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조원용,김민자,임기권,노정우,최원층,김형규 대한내과학회 1987 대한내과학회지 Vol.32 No.3
To see whether there is any clinical difference between urban residency and rural residency in KHF, and between oliguric type and non-oliguric type in urban residency KHF, we reviewed 123 KHF patients from Jan., 1981 to Dec., 1985 In urban residency, 28 patients lived in a city and have never been outside the city since last 2 months. In oliguric type of urban residency, 14 patients had lesser than 400 ml of urine in a day. We reviewed clinical findings, labratory findings, treatment and prognosis in cases of two types in urban residency KHF. The results were as follows; 1) The total number of urban residency was 28cases (22.8%) in 123cases of KHF. 2) In urban residency, male to female ratio was 4.6:1 and most common in 3rd decade. 3) The oliguric type in urban residency is 14cases (50%) 4) On clinical findings, there were fever, nausea and abdominal pain commonly, and which were milder in non-oliguric type. 5) There were facial flushing, CVA tenderness and petechia commonly, and which were milder in nonoliguric type, 6) On labratory findings most cases showed leukocytosis, proteinuria and hematuria, and renal function were more deteriorated in oliguric type. 7) The non-oliguric patients were cured by supportive care except one cases, oliguric patients needed dialysis treatment in half cases. 8) Except two cases (7.8%), which were discharged moribundly due to prolonged shock state in oliguric type, the prognosis were good in both types of urban residency KHF, relatively.
실험적 급성 허혈성 신부전에서 칼슘 길항제의 투여가 신기능과 뇨 Prostaglandin E₂의 배설에 미치는 영향
조원용,김형규 고려대학교 의과대학 1990 고려대 의대 잡지 Vol.27 No.1
It has been proposed that calcium entry from the external medium increases intracellular free calcium to toxic levels during ischemic acute renal failure(ARF) , thereby converting cellular injury from a potentially reversible to an irreversible state. Because verapamil impedes calcium entrance into cells via voltage dependent slow calcium channels, it has been suggested that this agent may block calcium entry into renal cells, and protects renal function during ischemic injury. The renal prostaglandin E₂( PGE₂) is primarily synthesized in renal medulla and acts on kidney. The role of PGEz in ARF is well known as a compensatory system for an acute insult of the kidney. This study was designed to study the protective effect of systemic verapamil pretreatment on renal function and the influence on prostaglandin in experimental ischemic ARF in cats. And also the effect of the administration of piroxicam on the progress of ARF with verapamil pretreatment were evaluated. For these purpose, the experimental animals were divided into 3 groups, namely group Ⅰ (n=6) was ischemic ARF model by renal artery clamping for 60 minutes, group Ⅱ (n = 5) was ischmic ARF with systemic verapamil pretreatment (5㎍/min/kg), and gorup Ⅲ (n=7)was same as group Ⅱ with piroxicam pretreatment. The creatinine clearance and urinary PGE₂ were measured in each group before and after the renal artery clamp. 1. The creatinine clearance before and after the renal artery clamp were 10.79±7.19ml/min/kg and 2.09±l.70ml/min/kg in group Ⅰ , 3.41±1.56ml/min/kg and 0.12±0.05ml/min/kg in group Ⅱ and 6.30±5.60 and 0.80±0.70ml/min/kg. in group Ⅲ, respectively. 2. Creatinine clearance decreased significantly in group Ⅱ (96±2 % ) compared with group I (61±30%). 3. Urine PGE₂ in preischemic period of group Ⅰ 346±175ng/ml, group Ⅱ 159±102ng/ml, group Ⅲ 137±91ng/ml increased to group Ⅰ ; 355±ll4ng/ml, group Ⅱ 147±346ng/ml, group Ⅲ ; 355±114ng/mi in postischemic period. Urine PGE₂ excretion was relatively low in group Ⅱ and groupⅢ, compared with group Ⅰ , but not significant statistically. From these data, it was suggested that systemic verapamil pretreatment exerts no protective effect on ischemic ARF and that it may compromise compensatory mechanism of prostagiandin system in ischemic ARF.