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실험적으로 유발한 가토의 급성 상악동염에서 sialoglycoconjugates의 표현양상
조진학,황순재 고려대학교 의과대학 1996 고려대 의대 잡지 Vol.33 No.1
The present study was carried out in order to observe the changes in the expression of the sialoglycoconjugates of the rabbit sinus mucosa in the acute maxillary sinusitis model utilizing a biotin labeled lectins for light microscopy and lectin-gold complexes for eletron microscopy with three different lectins; Maackia amurensis (MAA), Wheat germ agglutinin (WGA) and Sambucus nigra (SNA). A comparison of the affinity of these lectins demonstrated the different distribution of sialoglycoconjugates in the ciliary layer and goblet cells. The normal sinus mucosa stained with three types of lectins showed that the sialoglycoconjugates were mainly distributed in the ciliary layer and goblet cells, and that their ultrastructural localization was restricted to the surface of the cilia, microvilli and secretory granules. Moreover, the main sugar residues of the sialoglycoconjugates were found to be consisted of Neu5Ac( 2,3)Gal, GlcNAc and Neu5Ac. Influenza A virus infection decreased the staining intensity of the mucosa with MAA, but not with WGA. In sinus mucosa infected with S. pneumoniae 7 days after Influenza A virus inoculation, however, these findings reverted to the staining intensity shown in the normal sinus mucosa. In addition, there was a hypersecretory activity of the hyperplastic and hypertrophic goblet cells which showed the intense reactivity with MAA and WGA. All of these changes in the staining intensity were also confirmed by the electron microscopic lectin-gold complexes. These results suggest that Neu5Ac(a2,3)Gal sugar residues may be required as protecting factor or modulator for Influenza A virus and s. pnumoinae infectivity.
A Case of Intranasal Angiofibroma -The Expression of Argurophilic Nucleolar Organizer Regions-
조진학,우광희,정인교,조진생,박경유 대한비과학회 1994 Journal of rhinology Vol.1 No.2
The angiofibroma is an unusual destructive but essentially benign neoplasm, mostly seen in the nasopharynx of adolescent males. Its occurrence within the nasal cavity as a primary tumor is extremely rare. The aim of this study is to describe the clinicopathological features and discuss the origin of this tumor as finding out the analysis of Argyrophilic nucleolar organizer regions(AgNORs) of the fibroblasts and endothelial cells of this rare tumor. The result of the analysis of AgNORs of the two components indicated that the fundamental elements were both of fibroblast cells and the vascular endothelial cells.
조진학,김수진 대한비과학회 1998 Journal of rhinology Vol.5 No.1
This study was conducted in order to observe ultrastructural changes in the expression of sialoglycoconjugates in maxillarysinus mucosa after inoculation of influenza A virus utilizing four different gold-labeled lectins:maackia amurensis (MAA),wheat germ agglutinin (WGA), sambucus nigra (SNA), and peanut agglutinin (PNA). A comparison of the affinities of thesegold-labeled lectins demonstrated the varying distributions of sialoglycoconjugates in the ciliary layer and the granules in gobletcells. Examination of normal sinus mucosa labeled with four gold-labeled lectins showed the distribution of sialoglycoconjugatesto be mainly in the ciliary layer and the granules in goblet cells and restricted to the surface of the cilia, microvilli and the secretorylight granules. The application of an influenza A virus infection decreased the labeling intensity of gold-labeled MAA inthe cilia and the secretory granules but not of WGA. SNA gold did not label the surface of the cilia and granules in either case. PNA gold particles, however, labeled the cilia and the secretory granules very weakly in normal sinus mucosa, but labeled moderatelyin cases of influenza A virus infection. These results suggest that the sugar residues of sialoglycoconjugates consist ofNeu5Ac(α2, 3)Gal, GlcNAc, Neu5Ac. They also suggest that the sugar residues serve as a protecting factor or modulator againstinfluenza A virus infection.
Inverted Papilloma Originating from the Nasal Septum: Report of a Case Treated by Endoscopic Removal
조진학,김승현,조진생,박경유 대한비과학회 1996 Journal of rhinology Vol.3 No.2
Inverted papilloma of the nasal cavity and paranasal sinuses is an uncommon, histologically benign lesion. However, its local aggressiveness, high rate of recurrence and malignant transformation have led most surgeons to radical removal of the tumor by lateral rhinotomy and en bloc resection of the ethmoid labyrinth. Since the introduction of the nasal endoscopes and radiologic advances, several cases of inverted papillomas that are limited to the nasal cavity and medial wall of the maxillary sinus have been treated by endoscopic surgery. The authors experienced a 58-year-old male patient with inverted papilloma originating from the nasal septum, which was treated by endoscopic removal.