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      • 휘발성 유기용매의 In vitro 대사속도 측정 장치의 개발

        황인영,이윤,Hwang, In-Young,Lee, Yoon 환경독성보건학회 1997 환경독성보건학회지 Vol.12 No.3

        Species, doses and routes extrapolation can be sucessfully carried out by using a physiologically-based pharmacokinetic (PBPK) approach. And PBPK approach to assess risk of hazardous chemicals is reasonable whatever the exposure scenarios are happened. Both partitioning coefficients of chemical between tissue and blood and enzymatic metabolic rate constants are key parameters to build up the PBPK model. In this study, we tried to estimate in vitro metabolic rate constants using a special apparatus instead to measure the in vivo constants which are used to PBPK simulation since the in vitro tests are less expensive and more convenient than in vivo tests. For the purpose, we designed and tested the new system to measure continuously the headspace concentration of VOC. The newly designed system is composed with a diffusion chamber which generates gaseous substrate, a reaction vessel with a recirculating pump to establish a closed system, an autbmatic sampler from a gas phase, a gas chromatography to analyze the headspace. In addition, a cold water condenser is attached between the reaction vessel and pump to reduce the content of gaseous moisture which interferes with chemical analysis. To validate the newly developed methodology, in vitro metabolic rate constants of trichloroethylene (TCE) as a prototype VOC were estimated by simulating observed results with an ACSL program. The simulated results are consistent to those estimated by the other research groups. This finding suggests that our newly designed closed system may be a useful apparatus to estimate in vitro metabolic rate constants for VOC.

      • KCI등재

        Peroxidase와 Lipoxygenase에 대한 농약의 저해작용

        황인영,장병선,박관화,노정구,Hwang, In-Young,Chang, Byeong-Seon,Park, Kwan-Hwa,Roh, Jung-Koo 한국환경농학회 1984 한국환경농학회지 Vol.3 No.2

        화학물질(化學物質)에 의(依)한 서양고추냉이와 사과의 peroxidase 및 정제된 대두(大豆) lipoxygenase 역가저해(力價沮害)를 조사(調査)하였다. 서양고추냉이와 사과의 peroxidase 역가(力價)에 저해효과(沮害效果)를 주는 농약중(農藥中) maneb가 zineb의 효과(效果)보다 컸으며 10,20,30ppm의 처리농도(處理濃度)에서 maneb는 12.5,23.0,34.5%, zineb는 9.5, 17.5,27.5%의 역가저해(力價沮害)를 보였다. Maneb와 zineb의 혼합체(混合體)인 mancozeb 를 500 ppm의 농도(濃度)로 사과나무에 철포(撤布)했을때 사과의 peroxidase 역가변화(力價變化)는 무처리구(無處理區)와 별 차이(差異)가 없었다. 대두(大豆)의 lipoxygenase 역가(力價)에 미치는 영향(影響)은 zineb의 경우 가장 저해도(沮害度)가 컸으며 phosphamidon과 carbofuran 이 또한 저해효과(沮害效果)가 있었다. 그러나 maneb는 저해효과(沮害效果)가 없었다. 10, 20, 30 ppm의 처리농도하(處理濃度下)에서의 lipoxygenase 역가저해도(力價沮害度)는 zineb가 14.0, 27.0, 40.0%, carbofuran이 6.5, 12.5, 20.0% 그리고 phosphamidon이 4.5, 9.0, 13.0%였다. 또한 이들 세농약(農藥)은 $100{\sim}200\;ppm$에서 100% lipoxygenase 역가저해(力價沮害)를 보였다. The effect on the activities of peroxidase and lipoxygenase by chemicals was determined. Peroxidase activities of horseradish and apple were inhibited strongly by maneb and comparativelyby mancozeb, zineb. The inhibitory rate of enzyme activity was ranged in $12.5{\sim}34.5%$ by maneb, $11.0{\sim}30.5%$ by mancozeb, and $9.7{\sim}27.5%$ by zineb in the level of $10{\sim}30\;ppm$ at the final concentration. No signification was in the peroxidase activity of apple during ripening between control and plot, treated with 500 ppm mancozeb. On the activity of purified soybean lipoygenase, zineb inhibited it more strongly than carbofuran or phosphamidon, but maneb did not have inhibitory effect on that. The inhibition ranges of $14.0{\sim}40.0%$ by zineb, $6.5{\sim}20.0%$ by carbofuran and $4.5{\sim}13.0%$ by phosphamidon were shown in the final pesticide concentration of $10{\sim}30$ ppm. But in $100{\sim}200$ ppm, lipoxygenase activity was almost inhibited by carbofuran and phosphamidon.

      • KCI등재

        살균제 Tricyclazole에 대한 안전성 평가 (I)

        황인영,최의주,노정구,Hwang, In-Young,Choi, Eui-Ju,Roh, Jung-Koo 한국환경농학회 1985 한국환경농학회지 Vol.4 No.1

        Tricyclazole을 수확전 $90{\sim}40$일에 $2{\sim}3$회 처리한 작물과 토양중에서의 수확시 잔류되는 tricyclazole의 양은 각각 현미가 $0.37{\sim}0.46ppm$, 백미가 $0.29{\sim}0.39ppm$, 볏짚이 $0.14{\sim}0.30ppm$ 및 토양이 $0.15{\sim}0.19ppm$이었다. 담수조건하에서의 tricyclazole의 분해 양상은 처리후 $2{\sim}3$주까지 비교적 빠른 속도로 분해가 진행되다가 그 이후로는 안전한 속도로 분해되었으며 그 때의 반감기는 $140{\sim}180$일이었다. 또한 토양 미생물의 생균수에 미치는 영향은 거의 없었으며 Salmonella, Saccharomyces 등을 이용한 돌연변이성 유무 실험에서는 대조구와 별차이가 없었다. Fate of tricyclazole in rice paddy system was studied. The effect on soil microorganism as well as the mutagenicity of the compound was also examined. The residues of tricyclazole in crops and soil with two times application before harvest were 0.37 in unpolished rice, 0.29 in polished rice, 0.14 in rice straw, and 0.15 ppm in paddy soil. With three times of application the residues were increased to 0.46, 0.39, and 0.19 ppm, respectively. Until $2{\sim}3$ weeks after treatment of pesticide the degradation of tricyclazole was progressed comparatively but very slowly afterward and the half life of that was about $140{\sim}180$ days. There was no effect for viable count of soil microorganisms and for mutagenic test by Salmonella and Saccharomyces systems.

      • KCI등재

        정부 규제가 국내 온라인 게임 시장에 미치는 영향: 시스템 다이내믹스 접근

        황인영 ( In Young Hwang ),박정훈 ( J Hun Park ) 한국시스템다이내믹스학회 2015 한국시스템다이내믹스 연구 Vol.16 No.4

        Mandatory shutdown policy of the juvenile protection act was enforced in December 2011 to prevent game addiction of the youth. However, the size of game market in Korea seems to be reduced significantly after implementation of the shutdown policy. The purpose of this study is to investigate the impact of current government regulations on Korean online game market. Based on empirical evidences and results from the related literature, we developed several causal loop diagrams(CLD) and system dynamics models. The CLD include sub-diagrams of innovation processes, user commitments, and operational costs. We conducted simulation analyses under various policy scenarios, adopting Normalized Unit Modelling By Elementary Relationship(NUMBER). Our results show that first, the impact of time regulation on the number of users is greater than the impact of content regulation. Second, the quality of domestic online game appears more elastic to regulations than the quality of foreign online game. The results of this study suggest that the deregulation in Korean online game market can narrow the gap in market outcomes between domestic and foreign online games. Some recommendations for future study are suggested.

      • SCOPUSKCI등재
      • KCI등재

        자료처리/저장장치 방열판의 View Factor 분석

        황인영(Inyoung Hwang),신소민(Somin Shin) 한국항공우주학회 2017 韓國航空宇宙學會誌 Vol.45 No.8

        지구관측위성에 탑재되는 자료처리/저장장치 방열판은 장비의 주기적인 고발열, 배치, 장착성 등 설계 특성으로 인해 쉴드가 장착된 홈 형태를 갖는다. 홈 형태 방열판의 영향성과 쉴드 방열판의 열성능을 확인하기 위해, 평판 방열판을 기준으로 홈 형태의 방열판과 쉴드 방열판을 비교하여 열진공 시험을 실시하였다. 시험결과를 바탕으로 view factor에 의한 열교환과 방열판의 온도를 이론해석적으로 분석하여 열 설계 성능비교의 타당성을 입증하였다. The radiator of the data storage and handling units onboard the earth observation satellite is a groove-type radiator covered with a shield because of the periodic high heat dissipation and design characteristics of arrangement and mountability of the unit. The effect of the groove-type radiator and that of the shield versus plane radiator were verified through the thermal vacuum test. Through the test result, the temperatures of the radiator and the heat exchange due to the view factor were analyzed by using the analytical method. Conclusively the thermal performance of the shield dissipation plate was verified.

      • KCI등재

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