영아에서 새로 진단된 혈소판감소증의 임상경과 및 결과

황누리,박경덕 대한소아혈액종양학회 2018 Clinical Pediatric Hematology-Oncology Vol.25 No.2

Background: Infants with immune thrombocytopenia (ITP) are at increased risk of high risk bleeding and vaccination-associated ITP. Infants with ITP respond favorably to treatment and are less likely to develop chronic ITP compared to older children. However the characteristics of this entity in infants have rarely been analyzed. We investigated the clinical characteristics and response to treatment of newly diagnosed ITP in infants under 1 year of age. Methods: We retrospectively reviewed the medical records of newly diagnosed ITP infants between 1 month to 11 months of age at Chonbuk National University Hospital from 2002 to 2017. The demographics, complete blood count, absolute lymphocyte count (ALC), absolute neutrophil count, vaccination history, upper respiratory infection, viral study (cytomegalovirus) and treatment of patients with ITP were reviewed. Results: A total of 85 patients satisfied the criteria for newly diagnosed ITP. Of these patients, 83 were in complete remission, 6 were in persistent remission, and 2 progressed to chronic ITP. As a result of the study, 57 patients (67%) were male. 71 patients (83.5%) were secondary ITP. Among secondary ITP, vaccination related ITP was the most common cause with 60 patients (84.5%). The mean at diagnosis was 4.3±3.2 month. There was no statistically significant difference in ALC between the time of diagnosis and treatment. Hemoglobin was 10.8 g/dL at diagnosis and increased significantly to 12.3 g/dL after treatment. Conclusion: Ninety-seven percent of ITP patients diagnosed under 1 year of age were in remission.

만성 조현병 환자에서 반복적 경두개자기자극에 대한 혈청 Brain-Derived Neurotrophic Factor의 반응 양상과 신경가소성의 특성

오지영(Ji-Young Oh),황누리(Nu-Ri Hwang),황태영(Tae-Young Hwang) 대한사회정신의학회 2017 사회정신의학 Vol.22 No.2

연구목적 : 본 연구는 정량화된 반복적 경두개자기자극에 대한 혈청 뇌유래신경영양인자 (Brain-Derived Neurotrophic Factor, BDNF)의단기 반응 양상을 통해 만성 조현병 환자의 뇌 신경가소성의 특성을 살펴보고 만성 조현병 환자의 치료적 접근에 대한 시사점을 찾고자 하였다. 방 법 : 오른손잡이인 20명의 만성 조현병 환자가 연구에 참여하였다. 2주 동안 연속적으로 좌측 배외측 전전두엽 피질 부위에 운동역치의 100%에 해당하는 20Hz의 반복적 경두개자기자극(총 20,000 자극)을 제공하였고 이후로 2주 동안은 자극을 제공하지 않았다. 기저 시점과 자극 개시 1주 및 2주 후 그리고 자극 종료 후 2주 시점에서 각각 혈청 BDNF를 측정하였으며 안정적인 약물 유지의 확인을 위하여 혈청 프로락틴 수치를 병행 측정하였다. 임상적 평가를 위하여 전반적 임상 인상 척도(Clinical Global Impression Scale, CGI)와 양성 및 음성 증후군 척도(Positive and Negative Syndrome Scale, PANSS)를 사용하였다. 결 과 : 총 18명이 연구를 완료하였다. 항정신병약물의 클로로프로마진 등가용량은 평균(표준편차) 1,325.69(767.58)mg이었다. 기저치 PANSS 전체 점수는 평균(표준편차) 68.44(6.05)였다. 혈청 BDNF 수치는 자극개시 후 2주 시점에서 기저치와 비교하여 유의한 차이를 나타내었다(p=0.038). 그러나 자극 종료 후 2주 시점에서는 차이의 유의성이 나타나지 않았다(p=0.185). 결 론 : 본 연구 결과는 만성 조현병 환자의 뇌 신경가소성이 제한적인 상태이며 일정 수준 이상의 지속적인 치료적 자극이 정신재활을 위한 치료적 측면에서 필요한 점을 시사하고 있다. Objective : For evidence-based activities for psychiatric rehabilitation in patients with chronic schizophrenia, it is necessary to investigate the capacity and characteristics in the brain neuroplasticity of patients with chronic schizophrenia. This study aimed at examining short-term response pattern of serum Brain-Derived Neurotrophic Factor (sBDNF) to the quantified stimuli applied with repetitive Transcranial Magnetic Stimulation (rTMS). Methods : Right-handed 20 inpatients with chronic schizophrenia were recruited. The handedness was assessed using Edinburgh Handedness Inventory. Consecutive 10-weekday sessions with 20Hz rTMS (a total of 20,000 stimuli) were applied over the left dorsolateral prefrontal cortex at 100% of motor threshold. There was no change in the medication for at least 2 weeks before enrollment and 4 weeks thereafter. Serum Prolactin level was co-measured for the reference of stable medication. Primary outcome measure was the change in the mean concentration of duplicated sBDNF (pg/ml). Clinical severity or change was measured using the Clinical Global Impression scale (CGI) and the Positive and Negative Symptom Scale (PANSS). Results : Eighteen participants (male, 10;female, 8) completed the study. The chlorpromazine equivalent (CPZE) of antipsychotics were 1,325.69 (761.58) mg. Baseline CGI-severity and total PANSS score were 4.61 (0.50) and 68.44 (6.05), respectively. In the level of sBDNF just after 2-week rTMS sessions, the differences from baseline were statistically significant (p=0.038). At 2 weeks after the completion of rTMS sessions, however, the significance in the level of sBDNF was not manifest (p= 0.185). Conclusion : The findings of this study showed that the neuroplastic capacity is limited in the brain of patients with chronic schizophrenia and persistent therapeutic stimuli over certain level in activities for psychiatric rehabilitation may be necessary due to the absence of cumulative effect, suggesting positive and negative implications to psychiatric rehabilitation in patients with chronic schizophrenia.

Clostridium 속 미생물 대사공학을 통한 butanol 생산

우지은,김민지,노현지,황누리,김진효,이상엽,장유신,Woo, Ji Eun,Kim, Minji,Noh, Hyeon Ji,Hwang, NuRi,Kim, Jin-Hyo,Lee, Sang Yup,Jang, Yu-Sin 한국미생물학회 2016 미생물학회지 Vol.52 No.4

Clostridium은 그람양성, 장간균으로 포자를 형성하는 절대혐기성 균이다. Clostridium은 다양한 기질을 이용할 수 있고, 유용 화합물 합성을 위한 building block으로 사용 가능한 대사산물을 생산할 수 있어, 최근 많은 관심을 끌고 있다. 특히, Clostridium을 이용하여 생산된 butanol은 차세대 연료로써 고려되고 있다. 수송용 연료로써 butanol은 1세대 바이오연료인 ethanol과 비교하여 더 높은 에너지 밀도와 낮은 흡습성을 보이는 것으로 알려져 있다. 최근, butanol 생산을 위한 Clostridium 대사공학이 활발히 진행되어 상당한 진보를 보이고 있다. 본 연구에서는 butanol 생산을 위한 Clostridium의 대사공학 전략을 리뷰하고, 관련 분야에 대해서 간략히 전망하였다. Clostridium is a genus of Gram-positive, rod shape, spore-forming obligate anaerobe. Recently, Clostridium has been attracted as a host for bio-based chemical production, due to its diversity of substrate utilization and the production ability for metabolites which can be used as a building block for chemical production. Especially, butanol produced from Clostridium has been considered as an alternative fuel. As a transportation fuel, butanol has a higher energy density and lower hygroscopicity compared to ethanol, the first generation biofuel. Recently, metabolic engineering of Clostridium has been massively conducted for butanol production. In this study, the metabolic engineering strategy of Clostridium for butanol production has been reviewed with a brief perspective.

Factors Associated with Caregiver Burden of Newly Diagnosed Dementia Patients: a Pilot Study

성수정,김인혜,임수현,민누리,이명주,한재현,권순현,유가희,조현준,박기정,조영탁,송주연,황재연 한국정신병리-진단분류학회 2023 精神病理學 Vol.27 No.2

Objectives: The burden on caregivers of dementia patients is a crucial factor in the quality of life and disease management for both the patient and the caregiver. However, research on caregiver burden at the time of initial dementia diagnosis is lacking. This study aims to investigate the factors related to caregiver burden in caregivers within three months of dementia diagnosis. Methods: A total of 85 caregivers, whose care recipients were aged 65 or older and had been diagnosed with dementia within the past three months, were surveyed. Caregivers whose care recipients were institutionalized were excluded from the study. The Caregiver Burden Inventory was used to measure caregiver burden. Socio-demographic factors of the patient and caregiver, clinical characteristics of the patient, caregiver's depressive symptoms, attitudes toward dementia, coping skills, and social support were examined. Results: Higher severity of dementia in the patient, female gender of the caregiver, cohabitation of caregiver and patient, and more severe depressive symptoms in the caregiver were significantly associated with higher caregiver burden. Additionally, caregivers using negative coping strategies, having negative attitudes toward dementia, and receiving less social support experienced higher caregiver burden. Multivariate regression analysis results showed that only caregiver's gender and depressive symptoms were significantly related to caregiver burden. Conclusions: Caregiver depressive symptoms at the time of initial dementia diagnosis were found to increase caregiver burden. It is essential to identify risk factors for caregiver burden from the early stages of diagnosis and implement interventions to reduce caregiver burden.

고속접속보안을 위한 EAP 재인증 프로토콜 개발에 관한 연구

문종식(Moon Jong Sik),안현정(Hyunjung An),황누리(Nuri Hwang),이옥연(Okyeon Yi),김신효(Kim Shin Hyo) 한국통신학회 2014 한국통신학회 학술대회논문집 Vol.2014 No.6