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갈근해기탕가미방(葛根解肌湯加味方)과 삼황세제가미방(三黃洗劑加味方) 병용이 NC/Nga 생쥐의 아토피 피부염에 미치는 영향
황치환,윤채성,송승현,원영호,황충연,Hwang, Chi-Hwan,Yun, Chae-Sung,Song, Seung-Hyeon,Weon, Young-Ho,Hwang, Chung-Yeon 대한한방안이비인후피부과학회 2008 한방안이비인후피부과학회지 Vol.21 No.2
Objectives: Galgeunhaegitang-gamibang(GH) and Samhwangseze-gamibang(SG) has been known that they are helpful for treatment of atopic dermititis clinically, but there is no report about the effect of GH and SG. So, author aimed to investigate the effects of GH and SG on atopic dermititis of NC/Nga mice. Methods : NC/Nga mice were divide into three group : normal, control, and experimental group. Atopic dermatitis was induced in the control and experimental group by spreading DNCB. Then GH was orally administered three times in a week for 8 weeks to the experimental group and SG was spreaded two times in a day for 8 weeks to the experimental group, while the control group was given normal saline. We observed changes of clinical skin severity score, serum IgE, IL-4, IL-4, IL-5, IL-6, IgM, IgGl, $IFN-{\gamma}$ and so on. We used one-way ANOVA test statistically(p<0.01). Results : Clinical skin severities of experiment group in 13 and 16weeks were significantly decreased by 48% and 55% compared to the control group. Serum IgE, IL-4, IL-5, IL-6, IgM, IgGl levels of experimental group were singnificantly decreased compared to the control group. Serum $IFN-{\gamma}$ level of the experimental group was significantly increased against control group. mRNA expression levels of IL-4, IL-5, IL-6 and CCR3 in the skin tissues of experimental group were significantly decreased compared to the control group. In contrary, $IFN-{\gamma}$y mRNA expression level were increased compared to the control group. Histological observation of the ear and skin tissues showed that the extents of inflammation and infiltrated immune cells in the epidermis and dermis of experimental group were highly deminished compared to the control group. Judging from that $IL-1{\beta}$, $TNF-{\alpha}$, IL-6 expression of gene, the effects of inflammatory cytokine revelation were significantly decreased compared to the control group. In the model inducing COX-2 activity in RAW 264.7 cell, COX-2 activity was significantly inhibited depending on the density of GH compared to the control serum. According to cell multiplication, examination of cell toxicity showed that GH is safe at the density of 10, 50, 100mg/l and even 1000mg/l. Conclusion : Accordin to the above results, it is considered that GH and SG is effective treatment for the atopic dermatitis.
동의보감(東醫寶鑑) 중(中) 마황(麻黃)이 주약(主藥)으로 배오(配伍)된 방제(方齊)의 활용(活用)에 대한 고찰(考察)
황치환,윤용갑,Hwang, Chi-Hwan,Yun, Young-Gab 대한한의학방제학회 2005 大韓韓醫學方劑學會誌 Vol.13 No.2
This report describes the remedial fields, symptoms, pathlogy, dosage, prescriptional constitution of 79 studies to the use of Herba Ephedrae main blended prescriptions from dongeubogam. The following conclusions were reached through investigations on the prescriptions that use Herba Ephedrae as a key ingredient Herba Ephedrae blended prescriptions are utilized for 26 therapeutic purposes, for example, in symptoms of cough, cold, wind. In particular, 20.2% of the prescriptions appear in the chapter of cough. Prescriptions that utilize Herba Ephearae as the main ingredient are used in the treatment of 47 different types of diseases, for example, in the treatment of wind-cold pathogen, cold, wind, exogenous febrile disease etc. Herba Ephedrae is most widely used in six pathogenic factors such as wind, cold, dampness, heat. The actual amount of Herba Ephedrae blended has ranged at a wide variety of amounts from 1 don to 2 don. It is widely applied with base prescriptions such as Mahwang-tang, Samyo-tang, Mahwangbujasesin-tang, Mahwangkanghwal-tang.
대황(大黃), 황금(黃芩), 황백(黃柏) 복합 추출물의 항균, 항염 및 항알레르기 효과에 대한 실험적 연구
손대범,송성필,황치환,홍석훈,황충연,Son, Dae-Beom,Song, Seong-Pil,Hwang, Chi-Hwan,Hong, Seok-Hoon,Hwang, Chung-Yeon 대한한방안이비인후피부과학회 2005 한방안이비인후피부과학회지 Vol.18 No.1
Herbal mixture water extract of (Rheum coreanum Scutellaria baikalensis, Phellodendron amurese), which exhibit several beneficial effects including acne and skin diseases, was tested for anti-microbial activity and anti-inflammation effects. The herbal mixture extract showed antimicrobial activity against Stapylococcus epidermis and Propionbacterium acne. The growth of Stapylococcus epidermis and Propionibacterium acne was inhibited completely by addition of 1.0% of the extract. Also in the present study we examined the mixture extract on compound 48/80 induced allergy and LPS induced cyclooxygenase-2(COX-2) gene expression in RAW264.7 macrophage. The results indicated the ear swelling and histamine release induced by compound 48/80 were dose-dependently reduced, ranging 18-36% and 10-61%, respectively. Furthermore the extract inhibited the expression of LPS-induced COX-2 proteins and mRNAs without an appreciable cytotoxic effects on RAW264.1 cells. The cytotoxicity of the extract using MTT assay showed the cytotoxicity of 6% and 13% against L929 cell line. Based on these results, it is concluded that the herbal mixture water extract can be applied to this acne and skin diseases therapy.
모바일 로봇을 위한 KNN과 Local Map Classification을 통한 실내 위치 인식 시스템
오승훈(Oh Seung Hoon),황치환(Hwang Chi Hwan),맹주현(Maeng Ju Hyun) 한국통신학회 2021 한국통신학회 학술대회논문집 Vol.2021 No.2
최근 사람의 일을 대신해 주는 서비스 로봇의 등장으로 실내 로봇 서비스의 관심도가 높아지면서 모바일 로봇에 대한 연구가 많이 진행되고 있다.[1]실내 로봇 서비스를 안정적으로 제공하기 위해서는 서비스 제공 주체인 로봇은 실시간 위치 정보를 알아야 한다. 이 위치 정보는 AP로부터의 RSSI(Received Signal Strength Indicator) 신호로 파악 가능하다. RSSI 신호의 세기가 변하면, 실제 거리와 예측하는 거리 사이의 오차가 발생될 수 있다. 이러한 문제를 개선하기 위하여 RSSI 신호의 세기가 변하더라도 거리의 오차를 고정시킬 수 있는 방안에 대한 연구가 필요하다. 본 논문은 거리 오차의 변동성을 줄이기 위해서 Local Map Classification과 KNN(K-Nearest Neighbor) Algorithm을 연동하는 기법을 제안한다. 실험으로 Local Map Classification을 적용하여 얻은 위치 측위 결과를 분석하였다. 이 결과로 앞서 말한 거리 오차의 변동성을 줄이기 위해서 Local Map Classification을 적용하면, 위치 정보를 한 지점에 고정할 수 있다는 사실을 확인하였다.