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트리테르페노이드의 코르티코이드 유사활성물질에 관한 연구 ( 2 ) 11 - 옥소올레아놀산 및 유도체의 합성과 그 항염증 활성
한병훈,조명선,한용남,박명환 ( Byung Hoon Han,Myung Sun Kim - Cho,Yong Nam Han,Myung Hwan Park ) 생화학분자생물학회 1984 BMB Reports Vol.17 No.1
The effect of 11-oxo-oleanlic acid [I] and its derivatives on carrageenin-induced edema in rat kind paw was investigated. The following derivatives were synthesized ; 11-oxo-oleanolic acid methylester [II] C_(31)H_(48)O₄ mp 196-198° was derived from [I] by methylation with CH₂N₂. 3-Oxo-oleanolic acid [III] C_(30)H_(46)O₃, mP 198-202° was obtained from oleanolic acid by CrO₃-pyridine oxidation. Oxidation of [III] by CrO₃-HAc produced 3,11-dioxooleanolic acid [IV] C_(30)H_(46)O₃, mp 268-270° VU (λ max) 252 ㎚ and 3,11-dioxo-oleanolic acid lactone [V] C_(30)H_(44)O₄, mp 265-267° as a by-product. [IV] showed strong competitive inhibition against corticoid-5β-reductase, K_i= 4. 2×10-qM, compared to 4. 6×10^(-4)M of [I]. The anti-inflammatory activities of 11-oxo-oleanolic acid derivatives were evaluated by rat kind paw carrageenin edema test after s.c, injection with 30㎎/㎏ doses. [I], [II], [IVY and [V] suppressed significantly the edema volumes by 63, 78, 70 and 66%, respectively, compared to 66% of hydrocortisone. The above results suggest that the replacement of OH group in C₃ position by ketone group increased the corticomimetic activity, but that the change on the steric structure in C and D rings by lactone formation reduced the activity increase. [II] showed the most powerful activities probably due to increased lipophilicity.
한병훈,박명환,우린근,우원식,한용남 ( Byung Hoon Han,Myung Hwan Park,Lin Keun Woo,Won Sick Woo,Yong Nam Han ) 생화학분자생물학회 1979 BMB Reports Vol.12 No.1
This paper is concerned with the studies on the effective components possessing antioxidant activity, with a view to demonstrate the anti-aging activity of Korean ginseng. Feeding the extract of Korean ginseng or its effective component to mice inhibited strongly the lipid peroxidaiion induced by ethanol intoxication. From the; extract of Korean red ginseng, one effective component, Compound A, mp. 143^0 C_6H_6O₃, was isolated by chromatographic purification and its chemical structure was determine! as 3-hydroxy-2-methyl-γ-pyrone (maltol).
Studies on the Metabolic Fates of Ginsenosides
한병훈,박명한,김두화,홍순근,Han, Byung-Hoon,Park, Myung-Hwan,Kim, Doo-Hwa,Hong, Soon-Keun 생화학분자생물학회 1986 한국생화학회지 Vol.19 No.3
$^3H$-ginsenosides-$Rb_1$, Re. $Rg_1$을 이용하여 이들 물질의 위장관내 흡수 장기내분포, 배설, 단백질 결합 및 세포내분포 등에 대하여 조사하였다. 그 결과를 요약하연 다음과 같다. 1. Ginsenoside들의 생쥐 위장관내 흡수는 개체에 따라서 10-50%의 범위에서 변동된다. 약용량 상응량 이상으로 투여하면 흡수률을 감소시키는 것 같다. 2. Ginsenoside들을 경구투여하면 위장관 내에서 현저하게 분해가 되는데 뇨에는 주로 미분해물질이 배설되었다. 26시간 동안 뇨중배설의 총량은 투여량의 1-2%에 불과하였다. 3. 위장관내 흡수율은 투여량에 의하여 현저한 영향을 받지만 조직중에 잔류하는 양은 거의 변동이 없는데 폐의 경우 ginsenoside Rx로 환산하여 $2.2{\times}10^{-6}\;mol$ 농도에 해당된다. 4. $^3H$-ginsenosides는 주로 폐, 간, 신장 등 배설과 관련된 기관에 많이 분포되지만 범세포적인 분포를 하고 있으며 뇌에도 소량은 분포되었다. 5. 세포내분포 실험에서 mitochondria 분획에는 분포되지 않은 것으로 나타났다. 6. $^3H$-ginsenosides-$Rb_1$은 혈청 또는 조직 Homogenate의 고분자 막성분과 강한 결합력을 나타내고 있으며 $Rg_1$은 약한 결합력을 나타내고 Re는 전혀 결합을 하지 않았다. Using $^3H$-ginsenosides $Rb_1$, Re, and $Rg_1$, gastrointestinal absorption, organ distribution, excretion, protein binding, and subcellular distribution of them were studied. The results are summarized as following; 1) The absorptions of $^3H$-ginsenosides in the gastro-intestinal ract of mice showed individual variation between 10-50%. Higher dosage of $^3H$-ginsenosides above the pharmacological dosage seems to reduce the absorption rate. 2) After oral administration, all $^3H$-ginsenosides were markedly decomposed in GI tract, but major component excreted through urine was found to be the intact ginsenosides. The total amount of excreted radioactivity during 26 h was only 1-2% of the administered dose. 3) Although the absorption rates are markedly affected by the change in the dosage, the retention in tissue seems to give roughly a constant value around $2.2{\times}10^{-6}$ molar concentration as the ginsenosides Rx bases in lung. 4) $^3H$-ginsenosides were distributed mainly in lung, kidney, and liver but only a trace amount in brain. 5) In subcellular distribution experiments, $^3H$-ginsenosides $Rb_1$ was not found in the mitochondrial fraction. 6) On the equilibrium dialysis experiments, $^3H$-ginsenosides $Rb_1$ showed a strong binding affinity with the high molecular membrane fractions of organ homogenates and with serum proteins, but $^3H$-ginsenosides Re and $Rg_1$ showed very weak binding to the same fractions.
韓國人蔘의 抗酸化 活性 成分에 관한 硏究(IV) 抗酸化 活性 成分의 抗疲勞 效果
한병훈,박명환,한용남,신상철,Han, Byung-Hoon,Park, Myung-Hwan,Han, Yong-Nam,Shin, Sang-Chul 대한약학회 1984 약학회지 Vol.28 No.4
Active principles for the anti-fatigue activity of Panax ginseng were studied in mice using the swimming performance method. Ginseng water extract maximized the prolongation of swimming time 18 hours after administration. The potencies of anti-fatigue activities were found as in the order of ether soluble fraction and butanol soluble fraction as those of antioxidant activities previously determined. The anti-oxidant components, maltol, salicylic acid and vanillic acid isolated from the ether soluble fraction of Panax ginseng strongly exhibited the antifatigue activities, where as highly purified crystalline ginsenoside $4Rb_1$, Re and $4Rg_1$ did not.
단일 IF 방식 CW 레이더 센서의 방향 검출 알고리즘
한병훈,신현준,오창헌,Han, Byung-Hun,Shin, Hyun-Jun,Oh, Chang-Heon 한국정보통신학회 2015 한국정보통신학회논문지 Vol.19 No.12
CW 레이더 센서는 IF 출력 방식에 따라 단일 IF 방식과 이중 IF 방식이 있다. 움직이는 물체의 방향을 검출하기 위해서는 이중 IF 방식을 사용한다. 하지만 이중 IF 방식은 단일 IF 방식에 비해 회로가 복잡하며 부품 추가로 인해 가격이 높아진다. 본 논문에서는 단일 IF 방식 CW 레이더 센서에서 움직이는 물체의 방향을 검출할 수 있는 알고리즘을 제안한다. 물체가 움직일 때 발생하는 IF 출력단의 신호를 FFT를 수행하고 진폭의 변화에 따라 접근/정지/이탈을 판단한다. 알고리즘의 검증을 위해 함수발생기를 사용하여 가상의 신호를 발생시키고 신호의 진폭 변화에 따라서 방향을 정확하게 판단하는 것을 확인하였다. CW Radar Sensors can be categorized into Single and Dual by its IF output type. Dual IF type is used for detecting the direction of moving objects. However, Dual IF type has more complicated circuitry than Single IF type and higher cost due to more parts required. In this paper, we propose an algorithm for Single IF type CW radar sensors to detect the direction of moving objects. It performs FFT on signals created at IF output when an object moves and determines approach, stop and recede according to amplitude variations. In order to verify the algorithm, a function generator is used to create a virtual signal and confirmed that it accurately detects the directions according to amplitude variations.
인삼의 Dammarane Glycoside 성분의 대사에 관한 연구 ( 1 ) Panax Saponin A 의 흡수 및 배설에 관하여
한병훈,이은방,윤웅찬,우린근 ( Byung Hoon Han,Eun Bang Lee,Ung Chan Yoon,Lin Keun Woo ) 생화학분자생물학회 1976 BMB Reports Vol.9 No.1
The absorption and excretion of panax saponin A were studied. Panax saponin A was absorbed easily in the gastro-intestinal tract and was also readily excreted through the renal and bile routes in rabbits. A part of the saponin absorbed seems to be metabolized and the probable metabolite was detected in the urine, blood and bile juice.
Studies on the Antioxidant Components of Korean Ginseng [I]
한병훈,박명환,우린근,우원식,한용남,Han, Byung-Hoon,Park, Myung-Hwan,Woo, Lin-Keun,Woo, Won-Sick,Han, Yong-Nam 생화학분자생물학회 1979 한국생화학회지 Vol.12 No.1
한국인삼의 노화방지 효과를 입증하는 의도에서 인삼의 항산화활성을 다루었다. 인삼 또는 그 유효성분을 추출하여 마우스에 투여하면 알코홀 투여로 인하여 상승되는 지질 과산화물의 함량을 감소시켜주었으며 그 유효성분의 화학구조를 결정한 결과 3-hydroxy-2-methyl-$\gamma$-Pyrone (maltol)임을 밝혔다. This paper is concerned with the studies on the effective components possessing antioxidant activity, with a view to demonstrate the anti-aging activity of Korean ginseng. Feeding the extract of Korean ginseng or its effective component to mice inhibited strongly the lipid peroxidation induced by ethanol intoxication. From the extract of Korean red ginseng, one effective component, Compound A, mp. $143^{\circ}$, $C_6H_6O_3$, was isolated by chromatographic purification and its chemical structure was determined as 3-hydroxy-2-methyl-$\gamma$-pyrone (maltol).
생약의 물 추출물에 대한 혈소판 활성화인자 수용체 결합 저해활성 검색
한병훈,양현옥,김용철,한용남,Han, Byung-Hoon,Yang, Hyun-Ok,Kim, Yong-Chul,Han, Yong-Nam 대한약학회 1994 약학회지 Vol.38 No.4
Hot aqueous extracts of 130 herbal medicines were screened for platelet activating factor (PAE) receptor binding antagonistic activity using rabbit platelet. The results suggested that 4 medicinal plants including Biota orientalis are potential sources of PAF antagonists.
한병훈,우린근,우원식 ( Byung Hoon Han,Lin Keun Woo,Won Sick Woo ) 생화학분자생물학회 1975 BMB Reports Vol.8 No.2
The seasonal variations in the contents of ginseng components were analyzed with the samples harvested from April to October. The contents of soluble components such as sugars, amino acids, terpenoid and total methanol extract, increased gradually from April to July and remained almost constant from July to October. Therefore the quality of ginseng harvested at July will not be expected to be significantly different with that of October.