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한승엽(Seung Yup Han) 한국산학경영학회 1993 산학경영연구 Vol.6 No.-
The optional market segmentation pricing policy for rooms of hotels are investigated under the assumption of a linear demand function, and for four different situations: ① single price market, ② optimal segmentation of the unused capacity of a single-price-maeket, ③ optimal segmantation for all rooms, and ④ opimal segmentation for infiltration from higher priced to adjacent lower priced segments. The purpose of tis study is th show that with proper pricing policy, it would be possible to increase profits considerably. Such a profit increase might be achived by market segmentation coupled with product differentiation, where the different market segments are identified, sepefated, and in each segment a different price per room is called for. The different prices are determined based on the specific price elasticity typical for each market segment and the relavant costs. The pricing model implied in this study is based on basic economic pricing theory and optimization techniques. While somewhat complex in its mathmatical solution, it can be easily programmed for use by practitioners, avoiding the need to cope with the technical aspects of the solution. In section Ⅱ-1, the optimal single-market Single-price policy is evaluated. The optimal strategy under the constraint that only the previously unutilized rooms are segmented is analysed in section Ⅱ-2, while the optimal strategy without this constraint is determined in section Ⅱ-3. In section Ⅱ-4, the optimal market-segmentation pricing policy is derived for the case in which market seperation is allowed for all the rooms under the assumption of custtomer infiltration from each market segment to the adjacent lower priced segment Finally, some considerations relating to the practicality of the model as a decision support tool and the requirements for its implementation are discussed in section Ⅲ.
골 신연술을 시행받은 가토의 경골 성장골단판에서 골성장 지표와 길이 성장률과의 관계
이순혁,한승엽,변영수 고려대학교 의과대학 1997 고려대 의대 잡지 Vol.34 No.1
The rate of longitudinal bone growth in the physeal plate is modulated by the size of pool of proliferative chondrocyte, the rate of cell division of proliferative chondrocyte. the height of terminal hypertrophic chondrocyte and matrix production in the transverse septa. The parameters such as growth plate thickness and the rate of cell division by proliferating chondrocytes have been indentified as useful indices of longitudinal bone growth rate. Recently the height and volume of hypertrophics have been reported to be one of the decisive factors in modulating the longitudinal growth rate. Fracture. osteotomy or limb lengthening have been known to affect the longitudinal growth rate and, it can be assumed. they could change the relationship betweengrowth rate andparameters. The purposes of this study were to clarify the relationship betweenparameters and longitudinal bone growth in osteotomized and lengthened limbs and t o compare the relationship between the different groups which showed changed growth rate affected by the amount of lengthening. Sixteen eight weeks old New Zealand white rabbitswere allocated into four groups; Group Ⅰ was osteotomized and stabilized by external fixater but without lengthening, Group Ⅱ was lengthened 20% of total tibia1 length at a rate of 0.8mm/day with external fixater. Group Ⅲ was lengthened 30% at a rate of 0.8mm/day and Group Ⅳ was lengthened 40% t o 50% a t a rate of 3. Pmm/day. Left tibia was used for that procedure and right tibia was left as a control. In the proximal & distalphyses of both tibia, following measure ments were performed. The longitudinal growth rates were determined by tetracychine labeling and indirect light fluoroscence microscopy. The physeal thickness was histomorphologically measured and the proliferative rate of chondrocytes in physeal plate was assessed by immunohistochemical staining using anti-bromcdeoxyuridine monoclonal antibody. The results obtained were as follows ; 1) The physeal thickness and the number of proliferating chondrocytes had linearcorrelation with longitudinal growth rate in the physis of the lengthened or osteotomized tibia of rabbits. ) The relationship of the physeal thickness and the number of proliferating chondro cytes with longitudinal growth rate had highercorrelation coefficiency and different slope of regression in the proximalphysis of lengthened or osteotomized tibia of rabbits compared to that in the distal physis of lengthenedorosteotomizedtibia ofrabbits. 3) The relative contribution of the physeal thickness orthe number of proliferating chondrocytes tothe longitudinal growth rates varied following the varied amount or rate oflengtheninginthe physis of lengthened orosteotomizedtibia of rabbits. As a conclusion, physeal thickness and the number of proliferating chondrocytes are considered to be significant parameters of longitudinal growth ratein the osteotomized orlengthened limb, but they may contribute to longitudinal growth rate differently according to the location, ageand local condition of the physis.