa_2_O4 형광체 박만을 기판 온도를 550℃ 에 고정시키고 산소 분압을 100, 200, 300 mTorr로 변화시키며 Al_2O_3(0001) 기판 위에 펄스 레이저 증착법을 이용하여 증착하였다. 다른 산소 분압에서 성장한 박막들의 미세 결정구조와 형광특성을 조사하였으며, 산소분압이 증가할수록 박막의 결정성이 변화하였으며 박막의 조성비가 다름을 형광특성을 통하여 알 수 있었다. 발광 스펙트럼은 460 nm에서 최고 피크값을 나타내었으며, 300 nm에서 600 nm까지 갖는 넓은 밴드의 형광 특성을 나타내었다. 최적의 조건에서 성장된 박막의 형광 밝기를 고려해볼 때 Al_2O_3(0001) 기판이 우수한 ZnGa_2_O4 형광체 박막을 성장시킬 수 있는 기판들 중 하나임을 확인하였다. ZnGa_2_O4 thin film phosphors have been deposited using a pulsed laser deposition technique on Al_2O_3(0001) substrates at a substrate temperature of 550 ℃ with various oxygen pressures 100, 200 and 300 mTorr. The films grown under different growth oxygen pessures have been characterized using microstructural and luminescent measurements. The different photoluminescence (PL) characteristics with the increase in oxygen pressures may result from the change of the crystallinity and the composition ratio of Zn and Ga in the films. The luminescent spectra show a broad band extending from 300 to 600 nm peaking at 460 nm. The PL brightness data obtained from the ZnGa_2_O4 films grown under optimized conditions have indicated that the sapphire is a promising substrate for the growth of high quality ZnGa_2_O_4 thin film phosphor.