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Glufosinate Herbicide Intoxication Causing Unconsciousness, Convulsion, and 6th Cranial Nerve Palsy
박재석,곽수정,길효욱,김수영,홍새용 대한의학회 2013 Journal of Korean medical science Vol.28 No.11
Although glufosinate ammonium herbicides are considered safe when used properly, ingestion of the undiluted form can cause grave outcomes. Recently, we treated a 34-yr-old man who ingested glufosinate ammonium herbicide. In the course of treatment, the patient developed apnea, mental deterioration, and sixth cranial nerve palsy; he has since been discharged with full recovery after intensive care. This case report describes the clinical features of glufosinate intoxication with a focus on sixth cranial nerve palsy. Our observation suggests that neurologic manifestations after ingestion of a “low-grade toxicity herbicide” are variable and more complex than that was previously considered.
최종순,장성근,손태호,홍새용 한국환경생물학회 2004 환경생물 : 환경생물학회지 Vol.22 No.4
This study was focused on the risk assessment of whether radiofrequency electromagnetic fields generated by mobile phone is cytogenetically toxic or not. We conducted the effects of 835-MHz electromagnetic field (EMF) on DNA strand breaks in mouse thymic lymphoma L5178Y Tk±/- cells using alkaline comet assay. EMF frequency 835-MHz we chosen is one of the most popular communication frequency bands in Korean code-division multiple-access (CDMA) mobile phone system. The cells were exposed to 835-MHz EMF alone or 835-MHz EMF combined with cyclophosamide (CPA) or 4-nitroquinoline-1-oxide (4NQO) at specific absorption rate (SAR) of 4.0W kg-1 for 24 and 48 hrs. DNA damage expressed as tail moment was increased more than two-fold after exposure to 835-MHz EMF for 24 and 48 hr. In particular, CPA for 48 hr and 4NQO for 24 hr enhanced notably the tail moment to 9-fold and 16-fold in the presence of 835-MHz EMF, respectively, compared to each single treatment. From these results, it appears that exposure to CDMA-mobile phone radiation at 835-MHz frequency may potentiate DNA strand breaks of mouse thymic lymphoma L5178Y Tk±/- cells under the defined conditions of this study.
Diagnostic and Therapeutic Approach for Acute Paraquat Intoxication
길효욱,Jung-Rak Hong,장시형,홍새용 대한의학회 2014 Journal of Korean medical science Vol.29 No.11
Paraquat (PQ) has known negative human health effects, but continues to be commonlyused worldwide as a herbicide. Our clinical data shows that the main prognostic factor isthe time required to achieve a negative urine dithionite test. Patient survival is a 100%when the area affected by ground glass opacity is < 20% of the total lung volume onhigh-resolution computed tomography imaging 7 days post-PQ ingestion. The incidenceof acute kidney injury is approximately 50%. The average serum creatinine level reaches itspeak around 5 days post-ingestion, and usually normalizes within 3 weeks. We obtain twoconnecting lines from the highest PQ level for the survivors and the lowest PQ level amongthe non-survivors at a given time. Patients with a PQ level between these two lines areconsidered treatable. The following treatment modalities are recommended to preservekidney function: 1) extracorporeal elimination, 2) intravenous antioxidant administration,3) diuresis with a fluid, and 4) cytotoxic drugs. In conclusion, this review provides a generaloverview on the diagnostic procedure and treatment modality of acute PQ intoxication,while focusing on our clinical experience