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Comparison of the Effects of Cell Death between Pulsed and Continuous-wave Proton Beams
정명환,라세진,길재근,최병호,김계령 한국물리학회 2011 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.59 No.22
Most proton therapy machines are cyclotrons that can produce continuous wave-type proton beams. The Proton Engineering Frontier Project (PEFP) has been developing a 100-MeV proton linear accelerator since 2002, and recently, we have been trying to design a compact synchrotron as a proton therapy machine. These two kinds of accelerators are pulsed machines that have a high peak current that can deliver higher doses for a few microseconds compared to the cyclotron. To utilize a 100-MeV proton linear accelerator for basic studies of proton therapy, we studied the effect of a pulsed proton beam on biological organisms and compared it to the case of a continuouswave beam. To measure the apoptosis, we used 3-4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide (MTT) and a colony formation assay for lung and prostate cancer cells. As a result, the lung and prostate cancer cell killing effects caused by pulsed and continuous-wave protons were similar for the same absorbed dose levels. In conclusion, the killing effect on the tumor cell of a proton beam is determined by the total absorbed dose, not by dose rate.