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전력선 단선으로 인한 이상시 송전철탑의 안전성 평가방법
진석원,김종민,박종섭,강영종,Jin, Seok Won,Kim, Jong Min,Park, Jong Sup,Kang, Young Jong 한국강구조학회 2008 韓國鋼構造學會 論文集 Vol.20 No.1
최근 급증하는 전력수요 충족을 위해 송전선로 및 송전철탑의 대형화가 진행되고 있다. 국내 송전철탑 설계기준에서는 선로방향하중에 대해 상시와 이상시로 구분하여 검토하고 있다. 송전철탑 붕괴의 가장 큰 원인이 되고 있는 선로 단선으로 인한 이상시 철탑 주재의 안전성 검토가 필요하다. 국내 설계기준은 축력이 지배적인 트러스요소를 철탑에 적용하고 있으며, 단선으로 인한 불평형 하중을 암끝단에 재하하도록 하고 있다. 불평형 하중을 유발하는 단선은 두 곳에서 동시에 발생하는 경우까지 고려하고 있으며, 그 이상 여러 상의 전선이 동시에 단선되는 것은 고려하고 있지 않다. 이에 본 연구는 발생 가능한 모든 단선의 경우에 대해서 보요소를 적용한 유한요소해석을 실시하여 극한상태를 파악하고 국내 설계기준에 따른 안전성를 평가하였다. 유한요소해석 결과분석을 통해 철탑 주주재에는 이상시 휨응력의 영향력이 매우 크게 나타났으며, 비대칭 일측의 모든 전선이 단선된 경우 기존 철탑의 설계방법이 안전하지 않음을 알 수 있었다. 따라서 이상시 철탑의 경제성과 정확한 안전성 확보를 위해 부재의 극한상태와 이상시 발생빈도를 고려하는 설계법의 적용이 필요할 것으로 판단된다. A transmission tower was designed according to general and special load cases based on KEPCO Design Specifications. The special load case such as unbalanced load a cording to some broken wires has not been considered significantly. Therefore, this paper presents investigations on the stability and safety of main post members subjected to unbalanced load and design wind load. In this study, all cases totally considered. From the finite element analyses using LUSAS program, the stresses on the tower subjected to unbalanced load and design wind load were very high in comparison to the allowable stresses of the steel post member that was used. Some of the post member had higher stresses than the yield stress of the steel member. This paper also shows an example to improve the capacity of the post members using increased cross-section members. Based on the analyses results, when investigating the safety of the transmission tower, one must consider thenew design philosophy including ultimate strength of the member and reliability of the special loading cases.
A Tale of Two Models: Mouse and Zebrafish as Complementary Models for Lymphatic Studies
김준대,진석원 한국분자세포생물학회 2014 Molecules and cells Vol.37 No.7
Lymphatic vessels provide essential roles in maintaining fluid homeostasis and lipid absorption. Dysfunctions of the lymphatic vessels lead to debilitating pathological conditions, collectively known as lymphedema. In addition, lymphatic vessels are a critical moderator for the onset and progression of diverse human diseases including metastatic cancer and obesity. Despite their clinical impor-tance, there is no currently effective pharmacological therapy to regulate functions of lymphatic vessels. Recent efforts to manipulate the Vascular Endothelial Growth Factor-C (VEGFC) pathway, which is arguably the most important signaling pathway regulating lymphatic endo-thelial cells, to alleviate lymphedema yielded largely mixed results, necessitating identification of new targetable signaling pathways for therapeutic intervention for lym-phedema. Zebrafish, a relatively new model system to investigate lymphatic biology, appears to be an ideal model to identify novel therapeutic targets for lymphatic biology. In this review, we will provide an overview of our current understanding of the lymphatic vessels in verte-brates, and discuss zebrafish as a promising in vivo model to study lymphatic vessels.
Zebrafish as an Emerging Model for Dyslipidemia and Associated Diseases
Jun Ka,진석원 한국지질동맥경화학회 2021 지질·동맥경화학회지 Vol.10 No.1
Dyslipidemia related diseases such as hyperlipidemia and atherosclerosis are the leading cause of death in humans. While cellular and molecular basis on the pathophysiology of dyslipidemia has been extensively investigated over decades, we still lack comprehensive understanding on the etiology of dyslipidemia due to the complexity and the innate multimodality of the diseases. While mouse has been the model organism of choice to investigate the pathophysiology of human dyslipidemia, zebrafish, a small freshwater fish which has traditionally used to study vertebrate development, has recently emerged as an alternative model organism. In this review, we will provide comprehensive perspective on zebrafish as a model organism for human dyslipidemia; we will discuss the attributes of zebrafish as a model, and compare the lipid metabolism in zebrafish and humans. In addition, we will summarize current landscape of zebrafish-based dyslipidemia research.