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위암 출혈로 오인된 에리트로포이에틴 항체 양성 순수 적혈구 무형성증
양혜경 ( Hae Kyung Yang ),이경수 ( Kyeong Soo Lee ),김인호 ( In Ho Kim ),오현진 ( Hyun Jin Oh ),이해림 ( Hae Lim Lee ),이관현 ( Kwan Hyun Lee ),황대연 ( Dea Yeon Hwang ) 대한내과학회 2013 대한내과학회지 Vol.84 No.3
Caplan`s syndrome is characterized by multiple small distinct nodules with progressive massive fibrosis and rheumatic arthritis in pneumoconiosis. Although pleural effusions occur infrequently as an extra-articular manifestation, pleuritis can develop without joint involvement in patients with rheumatoid arthritis. We treated an 81-year-old man who had been diagnosed with silicosis with progressive massive fibrosis. He suffered from progressive dyspnea, and chest computed tomography (CT) and echocardiography revealed pleural and pericardial effusions. We speculated that the multiple serositis was related to a rheumatic disorder because the rheumatic factor was elevated in both the pleural and pericardial effusions. After corticosteroid treatment, the serositis improved. We suggest that this case is an atypical pattern of Caplan`s syndrome presenting as serositis without arthritis. Rheumatoid serositis should be considered as the cause of pleural or pericardial effusions in patients with pneumoconiosis. (Korean J Med 2013;84:428-432)
황진희,황대연,김용규,채갑용,강태석,임철주,김철규,장인석,김연주,백상기,조정식 식품의약품안전청 1998 식품의약품안전청 연보 Vol.2 No.-
SV4O Tag은 oncogenesis potential 때문에 진핵세포유전자의 organization 및 발현연구에 광범위하게 이용되어왔다. SV4O 739에 의한 종앙발생은 739발현이 G,기 세포에서 감소되고,5기, G2-M기 세포에서 각각 증가되가 매문에 G,기의 단축, G,-M기의 증가와 관련있음을 암시한다. 형질전환동물과 그 세포주는 SV4O fag과 세표주기조절 단백질들간의 상호작용에의한 tumorigenesis의 기작등을 분석연구하는데 효과적으로 제공필 수 있다. 본연구는 유방암형질전환마우스를 개발하기위하여 mouse mammary tumor virus(MMTV) LTR promoter의 조절하에서 SV4O Tag oncogene을 발현하도록하는 hybrid gene을 제작하여 마우을 수정란에 주입하였다. 그 결과 132수의 산자를 생산하였으며 이증 4마리의 형질전환동물을 확인하였으며, 이중 3마리를 line 형성을 위해 계대사육중이다. 앞으로 이들로부턴 tumor 형성확인,세포주 생산 및 인체질환모텔동물로서의 유용성을 평가하는데 매우 유용하다. Simian virus 40 (SV4O) large T antigen(Tag) have functions to initiate the precess that lead to the development of or·ethal and bulbourethal gland after 7 moBths of age in human. Tumor pro-gressing in these organs correlates to the level of 7ag that resulted in reduced the percentage ☞』 e,-phase eells and increased percentage of S- and Gr+M-phase cells in exponentially growing fecrobBeatcells. The effect is the result of reduced G, and increased e,M celt cycle phase duration caused by Tag.Transgenic animal model and its cell lines may provide an opportunity for analyBing molecuBar mocha-nisms involved in the tumorigenesis which are caused by the iuteractions between Tag a.Id cell cycleregulatory proteins. To generate transgenic model mice, a hybrid gene combining SV4O Tag viraloncogene under control of Inouse mammary tumor virus (MMTV)'LTR promoter were constructed(PMMST) and were then microinjcted into fertilized eggs of mice. By analyring of PCR from the mousetail DNA 4r3E132 founder were identified as a transgenic mice and were bred in our mice colony. ThesetransgeBic mouse are available for further analyzing of tissue-specifie expression.