봉약침 복합치료가 초기 회복지연에 따른 말초성안면마비 후유증에 미치는 영향

최철훈,송호섭 대한침구의학회 2009 대한침구의학회지 Vol.26 No.4

Objectives : This study was to investigate the effectiveness of bee venom phamacopuncture complex therapy on the sequelae of peripheral facial palsy. Methods : We observed the effectiveness of bee venom pharmacopuncture complex therapy on three patients who have residual symptoms of Bell’s palsy although early stage(0 to 3months) elapsed. H-B grade and Yanagiha’s total score was used for evaluating the patient. Results : 1. Deviation of the bee venom therapy on the sequelae of peripheral facial palsy, One patient was improved from 19 to 39, another patient was improved from 25 to 40, the third patient was improved from 15 to 26 on Yanagiha’s total score. 2. In the bee venom therapy on the sequelae of peripheral facial palsy, compared with baseline, at final, H-B grade and Yanagiha’s total score was increased. Conclusions : Bee venom phamacopuncture can be available for relieving residual symptom of bell’s palsy after the early stage.

국소적으로 진행된 자궁경부암 환자에서 선행보조 화학요법 (Mitomycin-C, Vincristine, Cisplatin)의 효과

최철훈,이제호,배덕수,김병기,김태중,이정원 대한부인종양학회 2006 Journal of Gynecologic Oncology Vol.17 No.1

목적: 국소적으로 진행된 자궁경부암에서 선행보조 화학요법으로써 MVC (mitomycin-C, vincristine, cisplatin) 병합요법의 효과를 알아보고자 하였다. 연구 방법: 46명의 환자를 대상으로 하였고 mitomycin-C 10 mg/m2, vincristine 1 mg/m2, cisplatin 75 mg/m2을 3주 간격으로 정맥투여하였다. 3주기의 항암요법 후 수술가능 여부에 따라 수술이나 방사선치료가 계획되었다. 결과: 임상적 완전 관해 23.9%와 조직학적 완전 관해 13.0%를 포함하여 82.6%의 환자에서 임상적으로 반응을 보였다. 모든 대상환자에서 항암요법 후 수술이 가능하였으며 항암요법의 가장 흔한 부작용으로는 Grade 1 이나 2의 오심과 구토증상이었다 (86.8%). 28개월의 중간 추적 관찰기간에 3년 무병생존율과 전체생존율은 각각 74.0%와 80.0%이었다. 초기의 종양 크기, 병리조직검사에서의 림프절 전이, 자궁방 침범 등이 무병생존율과 유의한 상관관계를 나타내었다 (P = 0.001, P = 0.040, P = 0.000, respectively). 수술 후 위험인자가 없는 경우에 시행한 보조방사선치료는 생존율의 향상을 가져오지 않았고 결과적으로 26명 (56.5%)의 환자는 방사선치료 없이 치료를 종결할 수 있었던 환자였다. 결론: 국소적으로 진행되었거나 bulky한 자궁경부암에서 선행보조 화학요법으로써의 MVC 병합요법은 심각한 부작용 없이 투여될 수 있으며 종양의 범위를 감소시켜 수술을 가능하게 하는데 효과적이었다. Objective: The efficacy and toxicity of neoadjuvant chemotherapy (NAC) with mitomycin-C, vincristine and cisplatin (MVC) were assessed in bulky cervical carcinoma patients. Methods: Forty-six patients with stage Ib2 to IIb bulky cervical cancer were treated with intravenous combination of mitomycin-C 10 mg/m2, vincristine 1 mg/m2 and cisplatin 75 mg/m2 every three weeks. Results: All 46 patients enrolled in this study underwent surgery after NAC. Toxic nonhematologic reactions consisted primarily of grade 1-2 nausea and vomiting (86.8%). Clinical responses occurred in 82.6% (38/46) of patients, including 23.9% (11/46) with a complete response (CR) and 13.0% (6/46) with a pathologically determined complete response. For a median follow up period of 28 months, the 3-year disease-free and overall survival rates were 74.0% and 80.0%, respectively. Pathologically confirmed lymph node metastasis or parametrial involvement or an initial tumor size ≥ 16 cm2 were associated with shorter disease-free survival. Adjuvant postoperative RT did not show a survival benefit in patients who had no indications for adjuvant therapy after surgery. Conclusion: Intravenous administration of MVC as a NAC seems to be well tolerated and beneficial in patients with loco-regionally advanced cervical cancer.

파형에 따른 말초성 안면신경마비의 전침 복합 치료 효과

최철훈,송호섭 대한침구의학회 2010 대한침구의학회지 Vol.27 No.5

Objectives : This study was to compare the effect of electroacupuncture therapy on peripheral facial paralysis according to the wave forms. Methods : We investigated 56 cases of inpatients with Peripheral Facial Paralysis, and divided them into two groups, One group was treated by electroacupuncture on interrupted wave, and the other was treated by electroacupuncture on dense-dispersed wave. We evaluated the effect of electroacupuncture in each group by using Gross Grading System of House-Brackmann and Yanagihara’s Unweighed Grading System. Results :1. In the interrupted wave and the dense-dispersed wave, compared with baseline, at final, Gross Grading System of House-Brackmann was significantly decreased and Yanagihara’s Unweighed Grading System was significantly increased. 2. At final, Interrupted wave showed significant decrease on the Gross Grading System of House- Brackmann and significant increase on Yanagihara’s Unweighed Grading System compared with dense-dispersed wave. Conclusions : These results suggested that interrupted wave should be more useful for improving symptoms related with peripheral facial paralysis than dense-dispersed wave.

산(11)

최철훈 문예운동사 1989 문예운동 Vol.- No.41

말초성(末梢性) 안면신경마비(顔面神經麻痺)의 취혈부위(取穴部位)에 따른 구치료(灸治療) 효과(效果) 비교(比較)

최철훈,송호섭,Choi, Chul-Hoon,Song, Ho-Sueb 대한침구의학회 2008 대한침구의학회지 Vol.25 No.3

Objectives : This study was to compare the effect of moxibustion therapy on peripheral facial para- lysis according to location of acupoint. Methods : We investigated 41 cases of inpatients with Peripheral Facial Paralysis, and divided them into two groups, One group was treated by moxibustion on local point(ML), and the other was treated by moxibustion on distant point(MD). We evaluated the effect of moxibustion in each group by using Gross Grading System of House-Brackmann(HB score) and Yanagihara's Unweighed Grading System(Y score). Results : 1. In ML and MD, compared with baseline, at final, HB score was significantly decreased and Y score was significantly increased. 2. At final, ML showed significant decrease on HB score and significant increase on Y score compared with MD. Conclusions : These results suggested that ML should be more useful for improving symptoms related with peripheral facial paralysis than MD.

合谷刺와 蜂藥鍼으로 치료한 수근관 증후군 환자 4례

최철훈,송호섭 대한침구의학회 2010 대한침구의학회지 Vol.27 No.3

Objectives : This study was to observe the effect of Hapgok needling and Bee Venom Acupuncture on a patient with neuralgia caused by Carpal Tunnel Syndrome. Methods : The patient were treated by Hapgok needling and Bee Venom Acupuncture at acupunture points following diagnosed as Carpal Tunnel Syndrome. Improvement of the symptoms was evaluated by VAS. Results : Carpal Tunnel Syndrome related symptoms of the patient were remarkably improved by Hapgok needling and Bee Venom Acupuncture therapy. Conclusions : These results suggested that Hapgok needling and Bee Venom Acupuncture should be one of the useful treatment methods for relieving the symptoms of Carpal Tunnel Syndrome.

B형 간염 표면 항원 양성자에서 편지를 이용한 추적 검진 권고의 효과

최철훈,송윤미,오주섭,변재준 대한가정의학회 2000 Korean Journal of Family Medicine Vol.21 No.9

Melittin Inhibits DU-145 Human Refractory Prostate Cancer Cell Growth Through Induction of Apoptosis Via Inactivation of NF-κB

최철훈,송호섭 대한침구의학회 2009 대한침구의학회지 Vol.26 No.3

목적 : 이 연구는 봉약침의 주요성분인 멜리틴이 NF-κB의 활성억제를 통하여 세포자멸사를 유도하고, 전립선 암세포주인 DU-145 세포의 성장을 억제하는지를 확인하고 멜리틴의 NF-κB 활성억제기전을 살펴보고자 하였다. 방법 : 멜리틴을 처리한 후 DU-145의 성장억제를 관찰하기 위해 WST-1 assay를 시행하였고, 세포자멸사의 관찰에는 DAPI staining assay를 통한 세포형태관찰을 시행하였으며, 염증관련유전자 발현 관찰에는 western blot analysis를 시행하였고, 세포자멸사와 연관된 NF-κB의 활성 변화를 관찰하기 위해 EMSA와 luciferase assay를 시행하였으며, DU-145에서 멜리틴과 NF-κB의 상호작용을 관찰하기 위해 transient transfection assay를 시행 시 세포생존율과 NF-κB의 활성 변동을 측정하였다. 결과 : DU-145 세포에 멜리틴을 처리한 후, 전립선암세포의 성장, 세포자멸사의 유발, 염증관련유전자 발현 및 NF-κB의 활성, NF-κB의 p50 치환 후 NF-κB의 활성과 DU-145 세포 증식에 미치는 영향을 관찰하여 다음과 같은 결과를 얻었다. 1. DU-145 세포에서 멜리틴을 처리한 후 세포자멸사가 유도되어 세포성장이 억제되었다. 2. DU-145 세포에서 멜리틴을 처리한 후 염증관련유전자 발현 및 NF-κB의 활성에 유의한 감소를 나타내었다. 3. DU-145 세포에서 NF-κB의 p50와 IKK들을 치환하여 작용기를 없애고 멜리틴을 처리하였을 경우에도 세포활성 및 NF-κB의 활성의 유의한 감소를 나타내었다. 결론 : 이상의 결과는 멜리틴이 NF-κB의 활성 억제를 통하여 인간 전립선암 세포주인 DU-145의 세포자멸사를 유발함으로써 증식억제 효과가 있음을 입증한 것으로 전립선암의 예방과 치료에 대한 효과적인 치료제 개발에 도움이 될 것으로 기대된다. 다만 그 기전에서 멜리틴은 기존연구와 달리 NF-κB p50 및 IKK들의 작용기와 직접적으로 상호작용을 하지는 않는 것으로 보이므로 심화 연구를 요한다.

동백

최철훈 문예운동사 1990 문예운동 Vol.- No.42

포석정 회고

최철훈 문예운동사 1993 문예운동 Vol.- No.49