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Lactobacillus 가 함유된 발효유에 의한 인체 위점막에서의 Helicobacter pylori 억제효과
박민정(Min Jung Park),김주성(Joo Sung Kim),임정윤(Jeong Yoon Yim),정현채(Hyun Chae Jung),송인성(In Sung Song),유은실(Eun Sil Yu),이정준(Jeong Jun Lee),허철성(Chul Sung Huh),백영진(Young Jin Baek) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.4
Background/Aims: The eradication rates of regimens for Helicobacter pylori (H. pylori) infections are still around 85%. Lactobacilli have been demonstrated to have in vivo and in vitro inhibitory effects on H. pylori infection. We aimed to evaluate the inhibitory effect of Lactobacillus on H. pylori in human stomach. Methods: Forty H. pylori-infected volunteers (21-44 yr, F:M=9:31) were randomized into two groups which were treated with 100 mL of fermented milk containing lactobacilli (Lactobacillus acidophilus, Lactobacillus casei) q.I.d. or 100 mL of placebo q.I.d. for 4 weeks. Before and after treatment, they underwent 13C-urea breath tests (13C-UBTs) and endoscopies with biopsies for rapid urease test and histological evaluation. The compliance evaluated via daily checking questionnaire was considered acceptable if they took 90% of assigned treatment. Results: All patients were compliant and the H. pylori density of antrum tended to decrease in treatment group compared with placebo group (p=0.072). Δ13CO2 analyzed by Wilcoxon rank sum test showed a significant decrease in treatment group compared with placebo group (p=0.0064). Three cases in treatment group were noted for negative conversions of both rapid urease test and 13C-UBT. Conclusions: A fermented milk containing lactobacilli may have an inhibitory effect of H. pylori infection and can be an adjunct to the standard anti-H.pylori regimen. (Korean J Gastroenterol 2001;38:233-240)
Bacteriophage의 Salmonella enterica serovar Enteritidis에 대한 in vitro 및 in vivo 효능 평가
차승빈,이원정,신민경,노유미,정명환,명길선,안영태,허철성,유한상,Cha, Seung-Bin,Rayamajhi, Nabin,Lee, Won-Jung,Shin, Min-Kyoung,Roh, Yu-Mi,Jung, Myung-Hwan,Myoung, Kil-Sun,Ahn, Young-Tae,Huh, Chul-Sung,Yoo, Han Sang 대한수의학회 2010 大韓獸醫學會誌 Vol.50 No.3
Salmonella (S.) Enterica infection ranks among the most common food borne bacterial infections worldwide. Although there are six subspecies of S. Enterica, the vast majority of human and animal infections are caused by strains belonging to subspecies 1 serovar Typhimurium and Enteritidis. Recent reports on antibiotic resistance of Salmonella spp. are rising steadily. The increasing problem of antibiotic resistance has rekindled interest in bacteriophage to therapy. Therefore, we investigated the efficacy of bacteriophage in S. enterica serovar Enteritidis infected mice and pigs by measuring of body condition, body weight, bacterial colonization and weight of organs based on the in vitro analysis. In vitro experiment, phage cultured with S. Enteritidis showed clear lysis pattern, the plaque forming unit (PFU) of our phage culture was $1.5{\times}10^{11}PFU/mL$, and phage showed its maximum activity at 4 h post inoculation. In mouse experiment, there was no significant difference among experimental groups in the general body conditions and body weight of mice. However, there was difference in weight of liver and spleen depending on the experimental group (p < 0.05). The weight of liver and spleen were reduced by the phage treatment. Also bacterial colonization in spleen and liver were significantly reduced by the phage treatment. In pig experiment, the general body conditions and body temperature exhibited not much difference among the pigs except few pigs in group 3 which showed poor body conditions. From the feces in each group, we could isolate the S. Enteritidis only from group 3. Bacterial enrichment culture was necessary for isolating the bacteria from 5 dpi and 10 dpi, however direct isolation was possible from 15 dpi feces. In phage treated group, postmortem lesion was better than non-phage treated group. Recently, antibiotic resistance concerns on the food-borne bacterial pathogens have been increasing because of the wide spread of the antibiotics resistance genes. This concern is widely transmitted to the human related public health. As one of the alternative treatments on the bacterial pathogens, attempt using phages have been made to control the bacterial diseases. The positive possibility of the trail using phage was observed to control the S. enterica serovar Enteritidis in this study even though the further analysis has been remained.