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PGE<sub>1</sub>-ethyl Ester함유 발기부전 치료용 요도주입 액제의 제조 및 평가
최한곤,유봉규,이종달,김정애,권태협,우종수,용철순,Choi, Han-Gon,Yoo, Bon-Kyu,Rhee, Jong-Dal,Kim, Jung-Ae,Kwon, Tae-Hyub,Woo, Jong-Soo,Yong, Chul-Soon 한국약제학회 2006 Journal of Pharmaceutical Investigation Vol.36 No.4
[ $PGE_1$ ]-ethyl ester intraurethral solutions were prepared in ethanol/propylene glycol mixture with penetration enhancer and viscosity-enhancing agent. The stability of $PGE_1$-ethyl ester in intraurethral solution was investigated at various temperature. Simultaneous determination of $PGE_1$-ethyl ester and $PGE_1$ was performed using a validated HPLC technique. In pentobarbital anesthetized cats, increase in intracavernous pressure(ICP), increase in penile length and duration of erectile response were determined after intraurethral application of $PGE_1$-ethyl ester solutions. $PGE_1$-ethyl ester solutions, when instilled into the eyes of rabbits, produces no noticeable irritation, or slight transient conjunctival irritation. From these results, ocular irritation of this solutions was judged as practically non-irritating. The stability study indicates that the therapeutically effective content in solution is well maintained for 46 weeks or longer when they are stored at $4^{\circ}C$. After intraurethral application of $PGE_1$-ethyl ester, ICP was increased and penile erection was induced. $PGE_1$-ethyl ester intraurethral solutions for erectile dysfunction could be developed and evaluated by employing feline erection model.
아세트아미노펜 액상좌제의 물리화학적 특성에 미치는 첨가제의 영향
최한곤(Han Gon Choi),정재희(Jae Hee Jung),유제만(Jei Man Ryu),이미경(Mi Kyung Lee),김인숙(In Sook Kim),이범진(Beom Jin Lee),김종국(Chong Kook Kim) 대한약학회 1998 약학회지 Vol.42 No.3
To optimize the formulation of acetaminophen liquid suppository, the effect of additives on the physicochemical properties of liquid suppository base was investigated. The physicochemical properties of P 407/P 188 (15/15%) (abbreviated in 15/15) and P 407/P l88 (15/20%) (abbreviated in 15/20) were measured after the addition of following additives; 2.5% acetaminophen as an active ingredient, vehicle components (5% ethanol, 5% propylene glycol, 5% glycerin), preservatives (0.1% sodium benzoate, 0,1% methylparahydroxybenzoate, 0.1% propylparahydroxybenzoate) and 1% of sodium chloride as an ionic strength controlling agent. Poloxamer gel was prepared with three different buffer solutions (pH 1.2, 4.0 and 6.8) and the physicochemical properties, gelation temperature, gel strength and bioadhesive force, were determined. In the results, the effect of additives on the physicochemical properties was dependent on their bonding capacities including hydrogen bonding and cross-linking bonding. Because the hydrogen-bonding capacities of acetaminophen, ethanol and propylene glycol were smaller than that of poloxamer, the binding force of poloxamer gel became weak by their putting in between poloxamer gel. Therefore, the gelation temperature (15/15, 35.7oC vs 37.0, 39.4 38.2oC; 15/20, 29.2oC vs 31.2, 32.0, 30.3 oC) increased, and gel strength (15/15, 4.03 see vs 2.72, 2.08, 3.12sec; 15/20, 300g vs 50, 50, 200g) and bioadhesive force (15/15, 6.8 X 102 dyne/cm2 vs 3.2, 6.0, 6.0 X 102 dyne/cm2; 15/20, 97.3 X 102 dyne/cm vs 11.1, 89.5, 92.0 X 102 dyne/cm2) decreased. Furthermore, the binding force of poloxamer gel became strong due to the hydrogen-bonding capacities of glycerin and the cross-liking bonding of sodium salt. Then, the gelation temperature (15/15, 35.0, 32.1oC; 15/20, 26.0, 21.0oC) decreased, and gel strength (15/15, 6.51 see, 300g; 15/20, 500, 650g) and bioadhesive force (15/15, 7.2, 81.6 X 102 dyne/cm2; 15/20, 112.3, 309.2 X 102 dyne/cm2) increased. The effect of pH on the physicochemical properties of poloxamer gel was dependent on the ingredients with which the buffer solutions were prepared. Poloxamer gels prepared with pH 1.2 and 4.0 buffer solutions had the increasing gelation temperature (15/15, 37.5, 38.1oC; 15/20, 33.1, 34.0oC) and the decreasing gel strength (15/15, 2.98, 3.81sec; 15/20, 200, 200g) and bioadhesive force (15/15, 7.0 X 102dyne/cm2; 15/20, 74.0-88.1 X 102dyne/cm2) owing to HCl. Poloxamer gel prepared with pH 6.8 buffer solutions had the decreasing gelation temperature (15/15, 27.2oC; 15/20, 22.3oC) and the increasing gel strength (15/15, 400g; 15/20, 550g) and bioadhesive force (15/15, 207.0 X 102dyne/cm2; 15/20, 215.0 X 102dyne/cm2) due to the cross-linking bonding of NaH2PO4 and K2HPO4.
건강한 지원자에 있어서 염산테르비나핀 함유 라미실정과 무조날정의 약물동력학적 비교
최한곤(Han Gon Choi),용철순(Chul Soon Yong),이종달(Jong Dhal Rhee),우종수(Jong Soo Woo),이경희(Kyung Hee Lee),유봉규(Bong Kyu Yoo) 대한약학회 2005 약학회지 Vol.49 No.4
Financial standing of National Health Insurance has been experiencing a grave deterioration during the last 4-5 years, and the yearly amount paid by the insurance for drug expense rose up to 4 trillion won recently. Furthermore, the ratio of drug expenses in the total expenditure of the insurance reached about 25%, showing the tendency to be levelled off. As a measure to improve the financial deterioration of the insurance and to encourage generic substitution among the health professionals, we compared pharmacokinetic parameters of brand name drug (Lamisil) and generic drug (Muzonal) containing terbinafine HCl in healthy volunteers. The area under the curve (AUC) of the two drugs showed 2220.4 ± 784.7 and 2143.1±861.6hr.mg/㎖ in the corresponding order and no statistically significant difference was identified. The peak concentration (Cmax) of the generic drug demonstrated 566.6±246.2 ng/㎖ compared to 550.8±204.0 of brand name drug, which was not significantly different either. Time to reach peak concentration showed about 6 minutes difference between the drugs, which has no clinical significance to the treatment of dermatomycosis and dermatophytosis.