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한국인 여성에서 다낭성난소증후군의 발생 위험도와 Catechol-O-Methyltransferase 유전자 다형성과의 관련성에 관한 연구
이지영,차윤정,허성은,권한성,이선주,손인숙,김수녕,성연아,정혜원,Lee, Ji Young,Cha, Yun Jeong,Hur, Seung Eun,Kwon, Han Sung,Lee, Sun-Joo,Sohn, In Sook,Kim, Soo Nyung,Seung, Yon A,Chung, Hye Won 대한생식의학회 2006 Clinical and Experimental Reproductive Medicine Vol.33 No.2
연구목적 : 한국인 여성에서 에스트로겐의 대사 및 불활성화와 관련된 COMT 유전자 다형성과 다낭성 난소증후군의 발생 위험도의 관련성을 알아보고자 하였다. 연구방법 : 연구대상자는 2003년 ESHRE의 진단기준을 만족하는 다낭성 난소증후군 여성 136명과 연령이 비슷하며 규칙적인 생리를 하는 여성 84명의 대조군을 대상으로 하였다. 연구대상자들의 genomic DNA는 혈액에서 추출하였으며, PCR 및 RFLP를 이용하여 유전자 다형성을 조사하였다. 결과 : COMT를 코딩하는 유전자의 exon4에서 $G{\rightarrow}A$로의 다형성을 조사한 결과 오히려 저활성 유전자형인 $COMT^{LL}$ 군에서 통계적으로 유의하게 다낭성 난소증후군의 발생 위험도가 낮아지는 것으로 나타났다(OR 0.241(CI 0.114~0.508)). 결론 : 이상의 결과로 볼 때 저활성 유전자형인 $COMT^{LL}$ 다형성 군에서 한국인 다낭성 난소증후군 발생이 감소하였으며, 에스트로겐 의존형 질환이 증가함에도 혈중 에스트라디올의 농도가 높지 않은 것은 다낭성 난소증후군 환자에서 $COMT^{HH}$ 다형성군이 증가되어 있는 것과 관련된 것으로 사료된다. Objective: To investigate whether polymorphism of Catechol-O-methyltransferase(COMT) gene is associated with the risk of polycystic ovary syndrome (PCOS) in Korean women. Methods: One hundred and thirty-six PCOS patients and eighty four controls were enrolled. Blood samples were collected from the patients diagnosed according to the 2003 revised criteria of the Rotterdam ESHRE/ASRM-sponsored PCOS consensus workshop group. Age matched women with regular menstruation from same geographic region were recruited as control subject. Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) of PCR products were done to determine all individuals' genotype. Results: In women with $COMT^{LL}$ genotype, there was decreased PCOS risk and this difference was statistically significant (OR 0.24, 95% CI 0.11~0.51). Conclusion: The results suggest that the $COMT^{LL}$ genetic polymorphism might be associated with PCOS risk in Korean women.
무릎 골관절염에서의 초음파 소견에 따른 소염진통제와 아세트아미노펜의 유효성 비교
도주호 ( Ju Ho Do ),허성은 ( Sung Eun Hur ),백승인 ( Seung In Paek ),나종명 ( Jong Myoung Nah ),김충현 ( Choong Hyun Kim ),이상헌 ( Sang Heon Lee ),박성환 ( Sung Hwan Park ),조철수 ( Chul Soo Cho ),김호연 ( Ho Youn Kim ),김완욱 ( 대한류마티스학회 2004 대한류마티스학회지 Vol.11 No.1
Objective: To compare the clinical efficacy between nonsteroidal antiinflammatory drugs (NSAIDs) and acetaminophen in knee osteoarthritis according to ultrasonographic findings. Methods: We administered 12 mg of NSAIDs (lornoxicam) plus misoprostol 300μg or 1,950 mg of acetaminophen in 40 randomly selected patients who fulfilled the ACR criteria for knee osteoarthritis. The effectiveness of these drugs on osteoarthritis was assessed by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score. In addition, we performed ultrasonography of the knee joints and assessed length of capsular distension, length of medial and lateral osteophyte, amount of joint effusion, and the presence of synovial proliferation. Results: There were significant correlations between WOMAC score and length of capsular distension and length of medial/lateral osteophyte. At 6 weeks, both lornoxicam and acetaminophen-treated patients had significant lower levels of WOMAC score compared to the entry into the trial (p<0.01 and p<0.05, respectively). As compared the clinical efficacy between the two groups, the lornoxicam-treated patients showed a greater decrease in WOMAC score than patients treated with acetaminophen (p=0.026). When we further divided the patients into the subgroups according to the sonographic severity, the patients with severe capsular distension (≥0.7 cm) or severe medial osteophyte (length of osteophytes ≥0.4 cm) showed better responses to lornoxicam than to acetaminophen in terms of the reduction of WOMAC score (p=0.008 for severe capsular distension, p=0.03 for severe medial osteophyte). However, in the subgroup with mild forms of capsular distension (<0.7 cm) or medial osteophytes (<0.4 cm), no difference was found in the reduction of WOMAC score 6 weeks after treatment with lornoxicam versus acetaminophen. Conclusion: Patients with osteoarthritis of the knee had significantly greater improvements in pain score over 6 weeks with lornoxicam than with acetaminophen, particularly in patients with severe forms of capsular distension and medial osteophyte on joint ultrasonography. Ultrasonography could be an useful tool to determine the usage of NSAIDs versus acetaminophen in knee osteoarthritis patients.
산후출혈처치에 있어 Sengstaken-Blankemore 튜브의 효용성
남안나 ( An Na Nam ),김경진 ( Kyong Jin Kim ),장병우 ( Byoung Woo Jang ),허성은 ( Seung Eun Hur ),이성기 ( Seong Ki Lee ),길기현 ( Ki Hyun Kil ),안미진 ( Mi Jin Ahn ),이지영 ( Ji Young Lee ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.11
Objective: To evaluate the effectiveness and identify the role of interventional procedure of tamponade treatment with modified Sengstaken- Blankemore (S-B) tube on control of postpartum hemorrhage (PPH) unresponsive to conventional medical treatment. Methods: This study was performed retrospectively on the clinical records of 90 patients who had experienced PPH at the department of Obstetrics and Gynecology of OO University Hospital from February, 2000 to September, 2005. We have actively applied tamponade balloon since 2004. As a result, tamponade balloon were applied to 17 patients. Medical records were reviewed such as clinical status, cause of bleeding, volume of balloon, duration of balloon, complication, success rate and additional treatment. Results: We have overall success rate of tamponade balloon in 11 (64.7%) of 17 patients of PPH. The causes of bleeding were subinvolution of uterus (100%), uterine atony (80%) and abnormal placentation (20%) in order of success rate. There was no major complication related to the tamponade procedure. We had compared final treatment during two period (before tamponade use v.s after tamponade use). 15 (33.3%) received invasive procedure and 8 (17.8%) received hysterectomy before tamponade use. However 10 (22.2%) received invasive procedure and just 1 (2.2%) received hysterectomy after tamponade use. Conclusion: Tamponade with modified S-B tube is effective on PPH unresponsive to conventional medical treatment and cuts down additional invasive procedure when tamponade treatment failed.