http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
내시경 점막하 박리술 시행 전 위선종과 점막암종에서 혈청 IL-6, VEGF, CRP의 예측인자로서의 중요성
장진석 ( Jin Seok Jang ),최석렬 ( Seok Reyol Choi ),한상영 ( Sang Young Han ),노명환 ( Myung Hwan Roh ),이종훈 ( Jong Hoon Lee ),이성욱 ( Sung Wook Lee ),정진숙 ( Jin Sook Jeung ),김민찬 ( Min Chan Kim ),손영기 ( Young Ki Son ) 대한소화기학회 2009 대한소화기학회지 Vol.54 No.2
Background/Aims: Endoscopic submucosal dissection (ESD) is commonly used for radical resection of gastric adenoma and mucosal cancer, but there is about 30% of discrepancy rate between the histology of the endoscopic biopsy and that of the resected specimen obtained from the same lesion by ESD. The aim of this study was to clarify the clinical significance of IL-6, VEGF, CRP before ESD. Methods: We investigated the correlation between serum IL-6, VEGF, CRP level and discrepancy rate of gastric neoplastic lesions (10 low-grade dysplasias, 18 high-grade dysplasias, and 25 early gastic cancers). Results: Serum levels of IL-6 in gastric adenoma and mucosal cancer patients were significantly higher than in healthy controls (p<0.05). Especially, serum IL-6 level of high-grade dysplasia patient was significantly higher than low-grade dysplasia and mucosal cancer patients, and the positive rate, sensitivity, and negative predictive value of serum IL-6 levels were higher in high-grade dysplasia patient compared to low-grade dysplasia patient and mucosal cancer patient. Serum levels of VEGF in patients with gastric adenoma and mucosal cancer were significantly higher than healthy controls (p<0.01). Serum levels of CRP in patients with mucosal cancer were significantly higher than in the controls (p<0.05), and the positive rate, sensitivity, and positive predictive value of serum CRP levels were higher in high-grade dysplasia and mucosal cancer patients compared to low-grade dysplasia patient. Conclusions: Serum levels of IL-6, VEGF, and CRP in patients with gastric neoplastic lesions were significantly higher than healthy controls, especially, serum IL-6 level of high grade dysplasia patient was significantly higher than low-grade dysplasia and mucosal cancer patients. (Korean J Gastroenterol 2009;54:99-107)
김기한,김민찬,최석렬,정갑중,김형호,Kim, Ki-Han,Kim, Min-Chan,Choi, Seok-Reyol,Jung, Ghap-Joong,Kim, Hyung-Ho 대한위암학회 2003 대한위암학회지 Vol.3 No.4
Purpose: Preoperative staging of gastric cancer is crucial because the treatment modality and the prognosis depend upon the stage of gastric cancer. Current treatment modalities for early gastric cancer have focused on the quality of life. Endoscopic ultrasonography (EUS) and abdominal computed tomography (CT) are commonly used diagnostic tools to evaluate the invasiveness (T stage) of the primary tumor. The purpose of this paper is to evaluate the sensitivity and the specificity of preoperative EUS and CT in comparison with postoperative pathology. Materials and Methods: From October 2001 to October 2002, EUS and abdominal CT were performed simultaneously on 75 patients who underwent radical gastric surgery for the treatment of gastric cancer. Through analyzing the clinical T stage and the pathologic T stage, We evaluated the diagnostic sensitivities and specificities of endoscopic ultrasonography and abdominal computed tomography. Results: The male-to-female sex ratio was 1 : 0.6 (males: 47, females: 28). The mean age was 55.4 years in males (range: $28\~81$) and 54.4 years in females (range: $23\∼77$). The clinical T stage based on EUS included 22 T1mm, 7 T1sm, 22 T2, and 24 T3. The clinical T stage based on CT included 20 Tx, 23 T2, and 32 T3. The permanent pathologic report confirmed 23 T1mm, 10 T1sm, 17 T2, 24 T3, and 1 T4. The sensitivity and specificity of EUS were $84.2\%\;and\;94.7\%$, respectively. However, the sensitivity and specificity of abdominal CT were $53.3\%\;and\;77.0\%$, respectively. Conclusion: Our data suggest that EUS is a very useful diagnostic tool for evaluating the T stage of gastric cancer because EUS has higher specificity than abdominal CT. Therefore, EUS may have a significant role as a preoperative diagnostic modality in patients undergoing minimally invasive surgery.
장진석 ( Jin Seok Jang ),이은주 ( Eun Joo Lee ),이성욱 ( Sung Wook Lee ),이종훈 ( Jong Hun Lee ),노명환 ( Myung Hwan Roh ),한상영 ( Sang Young Han ),최석렬 ( Seok Reyol Choi ),정진숙 ( Jin Sook Jeong ) 대한소화기학회 2007 대한소화기학회지 Vol.49 No.6
목적: 내시경점막하박리법(endoscopic submucosal dissection, ESD)은 큰 병소를 일괄절제할 수 있다는 장점이 있으나 시간이 오래 걸리고, 출혈과 천공과 같은 합병증의 발생률이 높다. 저자들은 위선종과 조기위암에서 ESD의 치료성적을 분석하여 ESD의 효율성과 안전성에 대해 알아보고자 하였다. 대상 및 방법: 2003년 1월부터 2005년 12월까지 동아대 학교병원에 입원하여 위선종 및 조기위암으로 진단되어 ESD을 받은 101명의 환자에서 총 101예의 병변을 대상으로 후향으로 조사하였다. 결과: 1) ESD가 시행된 병변의 평균 크기는 2.58 cm였다. 2) ESD군의 일괄절제율은 90.1%였으며, 이는 병변의 크기가 큰(≥3 cm) 경우에 유의하게 감소하였다. 3) 완전절제율은 83.2%로, 병변 크기에 따른 차이는 없었으나 저도형성이상과 고분화형조기위암에서 특히 완전 절제율이 높았다. 4) 출혈은 41.6%로 응급 수술이 필요할 만큼의 유의한 출혈은 없었고, 내시경 치료로 쉽게 지혈하였다. 5) 재발률은 2.0%였다. 결론: ESD법은 조기위암과 위선종의 치료법으로 효과적이고 비교적 안전한 방법으로 향후 장기적인 추적 관찰이 필요하다. Background/Aims: Endoscopic Submucosal Dissection (ESD) is a new endoscopic mucosal resection (EMR) technique which enables en bloc resection even in large and depressed lesions. The aims of this study were to assess the therapeutic efficacy and the safety of ESD in gastric adenoma and in early gastric cancer (EGC). Methods: We analyzed 101 lesions in 101 patients. ESD with insulated-tipped (IT) knife were performed in 52 adenomas and 49 EGCs from January 2003 to December 2005 in Dong-A University Hospital. Results: The mean size of the lesion was 2.58 cm (0.7-4.5 cm). En bloc resection rate was 90.1% which was influenced by size (p>0.05). Complete resection rate was 83.2% even in large or in malignant tumors (p>0.05). Bleeding after ESD occurred in 41.6%. Tumor recurrence rate was 2.0%. Conclusions: ESD with IT knife is effective for the treatment of EGC and gastric adenoma even in large or in malignant lesions without definite increased risk of complications. (Korean J Gastroenterol 2007;49:356-363)
김광진 ( Kwang Jin Kim ),최석렬 ( Seok Reyol Choi ),손승현 ( Seung Hyun Sohn ),이상 ( Sang Lee ),홍기봉 ( Ki Bong Hong ),금동주 ( Dong Joo Keum ),지삼룡 ( Sam Ryong Jee ),이종훈 ( Jong Hoon Lee ),한상영 ( Sang Young Han ),신우원 대한소화기학회 2002 대한소화기학회지 Vol.40 No.6
Neurofibromatosis type I is an autosomal dominant disorder that occurs once in 3,000 births. It is characterized by neurofibromas and caf?au lait spots of the skin. Neurofibromatosis type I gene is a tumor suppressor gene. Patients with neurofibromatosis type I are at an increased risk of developing neural neoplasms including optic glioma, astrocytoma, acoustic neuroma, neurilemmoma, and meningioma. The patients with neurofibromatosis type I showed high incidence of Wilm`s tumor, rhabdomyosarcoma, leukemia, and pheochromocytoma but rare incidence of colon cancer. We experienced a case of sigmoid colon cancer and multiple adenomatous polyps of the colon in a patient with sporadic neurofibromatosis type I. (Korean J Gastroenterol 2002;40:402-405)
위암 환자에서 Chronotherapy 의 부작용에 대한 고찰
윤욱돈(Uk Don Yun),최석렬(Seok Reyol Choi),지삼룡(Sam Ryong Jee),박성욱(Seong Wook Park),이태영(Tae Yeong Lee),이종훈(Jong Hun Lee),한상영(Sang Young Han) 대한소화기학회 2002 대한소화기학회지 Vol.40 No.4
Backgroud/Aims: Gastric cancer is one of the most common malignancy in Korea. In many reports, it has been known that chemotherapy does not improve survival rate of patients with gastric cancer. However, some Japanese reports showed that chemotherapy was effective. Side effects of chemotherapy increase with escalating dosage of chemotherapy drugs. There are some reports that chronotherapy could reduce the side effects and improve the survival rate in patients with gastric or colorectal cancer. We studied the side effects of chronotherapy in patients with gastric cancer. Methods: Fourteen patients with previously untreated gastric cancer received chronomodulated 5-FU ( 900 mg/m2/day, day 1-5) and cisplatin ( 90 mg/m2, day 1). Thirteen patients of control group received 5-FU ( 600 mg/m2/day, day 1-5) and cisplatin ( 60 mg/m2, day 1) during the daytime. The side effects of the two groups were evaluated for nausea and vomiting, diarrhea, peripheral neuropathy, mucositis, leukopenia, anemia, thrombocytopenia, and serum creatinine. Results: Compared to the control group, chronotherapy-treated group showed statistically significant decrease in nausea and vomiting ( p= 0.037), but not in others. Conclusions: Although only the incidence of nausea and vomiting was decreased significantly in the chronotherapy group, chronotherapy could be effective in reducing the side effects of chemotherapy in patients with gastric cancer considering that higher doses of drugs were used in the chronotherapy-treated group. ( Korean J Gastroenterol 2002; 40: 236-240)
식도절제술 환자에서 식도내압 및 위배출시간에 대한 고찰
지삼룡 ( Sam Ryong Jee ),최석렬 ( Seok Reyol Choi ),김광진 ( Kwang Jin Kim ),금동주 ( Dong Joo Keum ),홍기봉 ( Ki Bong Hong ),이종훈 ( Jong Hun Lee ),한상영 ( Sang Young Han ),최필조 ( Pill Jo Choi ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
〈목적〉 식도절제술은 식도암에 있어서 장기생존 및 증상의 호전을 위하여 치료원칙이 되며, 증상의 호전을 위한 고식적 수술로도 시행된다. 또한, 식도의 양성 협착 질환이나 식도 천공의 치료법으로도 행해진다. 그러나, 식도절제술후의 식도 운동기능의 양상과 위배출능에 대한 국내문헌은 찾아보기 힘든 실정이다, 이에 저자들은 식도절제술후 호소하는 증상과 식도내압 및 위배출시간과의 연관성을 알아보고자 하였다. 〈방법〉 1994년 10월부터 1998년 11월 사이에
5-FU 내성 대장암 세포주에서 생물학적 지표로서 단백 분해효소발현의 유용성
조몽(Mong Cho),최석렬(Seok Reyol Choi),이주일(Joo Il Lee),이철종(Cheol Jong Lee),김영식(Young S Kim) 대한내과학회 1999 대한내과학회지 Vol.57 No.3
There have been many reports that colon cancer responds poorly to chemotherapy. Several classes of matrix metalloproteinases(MMPs) have been implicated in the process of invasion of epithelial and endothelial basement membranes in several steps of tumor invasion and metastasis. This study was performed to determine the biologic behavior and the histopathological characteristics of a 5-FU resistant colon cancer cell line. Methods : We performed several biologic assays including liver colonization assay, cell adhesion assay, invasion assay and zymogram for protease activity using parental HT29 cell and 5-FU resistant HT29 cell (HT29-FU cell). Results : In liver colonization assay, HT29-FU cell revealed a 2.5-fold increase in the liver weight and tumor burden compared with HT29 cell. HT29-FU cell showed moderate increase in adhesion and invasion assays in comparison to HT29 cell. HT29-FU cell revealed increased activity of MMPs and serine protease. Xenograft tumors of HT29-FU cell formed moderately differentiated adenocarcinoma with more glandular formations of mucin. Conclusion : The increased expression of MMPs in 5-FU resistant colon cancer cell can explain poor prognosis. These are potentially poor prognostic indicators in 5-FU resistant colon cancer. Consequently, it can be suggested that modulation of MMPs is needed to prevent invasion and metastasis in colon cancer by using inhibitors of these enzymes. (Korean J Med 57:323-332, 1999)
지삼룡(Sam Ryong Jee),최석렬(Seok Reyol Choi),유승훈(Seung Hoon Ryu),박은희(Eun Hee Park),장진석(Jin Seok Jang),이종훈(Jong Hun Lee),한상영(Sang Young Han),신우원(Woo Won Shin) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.3
The hyperplastic gastric polyps comprise approximately 75% of all gastric epithelial polyps. However, coincidental gastric carcinoma has been rarely reported, being found in 1.5%-2.1% of patients with hyperplastic polyps. The size and the pathology of polyps seem to be important in the application of endoscopic removal. We present a 58-year-old female with well differentiated adenocarcinoma arising from a 1.0cm-sized hyperplastic polyp in the stomach. On the gastroscopic examination, five polyps were noted and their sizes ranged from 0.3cm to 1.0cm. She underwent the endoscopic polypectomy with snare or strip biopsy. Microscopically, focal cancerous change was observed in the largest one (1 cm size, Yamada’s type IV) on the greater curvature of the lower body. (Korean J Gastroenterol 2001;38:207-210)
장채령 ( Chae Ryeong Jang ),최석렬 ( Seok Reyol Choi ),조정환 ( Jeong Hwan Cho ),구영훈 ( Young Hun Koo ),한승호 ( Seung Ho Han ),유승훈 ( Seung Hoon Ryu ),이동현 ( Dong Hyun Lee ),장진석 ( Jin Seok Jang ),이종훈 ( Jong Hun Lee 대한소화기학회 2005 대한소화기학회지 Vol.45 No.6
Villous tumors of the stomach are somewhat rare with approximately 100 cases only reported in the literatures and have tendency to undergo malignant transformation as high as 72%. They are frequently multiple and associated with other gasrtrointestinal ne