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에탄올이 신경아세포종 B103세포의 Protein Kinase C Isozyme 활성에 미치는 영향
조효정(Hyo-Jung Cho),정영진(Young-Jin Chung),진승하(Sung-Ha Jin),오우균(Woo-Kyun Oh),김상원(Sang-Won Kim),강은정(Eun-Jung Kang),박진규(Jin-kju Park) 한국식품영양과학회 2004 한국식품영양과학회지 Vol.33 No.2
에탄올이 지속적으로 뇌 신경세포에 미치는 영향을 조사하기 위하여 흰쥐의 신경세포로부터 유래 된 B103 neuroblastoma cell을 사용하여 세포독성이 나타나지 않는 에탄올 농도(0, 50, 100, 200 mM)에서의 1, 2, 8, 18, 24시간 경과에 따라 유도되는 PKC α, γ, ε, ζ isozyme들의 양을 세포질분획과 세포막 분획으로 나누어 Western blot으로 각각 분석하였다. 100 mM의 에탄올 농도에서 분석된 PKC isozyme들 중 PKC-γ는 18시간대의 세포질에서, 그리고 PKC-ε은 8~18시간대의 세포막분획에서 각각 현저한 유도현상을 보였다. PKC-α는 200 mM의 에탄올 첨가 후 18시간과 24시간에 세포질과 세포막 분획에서 모두 대조군의 150%까지 현저한 증가를 나타낸 반면 PKC-ζ는 100, 200 mM 에탄올 농도에서 배양(18, 24시간 동안)한 세포의 세포막분획에서만 유도되었다. 그리고 50, 100, 200 mM의 에탄올 농도에서 24시간동안 배양한 세포질 분획에서 PKC-γ는 농도 의존적으로 감소하여 200 mM의 에탄올 농도에서는 대조군의 47%까지 현저한 감소를 나타내었으며, 세포내에 세포독성을 나타내지 않는 농도 특히 100~200 mM 농도범위의 에탄올을 첨가하여 24시간 동안 지속적으로 배양할 때 PKC-γ 및 ε이 관련된 신호전달체계가 억제됨을 보였다. 이는 에탄올이 PKC isozyme들의 상호간 조절을 통해 신호전달계 또는 신경전달 물질들의 변화에 영향을 줄 수 있음을 시사하며 에탄올의 중추신경계에 미치는 지속적 영향으로 나타나는 행동장애 및 뇌기능의 손상 또는 보호과정에 PKC-isozyme들이 관여할 수 있음을 시사한다. It is well known that long-term heavy ethanol intake causes alcoholic dementia, cerebellar degeneracy or Wernicke-Korsakoff syndrome and aggravates the conditions of many other neuro-psychotic disorders. Recently it is indicated that protein kinase C (PKC) plays an important role in the action of ethanol and in the neuro-adaptational mechanisms under chronic ethanol exposure. In order to investigate the effect of ethanol on PKC isoforms levels within the range of not showing any cytotoxicity, B103 neuroblastoma cell line transformed from murine central nervous system was employed and western blot analysis was carried out by using PKC isoform-specific antibodies. The changes of PKC-α, γ, ε and ζ level in the range of ethanol concentration 50~200 mM were examined at the exposure time 1, 2, 8, 18 and 24 hrs in both cytosolic and membrane fraction. A typical ethanol concentration inducing the PKC isozymes was 100 mM, and the transforming time ranges of PKC isozymes could be considered as two different parts to each PKC isoform such as initial (0~2 hrs) and prolonged (8~24 hrs) stages. PKC-γ and PKC-ε were clearly induced during the prolonged stages in cytosol at 18 hrs, and membrane fraction at 8 hrs and 18 hrs, respectively. On the other hand the PKC-α and PKC-ζ isozymes were largely induced in the prolonged stages at 18 hrs and 24 hrs, where the PKC-α isozyme was induced in both cytosol and membrane fractions at 200 mM ethanol concentration while the PKC-ζ isozyme was induced only in the membrane fractions at 100, 200 mM. At 200 mM ethanol concentration of 24 hrs incubation in the prolonged stage, the PKC-α was maximally induced by 150% of the control values whereas the PKC-γ was significantly decreased to 47% of the control values. These results suggest that 100~200 mM ethanol may modulate the signal transduction and neurotransmitter release in the central nervous system through the regulation of PKC isozymes, and the action of these isoforms may act differently each other in the cell.
자기애 성향에 따른 외모에 대한 사회문화적 태도 및 의복추구혜택에 관한 연구
조효정 ( Hyo Jung Cho ),조남혜 ( Nam Hae Cho ) 복식문화학회 2015 服飾文化硏究 Vol.23 No.1
The purpose of this study was to investigate the differences in female college students’ sociocultural attitude toward appearance and pursuit of clothing benefits according to their narcissism. Data collection was conducted through survey for female college students, and a total 221 questionnaires were used for data analyses. For analysis of data, frequency analysis, factor analysis, reliability analysis, and one-way ANOVA were applied. The results were summarized as follows. First, the factor analysis on narcissism resulted in two dimensional structures: self-initiated and other-dependent narcissism. The respondents were categorized into four narcissism groups, such as compositive, self-initiated, other-dependent, and withdrawn narcissism groups. Second, the factor analysis on sociocultural attitude toward appearance resulted in two dimensional structures: internalization and awareness. Five dimensions of pursuit of clothing benefits were identified: individuality, self-expression, fashion, comfort, and social recognition pursuit. Third, there were significant differences among the categorized narcissism groups in sociocultural attitude toward appearance and pursuit of clothing benefits. The results confirm that narcissism has an impact on sociocultural attitude toward appearance and pursuit of clothing benefits. It is expected that this study provides insight for apparel makers or retailers to develop their marketing strategies.
한국 섬유공학교육의 혁신을 위한 학회의 역할: 거시적 접근
류동일,조효정,정찬희,신윤숙,Yoo, Dong Il,Cho, Hyo Jung,Jung, Chan Hee,Shin, Younsook 한국섬유공학회 2015 한국섬유공학회지 Vol.52 No.5
The influx of innovation is urgently required to the fiber(textile) engineering education in Korea. In this review, we analyzed the present situation of both the industrial (engineering) ecosystem and the engineering education, and forecasted the direction where the fiber engineering education is going on. Rapid changes such as an increase in income level, a decrease in birth-rate, and reshaping the human lifestyle are taking place in Korea. Continuous improvement is required to the contents and the objectives of engineering education in each program. There are some serious problems for most of the students in universities, including a reduction in the credits for graduation, numerical decrease in entrance as well as graduation, the longer duration in universities, the increase in the unemployment ratio, the paradigm shift in education environment. To cope with the tremendous changes in industrial (engineering) ecosystem, we suggest that an expansion of using convergence technology, specialization for differentiation in education, improvement of educational content, and selective induction of an engineering accreditation system with the help of academic society are inevitable for the sustain-ability of fiber (textile) engineering education.
Predicting In-Hospital Drug-Induced Liver Injuries Using Long-Short Term Memory
Dulguun Dorjlkham(도르즐캄둘군),Juwon Baek(백주원),Hyo Jung Cho(조효정),Soon Sun Kim(김순선),Ji Eun Han(한지은),Jae Youn Cheong(정재연),Min Seo Shim(심민서),Kyoung Jin Lee(이경진),Tae Hyun Kim(김태현),Chi Yong Ban(반치용),Charmgil Ho 한국정보과학회 2022 한국정보과학회 학술발표논문집 Vol.2022 No.12